CN109432601A - Equipment for destroying and inhibiting patient's body pathological tissues fast-growth - Google Patents
Equipment for destroying and inhibiting patient's body pathological tissues fast-growth Download PDFInfo
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- CN109432601A CN109432601A CN201811229089.3A CN201811229089A CN109432601A CN 109432601 A CN109432601 A CN 109432601A CN 201811229089 A CN201811229089 A CN 201811229089A CN 109432601 A CN109432601 A CN 109432601A
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- A—HUMAN NECESSITIES
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- A61N2/00—Magnetotherapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
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- A—HUMAN NECESSITIES
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
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Abstract
The present invention discloses a kind of equipment for destroying and inhibiting patient's body pathological tissues fast-growth comprising: x is to electric field electrode, x >=2；Y signal source, the y signal source are arranged to the x to the permanent width electric field signal of any pair of output in electric field electrode, x >=y, y >=1；And control device, the control device exports permanent width electric field signal for controlling the y signal source respectively with on-fixed sequence within the unit time to the x to electric field electrode, so that the sequence that the x generates permanent width electric field to electric field electrode is not fixed, the perseverance width electric field is applied to the internal pathological tissues of patient and the fast-growth of the pathological tissues for destroying and inhibiting patient's body.Embodiment according to the present invention can form the rotating electric field of mono signal or dual signal 2 betweens of electric field electrodes, can also be 3 pairs to 4 betweens electric field electrodes, can be by the random unordered a variety of electric field mapping modes of pattern formation, and the rate for rotating or converting is adjustable.
Description
Technical field
The present invention relates to a kind of electronic equipments for medical field, more specifically to one kind for destroying and pressing down
The equipment of patient's body pathological tissues fast-growth processed.
Background technique
The basic principle of oncotherapy electric field (Tutor Treating Field, TTF) is established in electric field to swollen at present
On the basis of oncocyte mitosis hinders.The different frequency of electric field, different directions and varying strength show different
Tumor inhibitory effect.
Different frequencies are elaborated in a patent document (CN1976738B) of oncotherapy electric field founder Yoram Palti
Treatment of the rate electric field to tumour.The technology uses uniform AC electric field, when tumour cell mitosis is in late-anaphase and latter stage
When, when a cell will be split into two daughter cells, there is the geometry " cleavage groove " to play a crucial role in center, applies
Current line caused by electric field enters from a pole of daughter cell, and high aggregation is pierced by cleavage groove, then from another pole of cell.Quilt
The organelle of current line guidance is assembled to cleavage groove, increases film pressure at this, and final because of " hammering effectiveness ", makes cell from ovum
It is ruptured at dehiscence furrow.Specifically, cell division could be destroyed when direction of an electric field is only parallel with cell division long axis.The technology
The device frequency of use being related to be 50KHz-500KHz, electric field strength 0.1V/cm-10V/cm, wherein optimized frequency and preferably
Strength range is 100KHz-300KHz and 1V/cm-5V/cm respectively.Studies have shown that the most suitable inhibition frequency of melanoma and strong
Degree is 120KHz, 1.35V/cm, and inhibiting the optimum frequency of F-98 glioma is the (practice of two peak values of 170KHz and 250KHz
In take fixed value 200KHz), optimal strength 2.25V/cm.In practice in order to balance the sensitive frequency of different cells and point
Long axis direction is split, which more alternately emits two or more frequencies, and the conversion field direction during every kind of frequency in turn
For several times.360 degree rotation electricity is elaborated in an other patent document (CN101124011A) of Yoram Palti in further detail
Field direction inhibits tumour, is realized at least three electrodes using different alternating voltages, and rotation 4 times per second, rotation speed
Degree is the inverse of electric field frequency.
But these current instrument and equipment volumes are larger, and it is non-portable, and regular rotation is pressed in the direction of electric field, is swollen
Oncocyte is easy to generate biological tolerance to regular sexual stimulus, and effect will be affected after treating for a long time.
In addition, the effect of electric field treatment is inhibition growth of tumour cell, meanwhile, low frequency rotating magnetic field also can be to tumour cell
Inhibiting effect is played in growth.Clinically, many patient with brain tumors, it is especially postoperative, with the situation of brain function deficiency, packet
Linguistic function, motor function, memory function, emotional handicap etc., the magnetic field that the electric field of the variation of this equipment generates are included, and is combined
Magnetic field electrode can become the means for improving brain function in a manner of transcranial magnetic stimulation.Meanwhile through cranium direct current possessed by this equipment
Electrical stimulus patterns are used in combination together with electric field treatment, and the function of promoting normal nervous tissue improves, and improve life quality.
Summary of the invention
In view of problem possessed by previous electronic equipment, it is an object of that present invention to provide one kind can be improved therapeutic effect
The equipment for destroying and inhibiting patient's body pathological tissues fast-growth, for example, it may be portable device.
On the one hand, the present invention provides a kind of equipment for destroying and inhibiting patient's body pathological tissues fast-growth,
It include: x to electric field electrode, x >=1；Y signal source, the signal source are arranged to the x to any pair in electric field electrode
Export electric field signal, x >=y >=1；And control device, the control device are based on default mould for controlling the y signal source
Formula generates the electricity for the internal pathological tissues for being applied to patient to the x to any pair of output electric field signal in electric field electrode
, the fast-growth for the pathological tissues that the electric field is used to destroying and inhibiting patient's body.For example, the quantity of electric field electrode can be with
It is 1 pair, 2 pairs, 3 pairs or more right.Control device can control y signal source and be divided to x electric field electrode with on-fixed sequence
Not Shu Chu electric field signal so that x to electrode generate electric field sequence be not fixed.
In some embodiments, any pair of output electric field in electric field electrode is believed to the x based on preset mode
It number include: within the unit time to the output of each pair of electric field electrode close to the electric field signal of preset times, wherein to each pair of electric field electricity
The number of pole reality output electric field signal and the deviation of the preset times are no more than 80%.Optionally, based on preset mode to
The x includes: to export in advance within the unit time to each pair of electric field electrode to any pair of output electric field signal in electric field electrode
If the electric field signal of number.The unit time can be 0.1~12 second/period, such as be also possible to 0.1~4 second/period,
Such as 1 second.The preset times can be 1 time.
Alternatively, in the case of x >=2, based on preset mode to the x to any pair of output in electric field electrode
Electric field signal includes:
A. the x is put into wait select to gather electric field electrode；
B. from described wait select to choose any pair of electric field electrode in set, and electricity is exported to a pair of of electric field electrode of selection
Field signal；
C. by a pair of of electric field electrode of selection from it is described wait select set in remove；
D. described in judgement wait select whether set is sky if it is empty, then a is executed, then executes b if not empty.The output side
Formula is a kind of on-fixed sequence.
Alternatively, in the case of y=x >=2, based on preset mode to the x to any pair in electric field electrode
Exporting electric field signal includes: at least two pairs of electric field electrodes while to export electric field signal.Alternatively, be also possible to the same time to
At least a pair of of electric field electrode exports permanent width electric field signal.
