|
US4769330A
(en)
|
1981-12-24 |
1988-09-06 |
Health Research, Incorporated |
Modified vaccinia virus and methods for making and using the same
|
|
US4603112A
(en)
|
1981-12-24 |
1986-07-29 |
Health Research, Incorporated |
Modified vaccinia virus
|
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
GB8508845D0
(en)
|
1985-04-04 |
1985-05-09 |
Hoffmann La Roche |
Vaccinia dna
|
|
US4777127A
(en)
|
1985-09-30 |
1988-10-11 |
Labsystems Oy |
Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus
|
|
GB8702816D0
(en)
|
1987-02-07 |
1987-03-11 |
Al Sumidaie A M K |
Obtaining retrovirus-containing fraction
|
|
WO1989001973A2
(en)
|
1987-09-02 |
1989-03-09 |
Applied Biotechnology, Inc. |
Recombinant pox virus for immunization against tumor-associated antigens
|
|
AP129A
(en)
|
1988-06-03 |
1991-04-17 |
Smithkline Biologicals S A |
Expression of retrovirus gag protein eukaryotic cells
|
|
EP0487587A1
(en)
|
1989-08-18 |
1992-06-03 |
Chiron Corporation |
Recombinant retroviruses delivering vector constructs to target cells
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US6632976B1
(en)
|
1995-08-29 |
2003-10-14 |
Kirin Beer Kabushiki Kaisha |
Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene
|
|
DK0843961T3
(da)
|
1995-08-29 |
2007-05-21 |
Kirin Brewery |
Kimærisk mus og fremgangsmåde til at producere samme
|
|
KR20080059467A
(ko)
|
1996-12-03 |
2008-06-27 |
아브게닉스, 인크. |
복수의 ｖｈ 및 ｖｋ 부위를 함유하는 사람 면역글로불린유전자좌를 갖는 형질전환된 포유류 및 이로부터 생성된항체
|
|
DE60023451T2
(de)
|
1999-02-05 |
2006-07-20 |
Therapeutic Human Polyclonals, Inc., Mountain View |
Aus nicht-menschlichen transgenen tieren gewonnene menschliche polyklonale antikörper
|
|
IL154751A0
(en)
|
2000-08-03 |
2003-10-31 |
|
Humanized antibodies, recombination vectors, transgenic vectors and methods for the preparation of humanized antibodies from transgenic animals
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US7105348B2
(en)
|
2000-10-31 |
2006-09-12 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US6586251B2
(en)
|
2000-10-31 |
2003-07-01 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US20050144655A1
(en)
|
2000-10-31 |
2005-06-30 |
Economides Aris N. |
Methods of modifying eukaryotic cells
|
|
KR100857943B1
(ko)
|
2000-11-30 |
2008-09-09 |
메다렉스, 인코포레이티드 |
인간 항체의 제조를 위한 형질전환 트랜스염색체 설치류
|
|
GB0115256D0
(en)
|
2001-06-21 |
2001-08-15 |
Babraham Inst |
Mouse light chain locus
|
|
ES2368733T3
(es)
|
2002-07-18 |
2011-11-21 |
Merus B.V. |
Producción recombinante de mezclas de anticuerpos.
