KR100431564B1 - 인간 효과인자 세포 사이클 체크포인트 단백질 키나제의 촉매활성 도메인과, 그 억제제를 위한 물질 및 그억제제의 확인 방법 - Google Patents

인간 효과인자 세포 사이클 체크포인트 단백질 키나제의 촉매활성 도메인과, 그 억제제를 위한 물질 및 그억제제의 확인 방법

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Publication number
KR100431564B1
KR100431564B1 KR10-2000-0067280A KR20000067280A KR100431564B1 KR 100431564 B1 KR100431564 B1 KR 100431564B1 KR 20000067280 A KR20000067280 A KR 20000067280A KR 100431564 B1 KR100431564 B1 KR 100431564B1
Authority
KR
South Korea
Prior art keywords
hchk1
inhibitors
identification
protein kinase
catalytic domain
Prior art date
Application number
KR10-2000-0067280A
Other languages
English (en)
Other versions
KR20010051660A (en
Inventor
핑 첸
첸첸 칸
춘 루오
스테펜 마고시악
패트릭 오코너
템프직 러셀 안나
빈 구엔
제이 챈드 사루프
스미타 가울
마크 브라이언 앤더슨
얄리 덩
카렌 룬드그렌
제임스 레지스터
Original Assignee
아구론 파마슈티컬스, 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아구론 파마슈티컬스, 인크. filed Critical 아구론 파마슈티컬스, 인크.
Publication of KR20010051660A publication Critical patent/KR20010051660A/ko
Application granted granted Critical
Publication of KR100431564B1 publication Critical patent/KR100431564B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
KR10-2000-0067280A 1999-11-01 2000-11-01 인간 효과인자 세포 사이클 체크포인트 단백질 키나제의 촉매활성 도메인과, 그 억제제를 위한 물질 및 그억제제의 확인 방법 KR100431564B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16288799P 1999-11-01 1999-11-01
US09/460,421 US6670167B1 (en) 1999-11-01 1999-12-14 Catalytic domain of the human effector cell cycle checkpoint protein kinase materials and methods for identification of inhibitors thereof

Publications (2)

Publication Number Publication Date
KR20010051660A KR20010051660A (en) 2001-06-25
KR100431564B1 true KR100431564B1 (ko) 2004-05-22

Family

ID=26859143

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2000-0067280A KR100431564B1 (ko) 1999-11-01 2000-11-01 인간 효과인자 세포 사이클 체크포인트 단백질 키나제의 촉매활성 도메인과, 그 억제제를 위한 물질 및 그억제제의 확인 방법

Country Status (9)

Country Link
US (2) US6670167B1 (ko)
EP (1) EP1096014B1 (ko)
JP (1) JP2001161387A (ko)
KR (1) KR100431564B1 (ko)
AT (1) ATE337401T1 (ko)
AU (1) AU756175C (ko)
CA (1) CA2325228C (ko)
DE (1) DE60030229T2 (ko)
ES (1) ES2270772T3 (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670167B1 (en) * 1999-11-01 2003-12-30 Agouron Pharmaceuticals, Inc. Catalytic domain of the human effector cell cycle checkpoint protein kinase materials and methods for identification of inhibitors thereof
UA76977C2 (en) 2001-03-02 2006-10-16 Icos Corp Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers
GB0213186D0 (en) * 2002-06-08 2002-07-17 Univ Dundee Methods
US7108992B2 (en) * 2002-11-27 2006-09-19 St. Jude Children's Research Hospital ATM kinase compositions and methods
AU2004203977B2 (en) 2003-01-09 2010-06-17 Pfizer Inc. Diazepinoindole derivatives as kinase inhibitors
US20050266469A1 (en) * 2004-05-25 2005-12-01 Raymond Christopher K Alternatively spliced isoforms of checkpoint kinase 1 (CHK1)
MX2007000891A (es) * 2004-07-23 2007-04-18 Genentech Inc Cristalizacion de anticuerpos o fragmentos de ellos.
JP5001167B2 (ja) * 2004-12-16 2012-08-15 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｒｈｏキナーゼ（ｒｏｋ）調節物質を同定するための、ハイスループット酵素免疫吸着アッセイ法（ｈｔ−ｅｌｉｓａ）
WO2009148896A2 (en) 2008-05-29 2009-12-10 Nuclea Biotechnologies, LLC Anti-phospho-akt antibodies
CN102156823B (zh) * 2011-02-18 2015-04-22 复旦大学 一种靶向作用于蛋白激酶非活性构象的化合物筛选方法
KR20160099081A (ko) 2013-07-26 2016-08-19 업데이트 파마 인코포레이트 비산트렌의 치료 효과 개선용 조합 방법