Alternatively, x=y, each signal source only export electric field signal to a pair of of electric field electrode in the same time.
Optionally, the electric field signal can be sine wave signal, square-wave signal and sharp wave signal.
Wherein, the time for the electric field signal that each signal source is exported to a pair of of electric field electrode every time can be 0.1~3 second,
Such as 0.1~1 second, crest voltage can be 2~180V, and frequency can be 45~550KHz, such as 100~500KHz, such as
100~300KHz, such as 200KHz.Optionally, the sine wave signal includes simple signal, amplitude-modulated signal, FM signal, jump
Frequency signal.Wherein, the frequency of the Frequency Hopping Signal is beated within centre frequency ± 5%, and the frequency of the FM signal is in
It is swung within frequency of heart ± 5%.
Optionally, the frequency of the electric field can be 45~550KHz, and field strength can be 0.1~11V/cm.For example, electric field
Frequency can be 100~500KHz, such as 100~300KHz, such as 200KHz, field strength can be 0.7~4V/cm, such as
4V/cm.For example, electric field can be for permanent width electric field, i.e., the consistent electric field of peak amplitude generated by alternating current.
In some embodiments, the equipment may also include at least a pair of magnetic field electrode, have on the magnetic field electrode
Around to consistent coil, the control device controls the signal source and exports magnetic field signal to the magnetic field electrode to generate application
To the magnetic field of the internal pathological tissues of patient.Optionally, the 0.5~10Hz of frequency in magnetic field, field strength >=1mT.
In some embodiments, the equipment may also include at least a pair of of galvanic electrode, and the control device controls institute
Stating signal source is stimulated to the galvanic electrode output current signal with the electric current for generating the internal pathological tissues for being applied to patient.Institute
Stating current signal can be direct current signal, square-wave signal or sharp wave signal.When current signal is square-wave signal or sharp wave signal,
Its duty ratio is adjustable, depth is adjustable.Wherein, the 2~24V of direct-flow signal voltage, can take one of following forms or more
Kind: lasting, interrupted, ladder, tide or surge.When take discontinuously, ladder, tide or duty ratio is adjustable when surge form, depth
It is adjustable.
On the other hand, the present invention provides a kind of for destroying and inhibiting setting for patient's body pathological tissues fast-growth
It is standby, comprising: a electric field electrode of x ', x ' >=3；A signal source of y ', the signal source are arranged to any into the electric field electrode
Two output electric field signals, 0 < y '≤x '；And control device, the control device are based in advance for controlling the signal source
If any two output electric field signal of the mode into the electric field electrode is to generate the internal pathological tissues for being applied to patient
Electric field, the fast-growth for the pathological tissues that the electric field is used to destroying and inhibiting patient's body.For example, the quantity of electric field electrode can
Be 3,4,5 or more.It is electric to a electric field of x ' with on-fixed sequence that control device can control a signal source of y '
Any two of pole export electric field signal, so that the sequence that a electrode of x ' generates electric field is not fixed.
Optionally, any two output electric field signal based on preset mode into a electric field electrode of the x ' includes:
A. the combination of 2 electric field electrodes any in a electric field electrode of the x ' is put into wait select to gather；
B. from the combination wait select to choose any 2 electric field electrodes in set, and electricity is exported to 2 electric field electrodes of selection
Field signal；
C. by the combination of 2 electric field electrodes of selection from wait select set in remove, for example, to 2 electric field electricity of selection
Pole elects label, by 2 electric field electrodes with selected marker from wait select to remove in set；
D. judge whether wait select to gather be sky, if it is empty, then executes a, then executes b if not empty.The way of output is
For a kind of on-fixed sequence.
The present invention has following advantageous effects compared with the existing technology:
Equipment of the invention is a kind of equipment that can collect electric field, the multiple electric signal treatment disease of electric current and magnetic field, is convenient for
Patient carries wearing, can adjoint treatment whenever and wherever possible.
The configuration signal diversification of the equipment.Signal source can provide electric field signal (alternating signal), such as sine wave letter
Number, square-wave signal, sharp wave signal etc., wherein sine wave signal can be in single-frequency, amplitude modulation, frequency modulation, frequency hopping optionally.Signal source is also
Current signal (direct current signal) can be provided, the forms such as lasting, interrupted, ladder, tide or surge may be selected, interrupted, ladder, tide
Duty ratio is adjustable when nighttide or surge, depth is adjustable.
The electric field applying mode diversification of equipment.Equipment of the invention can not only form mono signal or double 2 betweens of electrodes
The rotating electric field of signal by the mode orderly switched one by one or random unordered can also switch one by one 3 pairs to 4 betweens electrodes
Mode forms a variety of electric field mapping modes, and the rate for rotating or converting is adjustable.Electric field generated not only may include electricity
The direct electric field of interpolar, can also include the instantaneous strong electrical field of low frequency, which can and frequency higher by 2 frequencies
Signal similar in rate is applied to the electrode of 2 pairs of directions intersection and dry due to wave in the region of 2 pairs of electrode directions intersection simultaneously
It relates to effect and generates, tumour cell when destroying in mitosis late-anaphase and latter stage.
The magnetic stimulation mode diversification of equipment.Magnetic field of the invention with magnetic field electrode to for generation unit, in the same direction to 2
Concatenated coil is subject to alternating signal (sine wave signal, square-wave signal, sharp wave signal etc.), or is subject to direct current signal and (may be selected
The forms such as lasting, interrupted, ladder, tide or surge, discontinuously, ladder, tide or duty ratio is adjustable, depth is adjustable when surge),
Magnetic field in the same direction is generated between this 2 coils.Using the potential change of the flux control nerve cell, reaching improves the metabolism of patient's intracerebral
With the purpose of bioelectrical activity.
The electric current stimulation mode diversification of equipment.Electric current stimulation of the invention with galvanic electrode to for applying unit, at 2 pairs
Being subject to direct current signal between electrode (may be selected the form of lasting, interrupted, ladder, tide or surge, interrupted, ladder, tide or surge
When duty ratio is adjustable, depth is adjustable), or be subject to square-wave signal, sharp wave signal, flow through target area, reaching improves patient's intracerebral
The purpose of metabolism and bioelectrical activity.
Detailed description of the invention
Figure 1A show according to embodiments of the present invention 1 for destroying and inhibit patient's body pathological tissues fast-growth
The electric field electrode of equipment is laid out；Figure 1B to Fig. 1 E respectively illustrates the generation of the electric field of according to embodiments of the present invention 1 equipment.
Fig. 2 shows according to embodiments of the present invention 2 for destroying and inhibiting patient's body pathological tissues fast-growth
Equipment.
Fig. 3 show according to embodiments of the present invention 3 for destroying and inhibit patient's body pathological tissues fast-growth
Equipment.
Fig. 4 show according to embodiments of the present invention 4 for destroying and inhibit patient's body pathological tissues fast-growth
Equipment.
Fig. 5 show according to embodiments of the present invention 5 for destroying and inhibit patient's body pathological tissues fast-growth
Equipment.
Fig. 6 A show according to embodiments of the present invention 6 for destroying and inhibit patient's body pathological tissues fast-growth
Equipment；Fig. 6 B shows the generation of according to embodiments of the present invention 6 interference electric field.