|
|
CN1717483A
(zh)
|
2002-10-04 |
2006-01-04 |
麒麟麦酒株式会社 |
人类人工染色体(hac)载体
|
|
US20050266008A1
(en)
*
|
2004-03-29 |
2005-12-01 |
Medarex, Inc. |
Human anti-IRTA-5 antibodies
|
|
AU2007235496B2
(en)
|
2006-03-31 |
2013-11-21 |
E. R. Squibb & Sons, L.L.C. |
Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
|
|
US20080226635A1
(en)
|
2006-12-22 |
2008-09-18 |
Hans Koll |
Antibodies against insulin-like growth factor I receptor and uses thereof
|
|
GB0700194D0
(en)
|
2007-01-05 |
2007-02-14 |
Univ Edinburgh |
Humanisation of animals
|
|
EP2583550A1
(en)
|
2007-03-13 |
2013-04-24 |
National Jewish Health |
Methods for generation of antibodies
|
|
DK2602323T3
(en)
|
2007-06-01 |
2018-04-16 |
Open Monoclonal Tech Inc |
Compositions and Methods for Inhibiting Endogenous Immunoglobin Genes and Producing Transgenic Human Idiotypic Antibodies
|
|
US8877688B2
(en)
*
|
2007-09-14 |
2014-11-04 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
|
RU2731084C2
(ru)
|
2008-06-27 |
2020-08-28 |
Мерюс Н.В. |
Продуцирующие антитела млекопитающие, не являющиеся человеком
|
|
US20120204278A1
(en)
|
2009-07-08 |
2012-08-09 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
US9445581B2
(en)
|
2012-03-28 |
2016-09-20 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
JP5944312B2
(ja)
|
2009-07-08 |
2016-07-05 |
カイマブ・リミテッド |
動物モデルおよび治療用分子
|
|
HUE026229T2
(en)
|
2010-02-08 |
2016-06-28 |
Regeneron Pharma |
Common light chain mouse
|
|
US20130185821A1
(en)
*
|
2010-02-08 |
2013-07-18 |
Regeneron Pharmaceuticals, Inc. |
Common Light Chain Mouse
|
|
CN103228130B
(zh)
|
2010-06-17 |
2016-03-16 |
科马布有限公司 |
动物模型及治疗分子
|
|
CA2806233C
(en)
|
2010-07-26 |
2021-12-07 |
Trianni, Inc. |
Transgenic animals and methods of use
|
|
ME03732B
(me)
|
2011-02-25 |
2021-01-20 |
Regeneron Pharma |
Miševi s ADAM6
|
|
EP2739740B1
(en)
|
2011-08-05 |
2019-10-02 |
Regeneron Pharmaceuticals, Inc. |
Humanized universal light chain mice
|
|
EP2758534B1
(en)
|
2011-09-19 |
2020-04-29 |
Kymab Limited |
Animals, repertoires & methods for the production of human antibodies
|
|
EP4091442A1
(en)
|
2011-09-19 |
2022-11-23 |
Kymab Limited |
Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
|
|
US9253965B2
(en)
|
2012-03-28 |
2016-02-09 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
GB201122047D0
(en)
|
2011-12-21 |
2012-02-01 |
Kymab Ltd |
Transgenic animals
|
|
AU2013204140B2
(en)
*
|
2012-03-06 |
2016-01-28 |
Regeneron Pharmaceuticals, Inc. |
Common light chain mouse
|
|
WO2013144567A1
(en)
|
2012-03-28 |
2013-10-03 |
Kymab Limited |
Transgenic non-human vertebrate for the expression of class - switched, fully human, antibodies
|
|
GB2502127A
(en)
|
2012-05-17 |
2013-11-20 |
Kymab Ltd |
Multivalent antibodies and in vivo methods for their production
|
|
US10251377B2
(en)
|
2012-03-28 |
2019-04-09 |
Kymab Limited |
Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
|
|
KR102126217B1
(ko)
|
2012-06-12 |
2020-06-24 |
리제너론 파마슈티칼스 인코포레이티드 |
제한된 면역글로불린 중쇄 유전자좌를 가지는 인간화된 비-인간 동물
|
|
CN103571872B
(zh)
|
2012-08-09 |
2016-11-23 |
山东国际生物科技园发展有限公司 |
一种能够表达人抗体的转基因动物的制备方法
|
|
HUE064063T2
(hu)
|
2012-12-14 |
2024-02-28 |
Omniab Inc |
Emberi idiotípusokat tartalmazó rágcsáló ellenanyagokat kódoló polinukleotidok és az ezeket tartalmazó állatok
|
|
KR20150115775A
(ko)
|
2013-02-06 |
2015-10-14 |
리제너론 파마슈티칼스 인코포레이티드 |
인간화된 동물을 이용한 b 세포 계통 기반의 면역원 설계
|
|
TR201810255T4
(tr)
*
|
2013-02-20 |
2018-08-27 |
Regeneron Pharma |
Modifiye edilmiş immunoglobulin ağır zincir sekanslarına sahip olan insan olmayan hayvanlar.
