KR100216429B1 - Cosmetic compositions for skin - Google Patents

Abstract

The present invention relates to a skin whitening composition, characterized in that it contains 0.01 to 10.00% by weight of harunoside which is a melanocyte pigment inhibitor. As a result, the production of melanin pigment cells can be suppressed and the pigmentation of the skin can be prevented from the skin, thereby maintaining the natural skin color of the skin, thereby providing white and clean skin.

Description

[Name of invention]

Skin cosmetic composition

Detailed description of the invention

[Purpose of invention]

[Technical field to which the invention belongs and the prior art in that field]

The present invention relates to a skin whitening composition, and more particularly, is characterized by containing harunoside which is a melanocyte pigment inhibitor.

Most women are interested in skin care, and they also use cosmetics to maintain their own skin beauty. However, even though modern women have a lot of interest in skin care, they are concerned about the appearance of the skin and freckles. Skin blemishes and freckles are skin diseases caused by an increase of melanin in the epidermis above a certain level.The mechanisms of the skin disease are internal factors such as female hormones and genetic factors and external factors such as self-righteousness in sunlight. Is found to be involved.

The most important factor in determining the color of skin is called a pigment called melanin, which produces melanocytes, which are organelles in melanocytes (pigment cells). Melanin production and metabolism of the skin goes through the process of melanin production in the melanosome, which moves away with the keratin as the movement in the skin proceeds. The melanin production process in melanosomes is that tyrosine proceeds to dihydroxyphenyl alanine (DOPA) by the action of tyrosinase (enzyme), and then dihydroxyphenyl alanine (DOPA) is oxidized to dopaquinone, which in turn is automatic. Oxidation proceeds to leuco dopachrome, dopachrome, 5,6-dihydroxy indole and indole 5,6-quinone, which are polymerized to produce tyrosine-melanin.

In order to suppress the blemishes and freckles of the skin, the inhibition of melanin production in melanocytes, reduction of melanin already produced, promoting the release of melanin in the epidermis, and selective toxicity to melanocytes should be considered. In addition, melanin production inhibition in melanocytes can be thought of as two types: tyrosinase activity or inhibition of tyrosinase reaction in non-cellular system. One of them is a form that directly inhibits tyrosinase activity or response in the non-cellular system, and the other is a form of melanin that inhibits tyrosinase biosynthesis or pigmentation of tyrosinase in pigment cells without directly inhibiting tyrosinase activity in the non-cellular system. It is a form that suppresses production. For these reasons, women with blemishes and freckles are using skin whitening agents, such as cosmetics, for the purpose of suppressing or reducing the production of melanin on the skin to make the skin intact. However, the skin lightening agents on the market so far do not show satisfactory effects with side effects.

[Technical problem to be achieved]

Accordingly, an object of the present invention is to provide a white and clean skin by suppressing the production of melanin pigment cells and fundamentally preventing pigmentation of the skin to maintain the natural skin color of the skin in order to solve the conventional problems.

[Configuration and Function of Invention]

According to the present invention, the object is achieved by a skin whitening composition, characterized in that it contains 0.01 to 10.00% by weight of the harrowoside which is a complex derivative of hydroquinone.

In addition, the skin whitening composition of the present invention preferably has a harrowoside of 1.00 to 5.00% by weight.

EMBODIMENT OF THE INVENTION Hereinafter, this invention is demonstrated in detail.

The inventors of the present invention have been investigating compounds such as arbutin, ascorbic acid derivatives, kojic acid, etc., which are generally widely used, and are more excellent in inhibiting the activity of tyrosinase. Working with the cells on the skin surface confirms that the skin color is white and clean, and completed the present invention. Harunoside, a complex derivative of such hydroquinone, is represented by the following Chemical Formula 1 and is commercially available under the trade name ETIOLINE from SEDERMA, France.

[Formula 1]

(Wherein R is an alkyl group having 1 to 6 carbon atoms)

The amount of harrowoside may be appropriately adjusted according to the formulation of the skin cosmetic composition so as to inhibit the activity of tyrosinase, but in general, 0.01 to 10.00% by weight, preferably 1.00 to 5.00% by weight based on the total amount of the skin cosmetic composition is appropriate. Do. If the amount is less than 0.01% by weight, the activity inhibitory effect of tyrosinase may not appear very much. On the contrary, even if it is blended in an amount of 10.00% by weight or more, a large increase in the activity inhibition effect cannot be expected.

The skin cosmetic composition of the present invention, in addition to the above components, components used in general skin whitening agents, for example, oily base, surfactant, moisturizer, left sunscreen, antioxidant, flavoring, pigment, preservative, pH adjuster, various vegetable Skin beauty components etc. can be mix | blended suitably as needed.