Fig. 7 show according to embodiments of the present invention 7 for destroying and inhibit patient's body pathological tissues fast-growth
The electric field electrode of equipment is laid out.
Fig. 8 show according to embodiments of the present invention 8 for destroying and inhibit patient's body pathological tissues fast-growth
The generation in the magnetic field of equipment.
Fig. 9 A to Fig. 9 E shows the fluidic cell figure of each test group for carrying out test cell line.
Specific embodiment
It is described in detail to various aspects of the present invention below in conjunction with the drawings and specific embodiments.Wherein, in attached drawing
Component be not necessarily drawn to scale, focus on that the principle of the present invention is illustrated.
In various embodiments of the present invention, well-known structure or material are not shown or do not elaborate.And
And described feature, structure or characteristic can combine in any way in one or more embodiments.In addition, this field
It will be appreciated by the skilled person that following various embodiments are served only for the protection scope for example, and is not intended to limit the present invention.
Can also be readily appreciated that, the component in each embodiment described herein and shown in the drawings can in a variety of different configurations or ratio into
Row arrangement and design.
[embodiment 1]
Figure 1A is the equipment for destroying and inhibiting patient's body pathological tissues fast-growth shown according to embodiment 1
The schematic diagram of electric field electrode layout.Figure 1B to Fig. 1 E is the schematic diagram that electric field electrode shown in Figure 1A applies electric field.
As shown in Figure 1A, may include 4 pairs of electric field electrodes according to the equipment of the present embodiment, be respectively by electric field electrode A1 and
Electric field electrode A2 constitute electric field electrode to A1, A2, the electric field electrode being made of electric field electrode B1 and electric field electrode B2 to B1,
B2, the electric field electrode being made of electric field electrode C1 and electric field electrode C2 is to C1, C2, and by electric field electrode D1 and electric field electrode D2
The electric field electrode of composition is to D1, D2.When in use, 4 pairs of electric field electrodes can surround the pathological tissues of patient's body, example
Such as, intracerebral lesion tissue T.The equipment of the present embodiment may also include 1 signal source and control device, in order to clearly show
Signal source and control device is omitted in Figure 1A in the layout of electric field electrode.
In one embodiment, the control device can include but is not limited to processor, memory etc., wherein institute
It states memory and is stored with control parameter and computer-readable instruction/program etc., the processor executes the computer-readable finger
Order/program exports electric field signal to control the signal source according to the control parameter to the electric field electrode.For example, institute
Stating control parameter includes unit time, the time interval for exporting electric field, to default time of each pair of electric field electrode output electric field signal
Number, the actual frequency of output electric field signal and deviation of preset times etc..Control device controls this signal source and is based on default mould
Any pair output electric field signal of the formula into 4 pairs of electric field electrodes, which refers to is stored in control device before use
For control electric field signal output mode.For example, the output based on preset mode can be within the unit time to each pair of
Electric field electrode exports the electric field signal of the preset times, such as exports described preset respectively to electric field electrode with on-fixed sequence
The electric field signal of number is also possible to electric field signal of the reality output close to preset times, such as actual frequency and preset times
Deviation be no more than 80%, etc..When signal source to electric field electrode to output electric field signal when can produce and be applied to patient's
The electric field of internal pathological tissues, the fast-growth for the pathological tissues which is used to destroying and inhibiting patient's body.When with non-solid
When determining Sequential output signal, the sequence that electric field electrode generates permanent width electric field is not fixed, i.e. 4 pairs of electric field electrodes random orderings or random real estate
Raw electric field, for example, each period generate electric field sequence can different or adjacent periods generate electric field sequence it is different.
Wherein, the unit time is 0.1~12 second/period, preset times 1.In the present invention, " preset times 1 " refer to
To be each period (such as 0.1~12 second) at least preset 1 electric field signal of output to each pair of electric field electrode, preset times can also
To be 2 or 3 or other numbers, actual output times may also and preset times there are deviations, such as it is inclined no more than 80%
Difference.Unit time is also possible to other times, such as 0.1~4 second/period etc..In actual use, begin to use in booting
Afterwards, the circulation in infinite a period can be carried out without artificially shutting down.
When in use, user (such as doctor, patient etc.) can be such that 4 pairs of electric field electrodes uniformly divide around pathological tissues
Cloth, so that the electric field generated intersects at pathological tissues T.
In alternative embodiments, control device may include programmable logic processing circuit, single-chip microcontroller, microcomputer etc.,
Its output that can be programmed to control electric field signal.Specifically, in order to realize based on preset mode into 4 pairs of electric field electrodes
Any pair of output electric field signal, the processing that the control device executes may include:
A. by 4 pairs of electric field electrodes (i.e. electric field electrode to A1, A2, electric field electrode to B1, B2, electric field electrode to C1, C2, with
And electric field electrode is to D1, D2) it is put into wait select to gather, such as [A1 and A2, B1 and B2, C1 and C2, D1 and D2]；
B. believe from wait select to choose any pair of electric field electrode in set, and to a pair of of electric field electrode of selection output electric field
Number；As shown in Figure 1B, electric field electrode is randomly selected to A1, A2, and electric field signal is sent to A1, A2 to electric field electrode, in this way, electric
Field plate A1 and electric field electrode A2 generates the electric field for surrounding pathological tissues T；
C. by a pair of of electric field electrode of selection from wait select set in remove, i.e., wait select set become [B1 and B2, C1 and
C2, D1 and D2]；
D. judge whether wait select to gather be sky, if it is empty, then executes a, then executes b if not empty.
As a result, as shown in Fig. 1 C to Fig. 1 E, selection electric field electrode to A1, A2 after, random selection electric field electrode to D1,
D2, electric field electrode is to B1, B2, and electric field electrode is to C1, C2.
This is a kind of processing of on-fixed sequence, can also otherwise on-fixed sequence.
After all electric field electrodes were to being carried out electric field and applying, by all electric field electrodes to being reentered into choice set
It closes, and electric field is randomly generated again.In this way, different order generate electric field, such random process mode is to pathological tissues example
Interference such as growth of tumour cell is stronger, can preferably inhibit and destroy its fast-growth.
Optionally, the electric field signal of output can be the signals such as sine wave, square wave or sharp wave, after exporting 0.1~3 second every time
Change a pair of of electric field electrode output.The frequency of the electric field of generation is 45~550KHz, and field strength is 0.1~11V/cm, for example, electric field
Frequency can be 100~300KHz, field strength can be 0.7~4V/cm, such as 4V/cm, electric field can be permanent width electric field etc..
