CN116209446B - 作为毒蕈碱性乙酰胆碱受体m4的正向别构调节剂的7-(哌啶-1-基)-4h-嘧啶并[1,2-b]哒嗪-4-酮衍生物 - Google Patents

作为毒蕈碱性乙酰胆碱受体m4的正向别构调节剂的7-(哌啶-1-基)-4h-嘧啶并[1,2-b]哒嗪-4-酮衍生物 Download PDF

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CN116209446B
CN116209446B CN202180061237.9A CN202180061237A CN116209446B CN 116209446 B CN116209446 B CN 116209446B CN 202180061237 A CN202180061237 A CN 202180061237A CN 116209446 B CN116209446 B CN 116209446B
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pyridazin
pyrimido
oxy
dihydrobenzo
dioxin
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CN116209446A (zh
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C·W·林斯利
P·J·康恩
D·W·恩格斯
A·R·格里格罗
K·J·坦普尔
M·F·隆
A·E·林奎特
L·A·贝克
T·詹森
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Vanderbilt University
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Vanderbilt University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
CN202180061237.9A 2020-07-15 2021-07-15 作为毒蕈碱性乙酰胆碱受体m4的正向别构调节剂的7-(哌啶-1-基)-4h-嘧啶并[1,2-b]哒嗪-4-酮衍生物 Active CN116209446B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063052085P 2020-07-15 2020-07-15
US63/052,085 2020-07-15
PCT/US2021/041836 WO2022015988A1 (en) 2020-07-15 2021-07-15 7-(piperidin-1-yl)-4h-pyrimido[1,2-b]pyridazin-4-one derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4

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CN116209446A CN116209446A (zh) 2023-06-02
CN116209446B true CN116209446B (zh) 2025-05-13

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US (3) US12331055B2 (https=)
EP (1) EP4182316A1 (https=)
JP (1) JP7766946B2 (https=)
KR (1) KR20230039701A (https=)
CN (1) CN116209446B (https=)
AU (1) AU2021308625A1 (https=)
BR (1) BR112023000760A2 (https=)
CA (1) CA3189217A1 (https=)
IL (1) IL299758B2 (https=)
MX (1) MX2023000580A (https=)
WO (1) WO2022015988A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4182316A1 (en) * 2020-07-15 2023-05-24 Vanderbilt University 7-(piperidin-1-yl)-4h-pyrimido[1,2-b]pyridazin-4-one derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4
WO2023114224A1 (en) 2021-12-13 2023-06-22 Sage Therapeutics, Inc. Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators
WO2023141511A1 (en) * 2022-01-19 2023-07-27 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor m4
EP4611127A4 (en) 2022-12-02 2025-12-31 Lg Energy Solution Ltd BATTERY BLOCK AND ITS MANUFACTURING PROCESS
AU2024259614A1 (en) 2023-04-18 2025-10-02 Vanderbilt University Thiazolopyridine derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4
KR20260035912A (ko) * 2023-06-22 2026-03-13 반더빌트유니버시티 무스카린성 아세틸콜린 수용체 m4의 양성 조절제
WO2025122733A1 (en) 2023-12-07 2025-06-12 Neumora Therapeutics, Inc. Crystalline forms of 7-((2r,4s)-4-((2,3-dihydrobenzo[b][1,4] dioxin-6-yl-2,2,3,3-d4)oxy)-2-methylpiperidin-1-yl)-8-methyl-4h-pyrimido[1,2-b]pyridazin -4-one
WO2026047494A1 (en) 2024-08-26 2026-03-05 Suven Life Sciences Limited 2-AMINO-PYRIMIDINE DERIVATIVES AS MUSCARINIC M4 RECEPTOR POSITIVE ALLOSTERIC MODULATORS (M4 PAMs)

Citations (2)

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CN105189482A (zh) * 2013-02-07 2015-12-23 武田药品工业株式会社 作为毒蕈碱m4受体激动剂的哌啶-1-基羧酸酯和氮杂卓-1-基羧酸酯
CN109862893A (zh) * 2016-11-07 2019-06-07 范德比尔特大学 毒蕈碱型乙酰胆碱受体m4的正向别构调节剂

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US9156833B2 (en) * 2012-07-16 2015-10-13 Barry University, Inc. Bitopic muscarinic agonists and antagonists and methods of synthesis and use thereof
US10329289B2 (en) * 2015-12-23 2019-06-25 Merck Sharp & Dohme Corp. 6,7-dihydro-5H-pyrrolo[3,4-B]pyridin-5-one allosteric modulators of the M4 muscarinic acetylcholine receptor
WO2017107087A1 (en) * 2015-12-23 2017-06-29 Merck Sharp & Dohme Corp. 6, 7-dihydro-5h-pyrrolo [3, 4-b] pyridin-5-oneallosteric modulators of the m4 muscarinic acetylcholine receptor
WO2018112843A1 (en) * 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor
WO2018112842A1 (en) * 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor
WO2018112840A1 (en) * 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. 6, 5-fused heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor
WO2019000238A1 (en) * 2017-06-27 2019-01-03 Merck Sharp & Dohme Corp. 5- (PYRIDIN-3-YL) OXAZOLE ALLOSTERIC MODULATORS OF M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
EP4182316A1 (en) * 2020-07-15 2023-05-24 Vanderbilt University 7-(piperidin-1-yl)-4h-pyrimido[1,2-b]pyridazin-4-one derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105189482A (zh) * 2013-02-07 2015-12-23 武田药品工业株式会社 作为毒蕈碱m4受体激动剂的哌啶-1-基羧酸酯和氮杂卓-1-基羧酸酯
CN109862893A (zh) * 2016-11-07 2019-06-07 范德比尔特大学 毒蕈碱型乙酰胆碱受体m4的正向别构调节剂

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US11884676B2 (en) 2024-01-30
KR20230039701A (ko) 2023-03-21
US20230286991A1 (en) 2023-09-14
EP4182316A1 (en) 2023-05-24
JP2023534803A (ja) 2023-08-14
IL299758A (en) 2023-03-01
IL299758B2 (en) 2026-04-01
BR112023000760A2 (pt) 2023-02-07
US12331055B2 (en) 2025-06-17
US20250263417A1 (en) 2025-08-21
CN116209446A (zh) 2023-06-02
US20230257381A1 (en) 2023-08-17
IL299758B1 (en) 2025-12-01
WO2022015988A1 (en) 2022-01-20
MX2023000580A (es) 2023-02-13
JP7766946B2 (ja) 2025-11-11
AU2021308625A1 (en) 2023-02-09
CA3189217A1 (en) 2022-01-20

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