KR100265691B1 - 1-131 automatic assembling and packing apparatus for 1-131 - Google Patents

Abstract

The present invention forms the base plate (9) forming the base portion, the powder supply device (10) for filling the absorbent (4) in the lower capsule (3), the U-shaped groove (6) is formed in the center of the absorbent (4) Measuring the radioactivity of the stock solution dispensing device 30 for dispensing the I-131 solution into the groove 6, the capsule assembling device 50 for assembling the upper and lower capsules 2 and 3, and the assembled upper and lower capsules 2 and 3 Radiation measuring device 70, rubber stopper assembly device 80 to fit the rubber stopper (7) in the vial (5) into which the assembled upper and lower capsules (2, 3), the rubber stopper assembled vials (5) metal cap (8) the vial capping device 90 and the upper and lower capsules (2, 3), the vial (5), the rubber to the working position of each device (10, 30, 50, 70, 80, 90) I-131 capsule assembly and packaging automation device consisting of a multi-joint robot 100 for moving the stopper (7) or metal cap (8), the encapsulation in the commercialization of radioactive isotopes such as I-131 And packaging seen By the assembly and packaging automation device of the invention, it can be made in an enclosed space such as a hot cell, eliminating the risk of radiation exposure of workers that may occur in the assembly and packaging process, and further enhancing and releasing the efficiency of such assembly packaging work. It is to improve the quality of I-131 and to reduce the production cost by uniformizing the quality of the product.

Description

Automatic assemblying and packing apparutus for I-131

The present invention relates to an apparatus for assembling and packaging an I-131 capsule, and more specifically, from I-131 stock solution to final packaging for commercial production of radioisotopes I-131 which are widely used for therapeutic or diagnostic purposes. I-131 capsule assembly and packaging automation device unmanned fully automated by integrating the steps into one.

Today, the use range and technology of radioisotopes are rapidly developing, and the annual usage in Korea reaches 100k Curie (Ci) on average annually. Although there is a general tendency to avoid radiation from radioisotopes, this high usage is due to the inherent properties of radioisotopes. Typical among the intrinsic properties is that a small amount of radiation having a strong penetrating power can be sufficiently emitted to detect or change the material.

This is why radioisotopes make a distinct contribution to industry, medicine, and scientific research. As of 1995, more than 1000 companies using radioisotopes were radiodestructive tests, radioisotope gauges, industrial radiotracers, in-vivo diagnosis and treatment, in-vitro diagnostics, in vitro radiation therapy, radiation sterilization, radiation food research, and radiation genetic engineering. The use of radioactive isotopes in various forms, such as research, contributes to the development of industrial technology, productivity improvement, pollution prevention, industrial safety, medical technology development and welfare, food production, food preservation, and basic science development. It is true.

However, in order to enjoy the full benefits of using radioactive isotopes, the supply must be smooth and domestic radioisotopes can be sufficiently supplied. Radioactive isotopes can be produced from nuclear reactors or accelerators. In Korea, since only 2MW research reactors have been operated until recently, they have to be produced on a small scale.

In recent years, however, multipurpose research reactors have been developed to improve the self-sufficiency of radioisotopes required in Korea.In addition, as a part of research and development for mass production of radioisotope products using such reactors, additional equipment suitable for mass production They also developed together.

In other words, in the past, radioactive isotopes were in low demand, and their production was small. Therefore, production has been carried out on a laboratory scale, and packaging, such as commercialization, has been reliant on manual labor. As a result, it could not meet the rapidly increasing demand.

Accordingly, the present invention has been made to solve the problems of the conventional I-131 commercialization method as mentioned above, it is shielded from the outside of the I-131 generated by radiation generated by neutron irradiation in the reactor Transfer to the inside of the unit cell, and in the capsule of the lower capsule supply process, positioning process, powder supply process, powder forming process, stock solution injection process, upper capsule supply and assembly process, radioactivity measurement process, inspection and discharge process After encapsulation and encapsulation, each unitized capsule is put into a vial to be commercialized as a final product, minimizing worker's radiation exposure during assembly and packaging of I-131, improving work efficiency, and uniformizing the product. The ultimate goal is to improve I-131 quality and reduce costs.

1 is a plan view showing one embodiment of the I-131 capsule assembly and packaging automation device according to the present invention.

2 is a side view seen from the bottom of FIG.

3 is a side view seen from the left end of FIG.

4 is a partial detailed perspective view of the movable bundle shown in FIGS. 1 and 2;

5 is a plan detail view of the stopper shown in FIGS. 1 and 3;

FIG. 6 is a longitudinal front view of the stopper pin assembled to the stopper of FIG. 5; FIG.

7 is a longitudinal side view of the powder supply device shown in FIG.

8 is a partially cutaway plan view of FIG. 7.

9 is a partial front cross-sectional view of the powder supply apparatus seen from the right end of FIG.

10 is a plan view of the bed of the powder supply device shown in FIG.

Figure 11 is a longitudinal side view of the stock solution dispensing apparatus shown in FIG.

12 is a plan view of FIG.

FIG. 13 is a partial side cross-sectional view taken along line AA of FIG. 12.

14 is a detailed cross-sectional view of the lower capsule shown in FIG.

FIG. 15 is a partial cutaway end side view of the capsule assembly shown in FIG. 1. FIG.

16 is a plan view of FIG. 15.

17 is a partially cut-away side view of the vial rubber stopper assembly shown in FIG. 1;

18 is a top view of FIG. 17.

19 is a plan view of the vial capping device shown in FIG.

20 is a plan view of FIG. 19.

21 is a plan view of the label printing and attaching device shown in FIG.

