CN114534091B - Apparatus for inhibiting tumor proliferation by electric field and control device thereof - Google Patents
Apparatus for inhibiting tumor proliferation by electric field and control device thereof Download PDFInfo
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- CN114534091B CN114534091B CN202210148916.6A CN202210148916A CN114534091B CN 114534091 B CN114534091 B CN 114534091B CN 202210148916 A CN202210148916 A CN 202210148916A CN 114534091 B CN114534091 B CN 114534091B
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Abstract
The present disclosure provides an apparatus for inhibiting tumor proliferation using an electric field and a control device thereof. In a first state of the device, the working time of the N pairs of electrode elements in each working period is equal, and no idle time exists in the working period; in the second state, the working time of any pair of electrode elements with the output alternating voltage smaller than the corresponding first voltage threshold value in each working period is adjusted and reduced relative to the working time of the electrode elements in the first state; in the third state, the working time of any pair of electrode elements is adjusted and reduced relative to the working time of any pair of electrode elements in the first state. The device enables the effective treatment time to be as long as possible and the treatment intensity to be as great as possible.
Description
Technical Field
The disclosure belongs to the technical field of tumor electric field treatment, and particularly relates to equipment for inhibiting tumor proliferation by using an electric field and a control device thereof.
Background
This section is intended to provide a background or context to the embodiments of the invention that are recited in the claims. The description herein is not admitted to be prior art by inclusion in this section.
An apparatus for inhibiting tumor proliferation by an electric field applies an alternating electric field to the lesion. Specifically, one or more pairs of electrode elements are attached to the skin surface of a user, and an alternating voltage is applied to a focal region by an alternating voltage source through an electrode patch.
Cells in the late anaphase or telophase stages of cell division are susceptible to damage by alternating electric fields having specific frequency and field strength characteristics. Thus, selective destruction of rapidly dividing cells can be achieved by applying an alternating electric field over a prolonged period of time at the focal region. Some dividing cells will be destroyed upon application of the electric field, while non-dividing cells are not damaged. This allows the selective destruction of rapidly dividing cells, such as tumor cells, without harming normal cells that do not divide.
The ac voltage applied to any pair of electrode elements should ideally be as large as possible to achieve a better therapeutic effect. But this can result in the electrode elements heating up too quickly and causing equipment shutdown or frequent alarms. The operating voltage of each pair of electrode elements of the device should be kept relatively high for a long time to obtain a better therapeutic effect.
Disclosure of Invention
An object of the present disclosure is to provide an apparatus for suppressing tumor proliferation using an electric field and a control device thereof.
The technical scheme adopted by the disclosure is as follows: a device for inhibiting tumor proliferation using an electric field, the device having N pairs of electrode elements for application to the skin of a user, N ≧ 2, each pair of electrode elements for applying an ac electric field at a target area on the body of the user, the different pairs of electrode elements applying ac electric fields at the target area in different directions, the ac voltages output by any one pair of electrode elements decreasing stepwise or decreasing stepwise as a temperature parameter of any one pair of electrode elements increases in a steady state, the pairs of electrode elements in an active state in any one duty cycle having no interruptions in operation and no overlaps with each other, the durations of the duty cycles being equal, comprising:
in a first state, the working time of each working cycle of the N pairs of electrode elements is equal, and no idle time exists in the working cycle, wherein the first state is a state that the alternating voltage applied to each pair of electrode elements is greater than the first voltage threshold corresponding to the pair of electrode elements;
in a second state, the working time of any pair of electrode elements with the output alternating voltage smaller than the corresponding first voltage threshold value in each working cycle is adjusted and reduced relative to the working time of the electrode elements in the first state, the working time of any pair of electrode elements with the output alternating voltage larger than the corresponding first voltage threshold value in each working cycle is equal, and no idle time exists in each working cycle, and the second state is a state that the alternating voltage applied to at least one pair of electrode elements is smaller than the corresponding first voltage threshold value of the pair of electrode elements and the alternating voltage applied to at least one pair of electrode elements is larger than the corresponding first voltage threshold value of the pair of electrode elements;
in a third state, the working time of any pair of electrode elements is adjusted to be shorter than the working time of any pair of electrode elements in the first state, and the third state is a state in which the alternating voltages applied to the N pairs of electrode elements are smaller than the corresponding first voltage threshold values.