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023571A1 (en) * 1992-05-12 1993-11-25 Fred Hutchinson Cancer Research Center Human cell cycle checkpoint genes
WO1997009433A1 (en) * 1995-09-06 1997-03-13 Icos Corporation Cell-cycle checkpoint genes
WO1999011795A1 (en) * 1997-09-05 1999-03-11 Icos Corporation Mammalian chk1 effector cell-cycle checkpoint protein kinase materials and methods
WO2000001274A1 (en) * 1998-05-28 2000-01-13 Norman Scott A Self-cleaning hair brush
WO2000003005A2 (en) * 1998-07-10 2000-01-20 Incyte Pharmaceuticals, Inc. Human checkpoint kinase
EP1096014A2 (en) * 1999-11-01 2001-05-02 Agouron Pharmaceuticals, Inc. Catalytic domain of the human effector cell cycle checkpoint protein kinase, Chk1, materials and methods for identification of inhibitors thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07109207B2 (ja) * 1990-10-18 1995-11-22 新キャタピラー三菱株式会社 負荷圧力補償型ロジック弁
US5595739A (en) 1993-05-07 1997-01-21 Abbott Laboratories Hepatitis B virus mutants, reagents and methods for detection
WO1997018323A2 (en) 1995-11-16 1997-05-22 Icos Corporation Cell-cycle checkpoint phosphatidylinositol- (pik-) related kinases, genes coding therefor and methods for assaying and modulating enzymatic activity
US5714329A (en) 1995-11-29 1998-02-03 Sequana Theraputics, Inc. Methods for the diagnosis of a genetic predisposition to cancer associated with variant CDK4 allele
WO1997039143A2 (en) 1996-04-17 1997-10-23 Abbott Laboratories Methods for the identification of novel antifungal agents
EP1036192B1 (en) 1997-12-05 2003-02-26 PHARMACIA & UPJOHN COMPANY Fluorescence-based high throughput screening assays for protein kinases and phosphatases
US20040005686A1 (en) * 2002-03-07 2004-01-08 Pharmacia Corporation Crystalline structure of human MAPKAP kinase-2

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023571A1 (en) * 1992-05-12 1993-11-25 Fred Hutchinson Cancer Research Center Human cell cycle checkpoint genes
WO1997009433A1 (en) * 1995-09-06 1997-03-13 Icos Corporation Cell-cycle checkpoint genes
WO1999011795A1 (en) * 1997-09-05 1999-03-11 Icos Corporation Mammalian chk1 effector cell-cycle checkpoint protein kinase materials and methods
WO2000001274A1 (en) * 1998-05-28 2000-01-13 Norman Scott A Self-cleaning hair brush
WO2000003005A2 (en) * 1998-07-10 2000-01-20 Incyte Pharmaceuticals, Inc. Human checkpoint kinase
EP1096014A2 (en) * 1999-11-01 2001-05-02 Agouron Pharmaceuticals, Inc. Catalytic domain of the human effector cell cycle checkpoint protein kinase, Chk1, materials and methods for identification of inhibitors thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Cell. 2000 Mar 17;100(6):681-92 *
Curr Biol 1997 Dec 1;7(12):977-86 *
Science. 1997 Sep 5;277(5331):1497-501 *

Also Published As

Publication number Publication date
ES2270772T3 (es) 2007-04-16
DE60030229D1 (de) 2006-10-05
US6670167B1 (en) 2003-12-30
EP1096014A2 (en) 2001-05-02
EP1096014A3 (en) 2002-09-25
CA2325228C (en) 2004-08-17
CA2325228A1 (en) 2001-05-11
AU756175C (en) 2005-03-03
JP2001161387A (ja) 2001-06-19
DE60030229T2 (de) 2007-08-23
KR20010051660A (en) 2001-06-25
US20030235899A1 (en) 2003-12-25
ATE337401T1 (de) 2006-09-15
AU6807900A (en) 2001-05-10
AU756175B2 (en) 2003-01-09
EP1096014B1 (en) 2006-08-23

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