KR100219126B1 - 비정형 헤모필루스의 고분자량 표면 단백질들 - Google Patents
비정형 헤모필루스의 고분자량 표면 단백질들 Download PDFInfo
- Publication number
- KR100219126B1 KR100219126B1 KR1019940703224A KR19940703224A KR100219126B1 KR 100219126 B1 KR100219126 B1 KR 100219126B1 KR 1019940703224 A KR1019940703224 A KR 1019940703224A KR 19940703224 A KR19940703224 A KR 19940703224A KR 100219126 B1 KR100219126 B1 KR 100219126B1
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- KR
- South Korea
- Prior art keywords
- protein
- hmw1
- molecular weight
- proteins
- hmw2
- Prior art date
Links
- 241000606790 Haemophilus Species 0.000 title abstract description 22
- 108010052285 Membrane Proteins Proteins 0.000 title description 3
- 102000018697 Membrane Proteins Human genes 0.000 title description 2
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 167
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 114
- 101100017567 Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2)) hlp1 gene Proteins 0.000 claims abstract description 11
- 101100395360 Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2)) hlp3 gene Proteins 0.000 claims abstract description 11
- 101150051207 hmw3 gene Proteins 0.000 claims abstract description 11
- 101150045401 hmw1 gene Proteins 0.000 claims description 80
- 101150107814 hmw2 gene Proteins 0.000 claims description 63
- 101100017570 Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2)) hlp2 gene Proteins 0.000 claims description 60
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 24
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- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
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- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 241001131785 Escherichia coli HB101 Species 0.000 description 1
- 101000806383 Fowlpox virus (strain NVSL) Uncharacterized protein FPV009/FPV252 Proteins 0.000 description 1
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- AFYNADDZULBEJA-UHFFFAOYSA-N bicinchoninic acid Chemical compound C1=CC=CC2=NC(C=3C=C(C4=CC=CC=C4N=3)C(=O)O)=CC(C(O)=O)=C21 AFYNADDZULBEJA-UHFFFAOYSA-N 0.000 description 1
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
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- BTIJJDXEELBZFS-QDUVMHSLSA-K hemin Chemical compound CC1=C(CCC(O)=O)C(C=C2C(CCC(O)=O)=C(C)\C(N2[Fe](Cl)N23)=C\4)=N\C1=C/C2=C(C)C(C=C)=C3\C=C/1C(C)=C(C=C)C/4=N\1 BTIJJDXEELBZFS-QDUVMHSLSA-K 0.000 description 1
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/851—Haemophilus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9205704.1 | 1992-03-16 | ||
| GB929205704A GB9205704D0 (en) | 1992-03-16 | 1992-03-16 | High molecular weight membrane proteins of non-typeable haemophilus |
| PCT/US1993/002166 WO1993019090A1 (en) | 1992-03-16 | 1993-03-16 | High molecular weight surface proteines of non-typeable haemophilus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR950700936A KR950700936A (ko) | 1995-02-20 |
| KR100219126B1 true KR100219126B1 (ko) | 1999-10-01 |
Family
ID=10712229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019940703224A KR100219126B1 (ko) | 1992-03-16 | 1993-03-16 | 비정형 헤모필루스의 고분자량 표면 단백질들 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US5549897A (ru) |
| EP (1) | EP0632814B1 (ru) |
| JP (1) | JP2810235B2 (ru) |
| KR (1) | KR100219126B1 (ru) |
| AT (1) | ATE222955T1 (ru) |
| AU (1) | AU669360B2 (ru) |
| BR (1) | BR9306109A (ru) |
| CA (1) | CA2131837C (ru) |
| DE (1) | DE69332243T2 (ru) |
| DK (1) | DK0632814T3 (ru) |
| ES (1) | ES2183812T3 (ru) |
| FI (1) | FI116838B (ru) |
| GB (1) | GB9205704D0 (ru) |
| NO (1) | NO316623B1 (ru) |
| PT (1) | PT632814E (ru) |
| RU (1) | RU2157816C2 (ru) |
| WO (1) | WO1993019090A1 (ru) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020164354A1 (en) * | 1998-09-30 | 2002-11-07 | Barenkamp Stephen J. | High molecular weight surface proteins of non-typeable haemphilus |
| US5977336A (en) * | 1993-03-16 | 1999-11-02 | St. Louis University | High molecular weight surface proteins of non-typeable haemophilus |
| AU696207B2 (en) * | 1993-03-16 | 1998-09-03 | St. Louis University | High molecular weight surface proteins of non-typeable haemophilus |
| US5834187A (en) * | 1994-07-19 | 1998-11-10 | Bactex, Inc. | Sequence and analysis of LKP pilin structural genes and the LKP pili operon of nontypable Haemophilus influenzae |
| ATE315648T1 (de) * | 1994-07-19 | 2006-02-15 | Wyeth Corp | Haemophilus influenzae (nt hi) lkp tip adhesin protein und nukleinsäure |