|
|
AU2014244020B2
(en)
|
2013-03-13 |
2020-06-04 |
Regeneron Pharmaceuticals, Inc. |
Mice expressing a limited immunoglobulin light chain repertoire
|
|
US9788534B2
(en)
|
2013-03-18 |
2017-10-17 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
SG11201508028QA
(en)
|
2013-04-16 |
2015-10-29 |
Regeneron Pharma |
Targeted modification of rat genome
|
|
US9783593B2
(en)
|
2013-05-02 |
2017-10-10 |
Kymab Limited |
Antibodies, variable domains and chains tailored for human use
|
|
TW201542816A
(zh)
|
2013-09-18 |
2015-11-16 |
Kymab Ltd |
方法、細胞與生物體
|
|
JP7133902B2
(ja)
|
2013-10-01 |
2022-09-09 |
カイマブ・リミテッド |
動物モデル及び治療用分子
|
|
EP3457840B1
(en)
|
2016-05-20 |
2024-04-10 |
Regeneron Pharmaceuticals, Inc. |
Methods for breaking immunological tolerance using multiple guide rnas
|
|
WO2018001241A1
(zh)
|
2016-06-28 |
2018-01-04 |
北京百奥赛图基因生物技术有限公司 |
一种pd-1基因修饰人源化动物模型的构建方法及其应用
|
|
US11279948B2
(en)
|
2016-08-31 |
2022-03-22 |
Biocytogen Pharmaceuticals (Beijing) Co., Ltd. |
Genetically modified non-human animal with human or chimeric OX40
|
|
WO2018041121A1
(en)
|
2016-08-31 |
2018-03-08 |
Beijing Biocytogen Co., Ltd |
Genetically modified non-human animal with human or chimeric ctla-4
|
|
DK3507373T3
(da)
|
2016-08-31 |
2023-10-30 |
Biocytogen Pharmaceuticals Beijing Co Ltd |
Genetisk modificeret ikke-menneskeligt dyr med human eller kimær pd-l1
|
|
WO2018041120A1
(en)
|
2016-08-31 |
2018-03-08 |
Beijing Biocytogen Co., Ltd |
Genetically modified non-human animal with human or chimeric tigit
|
|
WO2018068756A1
(en)
|
2016-10-14 |
2018-04-19 |
Beijing Biocytogen Co., Ltd |
Genetically modified non-human animal with human or chimeric btla
|
|
WO2018086594A1
(en)
|
2016-11-11 |
2018-05-17 |
Beijing Biocytogen Co., Ltd |
Genetically modified non-human animal with human or chimeric tim-3
|
|
WO2018086583A1
(en)
|
2016-11-11 |
2018-05-17 |
Beijing Biocytogen Co., Ltd |
Genetically modified non-human animal with human or chimeric lag-3
|
|
WO2018121787A1
(en)
|
2016-12-30 |
2018-07-05 |
Beijing Biocytogen Co., Ltd |
Genetically modified non-human animal with human or chimeric cd137
|
|
EP3570668A1
(en)
|
2017-01-19 |
2019-11-27 |
Open Monoclonal Technology, Inc. |
Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci
|
|
WO2018177441A1
(en)
|
2017-03-31 |
2018-10-04 |
Beijing Biocytogen Co., Ltd |
GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα
|
|
CN108588126B
(zh)
|
2017-03-31 |
2020-04-10 |
北京百奥赛图基因生物技术有限公司 |
Cd47基因人源化改造动物模型的制备方法及应用
|
|
GB201710984D0
(en)
|
2017-07-07 |
2017-08-23 |
Kymab Ltd |
Cells, vertebrates, populations & methods
|
|
CN109837307B
(zh)
|
2017-11-24 |
2023-09-19 |
中国科学院脑科学与智能技术卓越创新中心 |
建立含外源染色体的胚胎干细胞的方法
|
|
KR20210133234A
(ko)
|
2019-02-18 |
2021-11-05 |
바이오사이토젠 파마슈티컬스 (베이징) 컴퍼니 리미티드 |
인간화 면역글로불린 유전자좌를 갖는 유전적으로 변형된 비-인간 동물
|
|
EP4370539A1
(en)
|
2021-07-16 |
2024-05-22 |
Biocytogen Pharmaceuticals (Beijing) Co., Ltd. |
Genetically modified non-human animal with human or chimeric tfr1
|