[embodiment 2]
Fig. 2 shows the equipment for destroying and inhibiting patient's body pathological tissues fast-growth according to embodiment 2.This
Embodiment the difference from embodiment 1 is that, the equipment in the present embodiment may include 2 signal sources, i.e. signal source a and signal source b,
Wherein, electric field electrode is to the electric field electrode A1 in A1, A2 via switch KA1It is connect with signal source a and b, electric field electrode A2 is via opening
Close KA2It is connect with signal source a and b；Electric field electrode is to the electric field electrode B1 in B1, B2 via switch KB1Connect with signal source a and b
It connects, electric field electrode B2 is via switch KB2It is connect with signal source a and b；Electric field electrode is to the electric field electrode C1 in C1, C2 via switch
KC1It is connect with signal source a and b, electric field electrode C2 is via switch KC2It is connect with signal source a and b；Electric field electrode is in D1, D2
Electric field electrode D1 is via switch KD1It is connect with signal source a and b, electric field electrode D2 is via switch KD2It is connect with signal source a and b.This
Sample, controls the conducting and disconnection of the switch by control device (not shown), and signal source a and signal source b can be to any right
Electric field electrode exports electric field signal.For example, control device is when selection needs to export the electric field electrode of electric field signal to A1, A2,
Make switch KA1With switch KA2Any one signal source is connected, it, can also be with for example, signal source a and signal source b can be also turned on
It is respectively turned on signal source a or signal source b, the signal source being switched on exports electric field signal to corresponding electric field electrode.To so that electric
Field plate generates electric field to A1, A2.Control device be connected by arbitrarily selecting electric field electrode to corresponding a pair of switches and
It disconnects, to realize random selection electric field electrode to electric field is randomly generated.Wherein, the processing of control device can same embodiment
Processing described in 1.
[embodiment 3]
Fig. 3 shows the equipment for destroying and inhibiting patient's body pathological tissues fast-growth according to embodiment 3.This
Embodiment the difference from example 2 is that, signal source a is arranged to export B1, B2 A1, A2 and electric field electrode to electric field electrode
Electric field signal, signal source b are arranged to export electric field signal to D1, D2 to C1, C2 and electric field electrode to electric field electrode.It is specific and
Speech, electric field electrode is to the electric field electrode A1 in A1, A2 via switch KA1It is connect with signal source a, electric field electrode A2 is via switch KA2
It is connect with signal source a；Electric field electrode is to the electric field electrode B1 in B1, B2 via switch KB1It is connect with signal source a, electric field electrode B2
Via switch KB2It is connect with signal source a；Electric field electrode is to the electric field electrode C1 in C1, C2 via switch KC1Connect with signal source b
It connects, electric field electrode C2 is via switch KC2It is connect with signal source b；Electric field electrode is to the electric field electrode D1 in D1, D2 via switch KD1
It is connect with signal source b, electric field electrode D2 is via switch KD2It is connect with signal source b.Control device needs to export electric field letter in selection
Number electric field electrode to rear, make corresponding switch conduction, to select corresponding signal source to the electric field electrode to output electric field
Signal.Wherein, the processing of control device can be identical as processing described in embodiment 1.
[embodiment 4]
Fig. 4 shows the equipment for destroying and inhibiting patient's body pathological tissues fast-growth according to embodiment 4.This
Embodiment the difference from embodiment 1 is that, the equipment in the present embodiment may include 4 signal sources, respectively signal source a, signal
Source b, signal source c and signal source d.Signal source a exports electric field signal to A1, A2 to electric field electrode, and signal source b is to electric field electrode
Electric field signal is exported to B1, B2, signal source c exports electric field signal to C1, C2 to electric field electrode, and signal source d is to electric field electrode pair
D1, D2 export electric field signal, and control device needs to export the electric field electrode of electric field signal to rear in selection, select corresponding signal
Source is to the electric field electrode to output electric field signal.
Certainly, electric field electrode included by the equipment of the embodiment of the present invention is not limited to 4 pairs, can be 2 pairs, 3 pairs, 5 pairs, more
It is multipair etc., it can be selected according to actual needs.Signal source is also not necessarily limited to 2 or 4, can be 1,3,5, it is more
It is a etc., it can be selected according to actual needs, it is preferable that the number of signal source is not more than the logarithm of electric field electrode.Output
Electric field signal is also not necessarily limited to sine wave, square wave or sharp wave, is also not necessarily limited to 0.1~3 second, can be to the time that electrode exports every time
0.1~1 second, it can be 0.1~12 second or longer etc., can be selected according to actual needs.
The electric field signal of output is also possible to Frequency Hopping Signal, FM signal etc., and the frequency of Frequency Hopping Signal can be in center frequency
It beats within ± the 5% of rate, the frequency of FM signal is swung within centre frequency ± 5%.
[embodiment 5]
Fig. 5 is the signal according to the equipment for destroying and inhibiting patient's body pathological tissues fast-growth of embodiment 5
Figure.
As shown in figure 5, may include electric field electrode E1, E2, F1, F2 according to the equipment of the present embodiment, i.e. 2 pairs of electric field electrodes.
Also, the equipment of the present embodiment may include signal source e and f and control device (not shown).Electric field electrode E1 is via switch KE1
It is connect with signal source e and f, electric field electrode E2 is via switch KE2It is connect with signal source e and f, electric field electrode F1 is via switch KF1With
Signal source e is connected with f, and electric field electrode F2 is via switch KF2It is connect with signal source e and f.Control device is controlled based on preset mode
Any pair output electric field signal of the signal source e and f into 2 pairs of electric field electrodes, it is defeated to each pair of electric field electrode within the unit time
The electric field signal of preset times out.Specifically, control device passes through control switch KE1With switch KE2On-off control signal source
E and f exports electric field signal to E1, E2 to electric field electrode and control device passes through control switch KF1With switch KF2On-off come
It controls signal source e and f and electric field signal is exported to F1, F2 to electric field electrode.When signal source to electric field electrode to output electric field signal
Shi Suoshu electric field electrode can produce the electric field of pathological tissues T in the brain N for be applied to patient, and the electric field is for destroying and inhibiting to suffer from
The fast-growth of the intracorporal pathological tissues of person.Wherein, the unit time is 0.1~12 second/period, preset times 1.
When in use, user (such as doctor, patient etc.) can make 2 pairs of electric field electrodes to uniform around pathological tissues T
Distribution, so that the electric field generated intersects at pathological tissues.For example, signal source e is to electric field electrode to E1, E2 output electric field letter
Number, signal source f exports electric field signal to F1, F2 to electric field electrode.
Any pair of output electric field signal based on preset mode into 2 pairs of electric field electrodes includes: same to 2 pairs of electric field electrodes
When export electric field signal, maintain 0.1~3 second, in this way, generate 2 electric fields for being applied to the different directions of pathological tissues simultaneously, this
The electric field intersection of 2 different directions stimulates pathological tissues, inhibits its growth to generate instantaneous low frequency electric field in intersection, it
Suspend 0.1~3 second output electric field signal afterwards, later abovementioned steps repeatedly.
Wherein, the electric field signal of output is sine wave signal, and 2 electric field signal frequency is higher and frequency is close, defeated every time
Electric field signal 0.1~3 second out suspends 0.1~3 second.45~550KHz of frequency of electric field, 0.1~11V/cm of field strength.Intersection wink
When low frequency electric field field strength be the sum of 2 electric field strengths, frequency is the difference of 2 electric field frequencies.