The technical scheme adopted by the disclosure is as follows: a device for inhibiting tumor proliferation by using an electric field, the device is provided with N pairs of electrode elements, the electrode elements are used for being attached to the skin of a user, N is more than or equal to 2, each pair of electrode elements is used for applying an alternating current electric field on a target area of the body of the user, the directions of the alternating current electric fields applied on the target area by different pairs of electrode elements are different, the alternating current voltage output by any pair of electrode elements is gradually reduced or reduced in steps along with the increase of the temperature parameter of any pair of electrode elements in a stable state, the working time of each pair of electrode elements in a working state in any working period is not interrupted, the duration of each working period is equal, each working period is equally divided into N sub-working periods, at most one pair of electrode elements in the working state in each sub-working period, and each pair of electrode elements works in at most one sub-working period, the method comprises the following steps:
in a first state, the working time of each working cycle of the N pairs of electrode elements is equal, and no idle time exists in the working cycle, wherein the first state is a state that the alternating voltage applied to each pair of electrode elements is greater than the first voltage threshold corresponding to the pair of electrode elements;
in a second state, the working time of any pair of electrode elements with output alternating voltages smaller than the corresponding first voltage threshold value in each working cycle is adjusted and reduced relative to the working time of the electrode elements in the first state, the working time of any pair of electrode elements with output alternating voltages larger than the corresponding first voltage threshold value in each working cycle is equal to the working time of the electrode elements in the first state, and the second state is a state that the alternating voltages applied to at least one pair of electrode elements are smaller than the corresponding first voltage threshold value of the electrode elements and the alternating voltages applied to at least one pair of electrode elements are larger than the corresponding first voltage threshold value of the electrode elements;
in a third state, the working time of any pair of electrode elements is adjusted to be smaller than the working time of any pair of electrode elements in the first state, and the third state is a state in which the alternating voltages applied to the N pairs of electrode elements are smaller than the corresponding first voltage threshold values.
The technical scheme adopted by the disclosure is as follows: a control apparatus for a device for suppressing tumor proliferation using an electric field, comprising: at least one processor; and a memory communicatively coupled to the at least one processor; wherein the memory stores instructions executable by the at least one processor to enable the at least one processor to control the apparatus.
The technical scheme adopted by the disclosure is as follows: an apparatus for inhibiting tumor proliferation by using an electric field, comprising N pairs of electrode elements, wherein the electrode elements are used for being attached to the skin of a user, N is more than or equal to 2, each pair of electrode elements is used for applying an alternating current electric field on a target area of the body of the user, the directions of the alternating current electric fields applied on the target area by different pairs of electrode elements are different, the alternating current voltage applied on any pair of electrode elements is related to the temperature parameter of any pair of electrode elements, the alternating current voltage of any pair of electrode elements is reduced or reduced in steps along with the increase of the temperature parameter of any pair of electrode elements in a stable state, and the working period is equal in duration, and the apparatus also comprises the control device.
In the first state, there is no idle time and the inhibitory effect on tumor proliferation is maximized. In the second state, the working voltage of the electrode element with relatively high temperature is properly adjusted to be low, so that the condition that the equipment is stopped by alarming too fast is avoided, and the working time of the electrode element with relatively low temperature is not reduced or slightly increased, so that the inhibition effect on the tumor can be ensured to be as large as possible. In the third state, since the temperatures of the respective pairs of electrode elements are relatively high, the operating times of the respective pairs of electrode elements are suitably reduced. The effective treatment time received by the user is as long as possible and the treatment intensity is as great as possible.
Drawings
Fig. 1 is a block diagram of an apparatus for inhibiting tumor proliferation using an electric field according to an embodiment of the present disclosure.
Fig. 2 is a flowchart illustrating a control method of an apparatus for suppressing tumor proliferation using an electric field according to an embodiment of the present disclosure.
Fig. 3 is a flowchart illustrating a control method of an apparatus for suppressing tumor proliferation using an electric field according to another embodiment of the present disclosure.
Fig. 4 is a schematic structural diagram of a control device of an apparatus for inhibiting tumor proliferation using an electric field according to an embodiment of the present disclosure.
Detailed Description
The disclosure will be further described with reference to the embodiments shown in the drawings.
Referring to fig. 1, an apparatus for inhibiting tumor proliferation using an electric field generally comprises an ac voltage source 1, a plurality of pairs of electrode elements 21-24, a control device 3, and a temperature measuring element, not shown. The plurality of pairs of electrode elements will be referred to as N pairs of electrode elements, N.gtoreq.2.