FIG. 22 is a partially cutaway side view seen from the bottom of FIG. 21;

FIG. 23 is a side view seen from the right end of FIG. 21; FIG.

Explanation of symbols on the main parts of the drawings

1: I-131 capsule assembly and packaging automation device

2, 3: upper and lower capsule 4: absorbent

5: vial 7: rubber stopper

8: metal cap 9: base plate

10: powder supply device 30: stock solution distribution device

50: capsule assembly device 70: radioactivity measuring device

80: Vial rubber stopper assembly device 90: Vial capping device

100: articulated robot 110: label printing and attachment device

In order to achieve the above object, the present invention is commercialized by filling the upper and lower capsules, powder-absorbents in the upper and lower capsules, dispensing the I-131 solution, and then assembling the upper and lower capsules to measure radioactivity and then inserting and sealing the medicine bottles. An apparatus for assembling and packaging an I-131 capsule, comprising: a base plate for forming a base, a powder supply device for filling an absorbent into a lower capsule, and a U-shaped groove in the center of the absorbent to dispense an I-131 solution into the groove. Stock solution dispensing device, capsule assembly device for assembling the upper and lower capsules, radioactivity measuring device for measuring the radioactivity of the assembled upper and lower capsules, rubber stopper assembling device to fit the rubber stopper into the vial inserted into the assembled upper and lower capsules, metal Cap bottle capping device to seal with cap, powder supply device, capsule assembly device, radioactivity measuring device, bottle capping device, vial sealing device It intended to provide the upper and lower capsule, rubber septum, and I-131 capsule assembly and packaging automation device is configured as articulated robot for moving a metal cap or vial to a working position of the device.

Hereinafter, the I-131 capsule assembly and packaging automation device according to the present invention will be described in detail with reference to the accompanying drawings.

I-131 capsule assembly and packaging automation device of the present invention is a device for commercialization by encapsulating the radioisotope I-131 solution in capsules, upper and lower capsule supply, powder absorbent supply, I-131 solution distribution, capsule assembly, radioactivity measurement Automatic bottle packaging, label printing and labeling, and product sorting are performed automatically. It is made as small as possible to be installed inside a radiation-shielded hot cell, and the control console is installed outside the hot cell. It is intended to be performed remotely.

The I-131 capsule assembly and packaging automation device as shown in Figure 1 to Figure 3, generally, the base plate 9, powder supply device 10, stock solution distribution device 30, radioactivity measuring device 70, vial rubber stopper assembly device 80, vial capping device 90, label printing and attaching device 110 and their respective devices (10,30,50,70,80,90) (1) It consists of the articulated robot 100 which is made to operate the whole.

Here, the base plate 9 is in the form of a table to mount the various devices mentioned above and to facilitate the work of the operator. On this plate 9 is also placed the upper and lower capsules (2, 3), vials (5), rubber caps (7), metal caps (8) or the finished packaging for the production of I-131 capsules. Each panel 101, 103, 105, 107 is provided for waiting the capsule-filled vial 5. At this time, the installation position of each panel (101, 103, 105, 107) can be set arbitrarily regardless of any position if included in the working radius of the robot 100, the position of each other in the most suitable position according to the robot 100 control method or operation order. Is preferably determined. For example, as shown in FIG. 1, a plurality of upper and lower capsules 2 and 3 are provided in the panel 101, a plurality of rubber caps 7 are provided in the panel 103, and a plurality of medicine bottles 105 and a vial are provided in the panel 105. The plurality of metal caps 8 on the 105 and the panel 107 may be arranged in a state in which the plurality of packaging vials 5 are aligned vertically and horizontally, respectively.

A powder feeder 10 for supplying an absorbent 4 consisting of Na ₂ HPO ₄ powder used to fill the I-131 solution into the capsule into the lower capsule 3 is shown in FIGS. 7 to 9. The powder supply device 10 is generally installed in the powder container 14 for storing the absorbent 4, the stirring shaft 17 for smoothly introducing the absorbent, and the absorbent ( 4) The pressure rod 19 for extruding the absorbent into the lower capsule (3) during the feeding, the slider 21 for opening and closing the absorbent outlet 13 of the powder container 14, the slider 21 to the left and right to move the absorbent It is composed of a slide block 24 for loading the lower capsule (3) to be put in the input standby state.

The powder container 14 is, for example, a cylindrical cylinder, and is provided with a powder inlet 11 for injecting the absorbent 4 into one side wall, and the absorbent 4 in the inner chamber 12 communicating with the inlet 11. ), And a discharge port 13 for dispensing the absorbent added therein is formed at the bottom of one side wall. A cover 15 is installed at the upper opening of the powder container 14, and a stirring shaft 17 and a rotating motor 16 are mounted at the upper end of the cover 15, and the upper and lower surfaces are disposed on one side wall which is in the same line as the outlet 13. The pressurizing rod 19 is extended and installed, and the pressurizing cylinder 18 which causes the up-and-down movement of the pressurizing rod 19 is attached to the upper end of the pressurizing rod 19. As shown in FIG. The stirring shaft 17 which is interlocked with the rotary motor 16 is installed in the chamber 12 along the center line of the powder container 14, and the stirring shaft 17 is smoothly stirred by the absorbent 4 injected at the end of the stirring shaft 17. A stirring blade 25 is attached to enable discharge.

As shown in FIG. 7, the heater bracket 26 into which the powder container 14 is inserted and fixed therein is wound around the outer surface of the heater block 150 in the form of a band. By heating the (14), the water present in the air in the powder container 14 is removed to prevent the absorbent 4 from reacting with the water to solidify.

