KR0178115B1 - Preparation to promote hair growth - Google Patents

Preparation to promote hair growth Download PDF

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KR0178115B1
KR0178115B1 KR1019960041453A KR19960041453A KR0178115B1 KR 0178115 B1 KR0178115 B1 KR 0178115B1 KR 1019960041453 A KR1019960041453 A KR 1019960041453A KR 19960041453 A KR19960041453 A KR 19960041453A KR 0178115 B1 KR0178115 B1 KR 0178115B1
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hair
magnetized
hair follicle
sugar
carbon source
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KR19980022335A (en
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김중신
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김중진
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/83Electrophoresis; Electrodes; Electrolytic phenomena
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

본 발명은 멸균수를 착자기화시킨후 탄소원과 식물성잎 등 질소원을 첨가하여 PH 3.0 에서 30℃에서 약 10일간 발효시켜 발효 여과액을 수득한다.In the present invention, the sterilized water is magnetized and fermented at pH 3.0 at 30 ° C. for about 10 days by adding a carbon source and a nitrogen source such as vegetable leaves to obtain a fermentation filtrate.

이 발효액은 게르마늄(Ge) 등의 미량원소를 다량 함유하여 이들 성분이 자기 기억소자 역할과 기능을 담당하므로서 모낭세포의 혈류를 촉진하고 따라서 모낭 세포의 유전자 결함을 치유하므로서 모로발생을 촉진하고 탈모를 방지하게 된다.The fermentation broth contains a large amount of trace elements such as germanium (Ge), and these components play a role and function as a self-memory element, thereby promoting the blood flow of hair follicle cells, and thus promoting hair follicle development and hair loss by healing gene defects in hair follicle cells. Will be prevented.

Description

대머리 발모제 및 그 제조방법Bald hair regrowth and manufacturing method thereof

본 발명은 대머리 특히 남성 대머리 발모제 및 그 제조방법에 관한 것이다.The present invention relates to baldness, in particular male baldness, and a method for producing the same.

대머리는 남성 호르몬인 안드로겐의 생성이 지나치게 왕성하게 분비되어 모낭세포에 강하게 자극하여 모낭을 위축시키고 그 결과 모발성장을 지연하므로서 일어나는 것으로 알려져 있다.Baldness is known to occur because the production of androgen, a male hormone, is excessively secreted and strongly stimulated by hair follicle cells to shrink hair follicles and consequently delay hair growth.

안드레겐의 생성 분비는 모낭세포의 유전자(DNA)의 작용으로서 통상적으로 반성유전하는 것으로 알려져 있다.The production and release of androgen is commonly known to be semi- hereditary as an action of the hair follicle gene (DNA).

결국 대머리는 사춘기 이후 일반적으로 일어나는 유전적 질환으로 볼 수 있으며 부모 특히 부친쪽의 유전적 결함외에도 후전적 환경 즉, 스트레스가 원인되는 원형 탈모도 흔히 목격 된다.After all, baldness is a common genetic disease that occurs after puberty, and in addition to genetic defects in the parents, especially the father's, the epigenetic environment, that is, alopecia areata that causes stress is often observed.

원형 탈모 현상은 두피의 특정 부위에 동전모양으로 갑자기 탈모가 이루어지는 것을 말한다.Alopecia areata is a coin-shaped abrupt hair loss in a specific area of the scalp.

이것도 두피 특정부위의 모낭 세포의 유전적 질환임에는 틀림없다.This is also a genetic disorder of hair follicle cells in specific areas of the scalp.

미국의 질병통제센터(CDC)의 발표에 의하여도 대머리는 그렇지 않은 정상적인 남자 보다 2 배 이상의 심장병 발병율이 높다고 보고한바 있으며 따라서 안드로겐은 심장 및 혈관 내에서 동맥경화에도 관계하는 것으로 추정되고 있다.According to the US Centers for Disease Control (CDC), baldness has been reported to have a two-fold higher incidence of heart disease than normal men, and androgens are also believed to be involved in atherosclerosis in the heart and blood vessels.

