KR0163514B1 - Cosmetic composition for whitening - Google Patents

Abstract

The present invention relates to a whitening cosmetic composition, and more particularly, by adding betaine and licorice derivatives to a product using arbutin as a whitening active ingredient, whitening not only promotes percutaneous absorption of arbutin, but also significantly improves skin irritation. It relates to a cosmetic composition.

Description

Whitening Cosmetic Composition

The present invention relates to a whitening cosmetic composition, and more particularly, by adding betaine and licorice derivatives to a product using arbutin as a whitening active ingredient, a whitening cosmetic material that not only promotes percutaneous absorption of arbutin but also significantly improves skin irritation. It relates to a composition.

Human skin color is determined by a pigment called melanin, which is made by tyrosinase, an enzyme from tyrosine, an amino acid in the body. Because tyrosinase is more activated by ultraviolet light, it is well known that the skin turns black when exposed to a lot of sunlight.

Therefore, cosmetics exhibiting skin whitening effects in Korea and Japan form a large market, and most of them are products containing substances that are effective in inhibiting the activity of tyrosinase. The raw materials to be incorporated into the whitening cosmetics as an active inhibitor of conventional tyrosinase include ascorbic acid (vitamin C) and its derivatives, lettuce extract, green tea extract, aloe extract, aloe extract, golden extract, as well as kojic acid, Arbutin, oil-soluble licorice extract, and the like.

On the other hand, as one of the methods for enhancing the whitening effect, Japanese Patent Laid-Open Nos. 94-56642, 94-56643 and 94-56644 disclose one or two or more specific betaine derivatives (8-24 carbon atoms); There is an example of promoting the percutaneous absorption of arbutin by containing one each of a higher fatty acid, a higher alkyl sulfate ester salt or acylmethyltaurine, but they may promote the percutaneous absorption to some extent, but there is a problem of irritating the skin.

Therefore, the present inventors have intensively researched to invent a whitening cosmetic having excellent whitening effect and excellent skin stability. As a result, when betaine, which is a natural moisturizing ingredient, is added to a product using arbutin as an active ingredient, the solubility of arbutin is increased. Increasing the absorption, and the addition of dipotassium glycyrrhetinate or stearyl glycyrrhetinate as licorice derivative to this significantly lowered the skin irritation, thus completing the present invention.

Hereinafter, the present invention will be described in detail.

Arbutin used in the present invention is a natural sugar derivative that is present in a large amount in bilberry (bearberry, blueberry, cranberry, etc.) growing in fresh mountainous regions, and has an excellent effect on inhibiting the chemical composition of tyrosinase, a melanogenesis enzyme, and other existing compounds. It is represented by the following general formula (I) as a substance whose relative superiority has been demonstrated in terms of efficacy, effect, stability, and safety of hydroquinone, kojic acid, vitamin C, and the like as an active ingredient.

The licoriceic acid derivative used in the present invention is selected from one or two of stearyl glycyrrhetinate in which stearyl alcohol is bound to licorice obtained from licorice and dipotassium glycyrrhetinate in which licorice acid is neutralized with potassium hydroxide. Stearyl glycyrrhetinate is an oil-soluble component, dipotassium glycyrrhetinate is a water-soluble ingredient, and they are indomethacin, which is used as a medicine because of its excellent anti-inflammatory effect, stability and safety compared to licorice itself. It is shown to be equivalent to bisabolol, an anti-inflammatory substance that is typically used in cosmetics. However, indomethacin cannot be used in cosmetics for medicine, and bisabolol has been found to have significant side effects. Dipotassium glycerinate, a water-soluble derivative of licoriceic acid, also has an excellent anti-inflammatory effect, but is in the form of a salt, which results in limitations when applied to an emulsified product.

Betaine (betaine, trimethylglycine) used in the present invention is a natural substance obtained by separating and purifying from molasses which is a by-product of sugar beet, has excellent moisture retention, safety and stability, and is represented by the following general formula (II).

Hereinafter, the present invention will be described in more detail.