The heater block 26 and the powder container 14 are supported by the bed part 27 shown in FIG. 10, and the bed part 27 is the subplate 29 by the cover block 28 located at the lower ends of both sides. Is installed on the support. A pair of guide blocks 20 having inclined surfaces are bolted to the lower surface of the bed part 27, and along the guide blocks 20, a slider 21 having a dove tail cross section as shown in FIG. 9. ) Is installed to slide side to side.

A stopper 151 is attached to the right end of the guide block 20 to stop the movement of the guide block 20 by being caught on the right end surface of the bed part 27. A pair of spring guides 153 penetrates through the stopper 151. ) Is attached, and the spring guide 153 is supported in a horizontal state by a spring support 155 attached to the right end of the sub plate 29. In addition, a rebound spring 157 compressed between the spring support 155 and the stopper 151 is inserted around the spring guide 153. On the left end of the slider 21, a thin plate 159 serving as an opening / closing valve of the outlet 13 is formed to protrude to the left.

In the space between the upper surface of the subplate 29 and the cover block 28, a slide cylinder 22 is moved to the left and right. A slide block 24 is attached to the slide cylinder 22. On the left side of the block 24, a seating block 23 is inserted and installed for loading the lower capsule 3, wherein the seating block 23 is provided with an outlet 13 when the slide block 24 is at the bottom dead center. It is installed at the position coming on the same line. In addition, the upper left portion of the slide block 24 into which the seating block 23 is inserted is slightly protruded upward to form the locking jaw 161 so as to press the slider 21 to the right at a position adjacent to the right dead center.

The stock solution dispensing device 30, which is configured to dispense the I-131 solution into the lower capsule 3 filled with the absorbent 4 by the powder supply device 10, has a structure as shown in FIGS. One side plate 34a of the slide plate 32 and the rotating plate 34 branched in the shape of the slide plate 32 are formed to seat the lower capsule 3 by the capsule seating block 33 inserted into the upper right end. The support bracket 39 is attached to the holder 35 inserted through the groove 35, the groove forming shaft 36 gripped in the vertical direction by the holder 35, and the other branch plate 34b of the rotating plate 34. It consists of the dispenser 37 affixed perpendicularly | vertically by the following.

Here, the slide plate 32 is reciprocated from side to side by the slide cylinder 31 mounted on the sub plate 38, and the capsule seating block 33 inserted into the right side of the plate 32 is provided. Has a cylindrical cup shape to seat the lower capsule 3 by a seating groove 40 open at the top.

A vertically movable guide cylinder 41 is provided at a position opposite to the slide plate 32 on the sub plate 38. The upper end of the guide cylinder 41 is attached with a bracket plate 42, which is moved up and down by the cylinder 41, and the upper end of the bracket plate 42 also has a rotational driving force on the horizontal plane of the rotation plate 34. The rotary cylinder 43 which comes up is attached.

The holder 35, which is inserted through one branch plate 34a of the rotating plate 34 and suspended in the vertical direction, is fixed to the right end side of the branch plate 34a with a bolt 44, and The groove forming shaft 36 is integrally attached to the lower end by welding or the like. The groove forming shaft 36 is a rod-shaped member, which is moved up and down by the guide cylinder 41 as shown by the dotted line in FIG. 11, and is formed in a stepped form in which the diameter of the lower portion decreases closer to the lower end. The lower tip portion is formed by forming a U-shaped groove 6 as shown in FIG. 14 in the absorbent agent 4 in the lower capsule 3 mounted on the capsule seating block 33 while descending as the holder 35 is lowered. The forming tip 45 is used.

The dispenser 37 assembly, which is fastened to the other branch plate 34b of the rotating plate 34, has a structure as shown in FIG. 13, with a support bracket 39, a dispenser 37, and an I-131 stock solution container. 48). The support bracket 39 is bent in an L-shape and branched by an opening 49 penetrating at horizontal intervals in the horizontal portion to be inserted into two or more protrusions 46 protruding from the top of the branch plate 34b. It is fixed on the plate 34b. In addition, the dispenser 37 is attached to the vertical portion of the bracket 39 by a fastening means such as a bolt 47, and a predetermined amount of I in the U-shaped groove 6 of the absorbent agent 4 filled in the lower capsule 3. -131 Dispensing of the stock solution. In addition, the I-131 stock solution container 48 is installed on the rear surface of the vertical portion of the bracket 39 to communicate with the dispenser 37, and maintains the dispenser 37 with an appropriate amount of the I-131 stock solution.

Capsule assembling device 50 for assembling the upper capsule (2) to the lower capsule (3) is completed by the stock solution dispensing device 30, as shown in Figs. It consists of a capsule seating block 54, a capsule housing 58 adapted to support the capsule seating block 54, a clamp shaft 63 adapted to press the upper capsule 2, and a support portion thereof.

Each of the parts constituting the capsule assembly 50 is described in more detail as follows. First, the capsule seating block 54 has a sheet portion 51 through which the lower capsule 3 is loaded at the upper center position. The lower portion of the capsule seating block 54 is inserted into the capsule housing 58. The lift cylinder 53 is inserted coaxially along the axial direction, and the lift cylinder 53 is vertically moved from the bottom surface of the seat portion 51 to the upper surface which comes into contact with the bottom surface of the lower capsule 3. The push rod 52 is mounted.

The capsule housing 58 having a B-shaped body composed of a cylindrical body 55 forming a vertical portion and a base 57 forming a horizontal portion as a whole is fastened to insert the capsule seating block 54 on the center of the cylinder 55. A ball 163 is formed, and a lower portion of the lift cylinder 53 is inserted into the bottom center position of the fastening hole 163. In addition, the base 57, which is formed integrally with the cylinder 55 and extends to the left side, is bolted to the upper surface of the slide cylinder 56 so that the entire capsule housing 58 is left and right according to the left and right motion of the slide cylinder 56. Let's move.

