KR100242858B1 - Hair shampoo composition for the treatment of itching or dandruff - Google Patents

Abstract

The present invention relates to a hair shampoo composition having an anti-dandruff and anti-itch effect. Specifically, the present invention relates to hair shampoo compositions which contain niacin (nicotinic acid, nicotinamide or mixtures thereof) to exhibit antidandruff and anti-itch effects.

Description

Hair shampoo composition containing niacin

The present invention relates to a composition of hair shampoo containing niacin. More specifically, the present invention relates to a hair shampoo composition which contains nicotinic acid, nicotinamide or mixtures thereof, which exhibits anti-dandruff and anti-itch effects.

Traditional soaps or hair shampoos are used to clean the hair and scalp, and some consumers may experience itching or dandruff.

Cosmetic soaps or regular shampoos sometimes cause itching or dandruff on the scalp due to excessive cleaning, excessive conditioning, or unnecessary irritation. Although varying in degree, almost everyone can have itching or dandruff on a daily basis.

Itching or dandruff is not necessarily a symptom of the same cause. People who have dandruff almost have itching, but itching does not necessarily mean that they have dandruff. This itch or dandruff is caused by internal and external factors, such as: ① endocrine disturbances (endocrine disturbance), ② metabolic imbalance, carbohydrates, fat, etc., disorder in digestion, ③ Nervous system dearrangement such as stress, ④ biochemical changes in epithelial cells such as hyperproliferation of scalp cells, ⑤ genetic predisposition, as in the case of baldness External factors include ① hyperproliferation and increased activity of scalp microorganisms (especially increased reproduction of Pytirosporum ovale ), ② inflammation by external substances such as medicines and cosmetics, and ③ excessive exposure to contaminated outdoor air or ultraviolet light.

In order to escape from the itch or dandruff caused by these factors, anti-dandruff drugs, quasi-drugs, and cosmetics are used. Topical treatments are used. ① Anti-dandruff agents are used for proper bacteriocidal activity, ② anti-inflammatory properties. (Antiinflammatory effect), ③ Keratolitic effect, ④ It has the requirements of anti-hyperproliferation activity, and anti-dandruff substances known so far include tar, zinc-pyrithione, Pyroctone olamine, sulfur, selenium sulfide, crimazole, salicylic acid, camphor, menthol, captan, allantoin, and corticosteroids There is this.

These substances are not effective for both itching and dandruff, which have multiple causes and complex symptoms, making it difficult for consumers to choose products that are suitable for their condition. In addition, some products are manufactured by combining anti-dandruff drugs, but they are not satisfactory. Due to its excellent anti-inflammatory effect, the most effective corticosteroids for the relief of itching and dandruff are frequent problems due to their frequent side effects. In particular, there is no substance proved sebum secretion regulating ability and prevention of cell hyperdifferentiation.

After using cosmetic soap and hair shampoo, few consumers complain of itching of the scalp. Itching or dandruff caused by the use of cosmetic soaps or regular shampoos is a case where the scalp is caused by excessive washing, excessive conditioning, or unnecessary irritation. In order to solve this problem, the weight of shampoo prescription or anti-dandruff may be added, but it is not a clear solution. Therefore, it is necessary to develop or discover a substance exhibiting anti-itch and anti-dandruff effects by prescribing to cosmetics that should be used daily.

Prior to the present invention, niacin is an essential nutrient for cell energy metabolism and major enzyme production, and has been used as an antidote for arteriosclerosis, heart disease, and alcohol poisoning. In particular, it has a therapeutic effect on arthritis and a blood flow promoting effect. It has been known.

The present inventors found that niacin was prescribed and tested in hair cosmetics, such as shampoo, to improve dry skin and weak hair, and to exhibit anti-dandruff and particularly anti-itch effects.

The present invention provides a shampoo composition containing niacin. Niacin herein includes nicotinic acid, nicotinamide or mixtures thereof.

Niiacin is safe enough to be frequently used as a food additive, so it can be used for regular hair cosmetics. However, the present inventors also found that the stability of the material itself and the compatibility with other ingredients are excellent even when prescribed in shampoo products. It was.

Niacin-containing shampoo products according to the present invention shows a significant improvement in those who have a high sebum secretion or those with seborrheic dandruff and who are sensitive to itching.

