KR100285243B1 - 적어도 하나의 하이알루론산 에스테르를 함유하는 표면층을 포함하는 다층 부직 티슈 - Google Patents
적어도 하나의 하이알루론산 에스테르를 함유하는 표면층을 포함하는 다층 부직 티슈 Download PDFInfo
- Publication number
- KR100285243B1 KR100285243B1 KR1019950703336A KR19950703336A KR100285243B1 KR 100285243 B1 KR100285243 B1 KR 100285243B1 KR 1019950703336 A KR1019950703336 A KR 1019950703336A KR 19950703336 A KR19950703336 A KR 19950703336A KR 100285243 B1 KR100285243 B1 KR 100285243B1
- Authority
- KR
- South Korea
- Prior art keywords
- derivatives
- nonwoven fabric
- multilayer nonwoven
- hyaluronic acid
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 hyaluronic acid ester Chemical group 0.000 title claims abstract description 30
- 239000002344 surface layer Substances 0.000 title claims abstract description 24
- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 22
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 22
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 32
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 30
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000012528 membrane Substances 0.000 claims abstract description 20
- 239000000203 mixture Substances 0.000 claims abstract description 18
- 229920001059 synthetic polymer Polymers 0.000 claims abstract description 9
- 239000000853 adhesive Substances 0.000 claims abstract description 8
- 230000001070 adhesive effect Effects 0.000 claims abstract description 8
- 230000004663 cell proliferation Effects 0.000 claims abstract description 5
- 239000010410 layer Substances 0.000 claims description 60
- 238000000034 method Methods 0.000 claims description 31
- 235000010443 alginic acid Nutrition 0.000 claims description 17
- 229920000615 alginic acid Polymers 0.000 claims description 17
- 239000000835 fiber Substances 0.000 claims description 16
- 239000000783 alginic acid Substances 0.000 claims description 12
- 229960001126 alginic acid Drugs 0.000 claims description 12
- 102000008186 Collagen Human genes 0.000 claims description 11
- 108010035532 Collagen Proteins 0.000 claims description 11
- 239000002250 absorbent Substances 0.000 claims description 11
- 230000002745 absorbent Effects 0.000 claims description 11
- 229920001436 collagen Polymers 0.000 claims description 11
- 229920000642 polymer Polymers 0.000 claims description 11
- 239000000047 product Substances 0.000 claims description 11
- 150000004781 alginic acids Chemical class 0.000 claims description 10
- 229920002678 cellulose Polymers 0.000 claims description 10
- 239000001913 cellulose Substances 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 9
- 229920005615 natural polymer Polymers 0.000 claims description 9
- 229920001277 pectin Polymers 0.000 claims description 9
- 235000010987 pectin Nutrition 0.000 claims description 9
- 239000001814 pectin Substances 0.000 claims description 9
- 229920001817 Agar Polymers 0.000 claims description 8
- 229920000936 Agarose Polymers 0.000 claims description 8
- 229920002101 Chitin Polymers 0.000 claims description 8
- 229920001661 Chitosan Polymers 0.000 claims description 8
- 229920002148 Gellan gum Polymers 0.000 claims description 8
- 229920002683 Glycosaminoglycan Polymers 0.000 claims description 8
- 244000043261 Hevea brasiliensis Species 0.000 claims description 8
- 229920000954 Polyglycolide Polymers 0.000 claims description 8
- 229920005830 Polyurethane Foam Polymers 0.000 claims description 8
- 239000008272 agar Substances 0.000 claims description 8
- 229920003052 natural elastomer Polymers 0.000 claims description 8
- 229920001194 natural rubber Polymers 0.000 claims description 8
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 8
- 239000004633 polyglycolic acid Substances 0.000 claims description 8
- 239000004626 polylactic acid Substances 0.000 claims description 8
- 229920002635 polyurethane Polymers 0.000 claims description 8
- 239000004814 polyurethane Substances 0.000 claims description 8
- 239000011496 polyurethane foam Substances 0.000 claims description 8
- 229920002472 Starch Polymers 0.000 claims description 7
- 229920003175 pectinic acid Polymers 0.000 claims description 7
- 235000019698 starch Nutrition 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 229920001285 xanthan gum Polymers 0.000 claims description 7
- 229920000297 Rayon Polymers 0.000 claims description 6
- 238000010521 absorption reaction Methods 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- 229920001577 copolymer Polymers 0.000 claims description 6
- 230000035699 permeability Effects 0.000 claims description 6
- 238000001356 surgical procedure Methods 0.000 claims description 6
- 239000000230 xanthan gum Substances 0.000 claims description 6
- 235000010493 xanthan gum Nutrition 0.000 claims description 6
- 229940082509 xanthan gum Drugs 0.000 claims description 6
- 239000000701 coagulant Substances 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 239000004743 Polypropylene Substances 0.000 claims description 4
- 229920001971 elastomer Polymers 0.000 claims description 4
- 229920002627 poly(phosphazenes) Polymers 0.000 claims description 4
- 229920002492 poly(sulfone) Polymers 0.000 claims description 4
- 229920000728 polyester Polymers 0.000 claims description 4
- 229920001155 polypropylene Polymers 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 239000004793 Polystyrene Substances 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
- 239000000648 calcium alginate Substances 0.000 claims description 3
- 235000010410 calcium alginate Nutrition 0.000 claims description 3
- 229960002681 calcium alginate Drugs 0.000 claims description 3
