JPWO2022015110A5 - - Google Patents
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- JPWO2022015110A5 JPWO2022015110A5 JP2023503070A JP2023503070A JPWO2022015110A5 JP WO2022015110 A5 JPWO2022015110 A5 JP WO2022015110A5 JP 2023503070 A JP2023503070 A JP 2023503070A JP 2023503070 A JP2023503070 A JP 2023503070A JP WO2022015110 A5 JPWO2022015110 A5 JP WO2022015110A5
- Authority
- JP
- Japan
- Prior art keywords
- drug
- cancer
- jimt
- tumor
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20200088005 | 2020-07-16 | ||
| KR10-2020-0088005 | 2020-07-16 | ||
| KR1020210060721A KR102349925B1 (ko) | 2020-07-16 | 2021-05-11 | Fl118 약물을 포함하는 화합물 및 이를 이용한 면역접합체 |
| KR10-2021-0060721 | 2021-05-11 | ||
| PCT/KR2021/009204 WO2022015110A1 (ko) | 2020-07-16 | 2021-07-16 | Fl118 약물이 산 민감성 링커에 연결된 접합체 및 이를 이용한 면역접합체 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023534292A JP2023534292A (ja) | 2023-08-08 |
| JP2023534292A5 JP2023534292A5 (https=) | 2023-09-28 |
| JPWO2022015110A5 true JPWO2022015110A5 (https=) | 2023-09-28 |
| JP7660186B2 JP7660186B2 (ja) | 2025-04-10 |
Family
ID=79339522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023503070A Active JP7660186B2 (ja) | 2020-07-16 | 2021-07-16 | Ｆｌ１１８薬物が酸感受性リンカーに結合された複合体及びそれを用いた免疫複合体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230270867A1 (https=) |
| EP (1) | EP4183418A4 (https=) |
| JP (1) | JP7660186B2 (https=) |
| KR (3) | KR102349925B1 (https=) |
| CN (1) | CN116075321A (https=) |
| AU (1) | AU2021308834A1 (https=) |
| CA (1) | CA3189462A1 (https=) |
| WO (1) | WO2022015110A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119546346A (zh) * | 2022-05-04 | 2025-02-28 | 匹诺生物股份有限公司 | 与ddx5蛋白结合的喜树碱类药物与酸敏感性接头连接的缀合物及使用该缀合物的免疫缀合物 |
| JP2025523863A (ja) * | 2022-07-11 | 2025-07-25 | ピノットバイオ インコーポレイテッド | Ｄｄｘ５タンパク質に結合するカンプトセシン誘導体およびそのプロドラッグ |
| KR20240031183A (ko) | 2022-08-30 | 2024-03-07 | 주식회사 피노바이오 | 캄토테신계 약물이, 항원 결합 친화도가 낮은 항체에 링커를 통해 연결된 항체-약물 접합체 |
| KR20250163350A (ko) * | 2023-03-28 | 2025-11-20 | 한서 바이오 엘엘씨 | 리간드-세포 독성 약물 접합체 및 이의 약학적 용도 |
| WO2025170834A1 (en) * | 2024-02-06 | 2025-08-14 | Canget Biotekpharma, Llc | Fl118 complexes for targeting ddx5, ube2t or usp2a |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2632264B1 (en) * | 2010-10-29 | 2019-10-02 | Health Research, Inc. | Novel formulations of water-insoluble chemical compounds and methods of using a formulation of compound fl118 for cancer therapy |
| US10206918B2 (en) * | 2012-12-13 | 2019-02-19 | Immunomedics, Inc. | Efficacy of anti-HLA-DR antiboddy drug conjugate IMMU-140 (hL243-CL2A-SN-38) in HLA-DR positive cancers |
| SI2900277T1 (sl) * | 2012-12-13 | 2022-05-31 | Immunomedics, Inc. | Odmerki imunokonjugatov protiteles in SN-38 za boljšo učinkovitost in zmanjšano toksičnost |
| WO2015012904A2 (en) * | 2012-12-13 | 2015-01-29 | Immunomedics, Inc. | Antibody-sn-38 immunoconjugates with a cl2a linker |
| AU2014293670B2 (en) | 2013-07-23 | 2019-08-01 | Immunomedics, Inc. | Antibody-SN-38 immunoconjugates with a CL2A linker |
| SI3466976T1 (sl) | 2014-01-31 | 2021-12-31 | Daiichi Sankyo Company, Limited | Anti-her2 konjugat protitelesa-zdravila |
| WO2015148415A2 (en) | 2014-03-26 | 2015-10-01 | Canget Biotekpharma, Llc | Use of the fl118 core chemical structure platform to generate fl118 derivatives for treatment of human disease |
| TWI851577B (zh) | 2018-06-07 | 2024-08-11 | 美商思進公司 | 喜樹鹼結合物 |
-
2021
- 2021-05-11 KR KR1020210060721A patent/KR102349925B1/ko active Active
- 2021-07-16 US US18/016,331 patent/US20230270867A1/en active Pending
- 2021-07-16 WO PCT/KR2021/009204 patent/WO2022015110A1/ko not_active Ceased
- 2021-07-16 CA CA3189462A patent/CA3189462A1/en active Pending
- 2021-07-16 CN CN202180062303.4A patent/CN116075321A/zh active Pending
- 2021-07-16 KR KR1020210093769A patent/KR20220009916A/ko not_active Ceased
- 2021-07-16 AU AU2021308834A patent/AU2021308834A1/en not_active Abandoned
- 2021-07-16 JP JP2023503070A patent/JP7660186B2/ja active Active
- 2021-07-16 EP EP21841752.5A patent/EP4183418A4/en active Pending
- 2021-10-15 KR KR1020210137595A patent/KR102857180B1/ko active Active
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