JPWO2021133778A5 - - Google Patents
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- Publication number
- JPWO2021133778A5 JPWO2021133778A5 JP2022539046A JP2022539046A JPWO2021133778A5 JP WO2021133778 A5 JPWO2021133778 A5 JP WO2021133778A5 JP 2022539046 A JP2022539046 A JP 2022539046A JP 2022539046 A JP2022539046 A JP 2022539046A JP WO2021133778 A5 JPWO2021133778 A5 JP WO2021133778A5
- Authority
- JP
- Japan
- Prior art keywords
- oxybate
- mixed salt
- composition
- use according
- per day
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 salt oxybate Chemical class 0.000 claims 71
- 239000000203 mixture Substances 0.000 claims 41
- VWYANPOOORUCFJ-UHFFFAOYSA-N alpha-Fernenol Chemical compound CC1(C)C(O)CCC2(C)C3=CCC4(C)C5CCC(C(C)C)C5(C)CCC4(C)C3CCC21 VWYANPOOORUCFJ-UHFFFAOYSA-N 0.000 claims 10
- 229960003928 sodium oxybate Drugs 0.000 claims 10
- 239000007788 liquid Substances 0.000 claims 6
- AZRRVLSHRWGNRS-UHFFFAOYSA-L calcium;4-hydroxybutanoate Chemical compound [Ca+2].OCCCC([O-])=O.OCCCC([O-])=O AZRRVLSHRWGNRS-UHFFFAOYSA-L 0.000 claims 4
- QWZIZKOBUUSCLO-UHFFFAOYSA-L magnesium;4-hydroxybutanoate Chemical compound [Mg+2].OCCCC([O-])=O.OCCCC([O-])=O QWZIZKOBUUSCLO-UHFFFAOYSA-L 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- TXSIWDVUJVMMKM-UHFFFAOYSA-M potassium;4-hydroxybutanoate Chemical compound [K+].OCCCC([O-])=O TXSIWDVUJVMMKM-UHFFFAOYSA-M 0.000 claims 4
- 208000001573 Cataplexy Diseases 0.000 claims 2
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 claims 2
- 206010041349 Somnolence Diseases 0.000 claims 2
- 235000012054 meals Nutrition 0.000 claims 2
- 201000003631 narcolepsy Diseases 0.000 claims 2
- 238000004448 titration Methods 0.000 claims 2
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962953288P | 2019-12-24 | 2019-12-24 | |
US62/953,288 | 2019-12-24 | ||
US202062993372P | 2020-03-23 | 2020-03-23 | |
US62/993,372 | 2020-03-23 | ||
US202063000547P | 2020-03-27 | 2020-03-27 | |
US63/000,547 | 2020-03-27 | ||
US202063052676P | 2020-07-16 | 2020-07-16 | |
US63/052,676 | 2020-07-16 | ||
PCT/US2020/066561 WO2021133778A1 (en) | 2019-12-24 | 2020-12-22 | Gamma-hydroxybutyrate (ghb) dosing |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2023508975A JP2023508975A (ja) | 2023-03-06 |
JPWO2021133778A5 true JPWO2021133778A5 (ru) | 2023-12-22 |
Family
ID=74191949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022539046A Pending JP2023508975A (ja) | 2019-12-24 | 2020-12-22 | ガンマ-ヒドロキシ酪酸塩(ghb)投薬 |
Country Status (14)
Country | Link |
---|---|
US (2) | US20210186907A1 (ru) |
EP (1) | EP4081204A1 (ru) |
JP (1) | JP2023508975A (ru) |
KR (1) | KR20220119429A (ru) |
CN (1) | CN115209885A (ru) |
AU (1) | AU2020414694A1 (ru) |
BR (1) | BR112022012594A2 (ru) |
CA (1) | CA3162974A1 (ru) |
CL (1) | CL2022001743A1 (ru) |
CO (1) | CO2022010330A2 (ru) |
IL (1) | IL294176A (ru) |
MX (1) | MX2022007968A (ru) |
TW (1) | TW202135790A (ru) |
WO (1) | WO2021133778A1 (ru) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2020011961A (es) | 2010-03-24 | 2022-04-19 | Jazz Pharmaceuticals Inc | Formas de dosis de liberacion controlada para substancias de farmaco de alta dosis, solubles en agua e higroscopicas. |
US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
JP7472116B2 (ja) | 2018-11-19 | 2024-04-22 | ジャズ ファーマシューティカルズ アイルランド リミテッド | 耐アルコール性製剤 |
WO2020178695A1 (en) | 2019-03-01 | 2020-09-10 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU779354B2 (en) | 1998-12-23 | 2005-01-20 | Orphan Medical, Inc. | Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy |
JP2004509900A (ja) | 2000-09-22 | 2004-04-02 | オーファン メディカル,インコーポレイティド | 炭水化物、脂質、またはアミノ酸キャリアを含むγ−ヒドロキシブチレート組成物 |
US7610153B2 (en) * | 2002-02-13 | 2009-10-27 | Virginia Commonwealth University | Multi-drug titration and evaluation |
US7668730B2 (en) | 2002-12-17 | 2010-02-23 | JPI Commercial, LLC. | Sensitive drug distribution system and method |
US8778398B2 (en) | 2008-11-04 | 2014-07-15 | Jazz Pharmaceuticals, Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
US8771735B2 (en) | 2008-11-04 | 2014-07-08 | Jazz Pharmaceuticals, Inc. | Immediate release dosage forms of sodium oxybate |
US8591922B1 (en) * | 2012-12-14 | 2013-11-26 | Jazz Pharmacuticals, Inc. | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
US9050302B2 (en) | 2013-03-01 | 2015-06-09 | Jazz Pharmaceuticals Ireland Limited | Method of administration of gamma hydroxybutyrate with monocarboxylate transporters |
US9801852B2 (en) | 2013-08-30 | 2017-10-31 | Jazz Pharmaceuticals, Inc. | Devices and methods for facilitating and controlling use of a medication |
US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
-
2020
- 2020-12-22 AU AU2020414694A patent/AU2020414694A1/en active Pending
- 2020-12-22 MX MX2022007968A patent/MX2022007968A/es unknown
- 2020-12-22 WO PCT/US2020/066561 patent/WO2021133778A1/en active Application Filing
- 2020-12-22 BR BR112022012594A patent/BR112022012594A2/pt unknown
- 2020-12-22 JP JP2022539046A patent/JP2023508975A/ja active Pending
- 2020-12-22 CN CN202080097472.7A patent/CN115209885A/zh active Pending
- 2020-12-22 US US17/130,769 patent/US20210186907A1/en not_active Abandoned
- 2020-12-22 EP EP20842864.9A patent/EP4081204A1/en active Pending
- 2020-12-22 TW TW109145587A patent/TW202135790A/zh unknown
- 2020-12-22 CA CA3162974A patent/CA3162974A1/en active Pending
- 2020-12-22 IL IL294176A patent/IL294176A/en unknown
- 2020-12-22 KR KR1020227024876A patent/KR20220119429A/ko unknown
-
2021
- 2021-08-06 US US17/396,104 patent/US20210361601A1/en active Pending
-
2022
- 2022-06-24 CL CL2022001743A patent/CL2022001743A1/es unknown
- 2022-07-22 CO CONC2022/0010330A patent/CO2022010330A2/es unknown
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