JPWO2021186427A5 - - Google Patents

Info

Publication number

JPWO2021186427A5

JPWO2021186427A5 JP2022555992A JP2022555992A JPWO2021186427A5 JP WO2021186427 A5 JPWO2021186427 A5 JP WO2021186427A5 JP 2022555992 A JP2022555992 A JP 2022555992A JP 2022555992 A JP2022555992 A JP 2022555992A JP WO2021186427 A5 JPWO2021186427 A5 JP WO2021186427A5

Authority

JP

Japan

Prior art keywords

seq

acid sequence

variable region

chain variable

nucleic acid

Prior art date

2024-03-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000007523 nucleic acids Chemical group 0.000 claims 30
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 28
• 239000000427 antigen Substances 0.000 claims 19
• 108091007433 antigens Proteins 0.000 claims 19
• 102000036639 antigens Human genes 0.000 claims 19
• 239000012634 fragment Substances 0.000 claims 18
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 14
• 125000003275 alpha amino acid group Chemical group 0.000 claims 14
• 229940127121 immunoconjugate Drugs 0.000 claims 12
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
• 239000008194 pharmaceutical composition Substances 0.000 claims 8
• 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 4
• 102100034256 Mucin-1 Human genes 0.000 claims 4
• 229940127089 cytotoxic agent Drugs 0.000 claims 4
• 239000002254 cytotoxic agent Substances 0.000 claims 4
• 201000010099 disease Diseases 0.000 claims 4
• 208000035475 disorder Diseases 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 229940124597 therapeutic agent Drugs 0.000 claims 4
• 206010028980 Neoplasm Diseases 0.000 claims 3
• 231100000433 cytotoxic Toxicity 0.000 claims 3
• 230000001472 cytotoxic effect Effects 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 208000031513 cyst Diseases 0.000 claims 2
• 231100000599 cytotoxic agent Toxicity 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 231100000699 Bacterial toxin Toxicity 0.000 claims 1
• 206010011732 Cyst Diseases 0.000 claims 1
• 208000026292 Cystic Kidney disease Diseases 0.000 claims 1
• 230000005778 DNA damage Effects 0.000 claims 1
• 231100000277 DNA damage Toxicity 0.000 claims 1
• 241001529936 Murinae Species 0.000 claims 1
• 101000762949 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Exotoxin A Proteins 0.000 claims 1
• 206010038423 Renal cyst Diseases 0.000 claims 1
• 229940123237 Taxane Drugs 0.000 claims 1
• 206010043706 Thyroid cyst Diseases 0.000 claims 1
• 206010058900 Thyroid mass Diseases 0.000 claims 1
• 229940122429 Tubulin inhibitor Drugs 0.000 claims 1
• 229940122803 Vinca alkaloid Drugs 0.000 claims 1
• 230000002159 abnormal effect Effects 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 229940100198 alkylating agent Drugs 0.000 claims 1
• 239000002168 alkylating agent Substances 0.000 claims 1
• 238000004458 analytical method Methods 0.000 claims 1
• 229940045799 anthracyclines and related substance Drugs 0.000 claims 1
• 239000003080 antimitotic agent Substances 0.000 claims 1
• 239000000688 bacterial toxin Substances 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003534 dna topoisomerase inhibitor Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 1
• 210000005260 human cell Anatomy 0.000 claims 1
• 238000003364 immunohistochemistry Methods 0.000 claims 1
• 230000000937 inactivator Effects 0.000 claims 1
• 208000027866 inflammatory disease Diseases 0.000 claims 1
• 210000004185 liver Anatomy 0.000 claims 1
• 230000003211 malignant effect Effects 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 229910052697 platinum Inorganic materials 0.000 claims 1
• 150000003230 pyrimidines Chemical class 0.000 claims 1
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 1
• 229940044693 topoisomerase inhibitor Drugs 0.000 claims 1