JPWO2021137094A5 - - Google Patents

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JPWO2021137094A5
JPWO2021137094A5 JP2022540519A JP2022540519A JPWO2021137094A5 JP WO2021137094 A5 JPWO2021137094 A5 JP WO2021137094A5 JP 2022540519 A JP2022540519 A JP 2022540519A JP 2022540519 A JP2022540519 A JP 2022540519A JP WO2021137094 A5 JPWO2021137094 A5 JP WO2021137094A5
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thermistors
switches
electrode elements
pins
signal
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Priority claimed from PCT/IB2020/062309 external-priority patent/WO2021137094A1/en
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Claims (18)

被験者の体に交流電場を印可するための装置であって、
複数の電極要素と、
前記被験者の体に対して前記電極要素を保持するように構成される支持体と、
複数のサーミスタであって、前記サーミスタの各々が第1の端子および第2の端子を有し、前記サーミスタの各々が、前記電極要素のうちの対応するそれぞれ1つで温度を検知するように位置決めされる、複数のサーミスタと、
複数の第1のピンおよび第2のピンを有するコネクタと、
複数の第1の導体であって、その各々が、(a)前記第1のピンのうちのそれぞれ1つと、(b)前記電極要素のうちのそれぞれ1つと、(c)前記対応するサーミスタの前記第1の端子との間に導電性経路を実現する、複数の第1の導体と、
前記第2のピンと前記サーミスタのうちの少なくとも1つの前記第2の端子との間に導電性経路を実現する第2の導体と
を備える、装置。
A device for applying an alternating current electric field to a subject's body,
a plurality of electrode elements;
a support configured to hold the electrode element against the subject's body;
a plurality of thermistors, each thermistor having a first terminal and a second terminal, each of the thermistors positioned to sense temperature at a corresponding respective one of the electrode elements; a plurality of thermistors,
a connector having a plurality of first pins and a plurality of second pins;
a plurality of first conductors, each of which connects (a) a respective one of said first pins; (b) a respective one of said electrode elements; and (c) a respective one of said thermistor. a plurality of first conductors that realize a conductive path between the first terminal;
a second conductor providing a conductive path between the second pin and the second terminal of at least one of the thermistors.
すべての前記サーミスタの前記第2の端子が一緒に結線される、請求項1に記載の装置。 2. The apparatus of claim 1, wherein the second terminals of all the thermistors are wired together. すべての前記サーミスタの前記第2の端子が、(a)フレックス回路上の少なくとも1つのトレースと(b)少なくとも1つのワイヤのうちの少なくとも1つを使用して、一緒に結線される、請求項2に記載の装置。 5. The second terminals of all the thermistors are wired together using at least one of (a) at least one trace on a flex circuit and (b) at least one wire. 2. The device according to 2. 前記複数のサーミスタが直列に配置され、前記サーミスタのうちの第1のもので始まり、前記サーミスタのうちの最後のもので終了し、前記最後のサーミスタを除く前記サーミスタのうちの各々の前記第2の端子が、それぞれの後続のサーミスタの前記第1の端子に結線され、前記第2の導体が、前記コネクタの前記第2のピンと前記最後のサーミスタの前記第2の端子との間に導電性経路を実現する、請求項1に記載の装置。 the plurality of thermistors are arranged in series, starting with a first of the thermistors and ending with the last of the thermistors, the second of each of the thermistors excluding the last thermistor; are connected to the first terminal of each subsequent thermistor, and the second conductor is electrically conductive between the second pin of the connector and the second terminal of the last thermistor. 2. The device according to claim 1, for realizing a route. 前記第2の導体が、前記第2のピンと前記サーミスタのうちのただ1つの前記第2の端子との間に導電性経路を実現する、請求項1に記載の装置。 2. The apparatus of claim 1, wherein the second conductor provides a conductive path between the second pin and the second terminal of only one of the thermistors. 前記複数の電極要素が少なくとも4つの電極要素を備え、前記複数のサーミスタが少なくとも4つのサーミスタを備える、請求項1に記載の装置。 2. The apparatus of claim 1, wherein the plurality of electrode elements comprises at least four electrode elements and wherein the plurality of thermistors comprises at least four thermistors. 前記複数の電極要素が少なくとも9つの電極要素を備え、前記複数のサーミスタが少なくとも9つのサーミスタを備える、請求項1に記載の装置。 2. The apparatus of claim 1, wherein the plurality of electrode elements comprises at least nine electrode elements and wherein the plurality of thermistors comprises at least nine thermistors. 前記電極要素のうちの各々が、導電板と前記導電板上に配設される誘電体層とを備え、前記電極要素の各々の前記誘電体層が前記被験者の体に面するように、前記支持体が、前記被験者の体に対して前記電極要素を保持するように構成される、請求項1に記載の装置。 Each of the electrode elements comprises a conductive plate and a dielectric layer disposed on the conductive plate, and the dielectric layer of each of the electrode elements faces the subject's body. 2. The apparatus of claim 1, wherein a support is configured to hold the electrode element against the subject's body. すべての前記サーミスタの前記第2の端子が一緒に結線され、前記第2の導体が、前記第2のピンとすべての前記サーミスタの前記第2の端子との間に導電性経路を実現する、請求項1に記載の装置。 The second terminals of all the thermistors are wired together, and the second conductor provides a conductive path between the second pin and the second terminal of all the thermistors. The device according to item 1. 複数の電極要素を使用して被験者の体に交流電場を印可するための装置であって、前記複数の電極要素の各々がそれぞれのサーミスタと熱接触して配設され、