In the apparatus shown in fig. 1, a pair of electrode members 21, 22 and a pair of electrode members 23, 24 are provided. In other embodiments, the tumor proliferation inhibition by the electric field may comprise 3 or more pairs of electrode elements. Each pair of electrode elements is used for applying an alternating electric field to a target area of the user's body, and the directions of the alternating electric fields applied to the target area by different pairs of electrode elements are different.
The temperature measuring element is used for measuring the temperature of each electrode element. One or more temperature sensing elements may be disposed with respect to each electrode element. Based on the detection result of the temperature measuring element, the control device 3 can determine the temperature parameters of the pair of electrode elements. The temperature parameter of the pair of electrode elements is, for example, a maximum value or an average value among temperature values detected by the pair of electrode elements.
Devices that use electric fields to inhibit tumor proliferation typically include at least 2 states after power-on, one being a power-on state and one being a steady state after the power-on state. In the start-up state, the output voltage between the pairs of electrode elements rapidly increases and then tends to stabilize, after which the output voltage between the pairs of electrode elements is dynamically stabilized in the steady state. The disclosed embodiments provide for the regulation of the output voltage between pairs of electrode elements in a steady state.
In a steady state, as the temperature parameter of any pair of electrode elements increases, the alternating voltage output by any pair of electrode elements is gradually reduced or stepped reduced, thereby inhibiting the temperature rise of the pair of electrode elements.
In any working period, the working time of any pair of electrode elements in the working state is continuous (namely, any pair of electrode elements only has one continuous working time, and the working time of any pair of electrode elements is not interrupted) and has no overlapping with the working time of any pair of electrode elements in other working states, and the duration of each working period is equal. In one working cycle, the sequence of the output ac voltage of each pair of electrode elements in the working state may be fixed or random, which is not limited by the present disclosure.
Referring to fig. 2, in some embodiments, a device for inhibiting tumor proliferation using an electric field includes the following states.
Since the electrode elements are attached to the skin of the user at different positions and the equivalent impedance of the load between the electrode elements is different, the first voltage threshold corresponding to each pair of electrode elements may be different when the electrode elements are attached to the skin of the user at fixed positions.
The idle time is a time when all counter electrode elements do not output the alternating voltage. When the output ac voltage from one pair of electrode elements is switched to the output ac voltage from the other pair of electrode elements, a slight idle time is allowed. This small idle time, which may be ignored, is, for example, 2 ms.
For example, when the device has 3 pairs of electrode elements, such as 1 pair of electrode elements outputting an ac voltage smaller than its corresponding first voltage threshold and the other 2 pairs of electrode elements outputting an ac voltage larger than their corresponding first voltage thresholds, the duration of one duty cycle is denoted as T, and then the duty cycle of the first 1 pair of electrode elements is reduced, for example, to
The working time of the other two pairs of electrode elements is
For example, when the device has 3 pairs of electrode elements, the ac voltages output by the 3 pairs of electrode elements are all smaller than the self-corresponding first voltage threshold, and then the operating time of the 3 pairs of electrode elements is all smaller than
In the first state, there is no idle time and the inhibitory effect on tumor proliferation is maximized. In the second state, the working voltage of the electrode element with relatively high temperature is properly adjusted to be low, so that the phenomenon that the equipment is stopped by alarming too fast is avoided, and the working time of the electrode element with relatively low temperature is slightly increased, so that the inhibition effect on the tumor can be ensured to be as large as possible. In the third state, since the temperatures of the respective pairs of electrode members are relatively high, the operating times of the respective pairs of electrode members are suitably reduced. The effective treatment time received by the user is as long as possible and the treatment intensity is as large as possible.
Optionally, in the second state and/or in the third state, an operating time of any pair of electrode elements, of which the output alternating-current voltage is smaller than the corresponding first voltage threshold value, in each operating cycle is determined according to the operating voltage of the any pair of electrode elements and a second voltage threshold value corresponding to the any pair of electrode elements, where the second voltage threshold value corresponding to each pair of electrode elements is smaller than the corresponding first voltage threshold value.
The working voltage of a pair of electrode elements is greater than the corresponding first voltage threshold, and the inhibition effect of the electric field between the pair of electrode elements on the tumor is better. If the working voltage of a pair of electrode elements is less than the corresponding second voltage threshold, the inhibition effect of the electric field between the pair of electrode elements on the tumor is poor or even ineffective. The ratio of the first voltage threshold to the second voltage threshold, which can correspond to the same pair of electrode elements, is typically around 1.05.