The present invention is 0.1 to 20% by weight of arbutin, 0.01 to 2.0% by weight of licorice derivatives, a mixture of betaine alone or betaine, one or two or more selected from glycerin, 1,3-butylene glycol and propylene glycol 2 It is characterized by containing 20% by weight. In this case, when the content of albumin is less than 0.1% by weight, the amount is very small, so it is difficult to expect a whitening effect, and when it exceeds 20% by weight, it is difficult to formulate because of poor solubility. In addition, the content of the licorice acid derivative is most preferably 0.01 to 2.0% by weight because it is difficult to expect the effect at less than 0.01% by weight, since the effect does not increase so much when more than 2.0% by weight. For the same reason betaine is also preferably 1 to 20% by weight.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples.

[Examples 1-2 and Comparative Examples 1-3]

As shown in Table 1, Examples 1 and 2 use dipotassium glycyrrhetinate as an anti-inflammatory component in a conventional cosmetic lotion formulation, and betaine alone (Example 1) or betaine glycerin to betaine 5: It was prepared by mixing (Example 2) at a ratio of 5, Comparative Example 1 was used alone glycerol, Comparative Example 2 was used propylene glycol, Comparative Example 3 was used by mixing glycerine and propylene glycol. According to the composition of Table 1, the aqueous phase and alcohol phase were each completely dissolved by stirring at room temperature, and then, while slowly adding the alcohol phase to the aqueous phase, the mixture was stirred at 500 to 100 rpm for 5 minutes.

[Examples 3-6 and Comparative Examples 4-7]

As shown in Table 2, Examples 3 to 6 used stearyl glycyretinate as an anti-inflammatory component in an emulsified essence product, and Example 3 used betaine alone as a transdermal absorption accelerator. A mixture of glycerin and betaine, Example 5 was prepared by mixing 1,3-butylene glycol with betaine, and Example 6 was prepared by mixing glycerin and 1,3-butylene glycol with betaine. 4 is glycerin alone, Comparative Example 5 is 1,3-butylene glycol as a single tok, Comparative Example 6 is a mixture of glycerin and 1,3-butylene glycol, Comparative Example 7 to betaine Glycerin and 1,3-butylene glycol were mixed and used, and Comparative Examples 6 to 7 were prepared without using stearyl glycyrrhetinate as an anti-inflammatory component.

According to the composition of Table 2, the oil phase was melted at 65 ° C. and the water phase at 60-65 ° C. according to the composition shown in Table 2, followed by stirring at 4000 to 5000 rpm for 2 to 4 minutes while gradually adding the oil phase to the water phase using a homomixer. Subsequently, the neutralizing agent, ethanol, preservative, and fragrance were slowly added thereto, stirred at 4000 to 5000 rpm for 4 to 5 minutes, and cooled to room temperature.

[Skin primary irritation test (patch test)]

In order to examine the skin irritation properties of the products prepared according to the above examples and comparative examples, a certain amount (approximately 0.2 g) of each sample was applied to the back of the healthy adult males and females, and the pin chamber was removed. After a lapse of time, the change of skin condition was visually read, and the results are shown in Table 3.

As can be seen from the results of Table 3, Comparative Examples 3, 6, and 7, in which no licorice derivatives were added, exhibited higher stimulation than other examples.

[Percutaneous absorption measurement test]

In order to evaluate the transdermal absorption promoting effect on arbutin, a skin permeation test was conducted using the skin of hairless mice. 48 microliters of sample were injected into the skin surface of 15.0mm diameter, and the amount of arbutin permeated after 24 hours using a transdermal absorption apparatus (Franz diffusion cell, Hanson) was analyzed by HPLC (High Pressure Liquid Chromatography). Quantification is shown in Table 4 as the transmittance (%).

From the results of Table 4, it can be seen that Examples 3 to 6 containing betaine were significantly promoted percutaneous absorption compared to Comparative Examples 4 to 6 not containing it.

Claims (4)

Arbutin 0.1-20% by weight, licorice derivatives 0.01-2.0% by weight, betaine alone or betaine 1-20% by mixing one or two or more selected from glycerin, 1,3-butylene glycol and propylene glycol A whitening cosmetic composition, characterized in that it contains%. The whitening cosmetic composition according to claim 1, wherein arbutin is represented by the following general formula (I). The whitening cosmetic composition according to claim 1, wherein the licorice derivative is dipotassium glycyrrhetinate or stearyl glycyrrhetinate. The whitening cosmetic composition according to claim 1, wherein the betaine is an amino acid derivative derived from a natural plant represented by the following general formula (II).