JPH03236321A - Skin drug for external use - Google Patents
Skin drug for external useInfo
- Publication number
- JPH03236321A JPH03236321A JP2032197A JP3219790A JPH03236321A JP H03236321 A JPH03236321 A JP H03236321A JP 2032197 A JP2032197 A JP 2032197A JP 3219790 A JP3219790 A JP 3219790A JP H03236321 A JPH03236321 A JP H03236321A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- drug
- external use
- estrogens
- kojic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940079593 drug Drugs 0.000 title abstract description 7
- 239000003814 drug Substances 0.000 title abstract description 7
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229960004705 kojic acid Drugs 0.000 claims abstract description 18
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229940011871 estrogen Drugs 0.000 claims abstract description 10
- 239000000262 estrogen Substances 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims description 16
- 230000000694 effects Effects 0.000 abstract description 18
- 239000004615 ingredient Substances 0.000 abstract description 6
- 239000006071 cream Substances 0.000 abstract description 5
- 230000037075 skin appearance Effects 0.000 abstract description 5
- -1 coloring matter Substances 0.000 abstract description 4
- 238000007796 conventional method Methods 0.000 abstract description 3
- 239000002537 cosmetic Substances 0.000 abstract description 3
- 239000006210 lotion Substances 0.000 abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 3
- 239000002253 acid Substances 0.000 abstract description 2
- 150000007513 acids Chemical class 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract description 2
- 150000001298 alcohols Chemical class 0.000 abstract description 2
- 239000003599 detergent Substances 0.000 abstract description 2
- 239000003906 humectant Substances 0.000 abstract description 2
- 239000003921 oil Substances 0.000 abstract description 2
- 239000002674 ointment Substances 0.000 abstract description 2
- 239000003755 preservative agent Substances 0.000 abstract description 2
- 239000004094 surface-active agent Substances 0.000 abstract description 2
- 238000004040 coloring Methods 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 239000003002 pH adjusting agent Substances 0.000 abstract 1
- 239000002304 perfume Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 34
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 229920002674 hyaluronan Polymers 0.000 description 3
- 229960003160 hyaluronic acid Drugs 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 229960005309 estradiol Drugs 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 description 1
- PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 description 1
- URJOWNUVTORLNY-UHFFFAOYSA-N (5-hexadecanoyloxy-4-oxopyran-2-yl) hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OC1=CC(=O)C(OC(=O)CCCCCCCCCCCCCCC)=CO1 URJOWNUVTORLNY-UHFFFAOYSA-N 0.000 description 1
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 1
- PBBGSZCBWVPOOL-HDICACEKSA-N 4-[(1r,2s)-1-ethyl-2-(4-hydroxyphenyl)butyl]phenol Chemical compound C1([C@H](CC)[C@H](CC)C=2C=CC(O)=CC=2)=CC=C(O)C=C1 PBBGSZCBWVPOOL-HDICACEKSA-N 0.000 description 1
- 241000589220 Acetobacter Species 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 241000228143 Penicillium Species 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229940067596 butylparaben Drugs 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Polymers OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 description 1
- 150000005690 diesters Chemical class 0.000 description 1
- RGLYKWWBQGJZGM-ISLYRVAYSA-N diethylstilbestrol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(\CC)C1=CC=C(O)C=C1 RGLYKWWBQGJZGM-ISLYRVAYSA-N 0.000 description 1
- 229960000452 diethylstilbestrol Drugs 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 229960000735 docosanol Drugs 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 description 1
- 229960001348 estriol Drugs 0.000 description 1
- 229960003399 estrone Drugs 0.000 description 1
- 229960002568 ethinylestradiol Drugs 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 239000003676 hair preparation Substances 0.000 description 1
- 229950001996 hexestrol Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は、皮膚外用剤に関し、更に詳細には、皮膚を保
護、美化する効果に優れ、肌の柔軟性、弾力性及び皮膚
外観等を大幅に改善することができる皮膚外用剤に関す
る。[Detailed Description of the Invention] [Field of Industrial Application] The present invention relates to a skin preparation for external use, and more specifically, it has excellent skin protection and beautifying effects, and improves skin flexibility, elasticity, skin appearance, etc. This invention relates to an external preparation for skin that can significantly improve the skin.
