JP2844104B2 - External preparation for skin - Google Patents
External preparation for skinInfo
- Publication number
- JP2844104B2 JP2844104B2 JP2032197A JP3219790A JP2844104B2 JP 2844104 B2 JP2844104 B2 JP 2844104B2 JP 2032197 A JP2032197 A JP 2032197A JP 3219790 A JP3219790 A JP 3219790A JP 2844104 B2 JP2844104 B2 JP 2844104B2
- Authority
- JP
- Japan
- Prior art keywords
- skin
- external preparation
- kojic acid
- effect
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は、皮膚外用剤に関し、更に詳細には、皮膚を
保護、美化する効果に優れ、肌の柔軟性、弾力性及び皮
膚外観等を大幅に改善することができる皮膚外用剤に関
する。Description: TECHNICAL FIELD The present invention relates to an external preparation for the skin, and more particularly, it is excellent in the effect of protecting and beautifying the skin, and has the flexibility, elasticity and skin appearance of the skin. The present invention relates to a skin external preparation which can be significantly improved.
従来、皮膚を保護、美化し、肌の柔軟性、弾力性及び
皮膚外観等を改善するためには、美白効果を有するアス
コルビン酸、グルタチオン等や、皮膚を保護する効果を
有するヒアルロン酸等の成分を配合した皮膚外用剤が用
いられている。Conventionally, in order to protect and beautify the skin and improve skin flexibility, elasticity, skin appearance, and the like, components such as ascorbic acid and glutathione having a whitening effect, and hyaluronic acid and the like having a protective effect on the skin. An external preparation for skin containing is used.
しかしながら、これらの成分を含有する皮膚外用剤
は、効果が弱いばかりでなく、これらの外用剤を塗布し
ても、その作用は皮膚表面にしか及ばず、充分な効果を
得ることはできなかった。However, external preparations for skin containing these components are not only weak in effect, but even when these external preparations are applied, their effects only reach the skin surface, and sufficient effects cannot be obtained. .
このため、優れた皮膚改善作用を有する皮膚外用剤が
望まれていた。Therefore, a skin external preparation having an excellent skin improving effect has been desired.
かかる実情において、本発明者らは、鋭意研究を重ね
た結果、皮膚表面の美白効果に優れるコウジ酸及び／又
はその誘導体と、皮膚組織内部にヒアルロン酸を補給す
る作用を有するエストロゲン類を組み合わせることによ
り、相乗的に皮膚を保護、美化する効果を有し、肌の柔
軟性、弾力性及び皮膚外観等を大幅に改善する皮膚外用
剤が得られることを見出し本発明を完成した。Under such circumstances, the present inventors have conducted intensive studies, and as a result, have found that kojic acid and / or a derivative thereof having an excellent skin whitening effect is combined with estrogens having an action of replenishing hyaluronic acid inside skin tissue. As a result, the present inventors have found that a skin external preparation having a synergistic effect of protecting and beautifying the skin and significantly improving skin flexibility, elasticity, skin appearance and the like can be obtained, and completed the present invention.
すなわち、本発明は、（Ａ）及び（Ｂ） （Ａ）コウジ酸及び／又はその誘導体 （Ｂ）エストロゲン類の一種又は二種以上 を含有することを特徴とする皮膚外用剤を提供するもの
である。That is, the present invention provides (A) and (B) a skin external preparation comprising (A) kojic acid and / or a derivative thereof, and (B) one or more estrogens. is there.
本発明において、有効成分として用いられる（Ａ）成
分のコウジ酸又はその誘導体は、次の一般式（Ｉ） （式中、R1及びR2は、同一又は異なっても良く、水素原
子又は炭素数３〜22のアシル基又はアルキル基を示す） で表わされるものである。In the present invention, kojic acid or a derivative thereof as the component (A) used as an active ingredient is represented by the following general formula (I) (Wherein, R 1 and R 2 may be the same or different and represent a hydrogen atom or an acyl group or an alkyl group having 3 to 22 carbon atoms).
コウジ酸は、アスペルギルス属、ペニシリウム属、ア
セトバクター属等の微生物などによる発酵生成物から抽
出、精製したものでも、精製工程を省いた抽出物のまま
のものでもよく、さらに、合成によって得られるもので
もよい。Kojic acid may be extracted and purified from fermentation products of microorganisms such as Aspergillus, Penicillium, Acetobacter, etc., or may be the extract as it is without the purification step, and further obtained by synthesis. May be.
また、コウジ酸誘導体としては、上記コウジ酸から合
成されるものが使用でき、そのエステルとしては、例え
ばコウジ酸モノブチレート、コウジ酸モノカプレート、
コウジ酸モノパルミテート、コウジ酸モノステアレー
ト、コウジ酸モノシンナメート又はコウジ酸モノベンゾ
エートなどのモノエステル；コウジ酸ジブチレート、コ
ウジ酸ジパルミテート、コウジ酸ジステアレート又はコ
ウジ酸ジオレエートなどのジエステル等が挙げられる。As the kojic acid derivative, those synthesized from the above-mentioned kojic acid can be used, and as the ester thereof, for example, kojic acid monobutyrate, kojic acid monocaprate,
Monoesters such as kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate or kojic acid monobenzoate; diesters such as kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate or kojic acid diolate, and the like. .
