JPWO2023171587A5 - - Google Patents

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Publication number
JPWO2023171587A5
JPWO2023171587A5 JP2024506295A JP2024506295A JPWO2023171587A5 JP WO2023171587 A5 JPWO2023171587 A5 JP WO2023171587A5 JP 2024506295 A JP2024506295 A JP 2024506295A JP 2024506295 A JP2024506295 A JP 2024506295A JP WO2023171587 A5 JPWO2023171587 A5 JP WO2023171587A5
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JP
Japan
Prior art keywords
seq
double
stranded rna
rna consisting
strand
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JP2024506295A
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English (en)
Japanese (ja)
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JP7776924B2 (ja
JPWO2023171587A1 (https=
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Priority claimed from PCT/JP2023/008197 external-priority patent/WO2023171587A1/ja
Publication of JPWO2023171587A1 publication Critical patent/JPWO2023171587A1/ja
Publication of JPWO2023171587A5 publication Critical patent/JPWO2023171587A5/ja
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JP2024506295A 2022-03-08 2023-03-06 変異ＦＵＳの発現を選択的に抑制する修飾ｓｉＲＮＡ Active JP7776924B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022035727 2022-03-08
JP2022035727 2022-03-08
PCT/JP2023/008197 WO2023171587A1 (ja) 2022-03-08 2023-03-06 変異ＦＵＳの発現を選択的に抑制する修飾ｓｉＲＮＡ

Publications (3)

Publication Number Publication Date
JPWO2023171587A1 JPWO2023171587A1 (https=) 2023-09-14
JPWO2023171587A5 true JPWO2023171587A5 (https=) 2024-10-22
JP7776924B2 JP7776924B2 (ja) 2025-11-27

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ID=87935373

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Application Number Title Priority Date Filing Date
JP2024506295A Active JP7776924B2 (ja) 2022-03-08 2023-03-06 変異ＦＵＳの発現を選択的に抑制する修飾ｓｉＲＮＡ

Country Status (3)

Country Link
US (1) US20250101420A1 (https=)
JP (1) JP7776924B2 (https=)
WO (1) WO2023171587A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025163186A1 (en) * 2024-02-01 2025-08-07 Silence Therapeutics Gmbh Conjugated nucleic acids and nucleic acids comprising locked nucleosides and inverted nucleotides for inhibiting gene expression in a cell

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2731643C (en) 2008-07-22 2020-05-05 The General Hospital Corporation Fus/tls-based compounds and methods for diagnosis, treatment and prevention of amyotrophic lateral sclerosis and related motor neuron diseases
US20150045330A1 (en) 2012-01-17 2015-02-12 Kyoto University Prophylactic and therapeutic drug for amyotrophic lateral sclerosis and method of screening therefor
TW201808342A (zh) 2012-05-02 2018-03-16 喜納製藥公司 包含四ｇａｌｎａｃ之新穎結合物及傳送寡核苷酸之方法
KR101576602B1 (ko) * 2014-02-11 2015-12-10 한남대학교 산학협력단 퇴행성 신경계 질환 치료제 스크리닝 방법
WO2018185253A1 (en) * 2017-04-05 2018-10-11 Silence Therapeutics Gmbh Ligand modified double-stranded nucleic acids
US11492617B2 (en) 2017-08-08 2022-11-08 Ionis Pharmaceuticals, Inc Compositions and methods for modulation of protein aggregation
EP3775209A1 (en) 2018-04-05 2021-02-17 Silence Therapeutics GmbH Sirnas with at least two ligands at different ends
US20240229025A1 (en) * 2020-09-09 2024-07-11 Ohara Pharmaceutical Co., Ltd. siRNA AND USE THEREOF

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