The composition according to the invention preferably contains the following components:

1. Cleaning agent

In the present invention, most anionic surfactants can be used, but mainly alkyl sulfates, carboxylates, and protein-based or amino acid-based surfactants are used. They have alkyl radicals having _{8 to 22} carbon atoms or when ethylene oxide (EO) is added. The blending amount is 4 to 30%, particularly preferably 8 to 20%, based on the actual amount (based on the active amount) as a single or combination product.

Cationic surfactants that are frequently used as auxiliary cleaners or mild detergents include betaines such as cocamidopropyl betaine, sulfanes such as cocamidopropyl celtate, and imidazole surfactants such as coco amppocarboxyglycinate. Used as The length of these carbon chains is also C ₈ -C ₂₂ and is blended 1.5 to 10% in an actual amount as a single or a combination, and particularly preferably 2 to 6% is used. In particular, the anti-irritant effect and the conditioning effect appear in the product when the compounding ratio of the anion cleaner is adjusted to a 2: 1 to 3: 1 ratio.

2. Increased and bubble stabilizer

In general, amine oxides or alkanolamides are used, but among the alkanolamides of C ₈ -C ₂₄ , monoethanolamide or diethanolamide are used. Particularly preferred is lauric acid diethanolamide and cocamide. Diethanolamide, lauroyl diethanolamide or cocamide monoethanolamide are blended in a single or combined amount in an amount of 1 to 7%.

3. Polymer Conditioner

Polyquaternium-7, Polyquaternium-10, Polyquaternium-11, Polyquaternium-22 and Guahydroxypropyltrimonium chloride are available in the range of 0.1 to 1.5% as a single or combination, particularly preferably from 0.12 to It is compounded in 0.7% amount.

4. Moisturizer

Propylene glycol, hexylene glycol, sodium lactate and sodium pyrrolidone carboxylate (PCA-Na) can be used as a single or a combination of 0.3 to 3.5%. Especially preferably, it mix | blends 0.5-2.0% content.

5. Emulsions

Glycostearate is mainly used and the content is 0 to 3%.

6. Conditioner

An absolute amount of 0.1 to 3.0% is used as a single or a combination of alkyltrimethylammonium chloride, dialkyldimethylammonium chloride and trialkylmethylammonium chloride having C ₁₀ -C ₂₂ carbon atoms.

Another glittering agent and hair coating agent may be blended in an absolute amount of 0.1 to 2.5% as a single or a combination of dimethicone and amodimethicone, which are silicone compounds. The degree of polymerization of the dimethicone is expressed in viscosity up to 5,000 cps-Gum.

Fat alcohols are used to maintain the luster of hair and to give thixotropy in the product. Mainly, 0.15 to 1.5% of cecyl alcohol, stearyl alcohol and behenyl alcohol can be used as a single or a combination.

7. Other

Protein-based hair nutrients and plant and animal extracts that protect skin or hair can be mixed as needed.

The present invention is illustrated by the following examples. However, these examples should not be understood as limiting the present invention. The ratios described in these examples are based on the weight of the resulting composition.

(Example)

(Examples 1 to 4)

A nicotinic acid-containing shampoo composition prepared with the components and the component ratios as shown in Table 1 was prepared.

Raw material Standard prescription 1 Example 1 Example 2 Example 3 Example 4 Ammonium Lauryl Sulfate Sodium Lauryl Sulfate Cocamide DEA Cocamidopropyl Betaine Polyquaternium-10 Cationic Hydrolysis Animal Protein Propylene Glycol EDTA-2Nanicotinic Acid Preservative Pigment Citric Acid Flavor NaCl Pure Water 15.020.04.05.00.40.31.00.1- Quantitative volume pH 5.5 to 7.0 Volumetric quantity 100 15.020.04.05.00.40.31.00.10.05 Quantities pH 5.5 to 7.0 Quantities 100 15.020.04.05.00.40.31.00.10.3Property pH 5.5 to 7.0 Proper quantity up to 100 15.020.04.05.00.40.31.00.10.5 Suitable for pH 5.5 to 7.0 Suitable for 100 15.020.04.05.00.40.31.00.12.0 Suitable for pH 5.5 to 7.0 Suitable for 100

Among the raw materials, ammonium lauryl sulfate has a purity of 30.0%, sodium lauryl sulfate 28.0%, cocamidopropyl betaine 37.0%. Reference prescription 1 illustrates the configuration of the most common conditioning shampoo, and Examples 1 to 4 are prescriptions configured by varying nicotinic acid content.