これらコウジ酸及びその誘導体は、一種又は二種以上
を組合わせて用いることができ、また、皮膚外用剤の皮
膚改善作用及び経時安定性の点から、全組成中に0.0001
〜５重量％（以下、単に％で示す）、特に0.01〜３％配
合するのが好ましい。These kojic acid and derivatives thereof can be used alone or in combination of two or more.Moreover, from the viewpoint of the skin improving effect and the stability over time of the external preparation for skin, 0.0001 in the total composition.
-5% by weight (hereinafter simply indicated as%), particularly preferably 0.01-3%.
本発明の（Ｂ）成分であるエストロゲン類は、女性ホ
ルモンの一種であり、頭髪の生長を促し、脂腺の増大及
びその活動を抑制し、また表皮に関してもその角化を抑
制、緩慢化して、きめの細かい皮膚を作る作用を有す
る。また、色素の形式に対しても、ある程度抑制的に働
き、毛細血管に対しては拡張作用があるので、血流を促
進させる効果がある。さらに、エストロゲン類は皮膚組
織中のムコ多糖の合成機構に重要な働きかけをし、皮膚
内部にヒアルロン酸を補給する作用がある。エストロゲ
ン類としては、例えばエチニルエストラジオール、ホモ
エストロン、β−エストラジオール、エストロン、エス
トリオール、ジエチルスチルベストロール、ヘキセスト
ロール等が挙げられる。Estrogen, which is a component (B) of the present invention, is a kind of female hormone and promotes hair growth, suppresses the increase and activity of sebaceous glands, and also suppresses and slows down keratinization of the epidermis. Has the effect of creating fine-grained skin. In addition, it acts to suppress the form of the pigment to some extent and has a dilating effect on the capillaries, which has the effect of promoting blood flow. Further, estrogens play an important role in the mechanism of mucopolysaccharide synthesis in the skin tissue, and have an action of replenishing hyaluronic acid inside the skin. Estrogens include, for example, ethinyl estradiol, homoestrone, β-estradiol, estrone, estriol, diethylstilbestrol, hexestrol and the like.
これらエストロゲン類は、一種又は二種以上を組み合
わせて用いることができ、また、皮膚外用剤の皮膚改善
作用及び経時安定性の点から、全組成中に0.0001〜0.1
％、特に0.0005〜0.005％配合するのが好ましい。These estrogens can be used alone or in combination of two or more.Moreover, from the viewpoint of the skin improving effect of the external preparation for skin and the stability over time, 0.0001 to 0.1 in the total composition.
%, Particularly preferably 0.0005 to 0.005%.
さらに、本発明の皮膚外用剤には、前記必須成分の
他、通常の皮膚外用剤に用いられる水性成分、界面活性
剤、油剤、保湿剤、アルコール類、pH調製剤、防腐剤、
色素、酸化防止剤、増粘剤、香料、殺菌剤、紫外線吸収
剤、薬剤等を必要に応じて適宜配合することができる。Further, the skin external preparation of the present invention, in addition to the essential components, aqueous components, surfactants, oils, humectants, alcohols, alcohols, pH adjusters, preservatives used in ordinary skin external preparations,
A dye, an antioxidant, a thickener, a fragrance, a bactericide, an ultraviolet absorber, a drug, and the like can be appropriately compounded as needed.
本発明の皮膚外用剤は、必須成分であるコウジ酸及び
／又はその誘導体と、エストロゲン類を配合し、常法に
従って製造することができる。そして、乳液、クリー
ム、化粧水、パック、ファンデーション、毛髪化粧料、
洗浄料等や、その他分散状、顆粒状、軟膏状等の医薬
用、医薬部外用又は化粧用の皮膚外用剤として適用する
ことができる。The skin external preparation of the present invention can be produced according to a conventional method by blending kojic acid and / or a derivative thereof, which are essential components, with estrogens. And latex, cream, lotion, pack, foundation, hair cosmetics,
It can be applied as a cleansing agent or the like, or as an external preparation for skin of medicine, quasi-drug or cosmetic such as dispersion, granule and ointment.
次に試験例及び実施例を挙げて本発明を更に詳細に説
明するが、本発明はこれらに限定されるものではない。Next, the present invention will be described in more detail with reference to Test Examples and Examples, but the present invention is not limited thereto.
実施例１ 第１表に示す組成のモイスチャークリームを製造し、
肌の柔軟性、弾力性及び外観変化（色、ツヤ等）につい
て官能評価を行なった。結果を第２表に示す。Example 1 A moisture cream having a composition shown in Table 1 was produced.
