KR0138244B1 - Dentifrice compositions - Google Patents

Abstract

The present invention is an organic solvent extracted from a combination of three kinds of gallja, licorice, golden, and organic solvents, white paper, sesin, horse riding, donkey, phalanges, windproof, Cheongung, hwahwa, hard bones, licorice, ginger, black bean contains 7 or more It relates to a toothpaste composition characterized in that it contains 0.01 to 5% by weight based on the whole composition using a single or mixed extract of the complex preparation to be extracted with an organic solvent. The toothpaste composition of the present invention is very excellent in preventing, treating and preventing tooth decay.

Description

Toothpaste composition containing herbal extract

The present invention relates to a dentifrice composition containing a herbal extract excellent in the prevention and treatment of periodontal disease, and more particularly preventive of tooth decay, and more particularly by applying an extract extracted from a mixed medicinal herb to the dentifrice composition. It relates to a toothpaste composition filled with a therapeutic and caries prevention effect.

Various oral diseases appearing in the tissues of the oral cavity are caused by plaque composed of numerous bacteria present in the oral cavity, and the clinical and pathological significance thereof has been widely studied. Alexander, AG; J. Periodent, 42; 21- 28, 1971), Ash (MM; J. perio-dontol. 35; 424, 1964).

Ancient people can see the use of various herbal medicines to maintain oral health and to treat diseases.Ancient Chinese used herbal medicine to treat gingivitis, bleeding, etc. Poenixi people use honey, opium, rose oil, etc. in the Middle Ages, white wine, baked salt, etc. in the 14th and 15th centuries, used as a coating or dentifrice to prevent and treat periodontal disease.

The Oriental region introduces the use of herbal medicines as an application or dentifrice.

Recently, a lot of efforts have been made to inhibit the plaque bacterium by a mechanical method other than a mechanical method, and in particular, as a chemical agent, chlorohexidine, cetylpyryl chloride, antibiotics, and fluorine agents As the enzyme preparation, dextranase (Dextranase), etc. have been found to have a plaque suppression effect as a dentifrice or a coating agent has been used in various ways. As is known, herbal extracts have also been studied and applied to products in a variety of ways.

In Japanese Unexamined Patent Publication No. 55-120,509, herbal extracts such as bone extract, white leaf, fat milk, lotus root, and leaf lobe were formulated to obtain plaque bactericidal effect, and Japanese Patent Laid-Open Nos. 57-5641 and 57-85319 In the case of berberine extracted from yellowish white, Flavonol is disclosed in Japanese Patent Application Laid-Open No. 87-51613, and seed oil of moonshineweed in Japanese Patent Laid-Open No. 87-268613 is relegated (Gangin, etc .: green tea, myrrh, A Study on the Clinical and Microbiological Effects of Toothpaste Containing Echinacea Peel and Horse Riding Extract, Journal of the Korean Periodontal Science Society, 21 (1), 1-15, 1991) The method was applied to the product as a method to obtain the plaque bactericidal effect. These trials (Lee Man-seop; comparative study on the inhibitory effect of plaque formation between chemicals and herbal medicines, Kyung Hee University's eyes, 6, 7-17, 1984) were presented in Dong Bo-gam. Three kinds of sessin, respectively, were mixed with water to extract the plaque bacterium and gingival inflammation.

However, when the components were extracted from a single herbal medicine, the plaque bacterium inhibitory effect was shown to be good, but the gingival inflammation alleviating effect was weak. In addition, when the extract was used by extracting the water mixture, there was a problem that the efficacy or no effect, and when applied to the toothpaste product, its usability is not good.

Therefore, while the present invention is in progress to solve the fragmentary effect problem of the extract extracted from such a single herbal medicine and the effect degradation problem when using the complex preparation water extract, solvent extraction of the complex preparations mixed with a specific herbal medicine By applying to the toothpaste product was found to be excellent in plaque bacterial growth inhibitory effect and caries and periodontal disease prevention effect was completed the present invention.

In the present invention, the extract itself has been used for the prevention and treatment of oral diseases for a long time, but the feeling of use is not good due to the unique taste of the extract, and the prevention of oral diseases due to sugars, etc. . The therapeutic effect was weak.

Therefore, the present invention prevents oral disease. The herbal medicine that has been used for the treatment is used, but the extraction solvent is extracted using alcoholic water and other organic solvents, and the extraction method is an appropriate amount of the extraction solvent in the semantically controlled state. In addition, percolation (percolation), silver immersion method, cold acupuncture method or super critical extrator (super critical extrator) method is used, and the sugars such as glucose contained in the extract was removed as much as possible. Further, if necessary, the extract was adsorbed and filtered using an adsorbent such as activated carbon, diatomaceous earth, and acidic clay.

The complex preparations used in the present invention are Cheongeuntang (탕) and Okjisan (玉 地 散), the composition of the cheongeuntang is fivefold, five liquorice, golden (黄 金), jade Jisan is white paper, seshin, horseback riding, donkey, zigolpi, wind-break, cheongung, and hwahwa. ), Bonbon (藁 本), licorice (甘草), ginger (生薑), black bean (黑豆). The amount of these medicines can be adjusted and used as needed, but most suitably, in the case of Cheongeun-tang's complex, the same amount of herbal medicine is used as the weight ratio. , Horse riding, donkey, phalanges, windproof, cheonggung, hwahwa, gobon, licorice is a mixture of 3 to 5g each, 3 pieces of ginger, 100 black beans.

More specifically, the present invention relates to a toothpaste composition using an extract of a combination preparation of Cheongeun-tang and Okji-san alone or in combination, wherein the extract of each combination preparation is decompressed with respect to the general ingredients and compositions required for preparing the toothpaste. It relates to a toothpaste composition characterized by containing 0.01 to 5% by weight in concentrated to a state of soft extract acid or dry extract.

