KR100451885B1 - Extracts of pomegranate for stoping the hair from falling out and composition of cosmetics containing the extracts of pomegranate - Google Patents

Abstract

The present invention relates to a hair loss preventing pomegranate extract having a 5-alpha-reductase inhibitory activity and a cosmetic composition for preventing hair loss, comprising the same. According to the present invention, 5 alpha -ri which is the main cause of hair loss symptoms By suppressing the activity of ductase, it shows excellent hair loss prevention effect without causing any side effects in the human body.

[Index] Hair Loss Prevention, Pomegranate Extract, Cosmetics

Description

Hair loss prevention pomegranate extract and a cosmetic composition for preventing hair loss comprising the pomegranate extract {Extracts of pomegranate for stoping the hair from falling out and composition of cosmetics containing the extracts of pomegranate}

The present invention relates to a hair loss prevention pomegranate extract and a cosmetic composition for preventing hair loss, and more particularly, to a hair loss prevention cosmetic composition having an excellent effect of preventing hair loss by using an extract of pomegranate fruit and pomegranate seeds.

In modern society, as the occurrence of hair loss due to various effects such as stress, environmental pollution, drug addiction and misuse, perm, dyeing, use of hair dressings and genetic factors increases, interest in hair growth or hair growth increases. However, the medical knowledge and physiological effects of hair growth, hair growth have not yet made great progress.

There are two types of androgenetic alopecia, which are male hormone-dependent chronic type alopecia and hair loss caused by seborrheic dermatitis. The former is directly related to the amount of androgen hormones, and the latter is sebum-related disease. Testosterone, one of the male hormones, is dehydrotestosterone, one of the other male hormones, by 5 alpha-reductase. It is converted to dihydrotestosterone (DHT) and develops due to excess sebum production due to abnormal excess of this hormone.

Conventionally, antibacterial agents or exfoliants such as alpha hydroxy acid (AHA) and vitamin A have been used for the treatment of seborrheic dermatitis, but only a very limited amount is used due to the slight irritation or excessive skin irritation. It is used. Antimicrobials that are commonly used include antibiotics such as retracycline, and these antibiotics are known to have a high possibility of causing side effects such as bactericidal bleeding or photosensitivity.

In addition, studies have been reported to inhibit the activity of 5-alpha-reductase, which causes hair loss by converting testosterone to dihydrotestosterone (Yasuro sugimoto et al., Cation inhibit specifically type I 5α-reductase found in human skin, J. Invest.Dermatol., 104, 1995), its effect and effectiveness are known to be small and considerable care is required.

In addition, drugs to promote hair growth have already been disclosed, US Pat. No. 4,596,812 discloses Minoxidil of Upjohn Co. Ltd, and Japanese Patent No. 41/1985 discloses an odd carbon number. Eggplant discloses an alcohol and a derivative thereof, and Japanese Patent Laid-Open No. 20732/1986 discloses higher fatty acid alcohols having 22 to 34 carbon atoms. In addition, Korean Patent Publication No. 96-14776 describes the use of glycyl-L histidyl-L-lysine: copper (II) (GHL-Cu) derivatives as a cosmetic composition for promoting hair growth and hair growth promoting of warm-blooded animals. . However, these agents are prone to side effects such as hormones, the active ingredient is a synthetic compound, unstable in the human body, does not have a sufficient effect.

In the course of research to prevent or treat alopecia, the inventors found that 5 alpha-reductase converts testosterone, a male hormone, to dihydrotestosterone, and that the excess of this hormone causes hair loss symptoms. Confirming that pomegranate extract is effective in inhibiting the activity of the present invention will be completed.

Therefore, an object of the present invention is to provide a pomegranate extract excellent in hair loss effect and hair loss prevention cosmetic composition comprising the same without problems such as side effects in the human body as described above.

The present invention for achieving the above object is extracted with any one solvent selected from the group consisting of water, ethanol, propylene glycol, butylene glycol or a mixture of two or more thereof, 5 alpha-reductase inhibitory activity It provides a pomegranate extract for preventing hair loss.

In addition, the present invention provides a cosmetic composition for preventing hair loss, comprising the pomegranate extract for preventing hair loss.

In addition, the present invention provides a cosmetic using the cosmetic composition for preventing hair loss.

Hereinafter, the present invention will be described in more detail.