(Examples 5 to 8)

A nicotinamide-containing shampoo composition prepared with the components and component ratios as shown in Table 2 below was prepared.

Raw material Standard prescription 2 Example 5 Example 6 Example 7 Example 8 Ammonium lauryl sulfate sodium lauryl sulfate lauamide DEA coco ampocarboxyglycyanate polyquaternium-7 alkyltrimethylammonium chloride ethylene glycol stearate emulsified silicone gum cetyl alcohol propylene glycol EDTA-2Na nicotinamide preservative pigment citric acid perfume pure water 15.015.05.08.01.00.81.02.00.51.00.1-Proper volume pH 5.5 to 7.0 Volume 100 15.015.05.08.01.00.81.02.00.51.00.10.1 Quantity appropriate pH 5.5 to 7.0 quantity 100 15.015.05.08.01.00.81.02.00.51.00.10.5suitable for pHpH 5.5 to 7.0 suitable for 100 15.015.05.08.01.00.81.02.00.51.00.11.0 Quantity appropriate pH 5.5 to 7.0 quantity 100 15.015.05.08.01.00.81.02.00.51.00.12.0 Suitable for pH 5.5 to 7.0 Suitable for 100

Among the raw materials used, ammonium lauryl sulfate has a purity of 30.0%, sodium lauryl sulfate 28.0%, and alkyltrimethylammonium chloride has a purity of 50.0%. Reference Prescription 2 exemplifies the composition of the most common combined shampoos, and Examples 5 to 8 are prescriptions composed of different nicotinamide contents.

In order to test the anti-itch and anti-dandruff effect of niacin in the hair shampoo, the standard prescription and the examples of Table 1 and Table 2 were used in the test group based on the following procedure and the results were confirmed.

The test group consisted of 25 men and women in their 20s and 40s who were sensitive to dandruff or itching for each of Examples 1 to 8. The test period is set to a total of 5 weeks, and the test group using Examples 1 to 4 first uses the shampoo provided by the reference prescription 1 every 2 days for 2 weeks, and rests for 1 week, which Examples 1 to 4 provide for the remaining 2 weeks. The shampoo was used every 2 days and the results were observed. The test group using Examples 5 and 6 first used the shampoo provided by Reference Prescription 2 every two days for two weeks, and rested for one week, using the shampoo provided by Examples 5 to 8 every two days for the remaining two weeks. The results were observed and the results are as follows.

The degree of itching was as follows: ① The feeling of sensory by sensory was not changed as before use. ② Itching was alleviated. ③ Itching was eliminated. After the use of each test product, it was answered. When the itching was reduced or disappeared, the effective rate was calculated.

The degree and amount of dandruff was also determined using the Schrader method and the Dietrich-Bollert method after the use of the test product.

These results are shown in Tables 3 to 6 below.

Itching effect Itching worsened No change before use Itching has been alleviated Itching disappeared After use of standard prescription 1 1/100 (person) 90/100 9/100 - Example 1 Use Group 1/25 14/25 7/25 3/25 Example 2 Use Group - 8/25 13/25 4/25 Example 3 Use Group - 3/25 17/25 5/25 Example 4 Use Group - 2/25 13/25 10/25 After using standard prescription 2 3/100 91/100 6/100 - Example 5 Use Group 2/25 12/25 10/25 1/25 Example 6 Use Group - 8/25 12/25 5/25 Example 7 Use Group - 2/25 15/25 8/25 Example 8 Use Group 1/25 1/25 14/25 9/25

Criteria 1 was a general conditioning shampoo with a clear formulation, and most of the subjects did not feel the difference before use, but the part that relieved itching seemed to be caused by scalp cleaning.