| US5968769A (en) * | 1994-07-19 | 1999-10-19 | American Cyanamid Co. And Bactex, Inc. | Sequence and analysis of LKP pilin structural genes and the LKP pili operon of nontypable Haemophilus influenzae |
| US5643725A (en) * | 1994-07-19 | 1997-07-01 | American Cyanamid Company | Sequence and analysis of LKP pilin structural genes and the LKP pili operon of nontypable haemophilus influenzae |
| US6245337B1 (en) * | 1994-08-25 | 2001-06-12 | Washington University | Haemophilus adherence and penetration proteins |
| US6468765B1 (en) * | 1995-04-21 | 2002-10-22 | Human Genome Sciences, Inc. | Selected Haemophilus influenzae Rd polynucleotides and polypeptides |
| US6355450B1 (en) | 1995-04-21 | 2002-03-12 | Human Genome Sciences, Inc. | Computer readable genomic sequence of Haemophilus influenzae Rd, fragments thereof, and uses thereof |
| US6465631B1 (en) * | 1997-05-19 | 2002-10-15 | Duke University | Lipid a 4′ kinase |
| CA2345208C (en) * | 1998-10-07 | 2012-01-17 | Aventis Pasteur Limited | Protective recombinant haemophilus influenzae high molecular weight proteins |
| US6432669B1 (en) | 1998-10-07 | 2002-08-13 | Aventis Pasteur Limited | Protective recombinant Haemophilus influenzae high molecular weight proteins |
| US6974581B1 (en) * | 1998-12-15 | 2005-12-13 | Aventis Pasteur Limited | Multi-component vaccine comprising at least two antigens from haemophilus influenzae to protect against disease |
| GB9904183D0 (en) * | 1999-02-24 | 1999-04-14 | Smithkline Beecham Biolog | Novel compounds |
| US7785609B1 (en) | 1999-03-16 | 2010-08-31 | Sanofi Pasteur Limited | Recombinant Haemophilus influenzae adhesin proteins |
| MXPA02004222A (es) | 1999-10-29 | 2002-10-17 | Isle Coat Ltd | Cilindro grabado y metodo para fabricar el mismo. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9224584D0 (en) | 1992-11-23 | 1993-01-13 | Connaught Lab | Use of outer membrane protein d15 and its peptides as vaccine against haempohilus influenzae diseases |
| GB9304399D0 (en) * | 1993-03-04 | 1993-04-21 | Smithkline Beecham Biolog | Novel process |
| AU696207B2 (en) * | 1993-03-16 | 1998-09-03 | St. Louis University | High molecular weight surface proteins of non-typeable haemophilus |
-
1992
- 1992-03-16 GB GB929205704A patent/GB9205704D0/en active Pending
-
1993
- 1993-03-16 AU AU39168/93A patent/AU669360B2/en not_active Expired
- 1993-03-16 DE DE69332243T patent/DE69332243T2/de not_active Expired - Lifetime
- 1993-03-16 US US08/038,682 patent/US5549897A/en not_active Expired - Lifetime
- 1993-03-16 ES ES93908295T patent/ES2183812T3/es not_active Expired - Lifetime
- 1993-03-16 RU RU94042726/13A patent/RU2157816C2/ru active
- 1993-03-16 KR KR1019940703224A patent/KR100219126B1/ko not_active IP Right Cessation
- 1993-03-16 CA CA002131837A patent/CA2131837C/en not_active Expired - Lifetime
- 1993-03-16 WO PCT/US1993/002166 patent/WO1993019090A1/en active IP Right Grant
- 1993-03-16 JP JP5516604A patent/JP2810235B2/ja not_active Expired - Lifetime
- 1993-03-16 PT PT93908295T patent/PT632814E/pt unknown
- 1993-03-16 EP EP93908295A patent/EP0632814B1/en not_active Expired - Lifetime
- 1993-03-16 DK DK93908295T patent/DK0632814T3/da active
- 1993-03-16 AT AT93908295T patent/ATE222955T1/de active
- 1993-03-16 BR BR9306109A patent/BR9306109A/pt not_active IP Right Cessation
-
1994
- 1994-09-15 FI FI944273A patent/FI116838B/fi not_active IP Right Cessation
- 1994-09-15 NO NO19943431A patent/NO316623B1/no not_active IP Right Cessation
-
1996
- 1996-09-25 US US08/719,641 patent/US6218141B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NO943431L (no) | 1994-11-10 |
| ATE222955T1 (de) | 2002-09-15 |
| FI116838B (fi) | 2006-03-15 |
| EP0632814B1 (en) | 2002-08-28 |
| DK0632814T3 (da) | 2002-10-07 |
| FI944273A (fi) | 1994-11-15 |
| US5549897A (en) | 1996-08-27 |
| ES2183812T3 (es) | 2003-04-01 |
| RU2157816C2 (ru) | 2000-10-20 |
| PT632814E (pt) | 2003-01-31 |
| DE69332243T2 (de) | 2003-04-30 |
| WO1993019090A1 (en) | 1993-09-30 |
| GB9205704D0 (en) | 1992-04-29 |
| US6218141B1 (en) | 2001-04-17 |
| NO943431D0 (no) | 1994-09-15 |
| CA2131837C (en) | 2002-02-12 |
| EP0632814A1 (en) | 1995-01-11 |
| CA2131837A1 (en) | 1993-09-17 |
| EP0632814A4 (en) | 1996-03-13 |
| FI944273A0 (fi) | 1994-09-15 |
| JPH07506248A (ja) | 1995-07-13 |
| KR950700936A (ko) | 1995-02-20 |
| NO316623B1 (no) | 2004-03-15 |
| BR9306109A (pt) | 1997-11-18 |
| AU3916893A (en) | 1993-10-21 |
| DE69332243D1 (de) | 2002-10-02 |
| JP2810235B2 (ja) | 1998-10-15 |
| AU669360B2 (en) | 1996-06-06 |
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