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims description 3
- 150000004985 diamines Chemical class 0.000 claims description 3
- 229920002313 fluoropolymer Polymers 0.000 claims description 3
- 239000004811 fluoropolymer Substances 0.000 claims description 3
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims description 3
- 229920000058 polyacrylate Polymers 0.000 claims description 3
- 229920001296 polysiloxane Polymers 0.000 claims description 3
- 239000002243 precursor Substances 0.000 claims description 3
- 229920002554 vinyl polymer Polymers 0.000 claims description 3
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical class C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 claims description 2
- 229920000742 Cotton Polymers 0.000 claims description 2
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 claims description 2
- 239000004952 Polyamide Substances 0.000 claims description 2
- 239000004698 Polyethylene Substances 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 230000000181 anti-adherent effect Effects 0.000 claims description 2
- 230000002927 anti-mitotic effect Effects 0.000 claims description 2
- 150000001991 dicarboxylic acids Chemical class 0.000 claims description 2
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims description 2
- 230000000399 orthopedic effect Effects 0.000 claims description 2
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 claims description 2
- 229920002647 polyamide Polymers 0.000 claims description 2
- 239000000622 polydioxanone Substances 0.000 claims description 2
- 229920000573 polyethylene Polymers 0.000 claims description 2
- 229920000098 polyolefin Polymers 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 229920002223 polystyrene Polymers 0.000 claims description 2
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 2
- 239000011148 porous material Substances 0.000 claims description 2
- 239000002244 precipitate Substances 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 230000002787 reinforcement Effects 0.000 claims description 2
- 239000005060 rubber Substances 0.000 claims description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 claims 7
- 239000000806 elastomer Substances 0.000 claims 2
- 239000004971 Cross linker Substances 0.000 claims 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical class OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 claims 1
- 229920000881 Modified starch Polymers 0.000 claims 1
- HOPRXXXSABQWAV-UHFFFAOYSA-N anhydrous collidine Natural products CC1=CC=NC(C)=C1C HOPRXXXSABQWAV-UHFFFAOYSA-N 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000003080 antimitotic agent Substances 0.000 claims 1
- UTBIMNXEDGNJFE-UHFFFAOYSA-N collidine Natural products CC1=CC=C(C)C(C)=N1 UTBIMNXEDGNJFE-UHFFFAOYSA-N 0.000 claims 1
- 210000005069 ears Anatomy 0.000 claims 1
- 125000004494 ethyl ester group Chemical group 0.000 claims 1
- 235000019426 modified starch Nutrition 0.000 claims 1
- 239000005445 natural material Substances 0.000 claims 1
- 210000001331 nose Anatomy 0.000 claims 1
- 150000004756 silanes Chemical class 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- GFYHSKONPJXCDE-UHFFFAOYSA-N sym-collidine Natural products CC1=CN=C(C)C(C)=C1 GFYHSKONPJXCDE-UHFFFAOYSA-N 0.000 claims 1
- 229920002994 synthetic fiber Polymers 0.000 claims 1
- 238000002166 wet spinning Methods 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 241000005308 Orsa Species 0.000 description 3
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 239000003431 cross linking reagent Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 150000004820 halides Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002406 microsurgery Methods 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 150000004804 polysaccharides Chemical class 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 229920005789 ACRONAL® acrylic binder Polymers 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical class OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910000077 silane Inorganic materials 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Absorbent Articles And Supports Therefor (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITPD93A000024 | 1993-02-12 | ||
| ITPD930024A IT1263316B (it) | 1993-02-12 | 1993-02-12 | Tessuto non tessuto multistrato in cui uno degli strati e' costituito essenzialmente da esteri dell'acido ialuronico |
| PCT/EP1994/000397 WO1994017837A1 (en) | 1993-02-12 | 1994-02-11 | Multilayer nonwoven tissue containing a surface layer comprising at least one hyaluronic acid ester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR100285243B1 true KR100285243B1 (ko) | 2001-04-02 |
Family
ID=38583052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019950703336A Expired - Lifetime KR100285243B1 (ko) | 1993-02-12 | 1994-02-11 | 적어도 하나의 하이알루론산 에스테르를 함유하는 표면층을 포함하는 다층 부직 티슈 |
Country Status (3)
-
1994
- 1994-02-11 KR KR1019950703336A patent/KR100285243B1/ko not_active Expired - Lifetime
- 1994-07-30 TW TW083107002A patent/TW265259B/zh not_active IP Right Cessation
-
2007
- 2007-05-25 JP JP2007139145A patent/JP2007236974A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007236974A (ja) | 2007-09-20 |
| TW265259B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1995-12-11 |
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| Date | Code | Title | Description |
|---|---|---|---|
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Patent event date: 19950810 Patent event code: PA01051R01D Comment text: International Patent Application |
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