The effective rate of Example 1 in which 0.05% of nicotinic acid was prescribed was 40.0% (10/25), and the effective rate of Example 2 in which 0.03% of nicotinic acid was prescribed was 68.0% (20/25) and 0.5% of nicotinic acid. The effective rate was 88.0% (22/25), and Example 4 in which 2.0% of nicotinic acid was prescribed showed an effective rate of 92.0%. In the case of Example 4, three subjects who answered separately that the skin became hot and irritated to the eye mucosa immediately after use were three. The results suggest that nicotinic acid is an effective anti-itching agent, but it may be somewhat irritating to the skin when its content is excessive.

The standard prescription 2 is an opaque pearl-type combination shampoo, which means that the majority of the subjects did not feel the itch difference before use and the itch was reduced. Combination shampoos that are characterized by strong conditioning action may cause some itching.

Example 5 containing 0.1% nicotinamide had an effective rate of 44.0%, Example 6 containing 0.5% nicotinamide had an effective rate of 68.0%, and Example 7 containing 1.0% nicotinamide had an effective rate of 92.0%. Example 8 containing 2.0% of nicotinamide showed an effective rate of 92.0%, respectively. In addition, two of the subjects using Example 8 felt skin and eye irritation immediately after use.

As a result, nicotinamide also acts as an effective anti-itching agent, but when the content is too high, it may have side effects of irritating the skin and eye mucosa, and the effective ratio is stagnating at about 90.0%. It is judged to be less than%.

The two compounds, called niacin, nicotinic acid and nicotinamide both have similar effects. However, when prescribed in the form of nicotinic acid product is more acidic.

Effects on Common Dandruff Symptoms increased No change before use Symptoms have been reduced No symptoms After use of standard prescription 1 - 90/100 (persons) 9/100 1/100 Example 1 Use Group - 16/25 8/25 1/25 Example 2 Use Group - 11/25 11/25 3/25 Example 3 Use Group - 4/25 18/25 3/25 Example 4 Use Group - 4/25 14/25 7/25 After using standard prescription 2 - 94/100 6/100 - Example 5 Use Group - 16/25 8/25 1/25 Example 6 Use Group - 10/25 12/25 3/25 Example 7 Use Group - 2/25 16/25 7/25 Example 8 Use Group - 1/25 17/25 7/25

Effects on Psoriasis Symptoms increased No change before use Symptoms have been reduced No symptoms After use of standard prescription 1 - 94/100 (persons) 6/100 - Example 1 Use Group - 18/25 7/25 - Example 2 Use Group - 12/25 12/25 1/25 Example 3 Use Group - 7/25 17/25 1/25 Example 4 Use Group - 5/25 17/25 3/25 After using standard prescription 2 2/100 92/100 6/100 - Example 5 Use Group - 15/25 10/25 - Example 6 Use Group - 7/25 16/25 2/25 Example 7 Use Group - 4/25 18/25 3/25 Example 8 Use Group 1/25 3/25 17/25 5/25

The reduction of niacin (nicotinic acid and nicotinamide) on general dandruff and psoriasis dandruff tends to be slightly weaker than that of itching, but has an effective effect. Niacin was more effective in the normal conditioning shampoo than in the combined shampoo. As shown in the test results, the shampoo formulation shows the maximum effectiveness at around 1.0%.

Seborrhoic-dandruff effect Symptoms increased No change before use Symptoms have been reduced No symptoms After use of standard prescription 1 1/100 91/100 (persons) 8/100 - Example 1 Use Group 1/25 12/25 11/25 1/25 Example 2 Use Group - 8/25 16/25 1/25 Example 3 Use Group - 3/25 17/25 5/25 Example 4 Use Group - 2/25 13/25 10/25 After using standard prescription 2 1/100 92/100 7/100 - Example 5 Use Group - 12/25 12/25 1/25 Example 6 Use Group - 7/25 14/25 4/25 Example 7 Use Group - 3/25 14/25 8/25 Example 8 Use Group 1/25 1/25 13/25 10/25

As shown in the above results, niacin has a better effect on seborrheic dandruff and itching than general dandruff and psoriasis dandruff. The effectiveness of use was 92.0% (23/25) with 1.0% of nicotinic acid and nicotinamide in both products.

Claims (2)

Shampoo composition characterized in that it contains nicotinic acid, nicotinamide or mixtures thereof. The composition of claim 1, wherein the content of nicotinic acid, nicotinamide, or mixtures thereof is 2.0% or less by weight of the composition.