〔従来の技術及び発明が解決しようとする課題〕従来、
皮膚を保護、美化し、肌の柔軟性、弾力性及び皮膚外観
等を改善するためには、美白効果を有するアスコルビン
酸、グルタチオン等や、皮膚を保護する効果を有するヒ
アルロン酸等の成分を配合した皮膚外用剤が用いられて
いる。[Problems to be solved by conventional techniques and inventions] Conventionally,
In order to protect and beautify the skin and improve skin flexibility, elasticity, and skin appearance, ingredients such as ascorbic acid and glutathione, which have a whitening effect, and hyaluronic acid, which has a skin-protecting effect, are blended. External skin preparations are used.
しかしながら、これらの成分を含有する皮膚外用剤は、
効果が弱いばかりでなく、これらの外用剤を塗布しても
、その作用は皮膚表面にしか及ばず、充分な効果を得る
ことはできなかった。However, external skin preparations containing these ingredients,
Not only are their effects weak, but even when these external preparations are applied, their effects only reach the skin surface, and sufficient effects cannot be obtained.
このため、優れた皮膚改善作用を有する皮膚外用剤が望
まれていた。Therefore, there has been a demand for external preparations for skin that have excellent skin-improving effects.
かかる実情において、本発明者らは、鋭意研究を重ねた
結果、皮膚表面の美白効果に優れるコウジ酸及び／又は
その誘導体と、皮膚組織内部にヒアルロン酸を補給する
作用を有するエストロゲン類を組み合わせることにより
、相乗的に皮膚を保護、美化する効果を有し、肌の柔軟
性、弾力性及び皮膚外観等を大幅に改善する皮膚外用剤
が得られることを見出し本発明を完成した。Under these circumstances, as a result of extensive research, the present inventors have combined kojic acid and/or its derivatives, which have an excellent whitening effect on the skin surface, with estrogens, which have the effect of replenishing hyaluronic acid inside the skin tissue. The present invention has been completed based on the discovery that an external skin preparation can be obtained which synergistically protects and beautifies the skin and significantly improves skin flexibility, elasticity, skin appearance, etc.
すなわち、本発明は、（Ａ）及び（Ｂ）（Ａ）コウジ酸
及び／又はその誘導体
（Ｂ）エストロゲン類の一種又は二種以上を含有するこ
とを特徴とする皮膚外用剤を提供するものである。That is, the present invention provides an external skin preparation characterized by containing one or more of (A) and (B) (A) kojic acid and/or its derivatives (B) estrogens. be.
本発明において、有効成分として用いられる（Ａ）成分
のコウジ酸又はその誘導体は、次の一般式（Ｉ）（式中
、Ｒ１及びＲ２は、同−又は異なっても良く、水素原子
又は炭素数３〜２２のアシル基又はアルキル基を示す）
て表わされるものである。In the present invention, the component (A) used as an active ingredient, kojic acid or a derivative thereof, has the following general formula (I) (wherein R1 and R2 may be the same or different, and have a hydrogen atom or a carbon number 3 to 22 acyl or alkyl groups).
コウジ酸は、アスペルギルス属、ペニシリウム属、アセ
トバクター属等の微生物などによる発酵生成物から抽出
、精製したものでも、精製工程を省いた抽出物のままの
ものでもよく、さらに、台底によって得られるものでも
よい。Kojic acid may be extracted and purified from fermentation products by microorganisms such as Aspergillus, Penicillium, Acetobacter, etc., or it may be the same as the extract without the purification process. It can be anything.
また、コウジ酸誘導体としては、上記コウジ酸から台底
されるものが使用でき、そのエステルとしては、例えば
コウジ酸モノブチレート、コウジ酸モノカプレート、コ
ウジ酸モノパルミテート、コウジ酸モノステアレート、
コウジ酸モノシンナメート又はコウジ酸モノベンゾエー
トなどのモノエステル；コウジ酸ジブチレート、コウジ
酸ジパルミテート、コウジ酸ジステアレート又はコウジ
酸ジオレエートなどのジエステル等が挙げられる。Further, as the kojic acid derivative, those derived from the above-mentioned kojic acid can be used, and the ester thereof includes, for example, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate,
Monoesters such as kojic acid monocinnamate or kojic acid monobenzoate; diesters such as kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate or kojic acid dioleate, and the like.
これらコウジ酸及びその誘導体は、一種又は二種以上を
組合わせて用いることができ、また、皮膚外用剤の皮膚
改善作用及び経時安定性の点から、全組成中に０．００
０１〜５重量％（以下、単に％で示す）、特に０．０１
〜３％配合するのが好ましい。These kojic acids and their derivatives can be used singly or in combination of two or more, and from the viewpoint of the skin improving effect and stability over time of the external skin preparation, it is recommended that 0.00% of the total composition be used.