이 같은 점에서 대머리 치료는 물론 심장질환의 퇴치를 위해서는 유전자적 접근이 필요하며 특히 대머리 치료에 있어서는 절단된 유전자를 제거하고 정상적인 모발 유전자를 도입하는 방안이 필요하다.In this regard, the treatment of baldness as well as the eradication of heart disease requires a genetic approach, especially in the treatment of baldness, it is necessary to remove the truncated gene and introduce a normal hair gene.

그러나 임상적인 대머리 치료법으로서 발모제가 제약회사들로 부터 많이 연구되어 왔다.However, as a treatment for clinical baldness, hair regrowth has been studied by pharmaceutical companies.

미녹시딜(minoxydil)은 그 하나로서 두피모낭 주위의 혈류를 개선하여 영양을 공급하는 약제로서 1979년 미국 FDA가 공식 인정한 대머리 치료제이다.Minoxydil (minoxydil) is one of the medicines to improve the blood flow around the scalp hair follicles and nourish the bald drug approved by the US FDA in 1979.

이는 두피 혈관 확장제로서 모발성장에 유용한 영양을 공급하게 하는 역할을 하므로서 대머리를 치료코자 시도 된 약물이다.It is a drug that attempts to treat baldness by acting as a scalp vasodilator to provide useful nutrition for hair growth.

그러나 이 제품은 미녹시딜제제 30%에서만 유효하여 하루 2회씩 평생을 발라야 하는 단점이 있으며 특정인에게는 전혀 효력이 없는 것으로 알려져 있다.However, this product is effective only in 30% of minoxidil, so it has a disadvantage of applying twice a day for life, and it is known that it is ineffective for a specific person.

한편, 디펜 사이크로 프로펜(DPCP) 치료법이 알려져 있으나 이는 탈모 된 모낭 주위에 있는 임파구의 면역기능을 높혀 모낭을 활성화시키는 방법이다.On the other hand, defensive cyclopropene (DPCP) treatment is known, but this is a method of activating the hair follicles by increasing the immune function of lymphocytes around the hair follicles that have been lost.

이 치료법은 탈모부위에 알레르기성 피부염을 일으켜 모낭을 자극하는 요법으로서 치료의 문제점이 있어 왔다.This treatment has been problematic for treating hair follicles by causing allergic dermatitis to stimulate hair follicles.

위의 몇가지 요법의 단점은 후천적 원형탈모증이 아닌 선천적, 유전적 탈모질환의 치료에는 그 유효성이 매우 떨어지는 것이 사실이다.The disadvantages of some of the above therapies are that they are very ineffective in treating congenital and alopecia areata, rather than acquired alopecia areata.

그래서 나온 방법이 머리카락 이식 수술법이다.That's how hair transplantation works.

그러나 이 방법도 수천개 이상의 모발을 일일이 이식하여야 하기 때문에 과다비용 지출과 치료기간이 장기화되는 문제점이 수반되고 있다.However, this method also involves the problem of excessive expenses and prolonged treatment periods because thousands of hairs must be transplanted one by one.

이 같은 문제점들을 볼때 선천적 또는 후천적 대머리 치료 연구의 요점은 안드로겐 작용의 메카니즘의 규명과 유전적 치료방법의 개발이라 할 수 있다.In view of these problems, the point of research on innate or acquired baldness treatment is the identification of the androgen mechanism and the development of genetic therapy.

본 발명은 이 같은 점에 고려하여 모발은 손, 발톱과 달리 발생, 생장, 사망의 주기를 가지는 점에 착안하였다.In view of this, the present invention focuses on the fact that hair has a cycle of development, growth, and death unlike hands and toenails.

성장기의 머리카락은 1개월에 1 CM 정도 자라며 그후 안드로겐이 분비되어 혈액순환이 지연되면서 모낭이 위축되면 모발이 가늘어지거나 탈모되게 된다.Growth hair grows about 1 CM per month, after which the androgen is secreted and blood circulation is delayed, causing hair follicles to shrink or hair loss.