Since the electrode elements are attached to the skin of the user at different positions and the equivalent impedance loaded between the electrode elements is different, the second voltage thresholds corresponding to each pair of electrode elements may be different when the attachment positions of the electrode elements to the skin of the user are fixed.
The larger the value of the operating voltage of a pair of electrode elements is lower than its corresponding second voltage threshold, the shorter the operating time of the pair of electrode elements should be.
For example, in the second state and/or in the third state, the working time of any pair of electrode elements, of which the output alternating voltage is smaller than the corresponding first voltage threshold value, in each working cycle is determined according to the following formula:
wherein, T j J is more than or equal to 1 and less than or equal to N, T is the duration of the working period, K is the working time of a pair of electrode elements which output alternating voltage and are less than the corresponding first voltage threshold and are numbered j in each working period 1 Is a proportionality coefficient, U j Output voltage of a pair of electrode elements with number j, U j2 A second voltage threshold, U, corresponding to a pair of electrode elements numbered j i Output voltage of a pair of electrode elements numbered i, U i2 I is more than or equal to 1 and less than or equal to N, and the second voltage threshold value is corresponding to the electrode element pair with the number i.
Optionally, in the second state and/or in the third state, the working time of any pair of electrode elements, of which the output alternating voltage is smaller than the corresponding first voltage threshold value, in each working cycle is determined according to the working current of the any pair of electrode elements.
For example, in the second state and/or the third state, the working time of any pair of electrode elements, of which the output alternating voltage is smaller than the corresponding first voltage threshold value, in one working cycle is determined according to the following formula:
wherein, T j The working time of a pair of electrode elements with the output alternating voltage being less than the corresponding first voltage threshold value and numbered j in each working period is more than or equal to 1 and less than or equal to N, T is the duration of the working period, K 2 Is a proportionality coefficient, I j Operating current of a pair of electrode elements numbered j, I i I is more than or equal to 1 and less than or equal to N for the working current of the pair of electrode elements with the number of i.
Optionally, the apparatus further comprises: and sending out prompt information of abnormal operation of the equipment to the user in a fourth state, wherein the fourth state is a state that the alternating voltages applied to the N pairs of electrode elements are all smaller than the corresponding second voltage threshold values.
In the fourth state, the working voltage of each pair of electrode elements is relatively low in the fourth state, and no safety problem exists, so that the device can be stopped, and only a user is prompted that the current device works abnormally. When the temperature parameter of each pair of electrode elements is increased to exceed a certain limit, an alarm is required to prompt.
Optionally, in the third state, the idle time in each duty cycle is continuous. I.e. if there is an idle time in each duty cycle, the idle time is not spaced. Of course, after the operating time of each pair of electrode elements is determined, the total duration of the idle time is also determined. The idle time may also be divided into multiple segments.
Referring to fig. 3, further embodiments of the present disclosure provide a device for inhibiting tumor proliferation by using an electric field, the device having N pairs of electrode elements for attaching to the skin of a user, N ≧ 2, each pair of electrode elements for applying an ac electric field to a target region of the body of the user, different pairs of electrode elements applying ac electric fields to the target region in different directions, in a steady state, with an increase in a temperature parameter of any one pair of electrode elements, an ac voltage output by any one pair of electrode elements being gradually or stepwise decreased, working times of the pairs of electrode elements in a working state in any one working period being continuous, durations of the working periods being equal, each working period being equally divided into N sub-working periods, and a maximum of one pair of electrode elements in a working state in each sub-working period, each pair of electrode elements is operated at most in one sub-duty cycle, the device comprising the following states.
This embodiment is different from the embodiment shown in fig. 2 in that when the operation time of one pair of electrode elements is shortened, the operation time of the remaining electrode elements is not increased. The operating time of each pair of electrode elements is independently determined. And the idle time is spread out for each sub-duty cycle.
