JPWO2022015736A5 - - Google Patents
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- Publication number
- JPWO2022015736A5 JPWO2022015736A5 JP2023501802A JP2023501802A JPWO2022015736A5 JP WO2022015736 A5 JPWO2022015736 A5 JP WO2022015736A5 JP 2023501802 A JP2023501802 A JP 2023501802A JP 2023501802 A JP2023501802 A JP 2023501802A JP WO2022015736 A5 JPWO2022015736 A5 JP WO2022015736A5
- Authority
- JP
- Japan
- Prior art keywords
- raf
- antibody
- inhibitor
- mek
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 73
- 102100033479 RAF proto-oncogene serine/threonine-protein kinase Human genes 0.000 claims description 38
- 229940125436 dual inhibitor Drugs 0.000 claims description 31
- 229940124783 FAK inhibitor Drugs 0.000 claims description 18
- 206010028980 Neoplasm Diseases 0.000 claims description 18
- 201000011510 cancer Diseases 0.000 claims description 18
- 150000003839 salts Chemical class 0.000 claims description 12
- 230000035772 mutation Effects 0.000 claims description 6
- 229940124647 MEK inhibitor Drugs 0.000 claims description 5
- 230000009977 dual effect Effects 0.000 claims description 5
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims description 5
- 208000030808 Clear cell renal carcinoma Diseases 0.000 claims description 4
- 206010073251 clear cell renal cell carcinoma Diseases 0.000 claims description 4
- 201000006585 gastric adenocarcinoma Diseases 0.000 claims description 4
- 229940121514 toripalimab Drugs 0.000 claims description 4
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 claims description 2
- 206010052747 Adenocarcinoma pancreas Diseases 0.000 claims description 2
- 201000000274 Carcinosarcoma Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 2
- 208000005431 Endometrioid Carcinoma Diseases 0.000 claims description 2
- 102100029974 GTPase HRas Human genes 0.000 claims description 2
- 102100030708 GTPase KRas Human genes 0.000 claims description 2
- 102100039788 GTPase NRas Human genes 0.000 claims description 2
- 101000584633 Homo sapiens GTPase HRas Proteins 0.000 claims description 2
- 101000584612 Homo sapiens GTPase KRas Proteins 0.000 claims description 2
- 101000744505 Homo sapiens GTPase NRas Proteins 0.000 claims description 2
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010035603 Pleural mesothelioma Diseases 0.000 claims description 2
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims description 2
- 208000034254 Squamous cell carcinoma of the cervix uteri Diseases 0.000 claims description 2
- 201000005969 Uveal melanoma Diseases 0.000 claims description 2
- 229960003852 atezolizumab Drugs 0.000 claims description 2
- 229950002916 avelumab Drugs 0.000 claims description 2
- 229940121530 balstilimab Drugs 0.000 claims description 2
- 230000002051 biphasic effect Effects 0.000 claims description 2
- 206010005084 bladder transitional cell carcinoma Diseases 0.000 claims description 2
- 201000001528 bladder urothelial carcinoma Diseases 0.000 claims description 2
- 210000000481 breast Anatomy 0.000 claims description 2
- 229950007712 camrelizumab Drugs 0.000 claims description 2
- 208000011892 carcinosarcoma of the corpus uteri Diseases 0.000 claims description 2
- 229940121420 cemiplimab Drugs 0.000 claims description 2
- 201000006612 cervical squamous cell carcinoma Diseases 0.000 claims description 2
- 208000030381 cutaneous melanoma Diseases 0.000 claims description 2
- 229950008937 defactinib Drugs 0.000 claims description 2
- 229950009791 durvalumab Drugs 0.000 claims description 2
- 201000003683 endocervical adenocarcinoma Diseases 0.000 claims description 2
- 201000003914 endometrial carcinoma Diseases 0.000 claims description 2
- 208000028730 endometrioid adenocarcinoma Diseases 0.000 claims description 2
- 229940066764 geptanolimab Drugs 0.000 claims description 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 2
- 206010073096 invasive lobular breast carcinoma Diseases 0.000 claims description 2
- 201000005249 lung adenocarcinoma Diseases 0.000 claims description 2
- FWLMVFUGMHIOAA-UHFFFAOYSA-N n-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide Chemical group C1=CC(C(=O)NC)=CC=C1NC1=NC=C(C(F)(F)F)C(NCC=2C(=NC=CN=2)N(C)S(C)(=O)=O)=N1 FWLMVFUGMHIOAA-UHFFFAOYSA-N 0.000 claims description 2
- 229960003301 nivolumab Drugs 0.000 claims description 2
- 201000002094 pancreatic adenocarcinoma Diseases 0.000 claims description 2
- 229960002621 pembrolizumab Drugs 0.000 claims description 2
- 229950010773 pidilizumab Drugs 0.000 claims description 2