본 발명은 탈모의 유전학적 원인을 제거하므로서 두피 모낭세포의 혈류를 왕성하게 하고 모낭 위축을 억제하므로서 탈모를 방지하며 이미 탈모 된 두피에는 새롭게 모근을 형성하여 머리카락을 자라도록 하는 대머리 발모제 및 그 제조방법을 제공함을 그 목적으로 한다.The present invention prevents hair loss by stimulating blood flow of scalp hair follicle cells by removing the genetic cause of hair loss, and prevents hair loss by inhibiting hair follicle atrophy. To provide that purpose.

이하 대머리 발모제와 그 제조방법을 공정별로 상세히 설명 한다.Hereinafter, the bald hair restorer and its manufacturing method will be described in detail for each process.

[제 1 공정 (물의 착자화 공정)][First step (water magnetization step)]

수도수, 광천수, 용천수 등 멸균수를 착자기 장치에 걸어 착자화 시킨다.Sterile water, such as tap water, mineral water, and spring water, is magnetized on a magnetizer device.

[제 2 공정 (초산발효공정)][2nd process (acetic acid fermentation process)]

착자화 된 멸균수에 설탕, 홍차잎 등 식물성잎을 선택하여 투입하고 스타터로서 공지 된 초산균을 접종하여 발효시킨후 PH 3.0 이 될때 까지 약 10일후 발효를 중지시킨다.Select the vegetable leaves such as sugar and black tea leaves into the sterilized sterile water and inoculate them with fermented acetic acid bacteria known as starters.

다만, 이때 설탕은 백설탕, 황설탕, 흑설탕 중 선택하여 사용한다.However, the sugar is selected from white sugar, brown sugar, brown sugar.

[제 3 공정 (여과공정)][3rd process (filtration process)]

제 2 공정물을 여과기에 걸어 여과시키고 그 여액을 대머리 발모제로 사용한다.The second process is filtered through a filter and the filtrate is used as a bald hair restorer.

이 같은 공정을 거쳐 제조 된 대머리 발모제는 상온에서 시장제품화 하여도 변질되지 않는 특성이 있다.Bald hair regrowth produced through such a process has the characteristics that do not deteriorate even if the market product at room temperature.

본 발명 대머리 발모제의 제조 방법을 통상의 지식을 가진자가 용이하게 실시 할 수 있도록 실시예를 들어 설명하면 다음과 같다.When the present invention is described with reference to the embodiment so that a person skilled in the art can easily prepare a bald hair restorer as follows.

[실시예 1]Example 1

멸균수 1ℓ를 착자화기에 걸어 자화시켰다.1 L of sterile water was magnetized on a magnetizer.

자화된 멸균수 1ℓ에 백설탕 100g , 홍차잎 50g을 각각 투입하고 스타터로서 공지의 초산균을 접종하여 30℃에서 발효시켰다.100 g of white sugar and 50 g of black tea leaves were added to 1 L of magnetized sterilized water, and inoculated with known acetic acid bacteria as a starter and fermented at 30 ° C.

PH 가 3.0 이 되었을때 발효를 중지하기 까지 10일이 소요되었다.When the pH reached 3.0 it took 10 days to stop fermentation.

얻어진 초산발효물은 여과기에 걸어 여과하고 미발효물을 제거하였다.The obtained acetic acid fermentation was filtered through a filter to remove unfermented product.

[실시예 2]Example 2

착자화된 멸균수 1ℓ에 황설탕 100g을 사용하는 것 외에 질소원으로서 홍차잎 대신 설록차잎 50g을 대치하고 실시예 1과 같이 발효시켜 초산발효물 여과액 약 950g을 얻었다.In addition to using 100 g of sulfur sugar in 1 L of the magnetized sterilized water, 50 g of sulloc tea leaves were replaced with black tea leaves as a nitrogen source and fermented as in Example 1 to obtain about 950 g of acetic acid fermentation filtrate.

[실시예 3]Example 3

착자화된 멸균수 1ℓ에 흑설탕 100g을 사용하고 질소원으로서 감잎 50g을 사용하여 실시예 1과 같이 발효시켜 초산발효물을 얻고 여과하여 약 950g의 여액을 얻었다.Fermentation was carried out as in Example 1 using 100 g of brown sugar and 1 g of persimmon leaf as a nitrogen source, and filtered to obtain an acetic acid fermentation product.