On the opposite side of the sub plate 165 to which the slide cylinder 56 is attached, a guide cylinder 62 is mounted to move up and down. A bracket plate 59 is provided above the guide cylinder 62. The clamp plate 60 is bolted to the upper side of the bracket plate 59 in an offset state to the right. In the vicinity of the right end of the clamp plate 60, the clamp shaft 63 is attached to the position where the capsule sheet 51 comes on the same line when it comes to the left dead center, with the clamp shaft 63 inserted therein. Is in the form of a rod, and forms a pressing groove 61 that is curved such that the bottom surface has the same shape as the top surface of the upper capsule 2.

The radioactivity measuring device 70 adapted to measure the radioactivity of the I-131 solution injected into the upper and lower capsules 2 and 3 assembled by the capsule assembly device 50 is shown in detail in FIGS. 1 to 3. , Mounted on one side of the base plate 9, and composed of a frame pillar 71, a movable bundle 73, a vacuum shaft 74, a stopper 76, a movable cylinder 77, and an ion ionizer 75. do.

Here, the frame pillar 71 extends upwardly from the base plate 9, and guide rails 72 are vertically arranged on the side surfaces thereof. As shown in FIG. 4, the movable bundle 73, which is configured to move up and down along the guide rails 72, includes a transfer bed 77, a cylinder bracket 78, a shanghai cylinder 79, and a testing bar 176. ) Here, the transfer bed 77 is fitted to the guide rail 72 to move up and down along the frame pillar 71, the cylinder bracket 78 of the front surface of the transfer bed 77 extends forward, such as bolts It is to fasten the shangdong cylinder 79 by the fastening means.

The shankdong cylinder 79 attached to the front lower end of the cylinder bracket 78 moves the push bar 175 attached to the upper side up and down by a gap formed between the lower surface of the protrusion of the bracket 78. . In addition, the testing bar 176 mounted to the shanghai cylinder 79 in front of the push bar 175 is configured to grip the vacuum shaft 74.

In addition, the vacuum shaft 74 in the form of an elongated rod is gripped by the testing bar 176 located at the end of the movable bundle 73 to move up and down along the frame pillar 71, the stopper 76 Is mounted to the front of the movable cylinder 77 to move back and forth by the operation of the cylinder 77, the stopper pin 177 shown in FIG. 6 is inserted in the center as shown in more detail in FIG. The pinhole 178 is formed. The stopper pin 177 has a cup-shaped shape to be inserted into the pinhole 178, and the upper and lower capsules 2, which are moved by the multi-joint robot 100 to be in a standby state for introduction into the ion ionizing box 75, at the upper end thereof. A seating groove 178 on which 3) is seated is processed, and when the stopper 76 is retracted by the movable cylinder 77, the seating groove 178 is in the same line as the vacuum shaft 74.

The vacuum shaft 74 grips the upper and lower capsules 2 and 3 seated on the seating groove 178 on the lower surface by vacuum suction, and deeply inside the ion iontophore mounting groove 179 installed below the base plate 9. The upper and lower capsules 2 and 3 can be transported. Ion ionizer 75 is to measure the radioactivity of the upper and lower capsules (2, 3) transported by the vacuum shaft 74, formed on the bottom of the base plate 9 of the hot cell bottom diameter 500mm, depth 800mm It is seated in the ion iontophor mounting groove 179 and is fixed to the base plate 9 so that the depth can be adjusted according to the movement distance of the vacuum shaft 74.

17 and 18 is a device for assembling the rubber stopper 80 is a device for sealing the vial (5) into which the assembled upper and lower capsules (2, 3) is inserted with a rubber stopper (7), and the capsule assembly device (50) Although substantially similar in configuration, only the slide plate 83, which is intended to load the vial 5, and the buffer hammer 88, which is intended to fit the rubber stopper 7 into the vial 5, show different configurations.

Here, the slide plate 83 is formed on the upper surface one side of the vial sheet portion 81 is loaded with the vial (5), the lower surface is bolted to the slide plate 83 is moved left and right of the slide plate 83 The slide plate 83 is attached on the sub plate 170.

The buffer hammer 88 is attached to the cover plate 85 in a state where the slide plate 83 is in line with the seat portion 81 of the plate 83 when the slide plate 83 is located at the left dead center. And a shock head 86 for hitting the rubber plug 7 directly, and a shock absorber 87 for attenuating the shock transmitted by the push rod 169 from the shock head 86. At this time, the cover plate 85 to which the buffer hammer 88 is attached is bolted in an offset state to the bracket plate 84 attached to the top of the guide cylinder 167 so that the opposite side of the buffer hammer 88 can be moved up and down. have.

The vial capping device 90 shown in FIGS. 19 and 20 is likewise a device adapted to cap the rubber cap 7 portion of the vial 5 into which the rubber cap 7 is fitted with a metal cap 8 made of aluminum. It does not differ greatly in the capsule assembly apparatus 50 and its structure, and has only the different structures, such as the slide plate 93 and the pneumatic clamper 96 largely.

Here, the slide plate 93 has the same configuration as that of the slide plate 83, and the vial sheet portion 91 for loading the vial 5 on one side of the upper surface is formed, and likewise attached to the sub plate 171. The slide cylinder 92 makes it possible to move left and right.

