CA3189217A1 - 7-(piperidin-1-yl)-4h-pyrimido[1,2-b]pyridazin-4-one derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4 - Google Patents

7-(piperidin-1-yl)-4h-pyrimido[1,2-b]pyridazin-4-one derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4

Info

Publication number
CA3189217A1
CA3189217A1 CA3189217A CA3189217A CA3189217A1 CA 3189217 A1 CA3189217 A1 CA 3189217A1 CA 3189217 A CA3189217 A CA 3189217A CA 3189217 A CA3189217 A CA 3189217A CA 3189217 A1 CA3189217 A1 CA 3189217A1
Authority
CA
Canada
Prior art keywords
piperidin
oxy
dihydrobenzo
dioxin
pyridazin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3189217A
Other languages
English (en)
French (fr)
Inventor
Craig W. Lindsley
P. Jeffrey Conn
Darren W. Engers
Alison R. Gregro
Kayla J. TEMPLE
Madeline F. Long
Anna E. RINGUETTE
Logan A. BAKER
Thomas Jensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vanderbilt University
Original Assignee
Vanderbilt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vanderbilt University filed Critical Vanderbilt University
Publication of CA3189217A1 publication Critical patent/CA3189217A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
CA3189217A 2020-07-15 2021-07-15 7-(piperidin-1-yl)-4h-pyrimido[1,2-b]pyridazin-4-one derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4 Pending CA3189217A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063052085P 2020-07-15 2020-07-15
US63/052,085 2020-07-15
PCT/US2021/041836 WO2022015988A1 (en) 2020-07-15 2021-07-15 7-(piperidin-1-yl)-4h-pyrimido[1,2-b]pyridazin-4-one derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4

Publications (1)

Publication Number Publication Date
CA3189217A1 true CA3189217A1 (en) 2022-01-20

Family

ID=77051222

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3189217A Pending CA3189217A1 (en) 2020-07-15 2021-07-15 7-(piperidin-1-yl)-4h-pyrimido[1,2-b]pyridazin-4-one derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4

Country Status (11)

Country Link
US (3) US12331055B2 (https=)
EP (1) EP4182316A1 (https=)
JP (1) JP7766946B2 (https=)
KR (1) KR20230039701A (https=)
CN (1) CN116209446B (https=)
AU (1) AU2021308625A1 (https=)
BR (1) BR112023000760A2 (https=)
CA (1) CA3189217A1 (https=)
IL (1) IL299758B2 (https=)
MX (1) MX2023000580A (https=)
WO (1) WO2022015988A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4182316A1 (en) * 2020-07-15 2023-05-24 Vanderbilt University 7-(piperidin-1-yl)-4h-pyrimido[1,2-b]pyridazin-4-one derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4
WO2023114224A1 (en) 2021-12-13 2023-06-22 Sage Therapeutics, Inc. Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators
WO2023141511A1 (en) * 2022-01-19 2023-07-27 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor m4
EP4611127A4 (en) 2022-12-02 2025-12-31 Lg Energy Solution Ltd BATTERY BLOCK AND ITS MANUFACTURING PROCESS
AU2024259614A1 (en) 2023-04-18 2025-10-02 Vanderbilt University Thiazolopyridine derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4
KR20260035912A (ko) * 2023-06-22 2026-03-13 반더빌트유니버시티 무스카린성 아세틸콜린 수용체 m4의 양성 조절제
WO2025122733A1 (en) 2023-12-07 2025-06-12 Neumora Therapeutics, Inc. Crystalline forms of 7-((2r,4s)-4-((2,3-dihydrobenzo[b][1,4] dioxin-6-yl-2,2,3,3-d4)oxy)-2-methylpiperidin-1-yl)-8-methyl-4h-pyrimido[1,2-b]pyridazin -4-one
WO2026047494A1 (en) 2024-08-26 2026-03-05 Suven Life Sciences Limited 2-AMINO-PYRIMIDINE DERIVATIVES AS MUSCARINIC M4 RECEPTOR POSITIVE ALLOSTERIC MODULATORS (M4 PAMs)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9156833B2 (en) * 2012-07-16 2015-10-13 Barry University, Inc. Bitopic muscarinic agonists and antagonists and methods of synthesis and use thereof
WO2014122474A1 (en) 2013-02-07 2014-08-14 Takeda Pharmaceutical Company Limited Piperidin-1 -yl and azepin-1 -yl carboxylates as muscarinic m4 receptor agonists
US10329289B2 (en) * 2015-12-23 2019-06-25 Merck Sharp & Dohme Corp. 6,7-dihydro-5H-pyrrolo[3,4-B]pyridin-5-one allosteric modulators of the M4 muscarinic acetylcholine receptor
WO2017107087A1 (en) * 2015-12-23 2017-06-29 Merck Sharp & Dohme Corp. 6, 7-dihydro-5h-pyrrolo [3, 4-b] pyridin-5-oneallosteric modulators of the m4 muscarinic acetylcholine receptor
US10961253B2 (en) * 2016-11-07 2021-03-30 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor M4
WO2018112843A1 (en) * 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor
WO2018112842A1 (en) * 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor
WO2018112840A1 (en) * 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. 6, 5-fused heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor
WO2019000238A1 (en) * 2017-06-27 2019-01-03 Merck Sharp & Dohme Corp. 5- (PYRIDIN-3-YL) OXAZOLE ALLOSTERIC MODULATORS OF M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
EP4182316A1 (en) * 2020-07-15 2023-05-24 Vanderbilt University 7-(piperidin-1-yl)-4h-pyrimido[1,2-b]pyridazin-4-one derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4

Also Published As

Publication number Publication date
US11884676B2 (en) 2024-01-30
KR20230039701A (ko) 2023-03-21
US20230286991A1 (en) 2023-09-14
EP4182316A1 (en) 2023-05-24
JP2023534803A (ja) 2023-08-14
IL299758A (en) 2023-03-01
IL299758B2 (en) 2026-04-01
BR112023000760A2 (pt) 2023-02-07
US12331055B2 (en) 2025-06-17
US20250263417A1 (en) 2025-08-21
CN116209446A (zh) 2023-06-02
US20230257381A1 (en) 2023-08-17
IL299758B1 (en) 2025-12-01
WO2022015988A1 (en) 2022-01-20
MX2023000580A (es) 2023-02-13
JP7766946B2 (ja) 2025-11-11
AU2021308625A1 (en) 2023-02-09
CN116209446B (zh) 2025-05-13

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