Prevention of periodontal disease when the ingredient is used at less than 0.01% by weight. Treatment and caries prevention effect is weak, when used more than 5% by weight of the unique taste of each component of the extract will reduce the feeling of use of the product. At this time, the preferred ratio is 0.05 to 3% by weight of the total composition alone or mixed.

The present invention prevents periodontal disease in the usual components of toothpaste. The present invention relates to a dentifrice composition characterized in that the chungeuntang is used alone or in combination with the complex preparation extract and the complex preparation extract of oxic acid.

Toothpaste composition according to the present invention may further contain sulfur white extract to increase its efficacy.

Other components of the present invention include conventional toothpaste components, and abrasives include calcium carbonate, calcium monohydrogen phosphate, precipitated silica, hydrous alumina, silica gel, insoluble sodium metaphosphate, zirconium silicate, and the like. 20 to 60% by weight, preferably 20 to 50% by weight of the above mixture is used.

As the humectant, 20 to 60% by weight, preferably 20 to 50% by weight, of glycerine, solitol solution, and amorphous sorbitol solution alone or in combination of two or more thereof is used.

As the binder, 0.1 to 3.0% by weight, preferably 0.5 to 2.0% by weight of carrageenan, xanthan gum, carboxymethylcellulose sodium, carboxyvinyl polymer, sodium alginate, or the like may be used alone or in combination.

As the foaming agent, anionic surfactants such as sodium lauryl sulfate and sodium lauryl sarcosinate, sorbitan fatty acid esters, polyoxyethylene hardened castor oil, polyoxyethylene polyoxypropylene-based condensed polymer materials, etc., may be used alone or in a mixture of 0.5 to 5% by weight, suitably 0.5 to 2.5% by weight is used.

Examples of the sweetener include saccharin sodium, aspartame, and licorice acid, and are preferably 0.05 to 0.5% by weight, either alone or in combination of two or more thereof.

As the preservative, paraoxybenzoic acid ester, benzoic acid, sodium benzoate may be used alone or in combination of two or more kinds.As a medicament, a drug such as unsaturated sodium chlorohexidine, trinexamic acid, allantoin, capronic acid, etc. may be used. As a flavoring agent, a suitable amount of peppermint oil, spearmint oil, menthol, and carbon are mixed. As a pH adjuster, phosphoric acid, sodium phosphate, citric acid, sodium citrate, succinic acid, sodium succinate, tartaric acid and sodium stannate are used. The furnace is 5 to 8, using titanium oxide as the brightener, and preferably 0.1 to 2% by weight.

Experimental Example 1

Below is a bactericidal test of herbal extracts for oral microorganisms to specifically illustrate the present invention.

(1) Types of herbal extracts and preparation methods of extracts

① Licorice ② Hwangbaek ③ Hwangyeon ④ Cheongwisan Complex (Ridding 7.50g, Peel Skin 5.62g, Donkey, Hwangnyeon, Saenghwanghwang 3.75g) , Same amount of peppermint, windproof, licorice) ⑥ Cheongeun-tang complex (equal amount of gall, licorice, gold) ⑦ Hyunggaetang complex (equal amount of hyunghyeong, peppermint, horse riding, Sessin) ⑧ Okjisan complex (white paper) , Seshin, horse riding, donkey, phalanges, windproof, Cheongung, hwahwa, ancient bone, licorice each 3.75g, three ginger, 100 black beans)

100 ml of 95% ethanol is added to 100 g of the herbal medicines of the ① to ⑧ and the mixture is immersed at room temperature for 5 days. After 5 days, the filtrate was filtered and the filtrate was concentrated under reduced pressure to obtain a soft extract state. 5 g of 95% ethanol is diluted in 2 g of the weight of the soft extract, and 3 g of distilled water is added to make a solution of 10 g of each herbal extract.

(2) Test strain

① Rothia dentocariosa ATCC 19426

② Actinomyces Viscosus KTCT 9146

③ Streptococcus mutans NIDR 6715

④ Escherichia coli ATCC 8739

(3) Experimental method

0.2 g of each extract was added to 10 ml of BHI (Brain Heart Infusion), and then inoculated with the strain cultured for 1 to 2 days, and then cultured for 1 day.

(4) Experimental Results (Table 1)

The bactericidal test results showed beneficial effects in the extracts of Hwangbaek, Cheongeun-tang, and Okji-san.

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Claims (6)

Combination formulation containing three kinds of five kinds of organic ingredients, which are mixed with five kinds of gall, licorice and golden, and containing 7 or more of white paper, sessin, horse riding, ground, phalanx, windproof, cheonung, hwahwa, gobon, licorice, ginger and black bean Toothpaste composition characterized in that it contains 0.01 to 5% by weight based on the whole composition using a single or mixed extract extracted with an organic solvent. According to claim 1, wherein the combination of five times the ratio of five times, licorice, and gold to form a complex formulation and a combination formulation consisting of white paper, sessin, horse riding, donkey, phalanges, windbreak, cheongung, hwahwa, hard bone, licorice, ginger, black bean Toothpaste composition, characterized in that extracted with an organic solvent. According to claim 1, characterized in that the combination of white paper, sessin, horse riding, donkeys, phalanges, windproof, cheonggung, hwahwa, honbon, licorice each 3 to 5g, 3 pieces of ginger, 10 to 100 tablets Toothpaste composition. The toothpaste composition according to any one of claims 1 to 3, wherein the free saccharide and the pigment are removed from the extract. The toothpaste composition according to any one of claims 1 to 3, which is extracted by percolation, warm needle, cold needle, or supercritical extraction by the extraction method. The dentifrice composition according to any one of claims 1 to 3, further comprising a sulfur white extract.