In addition, a guide cylinder 173 is mounted on the opposite side of the slide cylinder 92 of the sub plate 171, and a bracket plate (1) which is moved up and down by the guide cylinder 173 on the upper portion of the guide cylinder 173 ( 94) is attached. At the end of the cover plate 95 bolted to the bracket plate 94 in an offset state, the pneumatic clamper is positioned at the same position as the vial sheet seat 91 when the slide plate 93 is in the left dead center. 96 is fixed through. This pneumatic clamper 96 is a widely used pneumatic clamper, and the lower edge portion of the metal cap 8 surrounding the rubber stopper 7 fitted to the vial 5 as shown in FIG. The neck portion is pressed to seal the medicine bottle 5. In this case, as the material of the metal cap 8, aluminum, which is generally excellent in workability and corrosion resistance, may be used.

The label printing and attaching device 110 illustrated in FIGS. 21 to 23 is a pivot mounted between the upper and lower double plates 111 and 111 ', the label printer 113 installed on the upper plate 111, and the upper and lower plates 111 and 111'. It consists of a cylinder assembly 114 and the labeling assembly 115 provided over the upper and lower plates 111 and 111 '.

Here, the label printer 113 is installed on the upper plate 111, as shown in Figure 22, the label roll 117, the label roll 117 is fitted therein and the label backing 118 label is removed Roller 119 is provided. And the semi-cylindrical label backing 118 support 120 having a diameter of the same length as the gap between the rollers (116, 119) the support pole 121 in the intermediate position of the rollers (116, 119) on the lower surface of the upper plate 111 It is rotatably attached to the center.

The rotating cylinder bundle 114 is mounted directly above the lower plate 111 'and causes the slide cylinder 112 to move left and right in the drawing 114 on the drawing, and is attached to the upper end of the slide cylinder 112 and is shown in FIG. By the push cylinder 122 causing the vertical movement, the rotary cylinder 123 is rotatably attached in the direction of the arrow (A) of Figure 21 from the upper end of the push cylinder 122, and by the connecting arm 124 It consists of a vacuum label adsorber 125 mounted at one end of the rotary cylinder 123.

Then, the labeling assembly 115 is a slide block 127 that moves straight to the left and right again, the vial rotation jig 129 of the top of the block 127, the vertical cylinder 130 for moving the jig 129 up and down and , Consists of a support roller 131 for supporting the vial (5) from the side. Here, in the slide block 127, a vial seating recess 126 in which the capping vial 5 is seated is processed at the right end, as shown in FIG. The vial rotating jig 129 is installed under the motor plate 132 so as to rotate the vial 5 seated in the seating groove 126 by the driving force of the motor 128.

The motor plate 132 is a guide shaft along the guide shaft 134 mounted on the upper plate 111 so that the rotary jig 129 can pass through the through hole 133 formed in the upper plate 111 to hold the vial. It reciprocates in a vertical direction by the driving force of the up-and-down cylinder 130 inserted in one side of 134. As shown in FIG. The one guide shaft 134 extends to the slide block 127 so that the vial support roller 131 can be fitted thereto. Now, a brief description will be given of an integrated process for manufacturing and packaging an I-131 capsule by the I-131 capsule assembly and packaging automation device according to the present invention, which is composed of the above-described devices.

First, the separated lower capsule is loaded correctly at a predetermined position. Then check if the lower capsule is loaded at the specified position. If the capsule is not loaded, stop the process and wait for the next command.

When the capsule is loaded in place, the powder feeder is operated to fill the lower capsule with a powder absorbent corresponding to about 90% of the lower capsule volume.

The lower capsule is then transferred to the stock dispensing device and the center of the powder in the capsule is pressed to form a concave groove so that the I-131 solution can be sufficiently absorbed by the absorbent in the next step. The dispenser is then used to inject the amount of I-131 stock solution entered into the computer into the absorbent in the lower capsule.

After I-131 solution is injected into the absorbent of the lower capsule, the lower capsule is transferred to the capsule assembly device and loaded in place, and the capsule is finished by covering the upper capsule and pressing it from above.

When the assembly of the upper and lower capsules is completed, the assembled upper and lower capsules are put into the radioactivity measuring device, the radioactivity is measured for 20 to 30 seconds, taken out and put into the vial for the next process.

When the bottle is put into the vial, the vial is transferred to the rubber stopper assembly device, the rubber stopper is fitted, and the bottle is transferred to the next bottle capping device to completely cap the bottle with the aluminum cap.

The capped vial is delivered to the label printing and attaching device, and the label is applied, and data values input to the computer are printed on the label according to the measured radioactivity.

Finally, the discharge of the defective product and inspection of the residue by the photo sensor completes the manufacture and packaging of the I-131 capsule.

Looking at each of these processes in more detail as follows.

Prior to operation, as shown in FIG. 1, the various components necessary for the packaging of the I-131 capsule assembly, namely, the upper and lower capsules (2, 3), the rubber cap (7), the vial (5), and the aluminum cap (8) Each of the panels 101, 103, 105 is placed in a working standby state.

Then, when the robot 100 is operated, the powder capsule shown in FIG. 7 is first supplied to the lower capsule 3 having the parts handling machine 102 of the robot 100 aligned with the capsule panel 101 according to a predetermined control sequence. It is loaded onto the seating block 23 of the device 10. At this time, check whether the lower capsule 3 is correctly loaded on the seating block 23.

When the loading of the lower capsule 3 is confirmed, the motor 16 is operated to operate the pressure cylinder 18 while stirring the absorbent stored by the stirring shaft 17 to the outlet 13 by the pressure rod 19. Pressurize the absorbent to be pushed out. At the same time, when the slide cylinder 22 is operated to move the slide block 24 to the right in FIG. 7 and reaches the right-side point, the slider 21 compresses the spring 157 by the latching jaw 161 and the guide block 20. To the right. In this way, when the thin plate 159 of the slider 21 moves to the right side, the discharge port 13 is opened, whereby the absorbent 4 pressurized by the pressure rod 19 moves in line with the discharge port 13. Into the lower capsule (3).

