JPWO2022023450A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2022023450A5 JPWO2022023450A5 JP2023505376A JP2023505376A JPWO2022023450A5 JP WO2022023450 A5 JPWO2022023450 A5 JP WO2022023450A5 JP 2023505376 A JP2023505376 A JP 2023505376A JP 2023505376 A JP2023505376 A JP 2023505376A JP WO2022023450 A5 JPWO2022023450 A5 JP WO2022023450A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- compound
- carboxylic acid
- phanephos
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063057531P | 2020-07-28 | 2020-07-28 | |
| US63/057,531 | 2020-07-28 | ||
| PCT/EP2021/071219 WO2022023450A1 (en) | 2020-07-28 | 2021-07-28 | Chiral synthesis of fused bicyclic raf inhibitors |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023535595A JP2023535595A (ja) | 2023-08-18 |
| JP2023535595A5 JP2023535595A5 (https=) | 2024-08-06 |
| JPWO2022023450A5 true JPWO2022023450A5 (https=) | 2024-08-06 |
| JP7832924B2 JP7832924B2 (ja) | 2026-03-18 |
Family
ID=77564067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023505376A Active JP7832924B2 (ja) | 2020-07-28 | 2021-07-28 | 縮合二環式ｒａｆ阻害剤のキラル合成 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20220041595A1 (https=) |
| EP (1) | EP4188923A1 (https=) |
| JP (1) | JP7832924B2 (https=) |
| KR (1) | KR20230058630A (https=) |
| CN (1) | CN116348465B (https=) |
| AU (1) | AU2021318923A1 (https=) |
| CA (1) | CA3187393A1 (https=) |
| IL (1) | IL300110A (https=) |
| MX (1) | MX2023001274A (https=) |
| WO (1) | WO2022023450A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023535790A (ja) | 2020-07-28 | 2023-08-21 | ジャズ ファーマシューティカルズ アイルランド リミテッド | 縮合二環式ｒａｆ阻害薬及びその使用方法 |
| CN114921508B (zh) * | 2022-07-22 | 2022-10-11 | 常熟药明康德新药开发有限公司 | (r)-6-羟基色满-3-羧酸的生物催化制备方法 |
| JP2025539426A (ja) | 2022-11-29 | 2025-12-05 | ジャズ ファーマシューティカルズ アイルランド リミテッド | （ｓ）－５－（（３－（４－（４－フルオロフェニル）－１ｈ－イミダゾール－２－イル）クロマン－６－イル）オキシ）－３，４－ジヒドロ－１，８－ナフチリジン－２（１ｈ）－オンの結晶形態 |
| EP4665725A2 (en) * | 2023-02-17 | 2025-12-24 | Jazz Pharmaceuticals Ireland Limited | Methods of treating solid tumors with mitogen activated protein kinase (mapk) pathway alterations |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3932657A (en) | 1973-11-12 | 1976-01-13 | The United States Of America As Represented By The United States Energy Research And Development Administration | Liposome encapsulation of chelating agents |
| GB1575343A (en) | 1977-05-10 | 1980-09-17 | Ici Ltd | Method for preparing liposome compositions containing biologically active compounds |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4452747A (en) | 1982-03-22 | 1984-06-05 | Klaus Gersonde | Method of and arrangement for producing lipid vesicles |
| JPS6058915A (ja) | 1983-09-12 | 1985-04-05 | Fujisawa Pharmaceut Co Ltd | 薬物含有脂質小胞体製剤 |
| US4744989A (en) | 1984-02-08 | 1988-05-17 | E. R. Squibb & Sons, Inc. | Method of preparing liposomes and products produced thereby |
| US5736155A (en) | 1984-08-08 | 1998-04-07 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US5077056A (en) | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US4830858A (en) | 1985-02-11 | 1989-05-16 | E. R. Squibb & Sons, Inc. | Spray-drying method for preparing liposomes and products produced thereby |
| US4921757A (en) | 1985-04-26 | 1990-05-01 | Massachusetts Institute Of Technology | System for delayed and pulsed release of biologically active substances |
| JPH0617309B2 (ja) | 1985-11-29 | 1994-03-09 | 株式会社ビタミン研究所 | アドリアマイシン包埋リポソ−ム製剤 |
| DE3611229A1 (de) | 1986-04-04 | 1987-10-08 | Basf Ag | Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinoidpraeparaten |
| MX9203808A (es) | 1987-03-05 | 1992-07-01 | Liposome Co Inc | Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos. |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| US5766635A (en) | 1991-06-28 | 1998-06-16 | Rhone-Poulenc Rorer S.A. | Process for preparing nanoparticles |
| DE69529054T2 (de) | 1994-02-28 | 2003-08-21 | Nanopharm Ag | System zur gezielten wirkstoffzufuhr, verfahren zu seiner herstellung und verwendung |
| US5800833A (en) | 1995-02-27 | 1998-09-01 | University Of British Columbia | Method for loading lipid vesicles |
| EP0825852B1 (en) | 1995-04-18 | 2004-07-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposome drug-loading method and composition |
| US8137699B2 (en) | 2002-03-29 | 2012-03-20 | Trustees Of Princeton University | Process and apparatuses for preparing nanoparticle compositions with amphiphilic copolymers and their use |
| US7850990B2 (en) | 2001-10-03 | 2010-12-14 | Celator Pharmaceuticals, Inc. | Compositions for delivery of drug combinations |
| CA2462376C (en) | 2001-10-03 | 2010-12-14 | Celator Technologies Inc. | Liposome loading with metal ions |
| CA2467064C (en) | 2001-11-13 | 2011-02-08 | Murray Webb | Lipid carrier compositions with enhanced blood stability |
| LT2653465T (lt) * | 2004-03-15 | 2016-09-12 | Janssen Pharmaceutica Nv | Opioidinio receptoriaus moduliatoriai |
| JP5001263B2 (ja) * | 2005-05-20 | 2012-08-15 | ドクター レディズ ラボラトリーズ （イーユー） リミテッド | ジフェニルアラニン誘導体作製のための不斉水素化 |
| GB201416186D0 (en) * | 2014-09-12 | 2014-10-29 | Redx Pharma Ltd | Compounds |
| CN109503659B (zh) * | 2019-01-03 | 2021-06-18 | 凯特立斯（深圳）科技有限公司 | 氧杂螺环双膦配体及其在α,β-不饱和羧酸不对称氢化中的应用 |
-
2021
- 2021-07-28 WO PCT/EP2021/071219 patent/WO2022023450A1/en not_active Ceased
- 2021-07-28 EP EP21763010.2A patent/EP4188923A1/en active Pending
- 2021-07-28 AU AU2021318923A patent/AU2021318923A1/en active Pending
- 2021-07-28 KR KR1020237006990A patent/KR20230058630A/ko active Pending
- 2021-07-28 CA CA3187393A patent/CA3187393A1/en active Pending
- 2021-07-28 CN CN202180064843.6A patent/CN116348465B/zh active Active
- 2021-07-28 JP JP2023505376A patent/JP7832924B2/ja active Active
- 2021-07-28 MX MX2023001274A patent/MX2023001274A/es unknown
- 2021-07-28 IL IL300110A patent/IL300110A/en unknown
- 2021-07-28 US US17/387,041 patent/US20220041595A1/en not_active Abandoned
-
2025
- 2025-07-14 US US19/268,592 patent/US20260049079A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112142735B (zh) | 一类稠和氰基吡啶类化合物、制备方法和用途 | |
| CN112300194B (zh) | 一类稠环吡啶酮类化合物、制备方法和用途 | |
| CN113754683A (zh) | 同位素取代的螺芳环化合物及其应用 | |
| AU2021400942A1 (en) | PRMT5 inhibitors | |
| AU2022217791A9 (en) | Tricyclic-amido-bicyclic prmt5 inhibitors | |
| CN112300160A (zh) | 一种螺芳环化合物、其制备及应用 | |
| Mu et al. | Access to phosphine-containing quinazolinones enabled by photo-induced radical phosphorylation/cyclization of unactivated alkenes | |
| CN114195804A (zh) | 一类哌啶稠环类化合物、制备方法和用途 | |
| JP2018532737A5 (https=) | ||
| JP2019537610A (ja) | Ｆｇｆｒ４阻害剤、その製造方法と薬学的な応用 | |
| JP2021529182A (ja) | Ｔｒｋ阻害剤としてのヘテロ環化合物 | |
| KR102421137B1 (ko) | 아미노치환 질소함유 축합고리 화합물 및 그의 제조방법과 용도 | |
| JP7832924B2 (ja) | 縮合二環式ｒａｆ阻害剤のキラル合成 | |
| CN116157128A (zh) | 吡唑并哒嗪酮化合物、其药物组合物及其用途 | |
| TWI913048B (zh) | 嘧啶並噻喃酮kras突變蛋白抑制劑的製備及其應用 | |
| CN110950876B (zh) | 一类呋喃并内酰胺类化合物、制备方法和用途 | |
| JPWO2022023450A5 (https=) | ||
| CN112778294A (zh) | 5-氨基异噁唑衍生物及其在制备多激酶抑制剂中的应用 | |
| JP7152794B2 (ja) | Ｆｇｆｒ阻害剤、その製造方法および応用 | |
| CN113906021A (zh) | 手性吲哚化合物及其用途 | |
| CN106317055A (zh) | 一类具有激酶抑制活性的化合物、制备方法和用途 | |
| CN116903609A (zh) | 一种化合物、包含其的药物组合物及其应用 | |
| CN111039941B (zh) | 一种含氮杂环化合物、其制备方法及应用 | |
| JP2026509288A (ja) | 芳香族アミド誘導体、その製造方法、およびその使用 | |
| JP2025541854A (ja) | カンプトテシン誘導体、医薬組成物及びその製造方法と使用 |