[embodiment 6]
Fig. 6 A show according to embodiments of the present invention 6 for destroying and inhibit patient's body pathological tissues fast-growth
Equipment；Fig. 6 B shows the generation of according to embodiments of the present invention 6 interference electric field.The present embodiment and the difference of embodiment 5 be,
Equipment in the present embodiment includes 4 pairs of electric field electrodes, i.e., electric field electrode is to E1, E2, and electric field electrode is to F1, F2, electric field electrode pair
G1, G2 and electric field electrode are to H1, H2.Wherein, signal source e can be defeated to F1, F2 to E1, E2 and electric field electrode to electric field electrode
Electric field signal out, signal source f can export electric field signal to H1, H2 to G1, G2 and electric field electrode to electric field electrode.Specifically,
Electric field electrode is to the electric field electrode E1 in E1, E2 via switch KE1It is connect with signal source e, electric field electrode E2 is via switch KE2With
Signal source e connection；Electric field electrode is to the electric field electrode F1 in F1, F2 via switch KF1It is connect with signal source e, electric field electrode F2 warp
By switch KF2It is connect with signal source e；Electric field electrode is to the electric field electrode G1 in G1, G2 via switch KG1It is connect with signal source f,
Electric field electrode G2 is via switch KG2It is connect with signal source f；Electric field electrode is to the electric field electrode H1 in H1, H2 via switch KH1With
Signal source f connection, electric field electrode H2 is via switch KH2It is connect with signal source f.Control device passes through control switch KE1And KE2、KF1
And KF2、KG1And KG2、KH1And KH2In switch on-off for any pair to select to need to export the electric field electrode pair of electric field signal, choosing
Corresponding signal source is selected to the electric field electrode to output electric field signal.
Specifically, including: based on preset mode output electric field signal
A. 4 pairs of electric field electrodes are put into wait select to gather；
B. from wait select to choose any 2 pairs of electric field electrodes in set, and electric field is exported simultaneously to 2 pairs of electric field electrodes of selection
Signal；
C. by two pairs of electric field electrodes of selection from wait select to remove in set；
D. judge whether wait select to gather be sky, if it is empty, then executes a, then executes b if not empty.
2 pairs of electric field electrodes export electric field signal simultaneously and maintain 0.1~3 second thereto, are applied to lesion simultaneously to generate 2
The electric field of the different directions of tissue, the electric field intersection of this 2 different directions are such as schemed to generate instantaneous high-frequency electric field in intersection
Shown in 6B.Backward other 2 pairs of electric field electrodes export electric field signal simultaneously and maintain 0.1~3 second, in this way, generating other 2 differences
The electric field in direction, the electric field intersection of this 2 different directions is to generate instantaneous high-frequency electric field in intersection.Aforementioned step repeatedly later
Suddenly.Control device needs to export the electric field electrode of electric field signal to rear in selection, selects corresponding signal source to the electric field electrode
To output electric field signal.
As described above, two signal sources, two pairs of electrodes export to a pair of of electric field electrode in each signal source same time and believe
Number, the direction of each pair of electric field electrode is intersected with the direction of other electrodes.When signal source simultaneously to electrode output signal when, in electrode
Low-frequency moment higher electric field can be generated due to the interference effect of wave to the intersection in direction.The frequency of this electric field is two
The difference of a signal source frequency.
Wherein, the electric field signal of output is sine wave signal, every time output electric field signal 0.1~3 second.The frequency 45 of electric field
~550KHz, 0.1~11V/cm of field strength.The field strength of the instantaneous low frequency electric field in intersection is the sum of 2 electric field strengths, and frequency is 2
The difference of electric field frequency.
Certainly, electric field electrode included by equipment of the invention is also not necessarily limited to 2 pairs or 4 pairs, can be 3 pairs, 5 pairs, it is more
Equity can be selected according to actual needs.Signal source is also not necessarily limited to 2 or 4, can be 1,3,5, more
Deng as long as can be selected according to actual needs no more than the logarithm of electric field electrode.The electric field signal of output is also unlimited
In sine wave, exporting the time is also not necessarily limited to 0.1~3 second, can be 0.1~12 second or longer etc., can according to actual needs into
Row selection.Electric field signal can also be exported simultaneously to 2 pairs of electric field electrodes incessantly every time, it can also be to 3 pairs, 4 pairs or multipair electric field
Electrode exports electric field signal simultaneously.
[embodiment 7]
Fig. 7 shows the equipment according to embodiment 7 for destroying and inhibiting patient's body pathological tissues fast-growth
The electric field of electric field electrode and generation.
As shown in fig. 7, may include 3 electric field electrodes I, J, K and unshowned 1 letter according to the equipment of the present embodiment
Number source and control device.Control device controls any two of this signal source based on preset mode into 3 electric field electrodes
Electric field signal is exported, to the electric field signal of two electric field electrode output preset times within the unit time.When signal source is to two
Electric field electrode can produce the electric field for being applied to the internal pathological tissues T of patient when exporting electric field signal, the electric field is for destroying
With the fast-growth for the pathological tissues T for inhibiting patient's body.Wherein, the unit time is 0.1~12 second, preset times 1, unit
Time is also possible to other times, such as 0.1~4 second etc., and preset times are also possible to 2,3 even more, actual frequencies
May and preset times there are deviations, such as the deviation no more than 80%.
When in use, user (such as doctor, patient etc.) can be such that 3 electric field electrodes uniformly divide around pathological tissues
Cloth, so that the electric field generated is applied at pathological tissues (as shown in Figure 7).
Any two based on from preset mode to 3 electric field electrodes export electric field signal
A. the combination (such as IJ, IK and JK) of 2 electric field electrodes any in 3 electric field electrodes is put into wait select to gather；
B. from the combination (such as IJ, IK or JK) wait select to choose any two electric field electrode in set, and to selection
Two electric field electrodes export electric field signal；
C. from the combination of two electric field electrodes wait select to remove selection in set, it is alternatively that, to two electricity of selection
Field plate elects label, by two electric field electrodes with selected marker from wait select to remove in set；
D. judge whether wait select to gather be sky, if it is empty, then executes a, then executes b if not empty.
The electric field signal of output is sine wave signal, and two electric field electrode outputs are changed after exporting 0.1~3 second every time.It produces
45~550KHz of frequency of raw electric field, 0.1~11V/cm of field strength, such as 100~300KHz, 2~5V/cm etc., electric field can
To be permanent width electric field etc..
Certainly, electric field electrode included by equipment of the invention is also not necessarily limited to 3, can be 4,5, more etc.,
It can be selected according to actual needs.Signal source is also not necessarily limited to 1, can be 2,3, more etc., as long as being not more than
The number of electric field electrode can be selected according to actual needs.The electric field signal of output is also not necessarily limited to sine wave signal,
The output time is also not necessarily limited to 0.1~3 second, can be 0.1~1 second, can be 0.1~12 second or longer etc., can be according to reality
It is selected.Electric field signal can also be exported to 2 electric field electrodes incessantly every time, it can also be to 4 electric field electrodes, 6
Electric field electrode, more even number electric field electrodes export electric field signal etc. simultaneously.