For example, when the device has 3 pairs of electrode elements, such as 1 pair of electrode elements outputting an ac voltage smaller than its corresponding first voltage threshold and the other 2 pairs of electrode elements outputting an ac voltage larger than their corresponding first voltage thresholds, the duration of one duty cycle is denoted as T, and then the duty cycle of the first 1 pair of electrode elements is reduced, for example, to
The working time of the other two pairs of electrode elements is
Optionally, in the second state and/or in the third state, an operating time of any pair of electrode elements, of which the output alternating voltage is smaller than the corresponding first voltage threshold value thereof, in each operating cycle is determined according to the operating voltage of the any pair of electrode elements and the corresponding first voltage threshold value of the any pair of electrode elements.
The greater the degree to which the operating voltage of a pair of electrode elements is lower than the corresponding first voltage threshold value, the higher the temperature of the pair of electrode elements, the shorter the operating time of the pair of electrode elements.
For example, in the second state and/or in the third state, the operating time of any pair of electrode elements, of which the output alternating voltage is smaller than the corresponding first voltage threshold value, in each operating cycle is determined according to the following formula:
wherein, T j J is more than or equal to 1 and less than or equal to N, T is the duration of the working period, K is the working time of a pair of electrode elements which output alternating voltage and are less than the corresponding first voltage threshold and are numbered j in each working period 3 Is a proportionality coefficient, U j Output voltage of a pair of electrode elements with number j, U j1 A first voltage threshold corresponding to a pair of electrode elements numbered j.
Based on the same inventive concept, referring to fig. 4, an embodiment of the present disclosure also provides a control apparatus of a device for suppressing tumor proliferation using an electric field, including: at least one processor; and a memory communicatively coupled to the at least one processor; wherein the memory stores instructions executable by the at least one processor to enable the at least one processor to control the apparatus.
The control means may particularly be realized by a Microcontroller (MCU).
Based on the same inventive concept, embodiments of the present disclosure further provide an apparatus for inhibiting tumor proliferation by using an electric field, including N pairs of electrode elements, where the electrode elements are configured to be attached to the skin of a user, N is greater than or equal to 2, each pair of electrode elements is configured to apply an ac electric field to a target area of the body of the user, directions of the ac electric fields applied to the target area by different pairs of electrode elements are different, an ac voltage applied to any one pair of electrode elements is related to a temperature parameter of any one pair of electrode elements, the ac voltage of any one pair of electrode elements decreases or decreases stepwise as the temperature parameter of any one pair of electrode elements increases in a steady state, and a duration of the working period is equal.
The embodiments in the disclosure are described in a progressive manner, and the same and similar parts among the embodiments can be referred to each other, and each embodiment focuses on the differences from the other embodiments.
The scope of the present disclosure is not limited to the above-described embodiments, and it is apparent that various modifications and variations can be made to the present disclosure by those skilled in the art without departing from the scope and spirit of the present disclosure. It is intended that the present disclosure also cover the modifications and variations of this invention provided they come within the scope of the appended claims and their equivalents.
Claims (12)
1. An apparatus for inhibiting tumor proliferation using an electric field, the apparatus having N pairs of electrode elements for application to the skin of a user, N ≧ 2, each pair of electrode elements for applying an ac electric field to a target area of the body of the user, the different pairs of electrode elements applying ac electric fields in different directions to the target area, the ac voltages output by any pair of electrode elements decreasing stepwise or decreasing stepwise as a temperature parameter of any pair of electrode elements increases in a steady state, the pairs of electrode elements in an active state during any one duty cycle having no interruption in their operation times and no overlap with each other, the duty cycles having equal durations, the apparatus comprising:
in a first state, the working time of each working cycle of the N pairs of electrode elements is equal, and no idle time exists in the working cycle, wherein the first state is a state that the alternating voltage applied to each pair of electrode elements is greater than the first voltage threshold corresponding to the pair of electrode elements;
in a second state, the working time of any pair of electrode elements with the output alternating voltage smaller than the corresponding first voltage threshold value in each working cycle is adjusted and reduced relative to the working time of the electrode elements in the first state, the working time of any pair of electrode elements with the output alternating voltage larger than the corresponding first voltage threshold value in each working cycle is equal, and no idle time exists in each working cycle, and the second state is a state that the alternating voltage applied to at least one pair of electrode elements is smaller than the corresponding first voltage threshold value of the pair of electrode elements and the alternating voltage applied to at least one pair of electrode elements is larger than the corresponding first voltage threshold value of the pair of electrode elements;
in a third state, the working time of any pair of electrode elements is adjusted to be shorter than the working time of any pair of electrode elements in the first state, and the third state is a state in which the alternating voltages applied to the N pairs of electrode elements are smaller than the corresponding first voltage threshold values.
