KR100418174B1 - 인다졸카르복스아미드 - Google Patents

인다졸카르복스아미드 Download PDF

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Publication number
KR100418174B1
KR100418174B1 KR1019970706456A KR19970706456A KR100418174B1 KR 100418174 B1 KR100418174 B1 KR 100418174B1 KR 1019970706456 A KR1019970706456 A KR 1019970706456A KR 19970706456 A KR19970706456 A KR 19970706456A KR 100418174 B1 KR100418174 B1 KR 100418174B1
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KR
South Korea
Prior art keywords
alkyl
mmol
naphthyl
phenyl
group
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1019970706456A
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English (en)
Korean (ko)
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KR19980703047A (ko
Inventor
존 티. 캐트로우
마를렌 엘. 코헨
마이클 제이. 마르티넬리
죤 엠. 쇼스
스티븐 피. 스완슨
데니스 씨. 톰슨
토마스 엠. 윌슨
Original Assignee
일라이 릴리 앤드 캄파니
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Publication of KR19980703047A publication Critical patent/KR19980703047A/ko
Application granted granted Critical
Publication of KR100418174B1 publication Critical patent/KR100418174B1/ko
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1019970706456A 1995-03-16 1996-03-14 인다졸카르복스아미드 Expired - Fee Related KR100418174B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40511995A 1995-03-16 1995-03-16
US08/405119 1995-03-16
US8/405119 1995-03-16
US08/485,956 US5654320A (en) 1995-03-16 1995-06-07 Indazolecarboxamides
US08/485956 1995-06-07

Publications (2)

Publication Number Publication Date
KR19980703047A KR19980703047A (ko) 1998-09-05
KR100418174B1 true KR100418174B1 (ko) 2004-03-19

Family

ID=23602353

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019970706456A Expired - Fee Related KR100418174B1 (ko) 1995-03-16 1996-03-14 인다졸카르복스아미드

Country Status (5)

Country Link
US (1) US5654320A (enExample)
KR (1) KR100418174B1 (enExample)
TW (1) TW312693B (enExample)
UA (1) UA44304C2 (enExample)
ZA (1) ZA961955B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2222532A1 (en) * 1995-05-31 1996-12-05 Nisshin Flour Milling Co., Ltd. Indazole derivatives having monocyclic amine
US5817489A (en) 1996-08-01 1998-10-06 Isis Pharmaceuticals, Inc. Di-nitrogen heterocycle compositions
IL125658A0 (en) * 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
US6339087B1 (en) * 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
US5914405A (en) * 1997-10-07 1999-06-22 Eli Lilly And Company Process for preparing 3-substituted indazoles
US6204274B1 (en) 1998-04-29 2001-03-20 American Home Products Corporation Indolyl derivatives as serotonergic agents
US6310066B1 (en) 1998-04-29 2001-10-30 American Home Products Corp. Antipsychotic indolyl derivatives
US6066637A (en) * 1998-06-19 2000-05-23 American Home Products Corporation Indolyl derivatives as serotonergic agents
TR200100361T2 (tr) * 1998-08-21 2001-06-21 Novartis Ag Yeni oral formülasyon
EP1112270B1 (en) 1998-09-10 2007-03-21 F. Hoffmann-La Roche Ag Dihydrobenzodioxine carboxamide and ketone derivatives as 5-ht4 receptor antagonists
NZ521978A (en) 2000-04-28 2004-10-29 Acadia Pharm Inc Compounds that affect cholinergic receptors and are particularly muscarinic agonists
KR20050098250A (ko) * 2003-01-17 2005-10-11 쓰레솔드 파마슈티컬스, 인코포레이티드 에너골리틱제를 사용한 양성 전립선 비대증의 치료 방법
ITMI20030287A1 (it) * 2003-02-18 2004-08-19 Acraf Indazolammidi dotate di attivita' analgesica metodo, per
ITMI20030972A1 (it) * 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
TWI351282B (en) * 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
ES2327142T3 (es) * 2004-11-05 2009-10-26 Theravance, Inc. Compuestos de quinolinona-carboxamida.
DE602005016446D1 (de) * 2004-11-05 2009-10-15 Theravance Inc 5-HT4-Rezeptoragonistenverbindungen
ES2347265T3 (es) * 2004-12-22 2010-10-27 Theravance, Inc. Compuestos de indazol-carboxamida.
EP1848716A1 (en) * 2005-02-17 2007-10-31 Theravance, Inc. Crystalline form of an indazole-carboxamide compound
EP1871772B1 (en) * 2005-03-02 2014-09-10 Theravance, Inc. Quinolinone compounds as 5-ht4 receptor agonists
EP2268268A2 (en) * 2008-03-24 2011-01-05 Wockhardt Research Centre Orally disintegrating compositions of rhein or diacerein

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3145215A (en) * 1961-12-19 1964-08-18 Sterling Drug Inc Indazole derivatives
JP2795460B2 (ja) * 1988-06-20 1998-09-10 協和醗酵工業株式会社 ピラゾロアクリドン誘導体
NZ230068A (en) * 1988-07-29 1991-07-26 Dainippon Pharmaceutical Co Indazole-3-carboxylic acid esters and amides of diaza compounds having 6,7, or 8 ring members: preparatory processes and pharmaceutical compositions
US4952857A (en) * 1989-03-24 1990-08-28 Quanscan, Inc. Scanning micromechanical probe control system
EP0410509A1 (en) * 1989-07-25 1991-01-30 Duphar International Research B.V New substituted 1H-indazole-3-carboxamides
HU211081B (en) * 1990-12-18 1995-10-30 Sandoz Ag Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same
JP3026845B2 (ja) * 1991-02-20 2000-03-27 日清製粉株式会社 ピペリジン誘導体
EP0596933A1 (en) * 1991-08-03 1994-05-18 Smithkline Beecham Plc 5-ht4 receptor antagonists
WO1993003725A1 (en) * 1991-08-20 1993-03-04 Smithkline Beecham Plc 5-ht4 receptor antagonists
WO1993005040A1 (en) * 1991-09-12 1993-03-18 Smithkline Beecham Plc Azabicyclic compounds as 5-ht4 receptor antagonists
DK0604494T3 (da) * 1991-09-12 1999-11-29 Smithkline Beecham Plc 5-HT4-receptorantagonister
WO1993024117A2 (en) * 1992-05-23 1993-12-09 Smithkline Beecham Plc Medicaments for the treatment of anxiety
JPH07508276A (ja) * 1992-06-27 1995-09-14 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ↓４受容体アンタゴニスト含有医薬品
MX9305947A (es) * 1992-09-29 1994-06-30 Smithkline Beecham Plc Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
TW251287B (enExample) * 1993-04-30 1995-07-11 Nissei Co Ltd
GB9310582D0 (en) * 1993-05-22 1993-07-07 Smithkline Beecham Plc Pharmaceuticals
DK60593D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse

Also Published As

Publication number Publication date
ZA961955B (en) 1997-09-11
US5654320A (en) 1997-08-05
TW312693B (enExample) 1997-08-11
UA44304C2 (uk) 2002-02-15
KR19980703047A (ko) 1998-09-05

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