KR100267164B1 - 반사파생성입자,이의제조방법및이의용도 - Google Patents

반사파생성입자,이의제조방법및이의용도 Download PDF

Info

Publication number
KR100267164B1
KR100267164B1 KR1019920015887A KR920015887A KR100267164B1 KR 100267164 B1 KR100267164 B1 KR 100267164B1 KR 1019920015887 A KR1019920015887 A KR 1019920015887A KR 920015887 A KR920015887 A KR 920015887A KR 100267164 B1 KR100267164 B1 KR 100267164B1
Authority
KR
South Korea
Prior art keywords
particles
acid
particle
reflecting
reflective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019920015887A
Other languages
English (en)
Korean (ko)
Other versions
KR930005618A (ko
Inventor
라이너쪼츠
폴커크로네
악셀발크.
위르겐그란데
Original Assignee
훽스트 악티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27202878&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100267164(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE4209488A external-priority patent/DE4209488A1/de
Application filed by 훽스트 악티엔게젤샤프트 filed Critical 훽스트 악티엔게젤샤프트
Publication of KR930005618A publication Critical patent/KR930005618A/ko
Application granted granted Critical
Publication of KR100267164B1 publication Critical patent/KR100267164B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Glanulating (AREA)
KR1019920015887A 1991-09-03 1992-09-02 반사파생성입자,이의제조방법및이의용도 Expired - Fee Related KR100267164B1 (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
DE4129187 1991-09-03
DE?P4129187.5? 1991-09-03
DEP4129187.5 1991-09-03
DEP4209488.7 1992-03-24
DEP4209487.9 1992-03-24
DE4209488A DE4209488A1 (de) 1992-03-24 1992-03-24 Echogene Partikel, Verfahren zu deren Herstellung und deren Verwendung
DE?P4209487.9? 1992-03-24
DE4209487 1992-03-24
DE?P4209488.7? 1992-03-24

Publications (2)

Publication Number Publication Date
KR930005618A KR930005618A (ko) 1993-04-20
KR100267164B1 true KR100267164B1 (ko) 2000-10-16

Family

ID=27202878

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920015887A Expired - Fee Related KR100267164B1 (ko) 1991-09-03 1992-09-02 반사파생성입자,이의제조방법및이의용도

Country Status (13)

Country Link
EP (1) EP0535387B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH05194276A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR100267164B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE141518T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU660039B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2077383A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE59206943D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK0535387T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2093160T5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3021038T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO305685B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ244147A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW222236B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6989141B2 (en) 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IN172208B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1990-04-02 1993-05-01 Sint Sa
US7083778B2 (en) 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
DE4219723A1 (de) * 1992-06-13 1993-12-16 Schering Ag Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
US5605673A (en) 1993-07-30 1997-02-25 Alliance Pharmaceutical Corp. Stabilized microbubble compositions for ultrasound
US6333021B1 (en) 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
AU6378096A (en) * 1995-06-07 1996-12-30 Brown University Research Foundation Spray dried polymeric microparticles containing imaging agen ts
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
PT904113E (pt) * 1996-03-05 2004-09-30 Acusphere Inc Gases fluorados microencapsulados para utilizacao como agentes de aquisicao de imagem
US5837221A (en) 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
CN101437551A (zh) * 2004-11-19 2009-05-20 皇家飞利浦电子股份有限公司 用于分子成像的超声造影剂
EP1741968A1 (en) * 2005-07-08 2007-01-10 Uponor Innovation Ab Clamping ring

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006987A1 (en) * 1988-01-28 1989-08-10 Jan Axel Svensson Coupling device in a cutaneous passageway

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107288A (en) † 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
US4265251A (en) * 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel
US4718433A (en) † 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US4900540A (en) † 1983-06-20 1990-02-13 Trustees Of The University Of Massachusetts Lipisomes containing gas for ultrasound detection
SE8701479L (sv) † 1987-04-09 1988-10-10 Carbomatrix Ab Metod foer inneslutning av biologiskt verksamma preparat samt anvaendning daerav
IE61591B1 (en) † 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
AU635200B2 (en) * 1988-02-05 1993-03-18 Schering Aktiengesellschaft Berlin Und Bergkamen Ultrasonic contrast agents, process for producing them and their use as diagnostic and therapeutic agents
US4957656A (en) † 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
FR2660864A1 (fr) * 1990-04-13 1991-10-18 Guerbet Sa Composition de contraste, procede de preparation de cette composition et application a l'imagerie.
US5137928A (en) * 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU636481B2 (en) † 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5236693A (en) * 1990-11-14 1993-08-17 Brigham And Women's Hospital Medical ultrasound contrast agent and method of using same
DE4219723A1 (de) † 1992-06-13 1993-12-16 Schering Ag Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006987A1 (en) * 1988-01-28 1989-08-10 Jan Axel Svensson Coupling device in a cutaneous passageway

Also Published As

Publication number Publication date
EP0535387B2 (de) 2001-10-04
TW222236B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1994-04-11
GR3021038T3 (en) 1996-12-31
KR930005618A (ko) 1993-04-20
JPH05194276A (ja) 1993-08-03
EP0535387A1 (de) 1993-04-07
ES2093160T3 (es) 1996-12-16
CA2077383A1 (en) 1993-03-04
EP0535387B1 (de) 1996-08-21
NO923424D0 (no) 1992-09-02
NZ244147A (en) 1994-09-27
NO305685B2 (no) 1999-07-12
NO305685B1 (no) 1999-07-12
DE59206943D1 (de) 1996-09-26
AU660039B2 (en) 1995-06-08
ES2093160T5 (es) 2002-03-16
NO923424L (no) 1993-03-04
ATE141518T1 (de) 1996-09-15
AU2203992A (en) 1993-03-11
DK0535387T3 (da) 1996-12-09

Similar Documents

Publication Publication Date Title
KR100267164B1 (ko) 반사파생성입자,이의제조방법및이의용도
JP3381930B2 (ja) 超音波造影剤
US5190982A (en) Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US7030208B2 (en) Biocompatible materials and probes
KR100637022B1 (ko) 반사발생도를 증가시키고 미세캡슐화된 기체의 희석을감소시키는 방법
EP0707474B1 (en) Medical use of organic aerogels and biodegradable organic aerogels
US6468506B1 (en) Process for producing polymeric microparticles, microparticles produced by said process and the use of such particles in medical diagnostics
AU703652B2 (en) Gas-filled microspheres with fluorine-containing shells
JP2001527547A (ja) 超音波コントラスト剤として、および、血流への薬剤デリバリーのために有用な微小パーティクル
JP2009507103A (ja) 架橋多糖およびタンパク質マトリックスならびにそれらの製造方法
US5613494A (en) Polycondensates which contain tartaric acid derivatives, processes for their preparation and use thereof
JPH11507294A (ja) 疎水性バリアを含む不溶性のガス充填マイクロスフェア
DE4209488A1 (de) Echogene Partikel, Verfahren zu deren Herstellung und deren Verwendung
Huang et al. Synthesis of mesoporous sodium hyaluronate microspheres via electrostatic spray method
MXPA99011840A (en) Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases
MXPA99009986A (en) Microparticles useful as ultrasonic contrast agents and for delivery of drugs into the bloodstream

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20030704

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20030704

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000