AC出力信号を発生するAC信号発生器と、
複数のピンを含むコネクタであって、前記ピンの各々が前記複数の電極要素のそれぞれ1つに対応する、コネクタと、
第1の複数のスイッチであって、前記第1の複数のスイッチの各々が、前記ピンのそれぞれ1つに前記AC出力信号を選択的に印可する、または印可しないのいずれかであるように構成される、第1の複数のスイッチと、
前記サーミスタの各々からの電気信号を受け入れ、対応する出力を発生するように構成される増幅器であって、前記サーミスタからの前記電気信号が、前記複数の電極要素に対応する同じピンを介して到達する、増幅器と、
前記増幅器の前記出力に基づいて、前記複数のピンの各々に印可される前記AC信号のデューティサイクルを個別に調整するように、前記第1の複数のスイッチを制御するように構成されるコントローラと
を備える、装置。
An apparatus for applying an alternating current electric field to a subject's body using a plurality of electrode elements, each of the plurality of electrode elements being disposed in thermal contact with a respective thermistor;
an AC signal generator that generates an AC output signal;
a connector including a plurality of pins, each pin corresponding to a respective one of the plurality of electrode elements;
a first plurality of switches, each of the first plurality of switches configured to either selectively apply or not apply the AC output signal to a respective one of the pins; a first plurality of switches;
an amplifier configured to accept an electrical signal from each of the thermistors and generate a corresponding output, the electrical signals from the thermistor arriving via the same pin corresponding to the plurality of electrode elements; an amplifier,
a controller configured to control the first plurality of switches to individually adjust the duty cycle of the AC signal applied to each of the plurality of pins based on the output of the amplifier; A device comprising:
前記コントローラが、(a)前記増幅器の前記出力に基づいて、前記電極要素のうちの少なくとも1つが他の電極要素より熱いときを判定し、(b)少なくとも1つのそれぞれのピンに印可される前記AC信号の前記デューティサイクルを減らすように、前記第1の複数のスイッチを制御するように構成される、請求項10に記載の装置。 the controller (a) determines when at least one of the electrode elements is hotter than another electrode element based on the output of the amplifier; and (b) applies the 11. The apparatus of claim 10, configured to control the first plurality of switches to reduce the duty cycle of an AC signal. 前記コントローラが、(a)前記増幅器の前記出力に基づいて、前記電極要素のうちの少なくとも1つが閾値レベルより熱いときを判定し、(b)少なくとも1つのそれぞれのピンに印可される前記AC信号の前記デューティサイクルを減らすように、前記第1の複数のスイッチを制御するように構成される、請求項10に記載の装置。 The controller (a) determines when at least one of the electrode elements is hotter than a threshold level based on the output of the amplifier; and (b) applies the AC signal to at least one respective pin. 11. The apparatus of claim 10, configured to control the first plurality of switches to reduce the duty cycle of . 前記複数の電極要素が少なくとも4つの電極要素を備え、前記複数のピンが少なくとも4つのピンを備え、前記第1の複数のスイッチが少なくとも4つのスイッチを備える、請求項10に記載の装置。 11. The apparatus of claim 10, wherein the plurality of electrode elements comprises at least four electrode elements, the plurality of pins comprises at least four pins, and the first plurality of switches comprises at least four switches. 前記複数の電極要素が少なくとも9つの電極要素を備え、前記複数のピンが少なくとも9つのピンを備え、前記第1の複数のスイッチが少なくとも9つのスイッチを備える、請求項10に記載の装置。 11. The apparatus of claim 10, wherein the plurality of electrode elements comprises at least nine electrode elements, the plurality of pins comprises at least nine pins, and the first plurality of switches comprises at least nine switches. 各々が前記複数のピンのうちのそれぞれ1つから前記増幅器の第1の入力に信号を経路指定するように配置される第2の複数のスイッチをさらに備え、
前記コントローラが、前記複数のピンの各々を順次選択し、前記サーミスタの各々からの温度読取値を順次得るように、前記第2の複数のスイッチを制御するようにさらに構成される、請求項10に記載の装置。
further comprising a second plurality of switches each arranged to route a signal from a respective one of the plurality of pins to a first input of the amplifier;
10. The controller is further configured to control the second plurality of switches to sequentially select each of the plurality of pins and sequentially obtain a temperature reading from each of the thermistors. The device described in.