Sensory evaluation was performed on skin flexibility, elasticity, and changes in appearance (color, gloss, etc.). The results are shown in Table 2.
（製法） A.（１）〜（８）を70℃に加熱し、均一に溶解する。(Preparation method) A. Heat (1) to (8) to 70 ° C and dissolve uniformly.
B.（９）〜（12）を70℃に加熱し、均一に溶解する。B. Heat (9)-(12) to 70 ° C. and dissolve uniformly.
C.AをＢに加え、撹拌乳化した後、冷却してモイスチャ
ークリームを得る。Add CA to B, stir and emulsify, then cool to obtain a moisture cream.
（評価方法） 女性パネル10名を１群とし、顔の左右半々に、それぞ
れ下記（Ｉ）又は（II）を１日１回塗布し、１ケ月後の
肌の状態を比較判定し、その人数により評価した。(Evaluation method) The following (I) or (II) was applied to the left and right halves of the face once a day, respectively, and the skin condition after one month was compared and determined. Was evaluated.
（Ｉ）本発明品と比較品１ （II）本発明品と比較品２ 第２表から明らかな如く、本発明のモイスチャークリ
ームは、比較品に比べ、肌の柔軟性、弾力性及び外観に
ついて、大幅な改善効果が認められた。(I) Inventive product and Comparative product 1 (II) Inventive product and Comparative product 2 As is clear from Table 2, the moisture cream of the present invention showed a significant improvement in skin softness, elasticity and appearance as compared with the comparative product.
実施例２ 乳液： ＜処方＞ （％） （１）ポリオキシエチレン（10）ソル 1.0 ビタンモノステアレート （２）ポリオキシエチレン（60）ソル 0.5 ビットテトラオレエート （３）グリセリルモノシテアレート 1.0 （４）ステアリン酸 0.5 （５）ベヘニルアルコール 0.5 （６）スクワラン 4.0 （７）精製ホホバ油 4.0 （８）ブチルパラベン 0.1 （９）コウジ酸モノパルミテート 1.0 （10）β−エストラジオール 0.0005 （11）メチルパラベン 0.1 （12）カルボキシビニルポリマー 0.07 （13）1,3−ブチレングリコール 5.0 （14）精製水 残量 （15）水酸化ナトリウム 0.025 （16）精製水 7.5 （17）香料 適量 ＜製法＞ A.（１）〜（10）を70℃にて加熱溶解する。Example 2 Emulsion: <Formulation> (%) (1) polyoxyethylene (10) sol 1.0 bitane monostearate (2) polyoxyethylene (60) sol 0.5 bit tetraoleate (3) glyceryl monocitearate 1.0 ( 4) Stearic acid 0.5 (5) Behenyl alcohol 0.5 (6) Squalane 4.0 (7) Refined jojoba oil 4.0 (8) Butyl paraben 0.1 (9) Kojic acid monopalmitate 1.0 (10) β-estradiol 0.0005 (11) Methyl paraben 0.1 ( 12) Carboxyvinyl polymer 0.07 (13) 1,3-butylene glycol 5.0 (14) Remaining purified water (15) Sodium hydroxide 0.025 (16) Purified water 7.5 (17) Perfume Appropriate amount <Production method> A. (1)- Heat and dissolve (10) at 70 ° C.
B.（11）〜（14）を70℃にて加熱溶解する。B. Heat and dissolve (11)-(14) at 70 ° C.
C.AにＢを加え、乳化する。C. Add B to A and emulsify.
D.Cに（15）〜（17）を加え、冷却して乳液を得た。(15) to (17) were added to D.C, and the mixture was cooled to obtain an emulsion.
以上詳述した如く、本発明の皮膚外用剤は、皮膚を保
護、美化する効果に優れ、肌の柔軟性、弾力性及び皮膚
外観等を大幅に改善する効果を有するものである。As described in detail above, the external preparation for skin of the present invention has an excellent effect of protecting and beautifying the skin, and has an effect of greatly improving skin flexibility, elasticity, skin appearance, and the like.
───────────────────────────────────────────────────── フロントページの続き (58)調査した分野(Int.Cl.6，ＤＢ名) A61K 31/35 A61K 31/565 A61K 7/00 ＣＡ（ＳＴＮ)──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int.Cl. 6 , DB name) A61K 31/35 A61K 31/565 A61K 7/00 CA (STN)
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2032197A JP2844104B2 (en) | 1990-02-13 | 1990-02-13 | External preparation for skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2032197A JP2844104B2 (en) | 1990-02-13 | 1990-02-13 | External preparation for skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03236321A JPH03236321A (en) | 1991-10-22 |
| JP2844104B2 true JP2844104B2 (en) | 1999-01-06 |
Family
ID=12352183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2032197A Expired - Lifetime JP2844104B2 (en) | 1990-02-13 | 1990-02-13 | External preparation for skin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2844104B2 (en) |
-
1990
- 1990-02-13 JP JP2032197A patent/JP2844104B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03236321A (en) | 1991-10-22 |
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