JPWO2022052964A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2022052964A5
JPWO2022052964A5 JP2023515253A JP2023515253A JPWO2022052964A5 JP WO2022052964 A5 JPWO2022052964 A5 JP WO2022052964A5 JP 2023515253 A JP2023515253 A JP 2023515253A JP 2023515253 A JP2023515253 A JP 2023515253A JP WO2022052964 A5 JPWO2022052964 A5 JP WO2022052964A5
Authority
JP
Japan
Prior art keywords
expression
functional
functional fragments
promotes
transcription factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2023515253A
Other languages
English (en)
Japanese (ja)
Other versions
JP7680072B2 (ja
JP2023540130A (ja
JP2023540130A5 (https=
Publication date
Priority claimed from CN202010934192.9A external-priority patent/CN114231489A/zh
Application filed filed Critical
Publication of JP2023540130A publication Critical patent/JP2023540130A/ja
Publication of JPWO2022052964A5 publication Critical patent/JPWO2022052964A5/ja
Publication of JP2023540130A5 publication Critical patent/JP2023540130A5/ja
Application granted granted Critical
Publication of JP7680072B2 publication Critical patent/JP7680072B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2023515253A 2020-09-08 2021-09-08 リプログラミング用機能性断片、組み合わせ、およびその用途 Active JP7680072B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010934192.9A CN114231489A (zh) 2020-09-08 2020-09-08 用于重编程的功能性片段、组合及其应用
CN202010934192.9 2020-09-08
PCT/CN2021/117302 WO2022052964A1 (zh) 2020-09-08 2021-09-08 用于重编程的功能性片段、组合及其应用

Publications (4)

Publication Number Publication Date
JP2023540130A JP2023540130A (ja) 2023-09-21
JPWO2022052964A5 true JPWO2022052964A5 (https=) 2024-07-30
JP2023540130A5 JP2023540130A5 (https=) 2024-07-30
JP7680072B2 JP7680072B2 (ja) 2025-05-20

Family

ID=80632100

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023515253A Active JP7680072B2 (ja) 2020-09-08 2021-09-08 リプログラミング用機能性断片、組み合わせ、およびその用途

Country Status (6)

Country Link
US (1) US20240026379A1 (https=)
EP (1) EP4212624A4 (https=)
JP (1) JP7680072B2 (https=)
KR (1) KR20230082024A (https=)
CN (2) CN114231489A (https=)
WO (1) WO2022052964A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117070477A (zh) * 2022-05-10 2023-11-17 纽伦捷生物医药科技（上海）有限公司 重组溶瘤病毒的重编程的功能性片段、组合及其应用
WO2025108407A2 (en) 2023-11-23 2025-05-30 Neuexcell Therapeutics (Suzhou) Co., Ltd. Gene therapy compositions and methods for treating glioma