Pomegranate extract for preventing hair loss in the present invention is obtained by extracting from the pomegranate (Punicagranatum L.), the pomegranate is a deciduous branch of the pomegranate (Punicaceae) refers to the fruit of the pomegranate tree, which is a broad-leaved large tree, eye stones, garnet, Also called pomegranate. Origin is known as Asia Minor, and is currently grown in large quantities in China, the United States, California, India, etc. It is planted in Korea as edible, ornamental, and medicinal. In early summer, dark vermilion flowers bloom, and in the fall, pomegranates round ripe. The bark and roots contain Pelletierine, which is used as an insect repellent. In Indonesia, the fruit is used for the treatment of gynecological diseases and redness. The bark of the fruit contains a lot of tannins and alkaloids. Stems, bark, leaves, etc. can also be used for dyeing, which can be dyed yellow by alkali tan, yellow, or aluminum tin.

Pomegranate contains 21.8% glucose and 24.56% fructose, which is significantly higher in sugar content than 100g. In addition, calcium, potassium, magnesium, zinc, iron and abundant minerals that perform important functions in our body, such as magnesium, zinc, iron and pomegranate containing only three mineral components at the same time. In addition, pomegranate contains vitamins such as vitamin B1, vitamin B2, and vitamin C, which provide good nutrients for controlling various functions and preventing diseases in the body.

Pomegranate seeds also contain isoflavones, 17 mg of vegetable estrogen per kilogram. Female skin is characterized by the action of female hormone estrogen (Estrogen), unlike males, it has the characteristics of elasticity, moisturization and skin tissues, less sebum secretion, less hair. However, as the reproductive organs, the site of estrogen secretion, age gradually deteriorate, aging and dryness of skin due to female hormone deficiency become more pronounced, skin becomes thinner, and elasticity decreases. Pomegranate seeds have a chemical structure similar to that of estrogens above and contain isoflavones, which are plant hormones that function not only as estrogens but also as extracts from soybeans and mussels, and act as anticancer agents.

In relation to such isoflavones, Korean Patent No. 1204411 describes the effect of inhibiting melanin production of isoflavones, and US Patent No. 5,679,806 undergoes a series of processes of extracting and purifying soybeans and ethanol using ethanol or methanol. A method of extracting only flavones is described, and US Pat. No. 4,524,067 describes a method for separating proteins, oligosaccharides, saponins, isoflavones, etc. after extracting using caustic soda from soybean.

In this way, by extracting pomegranate, which is not harmful to apply to our body while also contributing to many parts by exhibiting excellent efficacy, it is used to prevent and treat hair loss in the present invention.

Pomegranate extract in the present invention converts testosterone, a male hormone, to dihydrotestosterone and acts to inhibit the activity of 5-alpha-reductase, which causes hair loss due to excess of this hormone.

One example of a method for obtaining a pomegranate extract is as follows.

After drying the pomegranate until there is no change in weight, the pulverized product obtained by pulverization is put in a solvent, heated to a reflux extractor equipped with a cooling condenser for 60 to 100 ° C. for 2 to 4 hours, and then filtered through a filter cloth. Can be extracted more than once. Butylene glycol, propylene glycol, ethanol, water, etc. may be used as the solvent, and it is preferable to set the temperature condition of the reflux extractor to 60 to 100 ° C, which is difficult to extract below 60 ° C. This is because other impurities are extracted together when the temperature is exceeded. The extract thus obtained is combined and concentrated under reduced pressure with a distillation apparatus equipped with a cooling capacitor, followed by freezing or spray drying to obtain a dried pomegranate extract.

In order to contain the pomegranate extract obtained as described above in order to exhibit the effect of preventing hair loss, the content of the pomegranate extract to be included in the cosmetic is preferably 0.0001 to 10.0% by weight in dry weight, which is a distinct effect at less than 0.0001% by weight. This is because when it is not expected to exceed 10.0% by weight, there is no apparent increase in effect with the increase of the content. More preferably 0.001 to 5.0% by weight.

In addition, the present invention provides a cosmetic comprising a cosmetic composition for preventing hair loss containing a pomegranate extract, it can be prepared by blending the pomegranate extract in conventional hair cosmetic ingredients. The conventional hair cosmetic ingredients may be well known to those skilled in the art such as ethanol, cured castor oil (containing ethylene oxide), fragrances and dyes. In addition, hair loss prevention cosmetics in the form of hair tonic, hair cream, hair lotion, hair shampoo, hair rinse, hair spray, hair aerosol, pomade, powder, gel, such as a variety of solutions, sol gel, emulsion, oil, wax, aerosol, etc. It may be prepared in a form, and the present invention is not particularly limited thereto.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples, but the present invention is not limited by the following Examples.

Examples 1 to 4 and Comparative Example 1

Example 1

After drying the pomegranate until there is no change in weight, 100 g of the pulverized powder obtained by pulverization was put in 1 l of butylene glycol, and extracted by heating at 80 ° C. for 3 hours using a reflux extractor equipped with a cooling condenser. After filtering by filter paper No. 2, the insoluble substance was removed, and then concentrated under reduced pressure at 60 ° C. using a distillation apparatus equipped with a cooling capacitor, followed by freeze drying to obtain a dry weight of 22 g of pomegranate extract.