- 102000016914 ras Proteins Human genes 0.000 claims description 2
- 229940018007 retifanlimab Drugs 0.000 claims description 2
- 229940018073 sasanlimab Drugs 0.000 claims description 2
- 229940121497 sintilimab Drugs 0.000 claims description 2
- 201000003708 skin melanoma Diseases 0.000 claims description 2
- 229940125310 socazolimab Drugs 0.000 claims description 2
- 229950007213 spartalizumab Drugs 0.000 claims description 2
- 229940062046 sugemalimab Drugs 0.000 claims description 2
- 229940061918 tebotelimab Drugs 0.000 claims description 2
- 201000005290 uterine carcinosarcoma Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 1
- 229940052007 zimberelimab Drugs 0.000 claims 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063051320P | 2020-07-13 | 2020-07-13 | |
| US63/051,320 | 2020-07-13 | ||
| PCT/US2021/041439 WO2022015736A1 (en) | 2020-07-13 | 2021-07-13 | Combination therapy for treating abnormal cell growth |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023534009A JP2023534009A (ja) | 2023-08-07 |
| JPWO2022015736A5 true JPWO2022015736A5 (enExample) | 2024-07-23 |
Family
ID=79554253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023501802A Pending JP2023534009A (ja) | 2020-07-13 | 2021-07-13 | 異常な細胞成長を処置するための併用療法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230330088A1 (enExample) |
| EP (1) | EP4178573A4 (enExample) |
| JP (1) | JP2023534009A (enExample) |
| KR (1) | KR20230039684A (enExample) |
| CN (1) | CN116056699A (enExample) |
| AU (1) | AU2021307410A1 (enExample) |
| BR (1) | BR112023000675A2 (enExample) |
| CA (1) | CA3189383A1 (enExample) |
| IL (1) | IL299789A (enExample) |
| MX (1) | MX2023000589A (enExample) |
| WO (1) | WO2022015736A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4087840A4 (en) | 2020-01-10 | 2024-01-10 | Immuneering Corporation | MEK INHIBITORS AND THEIR THERAPEUTIC USES |
| CN116120461B (zh) * | 2022-04-29 | 2023-09-29 | 德琪(杭州)生物有限公司 | 新型抗药抗体以及其用途 |
| US11873296B2 (en) | 2022-06-07 | 2024-01-16 | Verastem, Inc. | Solid forms of a dual RAF/MEK inhibitor |
| CN119947725A (zh) * | 2022-09-30 | 2025-05-06 | 应世生物科技(南京)有限公司 | Fak抑制剂及诱导免疫原性细胞死亡的物质的药物组合及用途 |
| WO2024178274A2 (en) * | 2023-02-24 | 2024-08-29 | Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center | Methods of degrading raf(raf) protein in cells using mitogen-activated protein kinase kinase 1/2 (mek1/2) protein degraders |
| AU2024265078A1 (en) | 2023-05-04 | 2025-12-11 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| WO2025034702A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Rmc-6291 for use in the treatment of ras protein-related disease or disorder |
| WO2025080946A2 (en) | 2023-10-12 | 2025-04-17 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025079712A1 (ja) * | 2023-10-12 | 2025-04-17 | 中外製薬株式会社 | ドライバー変異を有するがん患者における分子標的薬併用療法 |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012290121B2 (en) * | 2011-08-01 | 2015-11-26 | Genentech, Inc. | Methods of treating cancer using PD-1 axis binding antagonists and MEK inhibitors |
| WO2015179075A1 (en) * | 2014-05-21 | 2015-11-26 | The Board Of Regents Of The University Of Texas System | Treatment for melanoma |
| AR101210A1 (es) * | 2014-07-15 | 2016-11-30 | Genentech Inc | Métodos de tratamiento de cáncer usando antagonistas de unión al eje pd-1 e inhibidores de mek |
| AU2016286091B2 (en) * | 2015-06-29 | 2021-02-04 | Verastem, Inc. | Therapeutic compositions, combinations, and methods of use |
| CN109663130B (zh) * | 2017-10-13 | 2021-06-29 | 江苏恒瑞医药股份有限公司 | Pd-1抗体和mek抑制剂联合在制备治疗肿瘤的药物中的用途 |
| JP2022547358A (ja) * | 2019-09-13 | 2022-11-14 | ジ インスティテュート オブ キャンサー リサーチ：ロイヤル キャンサー ホスピタル | 治療組成物、組み合わせ、及び使用方法 |
-
2021
- 2021-07-13 WO PCT/US2021/041439 patent/WO2022015736A1/en not_active Ceased
- 2021-07-13 KR KR1020237004543A patent/KR20230039684A/ko active Pending
- 2021-07-13 MX MX2023000589A patent/MX2023000589A/es unknown
- 2021-07-13 BR BR112023000675A patent/BR112023000675A2/pt unknown
- 2021-07-13 US US18/005,012 patent/US20230330088A1/en active Pending
- 2021-07-13 CA CA3189383A patent/CA3189383A1/en active Pending
- 2021-07-13 AU AU2021307410A patent/AU2021307410A1/en active Pending
- 2021-07-13 CN CN202180049487.0A patent/CN116056699A/zh active Pending
- 2021-07-13 EP EP21841921.6A patent/EP4178573A4/en active Pending
- 2021-07-13 IL IL299789A patent/IL299789A/en unknown
- 2021-07-13 JP JP2023501802A patent/JP2023534009A/ja active Pending
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