JPWO2022015988A5 - - Google Patents
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- Publication number
- JPWO2022015988A5 JPWO2022015988A5 JP2023502593A JP2023502593A JPWO2022015988A5 JP WO2022015988 A5 JPWO2022015988 A5 JP WO2022015988A5 JP 2023502593 A JP2023502593 A JP 2023502593A JP 2023502593 A JP2023502593 A JP 2023502593A JP WO2022015988 A5 JPWO2022015988 A5 JP WO2022015988A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrimido
- pyridazin
- oxy
- dihydrobenzo
- dioxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063052085P | 2020-07-15 | 2020-07-15 | |
| US63/052,085 | 2020-07-15 | ||
| PCT/US2021/041836 WO2022015988A1 (en) | 2020-07-15 | 2021-07-15 | 7-(piperidin-1-yl)-4h-pyrimido[1,2-b]pyridazin-4-one derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023534803A JP2023534803A (ja) | 2023-08-14 |
| JP2023534803A5 JP2023534803A5 (https=) | 2024-07-17 |
| JPWO2022015988A5 true JPWO2022015988A5 (https=) | 2024-07-17 |
| JP7766946B2 JP7766946B2 (ja) | 2025-11-11 |
Family
ID=77051222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023502593A Active JP7766946B2 (ja) | 2020-07-15 | 2021-07-15 | ムスカリン性アセチルコリン受容体ｍ４の陽性アロステリック調節因子としての７－（ピペリジン－１－イル）－４ｈ－ピリミド［１，２－ｂ］ピリダジン－４－オン誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US12331055B2 (https=) |
| EP (1) | EP4182316A1 (https=) |
| JP (1) | JP7766946B2 (https=) |
| KR (1) | KR20230039701A (https=) |
| CN (1) | CN116209446B (https=) |
| AU (1) | AU2021308625A1 (https=) |
| BR (1) | BR112023000760A2 (https=) |
| CA (1) | CA3189217A1 (https=) |
| IL (1) | IL299758B2 (https=) |
| MX (1) | MX2023000580A (https=) |
| WO (1) | WO2022015988A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4182316A1 (en) * | 2020-07-15 | 2023-05-24 | Vanderbilt University | 7-(piperidin-1-yl)-4h-pyrimido[1,2-b]pyridazin-4-one derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
| WO2023114224A1 (en) | 2021-12-13 | 2023-06-22 | Sage Therapeutics, Inc. | Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators |
| WO2023141511A1 (en) * | 2022-01-19 | 2023-07-27 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
| EP4611127A4 (en) | 2022-12-02 | 2025-12-31 | Lg Energy Solution Ltd | BATTERY BLOCK AND ITS MANUFACTURING PROCESS |
| AU2024259614A1 (en) | 2023-04-18 | 2025-10-02 | Vanderbilt University | Thiazolopyridine derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
| KR20260035912A (ko) * | 2023-06-22 | 2026-03-13 | 반더빌트유니버시티 | 무스카린성 아세틸콜린 수용체 m4의 양성 조절제 |
| WO2025122733A1 (en) | 2023-12-07 | 2025-06-12 | Neumora Therapeutics, Inc. | Crystalline forms of 7-((2r,4s)-4-((2,3-dihydrobenzo[b][1,4] dioxin-6-yl-2,2,3,3-d4)oxy)-2-methylpiperidin-1-yl)-8-methyl-4h-pyrimido[1,2-b]pyridazin -4-one |
| WO2026047494A1 (en) | 2024-08-26 | 2026-03-05 | Suven Life Sciences Limited | 2-AMINO-PYRIMIDINE DERIVATIVES AS MUSCARINIC M4 RECEPTOR POSITIVE ALLOSTERIC MODULATORS (M4 PAMs) |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9156833B2 (en) * | 2012-07-16 | 2015-10-13 | Barry University, Inc. | Bitopic muscarinic agonists and antagonists and methods of synthesis and use thereof |
| WO2014122474A1 (en) | 2013-02-07 | 2014-08-14 | Takeda Pharmaceutical Company Limited | Piperidin-1 -yl and azepin-1 -yl carboxylates as muscarinic m4 receptor agonists |
| US10329289B2 (en) * | 2015-12-23 | 2019-06-25 | Merck Sharp & Dohme Corp. | 6,7-dihydro-5H-pyrrolo[3,4-B]pyridin-5-one allosteric modulators of the M4 muscarinic acetylcholine receptor |
| WO2017107087A1 (en) * | 2015-12-23 | 2017-06-29 | Merck Sharp & Dohme Corp. | 6, 7-dihydro-5h-pyrrolo [3, 4-b] pyridin-5-oneallosteric modulators of the m4 muscarinic acetylcholine receptor |
| US10961253B2 (en) * | 2016-11-07 | 2021-03-30 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 |
| WO2018112843A1 (en) * | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor |
| WO2018112842A1 (en) * | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor |
| WO2018112840A1 (en) * | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | 6, 5-fused heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor |
| WO2019000238A1 (en) * | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | 5- (PYRIDIN-3-YL) OXAZOLE ALLOSTERIC MODULATORS OF M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
| EP4182316A1 (en) * | 2020-07-15 | 2023-05-24 | Vanderbilt University | 7-(piperidin-1-yl)-4h-pyrimido[1,2-b]pyridazin-4-one derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
-
2021
- 2021-07-15 EP EP21746304.1A patent/EP4182316A1/en active Pending
- 2021-07-15 CN CN202180061237.9A patent/CN116209446B/zh active Active
- 2021-07-15 WO PCT/US2021/041836 patent/WO2022015988A1/en not_active Ceased
- 2021-07-15 KR KR1020237005195A patent/KR20230039701A/ko not_active Withdrawn
- 2021-07-15 JP JP2023502593A patent/JP7766946B2/ja active Active
- 2021-07-15 BR BR112023000760A patent/BR112023000760A2/pt unknown
- 2021-07-15 US US18/005,301 patent/US12331055B2/en active Active
- 2021-07-15 MX MX2023000580A patent/MX2023000580A/es unknown
- 2021-07-15 CA CA3189217A patent/CA3189217A1/en active Pending
- 2021-07-15 IL IL299758A patent/IL299758B2/en unknown
- 2021-07-15 AU AU2021308625A patent/AU2021308625A1/en active Pending
-
2023
- 2023-03-22 US US18/187,868 patent/US11884676B2/en active Active
-
2025
- 2025-05-09 US US19/203,407 patent/US20250263417A1/en active Pending
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