[embodiment 8]
Fig. 8 is the signal according to the equipment for destroying and inhibiting patient's body pathological tissues fast-growth of embodiment 8
Figure.
As shown in figure 8, the equipment of the present embodiment, in addition to structure described in any one embodiment of Examples 1 to 7
Outside, further comprise 1 pair of magnetic field electrode, be respectively on the electrode of magnetic field around to consistent coil, control device controls signal source
Magnetic field signal is exported to magnetic field electrode to generate the magnetic field for the intracerebral lesion tissue for being applied to patient.Wherein, the frequency 0.5 in magnetic field
~10Hz, magnetic induction intensity are not less than 1mT.In use, by symmetrical 2 coil tandems in the same direction, the magnetic line of force of generation pass through this 2
A coil, therefore the magnetic field emitted can focus on the internal pathological tissues (specific target area) of patient high-effectly.Certainly, this hair
Magnetic field electrode included by bright equipment is also not necessarily limited to 1 pair, can be 2 pairs, 3 pairs, more equity, can according to actual needs into
Row selection.
[embodiment 9]
In the present embodiment, other than with structure described in any one embodiment of Examples 1 to 7, the equipment is also
Including 1 galvanic electrode, control device control signal source generates the body for being applied to patient to galvanic electrode output current signal
The electric current of interior pathological tissues stimulates.Current signal can be direct current signal, square-wave signal or sharp wave signal.When current signal is side
When wave signal or sharp wave signal, duty ratio can adjust according to actual needs, depth can adjust according to actual needs.Direct current signal
Voltage can be 2~24V.
For example, the galvanic electrode of the present embodiment can be configured to each position of patient (such as lesion region on head on demand
Place), electric current stimulation therapy is carried out to region of interest, and export the various informative of electric current, lasting, interrupted, ladder, tide may be selected
Or the form of surge.Discontinuously, when ladder, tide or surge, duty ratio can adjust according to actual needs, depth can be according to reality
It needs to adjust.
Certainly, galvanic electrode included by equipment of the invention is also not necessarily limited to 1, can be 2,3, more etc.,
It can be selected according to actual needs.Equipment of the invention can include electric field electrode, magnetic field electrode and galvanic electrode simultaneously,
Electric field electrode and magnetic field electrode or electric field electrode and galvanic electrode etc. can also be only included, can be selected according to actual needs
It selects.
Equipment of the invention is that one kind can use electric field, electric current, magnetic field, 2 close frequencies signals due to interference effect
Interference wave of generation etc. carries out noninvasive stimulation to brain target area, and to treat the integrated system of disease, including signal source, electrode (can
Dress electrode group) and control device, it can adjoint treatment whenever and wherever possible.Equipment of the invention can emit simultaneously electric field, electric current and
Magnetic field, while inhibiting tumor tissue growth, moreover it is possible to the potential change of nerve cell is adjusted, and reaching improves patient's intracerebral generation
Thank to the purpose with bioelectrical activity.
[embodiment 10]
The equipment of the present embodiment and the equipment of previous embodiment are similar comprising 3 signal sources, 3 pairs of electric field electrodes and control
Device processed, electric field electrode is respectively the electric field electrode pair being made of electric field electrode A1 ' and electric field electrode A2 ', by electric field electrode B1 '
With the electric field electrode B2 ' electric field electrode pair constituted and the electric field electrode pair that is made of electric field electrode C1 ' and electric field electrode C2 ',
Control device, control device be used for control 3 signal sources within the unit time into 3 pairs of electric field electrodes any pair (each
Signal source corresponds to each pair of electric field electrode) on-fixed sequentially export preset times permanent width electric field signal so that 3 pairs of electrodes each
Generate to a period different order the permanent width electric field for the internal pathological tissues for being applied to patient.
The processing of control device include: a. by 3 pairs of electric field electrodes (i.e. electric field electrode to A1 ', A2 ', electric field electrode to B1 ',
B2 ' and electric field electrode are to C1 ', C2 ') it is put into wait select to gather, such as [A1 ' and A2 ', B1 ' and B2 ', C1 ' and C2 ']；b.
From wait select to choose any pair of electric field electrode in set, and electric field signal is exported to a pair of of electric field electrode of selection；For example, with
Machine choose electric field electrode to A1 ', A2 ', and to electric field electrode to A1 ', A2 ' send electric field signal, in this way, electric field electrode A1 ' and
Electric field electrode A2 ' generates the electric field for surrounding pathological tissues T；C. by a pair of of electric field electrode of selection from wait select set in remove,
I.e. wait select set to become [B1 ' and B2 ', C1 ' and C2 ']；D. judge whether wait select to gather be sky, if it is empty, then executes a,
B is then executed if not empty.
As a result, for example, after selection electric field electrode is to A1 ', A2 ', random selection electric field electrode is to C1 ', C2 ', electric field electricity
Extremely to B1 ', B2 '.After all electric field electrodes were to being carried out electric field and applying, by all electric field electrodes to being reentered into wait select
Set, and electric field is randomly generated again.
Destruction and inhibition in order to illustrate equipment of the invention to pathological tissues fast-growth are thin below for people's glioma
Born of the same parents Ln229 has carried out 5 groups of test cell lines, respectively for 3 with different parameters the present embodiment equipment (test group a, b,
C), the comparative apparatus (control group) of sequence electric field treatment and without electric field treatment (blank group).The step of test cell line, is such as
Under:
One, Ln229 cell is cultivated.
It takes culture to one bottle of culture bottle of Ln229 cell T75 of 80% or more degrees of fusion, abandons culture medium, TrypLE is addedTM
5ml is incubated for 10 minutes at 37 DEG C, and 5ml culture medium (DMEM+5%FBS) is added and terminates digestion.It 300g centrifugal treating 5 minutes, abandons
Supernatant is added culture medium (DMEM+5%FBS), adjusts cell concentration to 1 × 105/ ml~2 × 105/ml.It willGlass
It after piece sterilizing, is placed in 35mm culture dish, every plus 100ul cell suspension, shaking make cell suspension be uniformly distributed in slide table
Face.Culture dish is placed in 37 DEG C of saturated humidity incubators after 2-4 hours, supplementing culture medium (DMEM+5%FBS) 2ml is placed in
It is incubated overnight in 37 DEG C of saturated humidity incubators.Thus Ln229 cell to be processed is obtained.
Two, apply electric field
Second day, slide is transferred in culture dish made of high dielectric constant material, before 37 DEG C of saturated humidities pass through
It states device power-on field and carries out culture 24 hours.Blank group omits the step, and it is small to be placed in culture 24 in 37 DEG C of saturated humidity incubators
When.
Three, apoptosis rate is detected
After culture, TrypLE is addedTMDigestion, is made cell suspension, and 300g centrifugal treating 5 minutes.Supernatant is abandoned, is added
Enter combination buffer (Banding Buffer) 195ul, mix, add the PI of the Annexin V and 10ul of 5ul, mixes, room
Temperature is protected from light incubation 30 minutes, is detected using flow cytometer.