2. The apparatus according to claim 1, wherein in the second state and/or in the third state, an operating time of any pair of electrode elements, of which the output ac voltage is smaller than the corresponding first voltage threshold value, in each operating cycle is determined according to the operating voltage of the any pair of electrode elements and the corresponding second voltage threshold value of the any pair of electrode elements, wherein the corresponding second voltage threshold value of each pair of electrode elements is smaller than the corresponding first voltage threshold value.
3. The apparatus according to claim 2, wherein in the second state and/or in the third state, the operating time of any pair of electrode elements outputting an ac voltage smaller than the corresponding first voltage threshold in each operating cycle is determined according to the following formula:
wherein, T j J is more than or equal to 1 and less than or equal to N, T is the duration of the working period, K is the working time of a pair of electrode elements which output alternating voltage and are less than the corresponding first voltage threshold and are numbered j in each working period 1 Is a proportionality coefficient, U j Output voltage of a pair of electrode elements with number j, U j2 A second voltage threshold, U, corresponding to a pair of electrode elements numbered j i Output voltage of a pair of electrode elements numbered i, U i2 I is more than or equal to 1 and less than or equal to N, and the second voltage threshold value is corresponding to the electrode element pair with the number i.
4. The apparatus according to claim 1, wherein in the second state and/or in the third state, an operating time of any pair of electrode elements, which output an alternating voltage smaller than its corresponding first voltage threshold, in each operating cycle is determined according to an operating current of the any pair of electrode elements.
5. The apparatus according to claim 4, wherein in the second state and/or in the third state, the working time of any pair of electrode elements with the output AC voltage smaller than the corresponding first voltage threshold in one working cycle is determined according to the following formula:
wherein, T j The working time of a pair of electrode elements with the output alternating voltage being less than the corresponding first voltage threshold value and numbered j in each working period is more than or equal to 1 and less than or equal to N, T is the duration of the working period, K 2 Is a proportionality coefficient, I j Operating current of a pair of electrode elements numbered j, I i I is more than or equal to 1 and less than or equal to N.
6. The apparatus of any of claims 2 to 5, further comprising: and in a fourth state, sending out prompt information of abnormal operation of the equipment to the user, wherein the fourth state is a state that the alternating voltages applied to the N pairs of electrode elements are all smaller than the corresponding second voltage threshold values.
7. The apparatus of claim 1, wherein in the third state, the idle time in each duty cycle is continuous.
8. An apparatus for inhibiting tumor proliferation by using an electric field, the apparatus having N pairs of electrode elements, N is larger than or equal to 2, each pair of electrode elements is used for applying an alternating current electric field on a target area of a user body, the directions of the alternating current electric fields applied on the target area by the different pairs of electrode elements are different, the alternating current voltage output by any pair of electrode elements is gradually reduced or reduced in steps along with the increase of the temperature parameter of any pair of electrode elements in a stable state, the working time of each pair of electrode elements in a working state in any working period is uninterrupted, the duration of each working period is equal, each working period is equally divided into N sub-working periods, at most one pair of electrode elements in a working state in each sub-working period, and each pair of electrode elements works in at most one sub-working period, the method is characterized in that:
in a first state, the working time of each working cycle of the N pairs of electrode elements is equal, and no idle time exists in the working cycle, wherein the first state is a state that the alternating voltage applied to each pair of electrode elements is greater than the first voltage threshold corresponding to the pair of electrode elements;
in a second state, the working time of any pair of electrode elements with output alternating voltages smaller than the corresponding first voltage threshold value in each working cycle is adjusted and reduced relative to the working time of the electrode elements in the first state, the working time of any pair of electrode elements with output alternating voltages larger than the corresponding first voltage threshold value in each working cycle is equal to the working time of the electrode elements in the first state, and the second state is a state that the alternating voltages applied to at least one pair of electrode elements are smaller than the corresponding first voltage threshold value of the electrode elements and the alternating voltages applied to at least one pair of electrode elements are larger than the corresponding first voltage threshold value of the electrode elements;
in a third state, the working time of any pair of electrode elements is adjusted to be smaller than the working time of any pair of electrode elements in the first state, and the third state is a state in which the alternating voltages applied to the N pairs of electrode elements are smaller than the corresponding first voltage threshold values.
