JPWO2021133778A5 - - Google Patents
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- Publication number
- JPWO2021133778A5 JPWO2021133778A5 JP2022539046A JP2022539046A JPWO2021133778A5 JP WO2021133778 A5 JPWO2021133778 A5 JP WO2021133778A5 JP 2022539046 A JP2022539046 A JP 2022539046A JP 2022539046 A JP2022539046 A JP 2022539046A JP WO2021133778 A5 JPWO2021133778 A5 JP WO2021133778A5
- Authority
- JP
- Japan
- Prior art keywords
- oxybate
- mixed salt
- composition
- use according
- per day
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 salt oxybate Chemical class 0.000 claims 71
- 239000000203 mixture Substances 0.000 claims 41
- VWYANPOOORUCFJ-UHFFFAOYSA-N alpha-Fernenol Chemical compound CC1(C)C(O)CCC2(C)C3=CCC4(C)C5CCC(C(C)C)C5(C)CCC4(C)C3CCC21 VWYANPOOORUCFJ-UHFFFAOYSA-N 0.000 claims 10
- 229960003928 sodium oxybate Drugs 0.000 claims 10
- 239000007788 liquid Substances 0.000 claims 6
- AZRRVLSHRWGNRS-UHFFFAOYSA-L calcium;4-hydroxybutanoate Chemical compound [Ca+2].OCCCC([O-])=O.OCCCC([O-])=O AZRRVLSHRWGNRS-UHFFFAOYSA-L 0.000 claims 4
- QWZIZKOBUUSCLO-UHFFFAOYSA-L magnesium;4-hydroxybutanoate Chemical compound [Mg+2].OCCCC([O-])=O.OCCCC([O-])=O QWZIZKOBUUSCLO-UHFFFAOYSA-L 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- TXSIWDVUJVMMKM-UHFFFAOYSA-M potassium;4-hydroxybutanoate Chemical compound [K+].OCCCC([O-])=O TXSIWDVUJVMMKM-UHFFFAOYSA-M 0.000 claims 4
- 208000001573 Cataplexy Diseases 0.000 claims 2
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 claims 2
- 206010041349 Somnolence Diseases 0.000 claims 2
- 235000012054 meals Nutrition 0.000 claims 2
- 201000003631 narcolepsy Diseases 0.000 claims 2
- 238000004448 titration Methods 0.000 claims 2
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962953288P | 2019-12-24 | 2019-12-24 | |
| US62/953,288 | 2019-12-24 | ||
| US202062993372P | 2020-03-23 | 2020-03-23 | |
| US62/993,372 | 2020-03-23 | ||
| US202063000547P | 2020-03-27 | 2020-03-27 | |
| US63/000,547 | 2020-03-27 | ||
| US202063052676P | 2020-07-16 | 2020-07-16 | |
| US63/052,676 | 2020-07-16 | ||
| PCT/US2020/066561 WO2021133778A1 (en) | 2019-12-24 | 2020-12-22 | Gamma-hydroxybutyrate (ghb) dosing |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023508975A JP2023508975A (ja) | 2023-03-06 |
| JPWO2021133778A5 true JPWO2021133778A5 (https=) | 2023-12-22 |
| JP2023508975A5 JP2023508975A5 (https=) | 2023-12-22 |
Family
ID=74191949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022539046A Pending JP2023508975A (ja) | 2019-12-24 | 2020-12-22 | ガンマ－ヒドロキシ酪酸塩（ｇｈｂ）投薬 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20210186907A1 (https=) |
| EP (1) | EP4081204A1 (https=) |
| JP (1) | JP2023508975A (https=) |
| KR (1) | KR20220119429A (https=) |
| CN (1) | CN115209885A (https=) |
| AU (1) | AU2020414694A1 (https=) |
| BR (1) | BR112022012594A2 (https=) |
| CA (1) | CA3162974A1 (https=) |
| CL (1) | CL2022001743A1 (https=) |
| CO (1) | CO2022010330A2 (https=) |
| IL (1) | IL294176A (https=) |
| MX (1) | MX2022007968A (https=) |
| TW (1) | TW202135790A (https=) |
| WO (1) | WO2021133778A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX391660B (es) | 2010-03-24 | 2025-03-21 | Jazz Pharmaceuticals Inc | Formas de dosis de liberacion controlada para substancias de farmaco de alta dosis, solubles en agua e higroscopicas |