Apoptosis early sign object Annexin V (FITC-A) and dead label PI (PE-A) are carried out using flow cytometer
Detection, the available fluidic cell figure as shown in Fig. 9 A to Fig. 9 E, wherein quadrant B+- represents the cell of early apoptosis, quadrant
B-+ represents the cell of dead, and quadrant B++ represents the cell of transition state, and the numerical value addition of this three quadrants can be calculated
Apoptosis rate.And cell is induced apoptosis and death means that its fast-growth is destroyed and inhibits, therefore apoptosis rate
It can more delicately detect the therapeutic effect of electric field.
Wherein, in test group a, equipment includes 3 pairs of electric field electrodes, and specific structure is as previously described.The unit of its electric field treatment
Time is 1 second/period, and preset times 1, i.e., on-fixed sequentially makes any right in 3 pairs of electrodes in 1 second unit time
1 permanent width electric field is generated, the permanent width electric field signal of output is sine wave signal, and the frequency of the permanent width electric field of generation is 200KHz,
Field strength is 4V/cm.The each permanent width electric field of each pair of electric field electrode changes a pair of of electric field electrode, 3 pairs of electric field electrodes after continuing 0.3 second
Equal rotation complete post gap 0.1 second (gap can be omitted) starts the period next time, and 3 pairs of electric field electrodes are pressed not in each period
Electric field (i.e. the electric field generation sequence of adjacent periods is different) are generated with sequence, entire electric field incubation time continues 24 hours.Such as figure
Shown in 9A, the apoptosis rate of test group a is 7.2.The same terms are repeated 10 times test, average value 7.34, standard deviation SD value
It is 0.517.
In test group b, equipment includes 3 pairs of electric field electrodes, and specific structure is as previously described.The unit time of its electric field treatment is
1 second/period, preset times 1, i.e., on-fixed sequentially made any pair in 3 pairs of electrodes to generate 1 in 1 second unit time
Secondary perseverance width electric field, the permanent width electric field signal of output are sine wave signal, and the frequency of the permanent width electric field of generation is 100KHz, and field strength is
4V/cm.The each permanent width electric field of each pair of electric field electrode changes a pair of electrodes, 3 pairs of complete post gaps of the equal rotation of electrode after continuing 0.3 second
Start within 0.1 second (gap can be omitted) period next time, 3 pairs of electric field electrodes press different order and generate electric field in each period
(i.e. the electric field generation sequence of adjacent periods is different), entire electric field incubation time continues 24 hours.As shown in Figure 9 B, test group b
Apoptosis rate be 4.15.The same terms are repeated 10 times test, average value 4.07, and standard deviation SD value is 0.302.
In test group c, equipment includes 3 pairs of electric field electrodes, and specific structure is as previously described.The unit time of its electric field treatment is
1 second/period, preset times 1, i.e., on-fixed sequentially made any pair in 3 pairs of electric field electrodes to produce in 1 second unit time
Raw 1 permanent width electric field, the permanent width electric field signal of output are sine wave signal, and the frequency of the permanent width electric field of generation is 300KHz, field
It is by force 4V/cm.The each permanent width electric field of each pair of electric field electrode changes a pair of electrodes, 3 pairs of equal rotations of electric field electrode after continuing 0.3 second
Start the period next time within complete post gap 0.1 second (gap can be omitted), 3 pairs of electric field electrodes press different order in each period
Electric field (i.e. the electric field generation sequence of adjacent periods is different) are generated, entire electric field incubation time continues 24 hours.As shown in Figure 9 C,
The apoptosis rate of test group c is 4.18.The same terms are repeated 10 times test, average value 4.09, and standard deviation SD value is
0.321。
In control group, what is used is also the equipment including 3 pairs of electric field electrodes, but control device controls signal source in unit
In other words every a pair of permanent width electric field signal for exporting 1 time in time by from permanent order to 3 pairs of electric field electrodes is pressed always
According to electric field electrode to A1 ', A2 ', electric field electrode generates corresponding permanent width electricity to the sequence of C1 ', C2 ' to B1 ', B2 ', electric field electrode
?.Therefore, in control group, 3 pairs of electric field electrodes was sequentially made to generate 1 permanent width electric field in 1 second unit time, output
Permanent width electric field signal is sine wave signal, and the frequency of the permanent width electric field of generation is 200KHz, field strength 4V/cm, and each pair of electrode is every
Secondary permanent width electric field changes a pair of of electric field electrode, 3 pairs of complete post gaps of the equal rotation of electric field electrode, 0.1 second (gap after continuing 0.3 second
Can be omitted) period, entire electric field incubation time continue 24 hours next time for beginning.As shown in fig. 9d, the cell of control group withers
Dying rate is 3.71.The same terms are repeated 10 times test, average value 3.87, and standard deviation SD value is 0.271.
In blank group, without electric field treatment.Therefore after testing, as shown in fig. 9e, the apoptosis rate of blank group is
2.60.The same terms are repeated 10 times test, average value 2.68, and standard deviation SD value is 0.472.
(R version 3.2.5) is analyzed using R language statistics.Test group a and blank group are subjected to statistical analysis, p
Value is 0.00235, and less than 0.05, therefore difference has significant.Test group a and control group are subjected to statistical analysis, p
Value is 0.00274, and less than 0.05, therefore difference has significant.Test group a and test group b is subjected to statistical analysis,
P value is 0.00009, and less than 0.05, therefore difference has significant.Test group a and test group c are subjected to statistics credit
Analysis, p value 0.00023, less than 0.05, therefore difference has significant.Test group b and test group c is subjected to statistics
Analysis, p value 0.8674, difference do not have significant.
According to above-mentioned data it is found that the equipment of on-fixed sequence electric field treatment of the invention can produce the fast-growth of cell
Raw apparent inhibition and destruction, and the effect of on-fixed sequence electric field treatment is substantially better than the effect of permanent order electric field treatment
Fruit, when electric field frequency is 200KHz, treatment effect is best.
Equipment of the invention can also realize the individuation of therapeutic modality, precision.In use, operation, biopsy are mentioned
After patient's pathological tissues for taking carry out cell culture, the waveform of electric field signal, frequency, strong is carried out for the sick cell of culture
Degree, rotary mode sensitization test obtain the electric field signal parameter of optimum composition method, and carry out to the electrode of wearable electrode group
Symmetrical or asymmetrical pairing forms the electric field across pathological tissues center, to setting individual parameter and be applied to disease
Become tissue, influences sick cell metabolism and mitosis and inhibit its growth.In subsequent therapeutic process, tracking understands patient
Situation, routine adjustment electric field signal parameter, electrode group riding position, to reach most effective treatment results.It can be with lasting, disconnected
The form of continuous, ladder, tide or surge carries out through cranium galvanic current stimulation brain, can with direction change or direction it is constant
(having lasting, interrupted, form when direction is constant) mode magnetic stimulation is carried out to brain
(transcranial magnetic stimulation), to reach the mesh for adjusting the potential change of nerve cell and improving patient's intracerebral metabolism and bioelectrical activity
's.