9. The apparatus according to claim 8, wherein in the second state and/or in the third state, the working time of any pair of electrode elements, which output an alternating voltage smaller than the corresponding first voltage threshold value, in each working cycle is determined according to the working voltage of the any pair of electrode elements and the corresponding first voltage threshold value of the any pair of electrode elements.
10. The apparatus according to claim 9, wherein in the second state and/or in the third state, the working time of any pair of electrode elements outputting an alternating voltage smaller than the corresponding first voltage threshold value in each working cycle is determined according to the following formula:
wherein, T j J is more than or equal to 1 and less than or equal to N, T is the duration of the working period, K is the working time of a pair of electrode elements which output alternating voltage and are less than the corresponding first voltage threshold and are numbered j in each working period 3 Is a proportionality coefficient, U j Output voltage of a pair of electrode elements with number j, U j1 Is numbered asj, a first voltage threshold corresponding to the pair of electrode elements.
11. A control device for an apparatus for inhibiting tumor proliferation using an electric field, comprising: at least one processor; and a memory communicatively coupled to the at least one processor; wherein the memory stores instructions executable by the at least one processor to enable the at least one processor to control the apparatus according to any one of claims 1 to 10.
12. A device for inhibiting tumor proliferation by means of an electric field, comprising N pairs of electrode elements for attachment to the skin of a user, N ≧ 2, each pair of electrode elements for applying an alternating electric field at a target area of the body of the user, the different pairs of electrode elements applying alternating electric fields at the target area in different directions, an alternating voltage applied to any one pair of electrode elements being related to a temperature parameter of the any one pair of electrode elements, the alternating voltage of the any one pair of electrode elements decreasing or stepwise decreasing in steady state as the temperature parameter of the any one pair of electrode elements increases, the duration of the duty cycle being equal, characterized in that the device further comprises a control apparatus according to claim 11.
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| PCT/CN2023/074380 WO2023155692A1 (en) | 2022-02-17 | 2023-02-03 | Device for inhibiting tumor growth by utilizing electric field, and method and apparatus for controlling same |
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| US20210196967A1 (en) * | 2019-12-31 | 2021-07-01 | Novocure Gmbh | Methods, systems, and apparatuses for managing temperatures induced by alternating fields |
| CN113350689A (en) * | 2021-06-08 | 2021-09-07 | 湖南安泰康成生物科技有限公司 | Equipment for inhibiting tumor proliferation by using electric field and detection method and device thereof |
| CN114534091B (en) * | 2022-02-17 | 2022-09-09 | 湖南安泰康成生物科技有限公司 | Apparatus for inhibiting tumor proliferation by electric field and control device thereof |
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| CA2835676A1 (en) * | 2011-05-09 | 2012-11-15 | Innovolink, Llc | Apparatus and method for heating a treatment region with an alternating electric field |
| CN109432601A (en) * | 2017-10-20 | 2019-03-08 | 湖南安泰康成生物科技有限公司 | Equipment for destroying and inhibiting patient's body pathological tissues fast-growth |
| CN111683613A (en) * | 2017-12-26 | 2020-09-18 | 盖乐世公司 | Optimization of energy delivery for various applications |
| CN113015553A (en) * | 2018-11-19 | 2021-06-22 | 诺沃库勒有限责任公司 | Array for delivering a tumor treatment field (TTField) with selectively addressable subelements |
| TW202138023A (en) * | 2019-12-31 | 2021-10-16 | 瑞士商諾沃庫勒有限責任公司 | Arrays for delivering tumor treating fields (ttfields) with individually accessible electrode elements and temperature sensors |
| CN212631448U (en) * | 2020-04-02 | 2021-03-02 | 河北普尼医疗科技有限公司 | Intermediate frequency alternating electric field tumor treatment device with temperature detection function |
| CN113008403A (en) * | 2021-02-08 | 2021-06-22 | 清华大学 | Electric field generating device and temperature measuring electrode device |
| CN113368389A (en) * | 2021-06-08 | 2021-09-10 | 湖南安泰康成生物科技有限公司 | Equipment for inhibiting tumor proliferation by using electric field and control method and device thereof |
| CN113663215A (en) * | 2021-10-22 | 2021-11-19 | 杭州维纳安可医疗科技有限责任公司 | Electric field generating apparatus, control method thereof, and computer-readable storage medium |
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| WO2023155692A1 (en) | 2023-08-24 |
| CN114534091A (en) | 2022-05-27 |
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