| US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12478604B1 (en) | 2016-07-22 | 2025-11-25 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12186296B1 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| BR112021006027A2 (pt) | 2018-11-19 | 2021-06-29 | Jazz Pharmaceuticals Ireland Limited | formulações de fármaco resistente a álcool |
| CN113473980A (zh) | 2019-03-01 | 2021-10-01 | 弗拉梅尔爱尔兰有限公司 | 在进食状态下具有改善的药代动力学的γ-羟基丁酸酯组合物 |
| TW202139986A (zh) | 2020-02-21 | 2021-11-01 | 愛爾蘭商爵士製藥愛爾蘭有限責任公司 | 治療原發性嗜睡症之方法 |
| US12582622B2 (en) | 2020-10-08 | 2026-03-24 | Jazz Pharmaceuticals Ireland Limited | Sodium oxybate to treat idiopathic hypersomnia |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1140061T3 (da) | 1998-12-23 | 2003-08-25 | Orphan Medical Inc | Mikrobiologisk sunde og stabile opløsninger af gamma-hydroxybutyratsalt til behandling af narcolepsi |
| ES2383673T3 (es) | 2000-09-22 | 2012-06-25 | Jpi Commercial, Llc | Composiciones de gamma-hidroxibutirato que contienen portadores de hidrato de carbonos |
| US7610153B2 (en) * | 2002-02-13 | 2009-10-27 | Virginia Commonwealth University | Multi-drug titration and evaluation |
| US7668730B2 (en) | 2002-12-17 | 2010-02-23 | JPI Commercial, LLC. | Sensitive drug distribution system and method |
| US8778398B2 (en) | 2008-11-04 | 2014-07-15 | Jazz Pharmaceuticals, Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
| US8771735B2 (en) | 2008-11-04 | 2014-07-08 | Jazz Pharmaceuticals, Inc. | Immediate release dosage forms of sodium oxybate |
| CN102946869B (zh) * | 2010-05-04 | 2016-08-03 | 爵士制药有限公司 | γ-羟基丁酸的速释制剂及剂型 |
| US8591922B1 (en) | 2012-12-14 | 2013-11-26 | Jazz Pharmacuticals, Inc. | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| US9050302B2 (en) | 2013-03-01 | 2015-06-09 | Jazz Pharmaceuticals Ireland Limited | Method of administration of gamma hydroxybutyrate with monocarboxylate transporters |
| US9801852B2 (en) | 2013-08-30 | 2017-10-31 | Jazz Pharmaceuticals, Inc. | Devices and methods for facilitating and controlling use of a medication |
| US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
-
2020
- 2020-12-22 US US17/130,769 patent/US20210186907A1/en not_active Abandoned
- 2020-12-22 TW TW109145587A patent/TW202135790A/zh unknown
- 2020-12-22 IL IL294176A patent/IL294176A/en unknown
- 2020-12-22 WO PCT/US2020/066561 patent/WO2021133778A1/en not_active Ceased
- 2020-12-22 CN CN202080097472.7A patent/CN115209885A/zh active Pending
- 2020-12-22 KR KR1020227024876A patent/KR20220119429A/ko not_active Withdrawn
- 2020-12-22 BR BR112022012594A patent/BR112022012594A2/pt unknown
- 2020-12-22 MX MX2022007968A patent/MX2022007968A/es unknown
- 2020-12-22 AU AU2020414694A patent/AU2020414694A1/en not_active Abandoned
- 2020-12-22 CA CA3162974A patent/CA3162974A1/en active Pending
- 2020-12-22 EP EP20842864.9A patent/EP4081204A1/en not_active Withdrawn
- 2020-12-22 JP JP2022539046A patent/JP2023508975A/ja active Pending
-
2021
- 2021-08-06 US US17/396,104 patent/US20210361601A1/en active Pending
-
2022
- 2022-06-24 CL CL2022001743A patent/CL2022001743A1/es unknown
- 2022-07-22 CO CONC2022/0010330A patent/CO2022010330A2/es unknown
-
2024
- 2024-05-01 US US18/652,039 patent/US20240285560A1/en not_active Abandoned
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