Testosterone, a 5alpha-reductase and a labeling substance (3H-1,2,4,5,6,7) purified from female rat livers to examine the efficacy of pomegranate extracts in inhibiting 5-alpha-reductase activity To the phosphate buffer (PH 6.6) containing the concentration of the pomegranate extract obtained in the above example was added to 0.0005, 0.005, 0.05, 0.5, 5.0% and reacted for 15 minutes at 37 ℃. Dihydrotestosterone converted by testosterone by the action of 5 alpha-reductase was extracted and quantified by HPLC and radioisotope measurement. As a relative value, the inhibition rate of 5 alpha-reductase activity is shown as the inhibition rate of Table 1.

[Examples 2 to 4]

As shown in Table 1, except that the extraction solvent, the weight of the pomegranate extract obtained by extraction, and the concentration of the pomegranate extract used to measure the degree of activity inhibition of 5 alpha-reductase was the same as in Example 1. The results are shown in Table 1.

division solvent Weight of Pomegranate Extract (g) Pomegranate extract concentration (%) DHT peak area % Inhibition Comparative example - - 0 14365 0 Example One Butylene glycol 28 0.0005 11213 22 0.005 6251 57 0.05 1125 92 0.5 0 100 5.0 0 100 2 Propylene glycol 21 0.005 6934 52 3 ethanol 17 0.005 7135 51 4 water 22 0.005 6723 53

Experimental Example: Experiment to prevent hair loss of cosmetics containing the pomegranate extract of Example 1

Residual water was added to 50.0% by weight of ethanol (95%), 0.5% by weight of cured caster oil (containing 40 moles of ethylene oxide), 1.0% by weight of glycerin, and 0.005% by weight of pomegranate extract. Hair lotion containing pomegranate extract was prepared by adding flavors or dyes, which were used in the same manner, and hair lotion was prepared in the same manner as above except that pomegranate extract did not contain the pomegranate extract.

In order to confirm the hair loss prevention effect of the hair lotion prepared as described above, 10 out of 20 male test subjects with alopecia were given hair lotions containing pomegranate extract, and the remaining 10 were given hair lotions without pomegranate extract. 1 day, 2 to 3 times, 2ml each applied to the site according to the degree of confirming the effect of using at least 1 month up to 3 months to evaluate the degree of effect is shown in Table 2, where the evaluation criteria is hair loss at tribal , 5 symptoms in case of noticeable symptoms and visual effects, 4 points in moderate, 3 points in mild, 2 points in invariant, and 1 point in case of deterioration of hair loss. Judgment was made.

division Hair Lotion with Pomegranate Extract Hair lotion without pomegranate extract Hair Loss at Tricycle 4.1 2.3 Subjective symptoms 4.0 2.7 Visual judgment 3.8 2.4 Synthesis 4.0 2.5

As shown in the results of the above embodiment, the cosmetic composition containing the pomegranate extract exhibits an excellent hair loss prevention effect without causing any side effects in the human body by inhibiting the activity of 5 alpha-reductase, which is the main cause of hair loss symptoms. It plays an important role in preventing and treating hair loss.

Claims (5)

Hair loss prevention pomegranate extract which is extracted with one or more solvents selected from the group consisting of water, ethanol, propylene glycol, butylene glycol and mixtures thereof, and has 5 alpha-reductase inhibitory activity. Extracted with one or more solvents selected from the group consisting of water, ethanol, propylene glycol, butylene glycol, and mixtures thereof, 0.001 to 5.0% by weight of the pomegranate extract for preventing hair loss having a 5 alpha-reductase inhibitory activity and the remaining amount. Hair loss prevention cosmetic composition, characterized in that comprises a cosmetic component of. The method of claim 2, The conventional cosmetic components are anti-hair loss cosmetic composition, characterized in that the components used in the manufacture of conventional cosmetics, such as ethanol, cured castor oil added to ethylene oxide, perfume, dyes. Extracted with one or more solvents selected from the group consisting of water, ethanol, propylene glycol, butylene glycol, and mixtures thereof, 0.001 to 5.0% by weight of the pomegranate extract for preventing hair loss having a 5 alpha-reductase inhibitory activity and the remaining amount. Cosmetics comprising a cosmetic composition for preventing hair loss, characterized in that comprises a cosmetic component of. The method of claim 4, wherein Cosmetics comprising a cosmetic composition for preventing hair loss, characterized in that the hair tonic, hair cream, hair lotion, hair shampoo, hair rinse, hair spray, hair aerosol, pomade, powder, or gel.