The lower capsule 3, in which the absorbent is added, is gripped by the parts handling unit 102 and moved to the stock solution supply device 30 shown in FIG. 11, and loaded into the capsule seating block 33 of the slide plate 32. When the loading is completed, the guide cylinder 41 and the rotary cylinder 43 operate to rotate the rotary plate 34 as shown by the dotted line in FIG. 11 and rotate in the direction of the arrow B of FIG. 36 is located on the same plane as the slide plate 32. At this time, the slide cylinder 31 is also operated to move the seating block 33 of the slide plate 32 to a position that is in line with the groove forming axis 36. Then, when the guide cylinder 41 returns to the position shown by the solid line, the absorbent 4 filled in the lower capsule 3 by the forming tip 45 of the groove forming shaft 36 is shown in FIG. The same U-shaped groove 6 is formed.

Then, when the rotary cylinder 43 is rotated in the direction of the arrow (C) of FIG. 12 and the dispenser 37 is on the same plane as the capsule seating block 33, as shown in FIG. 37 is opened to inject the internal I-131 stock solution into the U-shaped groove 6 of the lower capsule 3 located on the same line through the injection hole 37a. In this case, even if the injection is repeated several times, the I-131 stock solution can be replenished through the I-131 stock solution container 48, and thus, a certain amount of I-131 stock solution can be maintained in the dispenser 37 at all times.

In this way, the dispensing of the I-131 stock solution is completed by the lower capsule 3 parts handling unit 102 and is mounted on the capsule seating block 54 of the capsule assembly device 50 as shown in FIG. 15. Then, when the upper capsule 2 transferred by the parts handling machine 102 is placed on the lower capsule 3, the slide cylinder 56 is operated to move the capsule housing 58 to the left dead center in FIG. 15. Prior to this, the guide cylinder 62 is operated so that the clamp shaft 63 inserted through the clamp plate 60 is raised to the position shown by the dotted line in FIG. 15. Accordingly, the upper and lower capsules (2, 3) and the clamp shaft (63) seated on the capsule seat (51) are positioned on the same line, and the guide cylinder (62) is operated again, so that the clamp shaft (63) is lowered. The upper capsule 2 is pressed by the pressing groove 61 of the clamp shaft 63 and press-fitted to the outer circumferential surface of the lower capsule 3, and the assembly of the upper and lower capsules 2 and 3 is completed, and the assembly of the upper and lower capsules 2, 3) is raised by the push rod 52 of the lifting cylinder 3 so that the parts handling machine 102 is easy to hold.

The assembled upper and lower capsules 2 and 3 are transferred to the stopper 76 in the radioactivity measuring device 70 shown in FIG. 1 and placed on the stopper pin 177 shown in FIG. The stopper 76 is moved to the transfer point by the movable cylinder 77 so that the transfer operation of the machine 102 may be smooth. When the loading of the upper and lower capsules 2 and 3 on the stopper 76 is completed, the shankdong cylinder 79 of the movable bundle 73 shown in FIG. 4 is operated to move the testing bar 176 upwards. 74) Raise slightly. At the same time, the stopper 76 is retracted by the movable cylinder 77 so that the upper and lower capsules 2 and 3 are in line with the vacuum shaft 74, and then the vacuum shaft 74 is moved by the shankdong cylinder 79. The upper and lower capsules 2 and 3, which are lowered again and are in contact with the lower end of the vacuum shaft 74, are gripped by vacuum adsorption.

The upper and lower capsules 2 and 3 are gripped by the vacuum shaft 74 and then moved deeply into the ion ionizer mounting groove 179 as the movable bundle 73 guided by the guide rails 72 moves downward. In 75) the radioactive emissions are measured during the set time.

After the measured radiation amount is input to the control computer, the capsules 2 and 3 are again put into the vial 5 by the robot 100, and the vial 5 into which the capsule 3 is injected is the vial shown in FIG. 17. The capping device 80 is moved. When the vial 5 is inserted into the slide plate 83 seat portion 81 of the vial capping device 80, the rubber stopper 7 is aligned and placed on the opening of the vial 5 by the operation of the robot 100 again. The ground guide cylinder 167 and the slide cylinder 82 operate to move the vial cover plate 85 upward and the slide plate 83 to the left in the state shown in FIG. 17, and the vial 5 is fully buffered. The moment of being located on the same line as the hammer 88, the operation of the slide cylinder 82 is stopped. Then, the cover plate 85 descends to hit the rubber stopper 7 by the impact head 86 so as to fit the rubber stopper 7 into the opening of the vial 5. At this time, the shock absorber 87 attenuates the impact applied to the vial from the impact head 86.

The capping bottle 5 thus capped is transferred to the vial sealing device 90 by the robot 100 as shown in FIG. 19. Here, the vial 5 is inserted into the vial sheet portion 91 of the slide plate 93, and the cap 8 of the metallic material, which has been conveyed, is exactly inserted onto the rubber stopper 7 as shown. When insertion of the cap 8 is completed, the guide cylinder 173 and the slide cylinder 92 are operated to move the vial cover plate 95 upward and the slide plate 92 to the left in the drawing. The operation of the slide cylinder 92 is stopped at the position where 95) and the vial 5 come on the same line. Then, the guide cylinder 173 operates in the reverse direction, and the sealing operation of the vial 5 is completed by crimping the cap 8 by the pneumatic crimper 95 and pressing the bottle 8 of the vial 5.

