JPWO2022111425A5 - - Google Patents
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- Publication number
- JPWO2022111425A5 JPWO2022111425A5 JP2023532547A JP2023532547A JPWO2022111425A5 JP WO2022111425 A5 JPWO2022111425 A5 JP WO2022111425A5 JP 2023532547 A JP2023532547 A JP 2023532547A JP 2023532547 A JP2023532547 A JP 2023532547A JP WO2022111425 A5 JPWO2022111425 A5 JP WO2022111425A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- acid sequence
- sequence shown
- binding molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 43
- 108060003951 Immunoglobulin Proteins 0.000 claims 6
- 102000018358 immunoglobulin Human genes 0.000 claims 6
- 238000006467 substitution reaction Methods 0.000 claims 3
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 2
- 241001416177 Vicugna pacos Species 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000007792 addition Methods 0.000 claims 1
- 230000006229 amino acid addition Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000034287 fluorescent proteins Human genes 0.000 claims 1
- 108091006047 fluorescent proteins Proteins 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011332200.9A CN112480248B (zh) | 2020-11-24 | 2020-11-24 | 与cld18a2特异性结合的分子 |
| CN202011332200.9 | 2020-11-24 | ||
| PCT/CN2021/132218 WO2022111425A1 (zh) | 2020-11-24 | 2021-11-23 | 与cldn18.2特异性结合的分子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023551027A JP2023551027A (ja) | 2023-12-06 |
| JPWO2022111425A5 true JPWO2022111425A5 (he) | 2024-01-11 |
Family
ID=74934321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023532547A Pending JP2023551027A (ja) | 2020-11-24 | 2021-11-23 | Ｃｌｄｎ１８．２に特異的に結合する分子 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20240092891A1 (he) |
| EP (1) | EP4253411A1 (he) |
| JP (1) | JP2023551027A (he) |
| CN (2) | CN112480248B (he) |
| AU (1) | AU2021387558A1 (he) |
| CA (1) | CA3200052A1 (he) |
| WO (1) | WO2022111425A1 (he) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112480248B (zh) * | 2020-11-24 | 2023-05-05 | 三优生物医药(上海)有限公司 | 与cld18a2特异性结合的分子 |
| WO2022253155A1 (en) * | 2021-05-31 | 2022-12-08 | Shijiazhuang Yiling Pharmaceutical Co., Ltd. | Monoclonal antibodies against cldn18.2 and fc-engineered versions thereof |
| CN115611983A (zh) | 2021-07-14 | 2023-01-17 | 三优生物医药(上海)有限公司 | Cldn18.2结合分子及其用途 |
| KR20240044467A (ko) * | 2021-08-09 | 2024-04-04 | 하버 바이오메드 (상하이) 컴퍼니 리미티드 | Cldn18.2-표적화 항체, 이중특이적 항체, 및 이들의 용도 |
| WO2023025306A1 (zh) * | 2021-08-27 | 2023-03-02 | 三优生物医药(上海)有限公司 | 靶向pd-l1和cldn18.2的双特异性抗体及其制备方法和应用 |
| CN115991784A (zh) | 2021-10-19 | 2023-04-21 | 宝船生物医药科技(上海)有限公司 | 抗cd47-cldn18.2双特异性抗体及其用途 |
| WO2023078386A1 (zh) * | 2021-11-05 | 2023-05-11 | 正大天晴药业集团股份有限公司 | 抗cldn18.2抗体及其用途 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH591382A5 (he) | 1974-05-28 | 1977-09-15 | Ferag Ag | |
| USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| EP0435911B1 (en) | 1988-09-23 | 1996-03-13 | Cetus Oncology Corporation | Cell culture medium for enhanced cell growth, culture longevity and product expression |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| DK0590058T3 (da) | 1991-06-14 | 2004-03-29 | Genentech Inc | Humaniseret heregulin-antistof |
| DK1589107T3 (da) | 1992-08-21 | 2010-04-26 | Univ Bruxelles | Immonuglobuliner uden lette kæder |
| AU2002357060A1 (en) | 2001-12-03 | 2003-06-17 | Abgenix, Inc. | Antibody categorization based on binding characteristics |
| EP1790664A1 (en) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
| WO2012055030A1 (en) * | 2010-10-25 | 2012-05-03 | National Research Council Of Canada | Clostridium difficile-specific antibodies and uses thereof |
| DK3254695T3 (da) * | 2012-05-23 | 2020-11-30 | Astellas Pharma Inc | Kombinationsterapi, der involverer antistoffer mod claudin 18.2 til behandling af cancer |
| WO2016165762A1 (en) * | 2015-04-15 | 2016-10-20 | Ganymed Pharmaceuticals Ag | Drug conjugates comprising antibodies against claudin 18.2 |
| AU2019232762B2 (en) * | 2018-03-08 | 2023-11-16 | Phanes Therapeutics, Inc. | Anti-claudin 18.2 antibodies and uses thereof |
| CN111848809A (zh) * | 2019-04-08 | 2020-10-30 | 上海健信生物医药科技有限公司 | 靶向Claudin18.2的CAR分子、其修饰的免疫细胞及用途 |
| CN111518214B (zh) * | 2019-02-03 | 2023-09-22 | 上海健信生物医药科技有限公司 | 靶向cldn18.2的双特异性抗体及其制备方法和应用 |
| CN111867630B (zh) * | 2018-06-17 | 2023-10-13 | 上海健信生物医药科技有限公司 | 靶向cldn18.2的抗体、双特异性抗体、adc和car及其应用 |
| CN116333141A (zh) * | 2019-01-15 | 2023-06-27 | 浙江道尔生物科技有限公司 | 抗cld18a2纳米抗体及其应用 |
| CN109762067B (zh) * | 2019-01-17 | 2020-02-28 | 北京天广实生物技术股份有限公司 | 结合人Claudin 18.2的抗体及其用途 |
| CN111961135B (zh) * | 2020-07-13 | 2022-08-16 | 北京亦庄国际蛋白药物技术有限公司 | 一种用于预防或治疗癌症的抗体 |
| EP4225798A1 (en) * | 2020-10-12 | 2023-08-16 | Janssen Biotech, Inc. | Biosynthetic materials and methods for multidirectional biotransportation |
| CN112480248B (zh) * | 2020-11-24 | 2023-05-05 | 三优生物医药(上海)有限公司 | 与cld18a2特异性结合的分子 |
-
2020
- 2020-11-24 CN CN202011332200.9A patent/CN112480248B/zh active Active
-
2021
- 2021-11-23 JP JP2023532547A patent/JP2023551027A/ja active Pending
- 2021-11-23 WO PCT/CN2021/132218 patent/WO2022111425A1/zh active Application Filing
- 2021-11-23 US US18/254,206 patent/US20240092891A1/en active Pending
- 2021-11-23 CA CA3200052A patent/CA3200052A1/en active Pending
- 2021-11-23 AU AU2021387558A patent/AU2021387558A1/en active Pending
- 2021-11-23 CN CN202180078658.2A patent/CN116568809A/zh active Pending
- 2021-11-23 EP EP21896926.9A patent/EP4253411A1/en active Pending
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