For example, these electrodes may be mounted at wearable electrode when the equipment is used for the diseased region of patients head
So as to patient's use on cap.Electrode can be composite flexible coupling electrode, and two-sided is conductive substrates, is on one side metal, separately
It is on one side Signa Gel, centre is conducting medium, and multi-disc electric field electrode can be combined into one group and carry out using each group is considered as
An electric field electrode in above-described embodiment, every group of electric field electrode is in honeycomb structure, and the free posture of monolithic is to adapt to head arc
Degree, such architecture signals coupling efficiency is high, wears comfortable, excellent performance.Positioned at the week of the electric field electrode at electric field electrode group center
Side uniformly configures dotted, sheet or cricoid contact electrode (galvanic electrode), is used for stimulus of direct current.May be used also in each electrode group
With coil, to generate magnetic field, the magnetic field of transmitting high-effect can focus on specific target area.
Electrode position can be positioned in conjunction with MRI image and infrared camera navigation when in use, such as can be in electrode
It is marked on cap, precisely determines the region for applying electric field and magnetic field, electric current, can carried out by the electrode to wearing electrode group pair
Pairing claim or asymmetrical, forms the electric field across pathological tissues center, is applied to pathological tissues from accurate.
Term and wording used in description of the invention are just to for example, be not intended to constitute restriction.Ability
Field technique personnel should be appreciated that under the premise of not departing from the basic principle of disclosed embodiment, to above embodiment
In each details can carry out various change.Therefore, protection scope of the present invention is only determined by claim, in the claims,
Unless otherwise indicated, all terms should be understood by the broadest reasonable meaning.
Claims (17)
1. a kind of equipment for destroying and inhibiting patient's body pathological tissues fast-growth, comprising:
X is to electric field electrode, x >=2；
Y signal source, the y signal source are arranged to the x to the permanent width electric field letter of any pair of output in electric field electrode
Number, x >=y, y >=1；And
Control device, the control device is for controlling the y signal source within the unit time with on-fixed sequence to the x
The permanent width electric field signal of preset times is exported respectively to electric field electrode, so that the x generates the suitable of permanent width electric field to electric field electrode
Sequence is not fixed, and the perseverance width electric field is applied to the internal pathological tissues of patient for destroying and inhibiting the lesion group of patient's body
The fast-growth knitted.
2. equipment as described in claim 1, which is characterized in that the unit time is 1 second/period, and the preset times are
1。
3. equipment as claimed in claim 2, which is characterized in that the frequency of the perseverance width electric field is 100~300KHz, and field strength is
0.7~4V/cm.
4. equipment as claimed in claim 3, which is characterized in that
Exporting permanent width electric field signal respectively to electric field electrode to the x with on-fixed sequence includes:
A. the x is put into wait select to gather electric field electrode；
B. from described wait select to choose any pair of electric field electrode in set, and permanent width electricity is exported to a pair of of electric field electrode of selection
Field signal；
C. by a pair of of electric field electrode of the selection from it is described wait select set in remove；
D. described in judgement wait select whether set is sky if it is empty, then a is executed, then executes b if not empty.
5. equipment as claimed in claim 3, which is characterized in that the perseverance width electric field signal is selected from sine wave signal, square wave
In signal and sharp wave signal any one or it is more than one.
6. equipment as claimed in claim 5, which is characterized in that the electric field that each signal source is exported to a pair of of electric field electrode every time
The time of signal is 0.1~1 second, and crest voltage is 2~180V.
7. equipment as described in claim 1, which is characterized in that export permanent width electricity at least a pair of of electric field electrode in the same time
Field signal.
8. equipment as described in claim 1, which is characterized in that x=y, each signal source same time is only to a pair of of electric field electricity
Pole exports permanent width electric field signal.
9. equipment as described in claim 1, which is characterized in that the equipment further includes at least a pair of magnetic field electrode, the magnetic
With around to consistent coil on field plate, the control device is also used to control the y signal source to the magnetic field electrode
Magnetic field signal is exported to generate the magnetic field for the internal pathological tissues for being applied to patient.
10. equipment as claimed in claim 9, which is characterized in that the magnetic induction intensity >=1mT in the magnetic field.
11. equipment as described in claim 1, which is characterized in that the equipment further includes at least a pair of of galvanic electrode, the control
Device processed is also used to control the y signal source and is applied to trouble at least a pair of of galvanic electrode output current signal to generate
The electric current of the internal pathological tissues of person stimulates.
12. equipment as claimed in claim 11, which is characterized in that the current signal is direct current signal, square-wave signal or point
Wave signal, when current signal is square-wave signal or sharp wave signal, duty ratio is adjustable, depth is adjustable.
13. equipment as claimed in claim 12, which is characterized in that 2~24V of voltage of the direct current signal.
14. equipment as claimed in claim 13, which is characterized in that the direct current signal takes one of following forms or more
Kind: lasting, interrupted, ladder, tide or surge.
15. equipment as claimed in claim 14, which is characterized in that the direct current signal takes interrupted, ladder, tide or surge
Duty ratio is adjustable when form, depth is adjustable.
16. a kind of equipment for destroying and inhibiting patient's body pathological tissues fast-growth, comprising:
A electric field electrode of x ', x ' >=3；
A signal source of y ', a signal source of y ' are arranged to any two into a electric field electrode of the x ' and export permanent width electric field
Signal, y '≤x '；And
Control device, the control device is for controlling a signal source of the y ' within the unit time with on-fixed sequence to described
Any two in a electric field electrode of x ' export permanent width electric field signal, so that a electric field electrode of the x ' generates the suitable of permanent width electric field
Sequence is not fixed, and the perseverance width electric field is applied to the internal pathological tissues of patient for destroying and inhibiting the lesion group of patient's body
The fast-growth knitted.
17. equipment as claimed in claim 16, which is characterized in that
Any two within the unit time with from on-fixed sequence to a electric field electrode of the x ' export permanent width electric field signal packet
It includes:
A. the combination of 2 electric field electrodes any in a electric field electrode of the x ' is put into wait select to gather；
B. from the combination wait select to choose any 2 electric field electrodes in set, and perseverance is exported to 2 electric field electrodes of selection
Width electric field signal；
C. by the combination of 2 electric field electrodes of the selection from it is described wait select set in remove；
D. described in judgement wait select whether set is sky if it is empty, then a is executed, then executes b if not empty.
Applications Claiming Priority (2)
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|---|---|---|---|
| CN2017109828815 | 2017-10-20 | ||
| CN201710982881 | 2017-10-20 |
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| CN201821709731.3U Active CN209475395U (en) | 2017-10-20 | 2018-10-22 | Equipment for destroying and inhibiting patient's body pathological tissues fast-growth |
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| CN113350689A (en) * | 2021-06-08 | 2021-09-07 | 湖南安泰康成生物科技有限公司 | Equipment for inhibiting tumor proliferation by using electric field and detection method and device thereof |
| CN113663215A (en) * | 2021-10-22 | 2021-11-19 | 杭州维纳安可医疗科技有限责任公司 | Electric field generating apparatus, control method thereof, and computer-readable storage medium |
| CN114225215A (en) * | 2021-12-31 | 2022-03-25 | 湖南安泰康成生物科技有限公司 | Electrode system |
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