실시예에서 얻은 초산 발효물은 본 발명의 특징인 황설탕과 사용되는 질소원인 홍차잎, 녹차잎, 감잎의 사용으로 인하여 발효물 내에 다량의 인체 세포활성 성분인 미량원소 특히 게르마늄(Ge)의 다량 생성 집적되는 것으로 확인되었다.Acetic acid fermentation obtained in the embodiment is a large amount of trace elements, especially germanium (Ge), a large amount of human cell active ingredient in the fermentation due to the use of sulfur sugar which is a feature of the present invention and black tea leaves, green tea leaves, persimmon leaves which are used as nitrogen It was confirmed that it is produced and integrated.

이 게르마늄 성분의 작용으로 모낭세포의 혈류를 촉진하고 그 결과 탈모억제와 모발생성을 촉진하였다.The action of this germanium component promotes blood flow to hair follicle cells, resulting in hair loss control and hair growth.

다시 말하면, 게르마늄 등 미량 원소는 자기화 된 상태의 멸균수를 만나 그 자기를 기억하여 자기 기억소자로서 역할과 기능을 수행하여 병든 모낭세포의 혈류를 촉진시켜 모근 형성에 관여하는 것으로 판단된다.In other words, trace elements such as germanium meet the sterile water in a magnetized state, and remember the magnetism to play a role and function as a magnetic memory device, thereby promoting blood flow of diseased hair follicle cells to be involved in hair root formation.

본 발명품 대머리 치료제를 탈모가 심한 환자 남성 50명을 상대로 1회 20분씩 1일 3회 요법으로 치료한 결과 최단 3일에서 최장 3개월에 걸쳐 대머리가 100% 치료되었다.The baldness treatment of the present invention was treated with three times a day for 20 minutes once daily for 50 males with severe hair loss, and 100% of baldness was treated over the shortest three days and up to three months.

본 발명의 대머리 치료제는 유전적 탈모증 환자는 물론 스트레스에 의한 후천적 원형탈모증 환자 모두에게 적용할 수 있는 매우 유용한 발명이다.The baldness treatment of the present invention is a very useful invention that can be applied to both patients with genetic alopecia as well as patients with acquired alopecia areata due to stress.

Claims (3)

멸균수를 착자화기에서 자화시키고 착자화된 물에 탄소원과 질소원을 넣어 공지 된 초산균을 스타터로 접종한후 PH 3.0 이 될때까지 30℃에서 약 10일 발효시켜서 발효여과액에 게르마늄(Ge) 등 자기기억소자가 되는 미량 원소를 다량 집적시켜서 되는 대머리 발모제.The sterile water is magnetized in a magnetizer, the carbon source and the nitrogen source are put in the magnetized water, and the known acetic acid bacteria are inoculated with a starter and fermented at 30 ° C. for about 10 days until the pH is 3.0. A bald hair restorer by integrating a large amount of trace elements that become memory elements. 멸균수 1ℓ를 착자화기에 걸어 자화시킨후 이 착자차된 물에 탄소원으로서 설탕, 질소원으로서 식물성잎을 넣고 공지 된 초산균을 스타터로서 접종한후 PH 3.0 이 될때까지 30℃에서 약 10일 발효한후 여과하여 그 여액을 얻는 공정을 결합하여서 되는 대머리 발모제 제조방법.1 liter of sterile water was magnetized by magnetizing, and then, the vegetable was added with sugar and nitrogen as a carbon source and inoculated with known acetic acid bacteria as a starter. A method for producing a bald hair restorer, comprising combining the step of obtaining the filtrate by filtration. 제2항에 있어서, 탄소원을 설탕으로 하고 질소원으로서는 홍차잎, 녹차잎, 감잎 중 어느하나를 선택함을 특징으로 하는 대머리 발모제 제조방법.The method of claim 2, wherein the carbon source is used as sugar and the nitrogen source is any one of black tea leaves, green tea leaves, and persimmon leaves.
KR1019960041453A 1996-09-21 1996-09-21 Preparation to promote hair growth KR0178115B1 (en)

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