The sealed vial 5 is finally transferred to the label printing and attaching device 110 shown in FIGS. 21 to 23 and the radioactivity measurement value, the manufacturing number, the manufacturing date, etc., measured by the radioactivity measuring device 70 are printed. The label is attached, first, the above items are printed on the label in the label printer 113. When the medicine bottle 5 capped in the mounting groove 126 of the slide block 127 is loaded, the slide block 127 is moved to the left side in the drawing, and the through hole 133 of the labeling assembly 115 of FIG. The position of the medicine bottle 5 is set in the labeling position which comes on the same line. At this time, the motor plate 132 is lowered by the up and down cylinder 130 to press the top of the vial with the rotary jig 129, and at the same time the support roller 131 approaches the vial and presses the side of the vial (5) (5) is in the labeling standby state.

Meanwhile, as the roller 116 shown in FIG. 11 rotates, the label roll 117 is released so that the label backing 118 is wound around the support 120 to partially drop the label from the backing 118. In this state, it is contact-adsorbed by the vacuum label adsorber 125 approaching from the right side according to the operation of the slide cylinder (112). At this time, the label adsorber 125 has a spring built therein so as to have elasticity when adsorption, thereby preventing the label from being damaged during adsorption.

In this way, when the label is adsorbed to the adsorber 125, the slide cylinder 112 of the rotating cylinder bundle 114 is returned to its original position, and by the operation of the rotary cylinder 123, the adsorber 125 moves to the arrow A in FIG. Rotate in the direction and come to the location marked by hidden lines. Subsequently, when the push cylinder 122 is operated, the label adsorber 125 advances in the direction of the arrow B and attaches the label adsorbed to the tip to the side of the vial 5 of the vial seating groove 126 that moves in the same line. do. Then, the cylinders 122 and 123 operate in the reverse order to the label adsorption operation and return to their original positions. Then, the motor 128 rotates to rotate the vial 5 partially labeled by the jig 129, and thus the vial 5. Labeling is completed by wrapping the label between the roller and the roller 131.

Thus, according to the I-131 capsule assembly and packaging automation device of the present invention, it is possible to assemble and package a large amount of I-131 capsules by remote control in the radiation-shielded hot cell to significantly increase the work efficiency and productivity It is possible to perform a more precise work than in the case of the manual work it is possible to homogenize the product. And best of all, the operator does not have to deal directly with the I-131 capsule, which almost completely eliminates the risk of radiation exposure from the operator, which can occur if.

Therefore, since the efficiency of assembly and packaging of the I-131 capsule can be maximized, the quality of the I-131 capsule can be improved and the cost can be reduced.

While the invention has been shown and described with respect to particular embodiments, it will be understood by those skilled in the art that various modifications and changes can be made without departing from the spirit and scope of the invention as indicated by the appended claims. Anyone can grow up easily.

Claims (12)

