KR100322355B1 - 아노머성플루오로리보실아민 - Google Patents

아노머성플루오로리보실아민 Download PDF

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Publication number
KR100322355B1
KR100322355B1 KR1019940023346A KR19940023346A KR100322355B1 KR 100322355 B1 KR100322355 B1 KR 100322355B1 KR 1019940023346 A KR1019940023346 A KR 1019940023346A KR 19940023346 A KR19940023346 A KR 19940023346A KR 100322355 B1 KR100322355 B1 KR 100322355B1
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KR
South Korea
Prior art keywords
compound
formula
reaction product
same
hydroxy protecting
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Expired - Fee Related
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KR1019940023346A
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English (en)
Korean (ko)
Other versions
KR950008529A (ko
Inventor
래리웨인허텔
찰스데이빗죤스
줄리언스탠리크로인
토마스에드워드매브리
Original Assignee
일라이 릴리 앤드 캄파니
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Application filed by 일라이 릴리 앤드 캄파니 filed Critical 일라이 릴리 앤드 캄파니
Publication of KR950008529A publication Critical patent/KR950008529A/ko
Application granted granted Critical
Publication of KR100322355B1 publication Critical patent/KR100322355B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Noodles (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Catalysts (AREA)
KR1019940023346A 1993-09-16 1994-09-15 아노머성플루오로리보실아민 Expired - Fee Related KR100322355B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/122,876 1993-09-16
US08/122,876 US5480992A (en) 1993-09-16 1993-09-16 Anomeric fluororibosyl amines

Publications (2)

Publication Number Publication Date
KR950008529A KR950008529A (ko) 1995-04-19
KR100322355B1 true KR100322355B1 (ko) 2002-11-30

Family

ID=22405359

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940023346A Expired - Fee Related KR100322355B1 (ko) 1993-09-16 1994-09-15 아노머성플루오로리보실아민

Country Status (15)

Country Link
US (3) US5480992A (enExample)
EP (1) EP0647654B1 (enExample)
JP (1) JP3762445B2 (enExample)
KR (1) KR100322355B1 (enExample)
AT (1) ATE186731T1 (enExample)
BR (1) BR9403572A (enExample)
CA (1) CA2130124C (enExample)
DE (1) DE69421665T2 (enExample)
DK (1) DK0647654T3 (enExample)
ES (1) ES2139714T3 (enExample)
FI (1) FI113179B (enExample)
GR (1) GR3032603T3 (enExample)
HU (1) HU220672B1 (enExample)
IL (2) IL110932A (enExample)
TW (1) TW342392B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6906495B2 (en) * 2002-05-13 2005-06-14 Splashpower Limited Contact-less power transfer
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
CA2641719A1 (en) * 2006-02-07 2007-08-16 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2270235B1 (enExample) * 1974-02-15 1982-09-03 Sanofi Sa
FR2315500A2 (fr) * 1975-06-24 1977-01-21 Labaz Procede de preparation d'un diazidocyclohexanediol
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4879377A (en) * 1983-11-18 1989-11-07 Bristol-Myers Company Nucleoside process
DE3587500T2 (de) * 1984-12-04 1993-12-16 Lilly Co Eli Tumorbehandlung bei Säugetieren.
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
JPH0232093A (ja) * 1988-06-08 1990-02-01 Merrell Dow Pharmaceut Inc 抗レトロウィルスジフルオロ化ヌクレオシド類

Also Published As

Publication number Publication date
US5541345A (en) 1996-07-30
GR3032603T3 (en) 2000-05-31
DE69421665D1 (de) 1999-12-23
ES2139714T3 (es) 2000-02-16
FI944281L (fi) 1995-03-17
FI113179B (fi) 2004-03-15
IL137248A0 (en) 2001-07-24
ATE186731T1 (de) 1999-12-15
HU220672B1 (hu) 2002-04-29
KR950008529A (ko) 1995-04-19
US5594155A (en) 1997-01-14
CA2130124C (en) 2004-08-10
DE69421665T2 (de) 2000-05-25
FI944281A0 (fi) 1994-09-15
TW342392B (en) 1998-10-11
BR9403572A (pt) 1995-05-16
US5480992A (en) 1996-01-02
JP3762445B2 (ja) 2006-04-05
IL110932A (en) 2003-05-29
EP0647654A3 (enExample) 1995-05-03
DK0647654T3 (da) 2000-03-13
EP0647654A2 (en) 1995-04-12
HUT72590A (en) 1996-05-28
HU9402646D0 (en) 1994-12-28
CA2130124A1 (en) 1995-03-17
IL110932A0 (en) 1994-11-28
JPH07149783A (ja) 1995-06-13
EP0647654B1 (en) 1999-11-17

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