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010053522A2 (en) * 2008-10-29 2010-05-14 The Regents Of The University Of California Methods for identifying and producing neural stem and progenitor cells and their progeny
WO2010144696A1 (en) 2009-06-11 2010-12-16 Burnham Institute For Medical Research Directed differentiation of stem cells
US9057053B2 (en) * 2010-01-19 2015-06-16 The Board Of Trustees Of The Leland Stanford Junior University Direct conversion of cells to cells of other lineages
EP2531599A4 (en) * 2010-02-04 2014-01-08 Vivoscript Inc COMPOSITIONS AND METHODS OF RENEWING CELLS WITHOUT GENETIC MODIFICATION FOR THE TREATMENT OF NEUROLOGICAL SUFFERING
WO2014037527A1 (en) * 2012-09-07 2014-03-13 Cambridge Enterprise Limited Maturation of mammalian cells by modulation of protein phosphorylation
US10076574B2 (en) 2013-10-25 2018-09-18 Wayne State University Methods, systems and compositions relating to cell conversion via protein-induced in-vivo cell reprogramming
EP3099786A1 (en) * 2014-01-29 2016-12-07 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Trans-differentiation of differentiated cells
WO2017081033A1 (en) * 2015-11-09 2017-05-18 Universite De Nice Sophia Antipolis Cell differentiation or reprogramming using fezf2 and lmo4
CN107435050B (zh) * 2017-06-20 2021-02-09 向孟清 一种将人或动物体细胞诱导为神经干细胞的方法
EP3418378B1 (en) * 2017-06-22 2024-12-25 HI-STEM gGmbH Im Deutschen Krebsforschungszentrum DKFZ Novel methods for the generation and use of human induced neural border stem cells
US20200018746A1 (en) * 2018-03-14 2020-01-16 The Broad Institute, Inc. Three-Dimensional Human Neural Tissues for CRISPR-Mediated Perturbation of Disease Genes
US20210228741A1 (en) * 2018-04-27 2021-07-29 University Of Washington Methods and compositions to stimulate retinal regeneration
US20200002679A1 (en) * 2018-06-05 2020-01-02 Kcellbio Banking Co., Ltd. Composition for cell regeneration comprising cells hypersecreting growth factors, and at least one of neural stem cells, neurons and gabaergic neurons
US20210268126A1 (en) * 2018-08-23 2021-09-02 Rutgers, The State University Of New Jersey Treating spinal cord injury (sci) and brain injury using gsx1
CN109385404B (zh) * 2018-10-19 2021-07-06 国典(北京)医药科技有限公司 一种诱导干细胞分化为神经元的方法及神经元与应用

Similar Documents

Publication Publication Date Title
CA2165969A1 (en) Vertebrate apoptosis gene: compositions and methods
JP2021520200A5 (https=)
CN109646668B (zh) 一种多肽用于制备防治阿尔茨海默病药物的用途
WO2021031810A1 (zh) Ptbp1抑制剂在预防和/或治疗功能性神经元死亡相关的神经系统疾病中的应用
CN112386699A (zh) Ptbp1抑制剂在预防和/或治疗功能性神经元死亡相关的神经系统疾病中的应用
JP7680072B2 (ja) リプログラミング用機能性断片、組み合わせ、およびその用途
Chen et al. Identification of Clec7a as the therapeutic target of rTMS in alleviating Parkinson's disease: targeting neuroinflammation
Zhai et al. Overexpressed ski efficiently promotes neurorestoration, increases neuronal regeneration, and reduces astrogliosis after traumatic brain injury
JP4494863B2 (ja) Ｖｈｌペプチド
JP2021534206A5 (https=)
JP7828619B2 (ja) 運動性神経細胞直接交差分化用因子
WO2021032068A1 (zh) Ptbp1抑制剂在预防和/或治疗功能性神经元死亡相关的神经系统疾病中的应用
JP7620338B2 (ja) 機能性ニューロンへのグリア細胞の分化転換を誘導するためのＮｅｕｒｏｇ２機能性断片送達システム、宿主細胞及び医薬組成物
US20250115650A1 (en) Direct transdifferentiation for treatment of neurological disease
JPWO2022052964A5 (https=)
JP2025515209A (ja) 組換え腫瘍溶解性ウイルスのリプログラミングさせる機能的断片、組み合わせ及びその応用
Dias et al. Perspective on Gene Therapy for Glaucoma
US6555369B2 (en) Method of stable integration of DNA into neurons
WO2024245132A1 (en) Optogenetic activation for signal transduction
CN114931652B (zh) 一种Hmga2基因在修复受损视网膜中的应用
Verhaagen et al. Gene Therapy for Spinal Cord Injury
RU2521225C2 (ru) Способ стимулирования регенерации спинного мозга с помощью генетически модифицированных клеток крови пуповины человека
JPWO2023051802A5 (https=)
HK40097397A (en) Functional fragment for reprogramming, composition, and application thereof
CN116970571A (zh) 一种再生gaba能神经元的方法及其在制备神经病理性疼痛基因治疗药物中的应用