Next, the present invention will be described in detail with reference to specific examples of lotion, but there is no intention to limit the present invention to these examples. The content unit of each component ratio shown in this Example is weight%.

Example 1 (Cosmetic Water)

First, harrowoside, 1, 3- butylene glycol, glycerin, citric acid, sodium citrate, and a pigment are dissolved in purified water in the component ratio shown in Table 1 below. Separately, ethanol, polyoxyethylene hydrogenated castor oil, methyl paraben, perfume, self-blocking agent and antioxidant are dissolved. Subsequently, separately dissolved components are added and solubilized to the purified water phase in which the harrowoside and the like are dissolved to obtain a lotion.

TABLE 1

Skin Whitening Experiment

Skin whitening effect was measured in the human panel with the lotion prepared according to the embodiment. First of all, 12 women with healthy skin are treated with paraphoromaldehyde beforehand, and then stained with DOPA and left for 16 hours to be sufficiently pigmented. Then, the skin condition was observed under a microscope while using the lotion of the experimental example as a daily use pattern. Skin whitening was evaluated according to the criteria of Table 2 below.

TABLE 2

Judgment standard of skin whitening degree

As a result, skin whitening results according to the use of the lotion are shown in Table 3.

TABLE 3

Skin whitening result of using lotion

As can be seen in Table 3, Examples 1 to 4 of the cosmetic composition containing the harrowoside of the present invention is excellent in the skin beauty effect compared to the comparative example of the cosmetic composition does not contain the harrowoside Able to know. In addition, it can be seen that as the content of the harrowoside increases, more women exhibit skin whitening effects. As a result, the skin cosmetic composition of the present invention can be guessed as having an excellent whitening effect by suppressing the production of melanin in the melanocytes to make white and clean skin texture.

Next, in addition to the lotion of Example 1, additional examples are shown for the case of latex and cream.

Example 2 (latex)

The oil phase part and the water phase part were prepared by the following component ratios, respectively, dissolved and maintained at 75 ° C., and then the oil phase part was added to the water phase part to emulsify it uniformly, and then cooled to 30 ° C. while stirring, filtered, and aged. The emulsion of the present invention is prepared.

(The upper part)

Stearic Acid 1.00

Cetostearyl Alcohol 0.70

Self-Emulsifying Glyceryl Monostearate 2.00

Purified Lanolin 1.00

Liquid Paraffin 5.00

Squalane 4.00

Propylparaben 0.10

Sorbitan Monostearate 0.30

Polyoxyethylene sorbitan monooleate 0.80

Methyl Polysiloxane 0 .40

Octylmethoxycinnamate0.50

Spices 0.25

(The upper part)

Methylparaben 0.20

Triethanolamine 0.20

1.3-butylene glycol 5.00

Glycerin 1.50

Carboxy Vinyl Polymer 0.20

Harrownoside 1.00

Remainder of purified water 100.00

Example 3 (cream)

The oil phase part and the water phase part were prepared by the following component ratios, respectively, dissolved and maintained at 75 ° C., and then the oil phase part was added to the water phase part to emulsify uniformly, and then cooled to 35 ° C. while stirring, filtered, and aged. The cream of the present invention is prepared.

(The upper part)

Stearic Acid 1.50

Beeswax 2.00

Microcrystalline Lead 0.50

Cetostearyl Alcohol 1.50

Self-Emulsifying Glyceryl Monostearate 3.50

Vaseline 2.00

Liquid Paraffin 7.00

Squalane 5.00

Caprylic / Capric Triglycerides 3.00

Butylparaben 0.15

Sorbitan Monostearate 1.00

Polyoxyethylene sorbitan monostearate 1.50

BH 0.01

Methyl Polysiloxane 0.40

Octylmethoxycinnamate 2.00

Spices 0.30

(The upper part)

Methylparaben 0.20

Imidazolidinylurea 0.10

Disodium ID 0.01

Triethanolamine 0.25

1.3-butylene glycol 8.00

Glycerin 3.00

Carboxyl Vinyl Polymer 0.12

Harrownoside 1.00

Remainder of purified water 100.00

[Effects of the Invention]

As described above, the skin cosmetic composition of the present invention can provide a skin whitening effect that maintains the original beauty of the skin by preparing the skin white and clean by the inhibitory action of tyrosinase activity of the harrownoside component.

Claims (2)

Skin whitening composition, the skin whitening composition characterized in that it contains 0.01 to 10.00% by weight of the harrowoside of the formula (1). [Formula 1] (Wherein R is an alkyl group having 1 to 6 carbon atoms) The skin whitening composition according to claim 1, wherein the harrowoside is 1.00 to 5.00 wt%.