01 to 5% by weight (hereinafter simply expressed as %), especially 0.01
It is preferable to mix it in an amount of ~3%.
本発明の（Ｂ）ｔＥ分であるエストロゲン類は、女性ホ
ルモンの一種であり、頭髪の生長を促し、脂腺の増大及
びその活動を抑制し、また表皮に関してもその角化を抑
制、緩慢化して、きめの細かい皮膚を作る作用を有する
。また、色素の形成に対しても、ある程度抑制的に働き
、毛細血管に対しては拡張作用があるので、血流を促進
させる効果がある。さらに、エストロゲン類は皮膚組織
中のムコ多糖の合成機構に重要な働きかけをし、皮膚内
部にヒアルロン酸を補給する作用がある。エストロゲン
類としては、例えばエチニルエストラジオール、ホモエ
ストロン、β−エストラジオール、エストロン、エスト
リオール、ジエチルスチルベストロール、ヘキセストロ
ール等が挙げられる。Estrogens, which is the (B) tE component of the present invention, is a type of female hormone that promotes hair growth, suppresses the increase and activity of sebaceous glands, and also suppresses and slows down the keratinization of the epidermis. It has the effect of creating fine-textured skin. Furthermore, it acts to some extent to suppress the formation of pigment, and has a dilating effect on capillaries, so it has the effect of promoting blood flow. Furthermore, estrogens have an important effect on the mucopolysaccharide synthesis mechanism in skin tissues, and have the effect of replenishing hyaluronic acid inside the skin. Examples of estrogens include ethinyl estradiol, homoestrone, β-estradiol, estrone, estriol, diethylstilbestrol, hexestrol, and the like.
これらエストロゲン類は、一種又は二種以上を組み合わ
せて用いることができ、また、皮膚外用剤の皮膚改善作
用及び経時安定性の点から、全組成中に０．０００１〜
０．１％、特にｏ、ｏｏｏｓ〜０００５％配合するのが
好ましい。These estrogens can be used alone or in combination of two or more, and from the viewpoint of the skin improvement effect and stability over time of the external skin preparation, 0.0001 to 0.0001 to
It is preferable to blend 0.1%, especially o,oos to 0005%.
さらに、本発明の皮膚外用剤には、前記必須成分の他、
通常の皮膚外用剤に用いられる水性成分、界面活性剤、
油剤、保湿剤、アルコール類、ｐＨ調整剤、防腐剤、色
素、酸化防止剤、増粘剤、香料、殺菌剤、紫外線吸収剤
、薬剤等を必要に応じて適宜配合することができる。Furthermore, the skin external preparation of the present invention includes, in addition to the above-mentioned essential ingredients,
Aqueous ingredients and surfactants used in regular skin preparations,
Oils, humectants, alcohols, pH adjusters, preservatives, pigments, antioxidants, thickeners, fragrances, bactericidal agents, ultraviolet absorbers, drugs, and the like can be added as appropriate.
本発明の皮膚外用剤は、必須成分であるコウジ酸及び／
又はその誘導体と、エストロゲン類を配合し、常法に従
って製造することができる。そして、乳液、クリーム、
化粧水、パック、ファンデーション、毛髪化粧料、洗浄
料等や、その細分散状、顆粒状、軟膏状等の医薬用、医
薬部外用又は化粧用の皮膚外用剤として適用することが
できる。The skin external preparation of the present invention contains kojic acid and/or essential ingredients.
Or a derivative thereof and an estrogen can be blended and produced according to a conventional method. And emulsion, cream,
It can be applied as lotions, packs, foundations, hair cosmetics, cleansing agents, etc., and as pharmaceutical, external, or cosmetic skin preparations in the form of finely dispersed, granular, and ointment forms.
次に試験例及び実施例を挙げて本発明を更に詳細に説明
するが、本発明はこれらに限定されるものではない。Next, the present invention will be explained in more detail with reference to test examples and examples, but the present invention is not limited thereto.
実施例１
第１表に示す組成のモイスチャークリームを製造し、肌
の柔軟性、弾力性及び外観変化（色、ツヤ等）について
官能評価を行なった。結果を第２表に示す。Example 1 Moisture creams having the compositions shown in Table 1 were produced, and sensory evaluations were conducted for skin softness, elasticity, and changes in appearance (color, gloss, etc.). The results are shown in Table 2.
（製法）
Ａ、（１）〜（９）を７０℃に加熱し、均一に溶解する
。(Manufacturing method) A. Heat (1) to (9) to 70°C and uniformly dissolve.
