JP2021520200A5 - - Google Patents
Info
- Publication number
- JP2021520200A5 JP2021520200A5 JP2020554154A JP2020554154A JP2021520200A5 JP 2021520200 A5 JP2021520200 A5 JP 2021520200A5 JP 2020554154 A JP2020554154 A JP 2020554154A JP 2020554154 A JP2020554154 A JP 2020554154A JP 2021520200 A5 JP2021520200 A5 JP 2021520200A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- composition according
- neuronal cells
- expression level
- contact
- Prior art date
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862656322P | 2018-04-11 | 2018-04-11 | |
| US62/656,322 | 2018-04-11 | ||
| US201862718774P | 2018-08-14 | 2018-08-14 | |
| US62/718,774 | 2018-08-14 | ||
| PCT/US2019/027027 WO2019200129A1 (en) | 2018-04-11 | 2019-04-11 | Reprogramming of non-neuronal cells into neurons and methods and compositions to treat neurodegenerative diseases and disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021520200A JP2021520200A (ja) | 2021-08-19 |
| JP2021520200A5 true JP2021520200A5 (https=) | 2022-03-22 |
| JPWO2019200129A5 JPWO2019200129A5 (https=) | 2022-03-22 |
Family
ID=68164570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020554154A Pending JP2021520200A (ja) | 2018-04-11 | 2019-04-11 | 非神経細胞のニューロンへの再プログラミング、及び神経変性疾患または障害を治療するための方法と組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11702656B2 (https=) |
| EP (1) | EP3773749A4 (https=) |
| JP (1) | JP2021520200A (https=) |
| KR (1) | KR20200142537A (https=) |
| CN (1) | CN112312928A (https=) |
| AU (1) | AU2019252534A1 (https=) |
| CA (1) | CA3096691A1 (https=) |
| GB (2) | GB202017810D0 (https=) |
| WO (1) | WO2019200129A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022543722A (ja) * | 2019-08-16 | 2022-10-14 | センター フォー エクセレンス イン ブレイン サイエンス アンド インテリジェンス テクノロジー，チャイニーズ アカデミー オブ サイエンシーズ | 機能的ニューロン死に関連する神経系疾患の予防および／または治療におけるＰｔｂｐ１阻害剤の使用 |
| CN112386699A (zh) * | 2019-08-16 | 2021-02-23 | 中国科学院脑科学与智能技术卓越创新中心 | Ptbp1抑制剂在预防和/或治疗功能性神经元死亡相关的神经系统疾病中的应用 |
| US20230242873A1 (en) * | 2020-05-13 | 2023-08-03 | Figene, Llc | Fibroblast based therapy for treatment of parkinson's disease |
| US20240050589A1 (en) * | 2020-12-25 | 2024-02-15 | Shanghai Genemagic Biosciences Co., Ltd. | Treatment of neurological diseases |
| CN112661828B (zh) * | 2021-01-15 | 2022-04-01 | 武汉大学 | 一种突触素的抗原肽及其抗体与应用 |
| CN117279668A (zh) * | 2021-02-10 | 2023-12-22 | 上海鲸奇生物科技有限公司 | 胶质细胞向神经元转分化用于预防或治疗神经元功能缺失或死亡相关疾病 |
| CN112941019B (zh) * | 2021-03-18 | 2023-01-06 | 浙江大学 | 一种促进体细胞重编程的方法 |
| CN116144596A (zh) * | 2021-03-26 | 2023-05-23 | 广西大学 | 一种体外高效诱导人体细胞重编程为神经元细胞的方法 |
| CN113171369A (zh) * | 2021-04-16 | 2021-07-27 | 南通大学 | 多聚嘧啶序列结合蛋白在制备脊髓损伤的修复药物中的应用 |
| WO2022222974A1 (zh) * | 2021-04-21 | 2022-10-27 | 上海跃赛生物科技有限公司 | 一种质控和富集人多巴胺能神经前体细胞的方法 |
| CN120754249A (zh) * | 2021-09-30 | 2025-10-10 | 上海鲸奇生物科技有限公司 | 直接转分化治疗神经系统疾病 |
| KR102712694B1 (ko) * | 2021-10-20 | 2024-10-02 | 서울시립대학교 산학협력단 | 자가조립된 rna 구조체를 포함하는 직접교차분화 유도용 조성물 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9057053B2 (en) | 2010-01-19 | 2015-06-16 | The Board Of Trustees Of The Leland Stanford Junior University | Direct conversion of cells to cells of other lineages |
| US9206426B2 (en) * | 2010-03-05 | 2015-12-08 | The Trustees Of Columbia University In The City Of New York | Inhibitory RNAs to RNA binding proteins hnRNPA1, hnRNPA2 and PTB and uses thereof |
| US20140051085A1 (en) | 2011-03-01 | 2014-02-20 | The Scripps Research Institute | Direct reprogramming of human fibroblasts to functional neurons under defined conditions |
| US10561742B2 (en) * | 2012-07-19 | 2020-02-18 | The Penn State Research Foundation | Methods and compositions for treatment of disease or injury of the nervous system |
| WO2014071157A1 (en) * | 2012-11-01 | 2014-05-08 | The Regents Of The University Of California | Methods for engineering non-neuronal cells into neurons and using newly engineered neurons to treat neurodegenerative diseases |
| US9730975B2 (en) * | 2014-11-25 | 2017-08-15 | The Penn State Research Foundation | Chemical reprogramming of human glial cells into neurons for brain and spinal cord repair |
| WO2017003466A1 (en) * | 2015-06-30 | 2017-01-05 | University Of South Florida | Conversion of non-neuronal cells into neurons |
| US20180318260A1 (en) * | 2015-11-04 | 2018-11-08 | The Scripps Research Institute | Compositions and methods for treating cystic fibrosis |
| CN105950557B (zh) * | 2016-04-22 | 2019-10-25 | 中国科学院生物物理研究所 | 一种控制人神经细胞重编程的信号通路及其应用 |
-
2019
- 2019-04-11 CA CA3096691A patent/CA3096691A1/en active Pending
- 2019-04-11 EP EP19785091.0A patent/EP3773749A4/en not_active Withdrawn
- 2019-04-11 JP JP2020554154A patent/JP2021520200A/ja active Pending
- 2019-04-11 CN CN201980039567.0A patent/CN112312928A/zh active Pending
- 2019-04-11 GB GBGB2017810.9A patent/GB202017810D0/en not_active Ceased
- 2019-04-11 GB GB2017804.2A patent/GB2588307B/en not_active Expired - Fee Related
- 2019-04-11 KR KR1020207032064A patent/KR20200142537A/ko not_active Ceased
- 2019-04-11 WO PCT/US2019/027027 patent/WO2019200129A1/en not_active Ceased
- 2019-04-11 AU AU2019252534A patent/AU2019252534A1/en not_active Abandoned
-
2020
- 2020-08-06 US US16/986,798 patent/US11702656B2/en active Active
-
2023
- 2023-05-25 US US18/323,956 patent/US20240218362A1/en active Pending
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