Fill the capsules (2,3) separated up and down, the powdered absorbent (4) in the upper and lower capsules (2, 3), dispense the I-131 solution and then assemble the upper and lower capsules (2, 3) to measure radioactivity In the apparatus (1) for assembling and packaging a commercialized I-131 capsule by inserting and sealing in a vial (5) after passing through, the base plate (9) forming a base portion, and the absorbent (4), the lower capsule (3). ), A powder supply device (10) filled in the center, a U-shaped groove (6) is formed in the center of the absorbent (4) and the stock solution distribution device (30) for dispensing the I-131 solution in the groove (6), the upper and lower Capsule assembly device 50 for assembling capsules (2, 3), radioactivity measuring device (70) for measuring the radioactivity of the assembled upper and lower capsules (2, 3), the assembled upper and lower capsules (2, 3) is inserted Vial capping device 80 to fit the rubber stopper 7 to the vial (5), the vial sealing device 90 for sealing the capped vial (5) with a metal cap (8), and the powder supply station 10, each device in connection with the stock solution distribution device 30, the capsule assembly device 50, the radioactivity measuring device 70, the medicine bottle capping device 80, the medicine bottle sealing device 90 ( I-131, characterized in that it consists of a multi-joint robot 100 for moving the upper and lower capsules (2, 3) or the vial (5) to the working position of 10, 30, 50, 70, 80, 90. Capsule assembly and packaging automation. The upper and lower capsules (2, 3), the rubber stopper (7), the medicine bottle (5), the cap (8), or the medicine bottle (5) of which commercialization is finished, on the upper surface of the base plate (9). I-131 capsule assembly and packaging automation device, characterized in that each panel (101,103,105,107) for loading is installed. The powder supply apparatus 10 of claim 1, wherein the powder inlet 11 penetrates one side of the powder supply device 10, a chamber 12 is formed therein, and the powder outlet 13 penetrates through the lower side of the one side wall. It is installed along the central axis of the powder barrel 14 so as to rotate in the chamber 12 by a motor 16 mounted on the upper side of the powder container 14, the cover 15 of the powder container 14, A stirring shaft 17 having a stirring blade 25 in the upper portion of the powder cylinder 14 in a straight line in a straight line with the outlet port 13 so as to move up and down by a pressurized cylinder 18 installed at an upper end thereof. On the lower end of the slider 21 supported by the guide block 20 to move left and right along the lower surface of the powder container 14 to open and close the pressurized rod 19, the outlet 13, It is moved to the left and right by the attached slide cylinder 22 to press or release the slider 21 Assembly of the I-131 capsule, characterized in that it comprises a slide block 24 is inserted into the seating block 23 for the lower capsule (3) in a position coming in line with the outlet 13 when pressurized and Packaging Automation. The slide plate according to claim 1, wherein the stock solution dispensing device (30) is reciprocated from side to side by a slide cylinder (31) and a capsule seating block (33) is inserted into which the lower capsule (3) is seated at the right end. (32), guide cylinder (41) and rotary cylinder (43) reciprocating and rotational movement in the vertical and horizontal directions, respectively, and the U-shaped rotary plate 34, one end is divided into branch plates (34a, 34b) ), A groove forming shaft 36 attached to the holder 35 suspended from the end of one side branch plate 34a of the rotary plate 34 and extending in the vertical direction, and the other branch plate of the rotary plate 34. I-131 capsule assembly and packaging automation device, characterized in that the dispensing unit 37 is attached to the end of the 34b in a vertical direction by the support bracket (39). The rotary assembly of claim 1, wherein the capsule assembly device 50 is provided with a lower rod (3) seat portion (51) formed at a center of an upper end thereof, and a push rod (52) protruding from the seat portion (51) at a lower end thereof. Moving left and right with the capsule mounting block 54 in which the cylinder 53 is coaxially inserted and the cylinder 55 in which the fastening hole 163 into which the lower end of the rotary cylinder 53 is inserted at the center position is processed. A capsule housing 58 formed of a base 57 extending to the side of the cylinder 55 so as to be attached to the slide cylinder 56, and a bracket plate in line with the capsule seat portion 51 at the left dead center. A guide cylinder inserted into the position on the clamp plate 60 connected to 59 and having a pressing groove 61 coinciding with the upper surface of the upper capsule 2 on the lower surface thereof and connected to the bracket plate 59. Move up and down according to the up and down movement of 62 Is I-131 capsule assembly and packaging automation device, characterized in that the clamp comprises a shaft 63 to which. According to claim 1, The radioactivity measuring device 70 is installed on one side end of the base plate (9) extending along the frame pillar 71, along the guide rail 72 of the frame pillar 71 Movable bundle 73 which is to move up and down, the vacuum shaft 74 is coupled to the end of the movable bundle 73 to hold the assembled upper and lower capsules 2 and 3 by vacuum suction, the upper and lower A stopper 76 which is moved back and forth by the movable cylinder 77 so that the capsules 2, 3 can be placed on the same line as the vacuum shaft 74, and the upper and lower capsules inserted along the vacuum shaft 74 ( 2,3) I-131 capsule assembly and packaging automation device characterized in that it comprises an ion ionizing box (75) for measuring the radioactivity. The movable bundle 73 is a transfer bed 77, which is to move up and down along the guide rail 72, the cylinder bracket 78 is fastened to the front surface of the transfer bed (77). ), And is mounted to the front of the cylinder (79) through a shankdong cylinder (79) attached to the front lower end of the cylinder bracket (78), and a push bar (175) fastened to the upper end of the shankdong cylinder (79). I-131 capsule assembly and packaging automation device, characterized in that consisting of a testing bar (176). 2. The vial capping device (80) according to claim 1, wherein the vial capping device (80) includes a slide plate (83) attached to a slide cylinder (82) which is formed on a vial sheet portion (81) opened from an upper surface, and moves left and right, and a left yarn The penetrating insert is inserted into a position on the vial cover plate 85 connected to the vial sheet portion 81 of the slide plate 83 at the point and the bracket plate 84 in a straight line, and hits the rubber stopper 7. I-131 capsule assembly and packaging automation device comprising a shock hammer (86) consisting of a shock head (86) and a shock absorber (87) for attenuating the amount of impact applied by the impact head (86). 2. The vial sealing device (90) according to claim 1, wherein the vial sealing device (90) includes a slide plate (93) formed with a vial sheet portion (91) opened from an upper surface thereof and attached to a slide cylinder (92) moving left and right, The rubber stopper 7 is fixed in a position on the vial cover plate 95 connected to the bracket plate 94 in a straight line with the vial seat portion 91 of the slide plate 93 at the left dead center. I-131 capsule assembly and packaging automation device characterized in that it comprises a pneumatic crimper (96) which is to be sealed to the vial (5) by a cap (8). The label printing and attaching apparatus 110 of claim 1, wherein the label printing and attaching device 110 includes a label printed on the upper and lower double plates 111 and 111 ′, a label printer 113 installed on the top of the upper plate 111, and the label printer 113. Rotating cylinder bundle 114 for removing and moving to the vial (5), Label transfer assembly 115 for wrapping the label transferred from the rotating cylinder bundle 114 around the vial (5) and attached I-131 capsule assembly and packaging automation. The label cylinder of claim 10, wherein the rotating cylinder bundle 114 is in contact with the support 120 to remove the label from the label backing 118 by vacuum suction, and the left and right sides of the bundle 114. A slide cylinder 112 generating a motion, a push cylinder 122 attached to an upper end of the slide cylinder 112 to move the label adsorber 125 forward and backward, and a label adsorber attached to an upper end of the push cylinder 122 ( I-131 capsule assembly and packaging automation device, characterized in that consisting of a rotary cylinder (123) for rotating 125 at a right angle. The motor assembly of claim 10, wherein the labeling assembly (115) moves up and down along a slide block (127) and a guide shaft (134), which are loaded with a vial (5) to which a label is attached, and causes left and right movement. Rotating jig 129, the motor plate 132 to protrude to the lower surface of the 132 to rotate the vial (5) by the rotational force of the motor 128 mounted on the plate 132 top A vertical cylinder 130 which is integrally attached to the motor plate 132 and a side surface of the vial 5 held by the rotary jig 129 to move upward and downward of the rotary jig 129. I-131 capsule assembly and packaging automation device, characterized in that consisting of a support roller 131 is to press.