JPWO2021215514A1 - - Google Patents
Info
- Publication number
- JPWO2021215514A1 JPWO2021215514A1 JP2022517102A JP2022517102A JPWO2021215514A1 JP WO2021215514 A1 JPWO2021215514 A1 JP WO2021215514A1 JP 2022517102 A JP2022517102 A JP 2022517102A JP 2022517102 A JP2022517102 A JP 2022517102A JP WO2021215514 A1 JPWO2021215514 A1 JP WO2021215514A1
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0058—Antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
- C09B69/105—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing a methine or polymethine dye
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020077176 | 2020-04-24 | ||
| JP2020077176 | 2020-04-24 | ||
| JP2020129753 | 2020-07-30 | ||
| JP2020129753 | 2020-07-30 | ||
| PCT/JP2021/016361 WO2021215514A1 (ja) | 2020-04-24 | 2021-04-22 | 化合物及びこれを用いた標識生体物質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2021215514A1 true JPWO2021215514A1 (https=) | 2021-10-28 |
| JP7441306B2 JP7441306B2 (ja) | 2024-02-29 |
Family
ID=78269285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022517102A Active JP7441306B2 (ja) | 2020-04-24 | 2021-04-22 | 化合物及びこれを用いた標識生体物質 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US12559476B2 (https=) |
| EP (1) | EP4140999A4 (https=) |
| JP (1) | JP7441306B2 (https=) |
| CN (1) | CN115397923A (https=) |
| WO (1) | WO2021215514A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022025210A1 (ja) | 2020-07-30 | 2022-02-03 | 富士フイルム株式会社 | 化合物及びこれを用いた標識生体物質 |
| JPWO2024143263A1 (https=) | 2022-12-26 | 2024-07-04 |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001002374A1 (en) * | 1999-07-06 | 2001-01-11 | Surromed, Inc. | Bridged fluorescent dyes, their preparation and their use in assays |
| JP2003034696A (ja) * | 2001-07-19 | 2003-02-07 | Fuji Photo Film Co Ltd | 蛍光ヌクレオチド及びそれを用いた標識法 |
| JP2008538382A (ja) * | 2005-04-22 | 2008-10-23 | ジーイー・ヘルスケア・ユーケイ・リミテッド | 反応性蛍光標識試薬としての水溶性フルオロ置換シアニン色素 |
| JP2011506673A (ja) * | 2007-12-14 | 2011-03-03 | バイオティウム， インコーポレイテッド | 蛍光性化合物 |
| US20120156140A1 (en) * | 2010-12-21 | 2012-06-21 | Dyomics Gmbh | Fluorescent compounds |
| JP2012517436A (ja) * | 2009-02-06 | 2012-08-02 | ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド | 電荷均衡造影剤 |
| WO2012129128A1 (en) * | 2011-03-18 | 2012-09-27 | Biotium, Inc. | Fluorescent dyes, fluorescent dye kits, and methods of preparing labeled molecules |
| US20140255312A1 (en) * | 2013-03-07 | 2014-09-11 | Greg Hermanson | Cyanine compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2423806C (en) * | 2000-09-29 | 2009-12-22 | Molecular Probes, Inc. | Modified carbocyanine dyes and their conjugates |
| JP5089422B2 (ja) * | 2008-02-15 | 2012-12-05 | 岡本化学工業株式会社 | 感光性組成物およびそれを用いた平版印刷版用原版 |
| WO2012054784A1 (en) * | 2010-10-20 | 2012-04-26 | Li-Cor, Inc. | Fluorescent imaging with substituted cyanine dyes |
| WO2013130761A1 (en) | 2012-03-02 | 2013-09-06 | Pierce Biotechnology, Inc. | Indole derivatives as labeling dye for biomolecule |
| US11787764B2 (en) * | 2018-02-15 | 2023-10-17 | Children's National Medical Center | Heptamethine cyanines for use as fluorescent markers of the biliary and renal systems |
| JP7184600B2 (ja) | 2018-11-07 | 2022-12-06 | フクダ電子株式会社 | 手術看護師管理装置及びプログラム |
| JP7148428B2 (ja) | 2019-02-08 | 2022-10-05 | オリンパス株式会社 | 撮像装置および撮像方法 |
-
2021
- 2021-04-22 JP JP2022517102A patent/JP7441306B2/ja active Active
- 2021-04-22 EP EP21793291.2A patent/EP4140999A4/en active Pending
- 2021-04-22 WO PCT/JP2021/016361 patent/WO2021215514A1/ja not_active Ceased
- 2021-04-22 CN CN202180028519.9A patent/CN115397923A/zh active Pending
-
2022
- 2022-10-20 US US18/048,426 patent/US12559476B2/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001002374A1 (en) * | 1999-07-06 | 2001-01-11 | Surromed, Inc. | Bridged fluorescent dyes, their preparation and their use in assays |
| JP2003034696A (ja) * | 2001-07-19 | 2003-02-07 | Fuji Photo Film Co Ltd | 蛍光ヌクレオチド及びそれを用いた標識法 |
| JP2008538382A (ja) * | 2005-04-22 | 2008-10-23 | ジーイー・ヘルスケア・ユーケイ・リミテッド | 反応性蛍光標識試薬としての水溶性フルオロ置換シアニン色素 |
| JP2011506673A (ja) * | 2007-12-14 | 2011-03-03 | バイオティウム， インコーポレイテッド | 蛍光性化合物 |
| JP2012517436A (ja) * | 2009-02-06 | 2012-08-02 | ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド | 電荷均衡造影剤 |
| US20120156140A1 (en) * | 2010-12-21 | 2012-06-21 | Dyomics Gmbh | Fluorescent compounds |
| WO2012129128A1 (en) * | 2011-03-18 | 2012-09-27 | Biotium, Inc. | Fluorescent dyes, fluorescent dye kits, and methods of preparing labeled molecules |
| US20140255312A1 (en) * | 2013-03-07 | 2014-09-11 | Greg Hermanson | Cyanine compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115397923A (zh) | 2022-11-25 |
| WO2021215514A1 (ja) | 2021-10-28 |
| EP4140999A4 (en) | 2023-11-29 |
| JP7441306B2 (ja) | 2024-02-29 |
| US12559476B2 (en) | 2026-02-24 |
| US20230219932A1 (en) | 2023-07-13 |
| EP4140999A1 (en) | 2023-03-01 |
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