Ｂ、（１０）〜（１２）を７０℃に加熱し、均一に溶解
する。B. Heat (10) to (12) to 70°C to uniformly dissolve.
Ｃ，ＡをＢに加え、攪拌乳化した後、冷却してモイスチ
ャークリームを得る。Add C and A to B, stir and emulsify, and then cool to obtain a moisture cream.
（評価方法）
女性パネル１０名を１群とし、顔の左右率々に、それぞ
れ下記（Ｉ）又は（ｎ）を１日１回塗布し、１ケ月後の
肌の状態を比較判定し、その人数により評価した。(Evaluation method) A group of 10 female panelists applied the following (I) or (n) once a day to the left and right sides of their faces, and compared and judged the skin condition one month later. Evaluation was based on the number of people.
（Ｉ）本発明品と比較品１
（ｎ）本発明品と比較品２
以下余白
第２表から明らかな如く、本発明のモイスチャークリー
ムは、比較品に比べ、肌の柔軟性、弾力性及び外観につ
いて、大幅な改善効果が認められた。(I) Product of the present invention and comparative product 1 (n) Product of the present invention and comparative product 2 As is clear from Table 2 in the margin below, the moisture cream of the present invention improves skin flexibility and elasticity compared to the comparative product. A significant improvement in appearance was observed.
実施例２ 乳液：
く処方〉 （％）（１）
ポリオキシエチレン（１０）ツル １．０ビタンモ
ノステアレート
ポリオキシエチレン（６０）ツル ０．５ビツトテ
トラオレエート
（３）グリセリルモノステアレート １０（４）
ステアリン酸 ０．５（５）ベヘ
ニルアルコール ０５（６）スクワラン
４・０（７）精製ホホバ油
４．０（８）ブチルパラベン
０．１（９）コウジ酸モノパルミテート
１．０（１０）β−エストラジオール
０．０００５（１１）メチルパラベン
０．１（１２）カルボキシビニルポリマー
０．０７（２）
（１３） １．３−ブチレングリコール ５
．０（１４）精製水 残量（
１５）水酸化ナトリウム ０．０２５
（１６）精製水 ７．５（
１７）香料 適量〈製法〉
Ａ１１）〜（１０）を７０°Ｃにて加熱溶解する。Example 2 Emulsion: Formula> (%) (1)
Polyoxyethylene (10) Vine 1.0 Bitane Monostearate Polyoxyethylene (60) Vine 0.5 Bit Tetraoleate (3) Glyceryl Monostearate 10 (4)
Stearic acid 0.5(5) Behenyl alcohol 05(6) Squalane
4.0(7) Refined jojoba oil
4.0(8) Butylparaben
0.1(9) Kojic acid monopalmitate
1.0 (10) β-estradiol
0.0005(11) Methylparaben
0.1(12) carboxyvinyl polymer
0.07(2) (13) 1.3-Butylene glycol 5
．． 0 (14) Purified water remaining amount (
15) Sodium hydroxide 0.025
(16) Purified water 7.5 (
17) Flavor Appropriate amount <Production method> Heat and dissolve A11) to (10) at 70°C.
Ｂ、（１１）〜（１４）を７０℃にて加熱溶解する。B, (11) to (14) are heated and dissolved at 70°C.
Ｃ，ＡをＢに加え、乳化する。Add C and A to B and emulsify.
Ｄ、Ｃに（１５）〜（１７）を加え、冷却して乳液を得
た。(15) to (17) were added to D and C and cooled to obtain a milky lotion.
以上詳述した如く、本発明の皮膚外用剤は、皮膚を保護
、美化する効果に優れ、肌の柔軟性、弾力性及び皮膚外
観等を大幅に改善する効果を有するものである。As detailed above, the skin external preparation of the present invention has excellent skin protection and beautification effects, and has the effect of significantly improving skin flexibility, elasticity, skin appearance, etc.
以 上that's all
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2032197A JP2844104B2 (en) | 1990-02-13 | 1990-02-13 | External preparation for skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2032197A JP2844104B2 (en) | 1990-02-13 | 1990-02-13 | External preparation for skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03236321A true JPH03236321A (en) | 1991-10-22 |
| JP2844104B2 JP2844104B2 (en) | 1999-01-06 |
Family
ID=12352183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2032197A Expired - Lifetime JP2844104B2 (en) | 1990-02-13 | 1990-02-13 | External preparation for skin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2844104B2 (en) |
-
1990
- 1990-02-13 JP JP2032197A patent/JP2844104B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2844104B2 (en) | 1999-01-06 |
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