前記コネクタが追加ピンを含み、
前記追加ピンから前記増幅器の第2の入力に信号を経路指定するように配置される追加スイッチをさらに備える、請求項15に記載の装置。
the connector includes additional pins;
16. The apparatus of claim 15, further comprising an additional switch arranged to route a signal from the additional pin to a second input of the amplifier.
各々が前記複数のピンのうちのそれぞれ1つから前記追加ピンに信号を経路指定するように配置される第3の複数のスイッチをさらに備え、
前記第1の複数のスイッチからの所与のスイッチが開であるとき、前記コントローラが前記第3の複数のスイッチからのそれぞれ対応するスイッチを閉じるように、前記コントローラがさらに構成される、請求項16に記載の装置。
further comprising a third plurality of switches each arranged to route a signal from a respective one of the plurality of pins to the additional pin;
5. The controller is further configured such that when a given switch from the first plurality of switches is open, the controller closes a respective corresponding switch from the third plurality of switches. 16. The device according to 16.
各々が前記複数のピンのうちのそれぞれ1つから前記増幅器の第1の入力に信号を経路指定するように配置される第2の複数のスイッチと、
各々が前記複数のピンのうちのそれぞれ1つから前記増幅器の第2の入力に信号を経路指定するように配置される第3の複数のスイッチと
をさらに備え、
前記コントローラが、順番に前記サーミスタの各々の両方の端子に対応する前記複数のピンの対から前記増幅器の前記第1および第2の入力に信号を順次経路指定し、前記サーミスタの各々からの温度読取値を順次得るように、前記第2の複数のスイッチおよび前記第3の複数のスイッチを制御するようにさらに構成される、請求項10に記載の装置。
a second plurality of switches each arranged to route a signal from a respective one of the plurality of pins to a first input of the amplifier;
a third plurality of switches each arranged to route a signal from a respective one of the plurality of pins to a second input of the amplifier;
the controller sequentially routes signals from the plurality of pin pairs corresponding in turn to both terminals of each of the thermistors to the first and second inputs of the amplifier; 11. The apparatus of claim 10, further configured to control the second plurality of switches and the third plurality of switches to sequentially obtain readings.
JP2022540519A 2019-12-31 2020-12-21 Array for delivering tumor therapeutic fields (TT fields) with individually accessible electrode elements and temperature sensors Pending JP2023508585A (en)

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US11369790B2 (en) 2018-10-25 2022-06-28 Novocure Gmbh Delivering alternating electric fields (e.g., TTFields) to a subject's spinal anatomy
US20200146586A1 (en) 2018-11-14 2020-05-14 Novocure Gmbh Creating Accurate Computational Head Models of Patients Using Datasets Combining MRI and CT Images
US11040195B2 (en) * 2018-11-16 2021-06-22 Pacesetter, Inc. Systems and methods for reducing RF heating in implantable leads
WO2020104921A1 (en) 2018-11-19 2020-05-28 Novocure Gmbh Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements
MX2021002625A (en) 2018-11-29 2021-05-12 Novocure Gmbh Enhanced-flexibility transducer arrays for delivering ttfields (tumor treating fields).
US11276171B2 (en) 2019-01-08 2022-03-15 Novocure Gmbh Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (TTFields)
EP3939568A1 (en) 2019-02-22 2022-01-19 Novocure GmbH Treating gastric cancer using ttfields and drug in combination
KR20210126083A (en) 2019-02-26 2021-10-19 노보큐어 게엠베하 Frequency Determination of Tumor Treatment Plant Based on Electrical Characteristics of Target Cancer Cells
JP2022522936A (en) 2019-02-27 2022-04-21 ノボキュア ゲーエムベーハー Delivery of Tumor Treatment Electric Field (TTFIELDS) Using Implantable Transducer Array
EP3977991A1 (en) 2019-03-29 2022-04-06 Novocure GmbH Methods for reducing viability of ttfields-resistant cancer cells
US11291837B2 (en) 2019-04-17 2022-04-05 Novocure Gmbh Uploading data from an isolated system without compromising isolation
US11654279B2 (en) 2019-07-31 2023-05-23 Novocure Gmbh Applying tumor treating fields (TTFields) via electrodes embedded into skull implants
JP2022545344A (en) 2019-08-05 2022-10-27 ノボキュア ゲーエムベーハー sensitize cancer cells to tumor therapeutic fields (TT fields) by inhibiting IL11 activity
CN114364433A (en) 2019-08-30 2022-04-15 诺沃库勒有限责任公司 Cervical delivery of tumor therapy fields (TTfields)
JP2023507861A (en) 2019-09-10 2023-02-28 ノボキュア ゲーエムベーハー Method for reducing survival rate of cancer cells by applying alternating electric field to cancer cells and administering checkpoint inhibitor

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