JPWO2021132472A5 - - Google Patents
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- Publication number
- JPWO2021132472A5 JPWO2021132472A5 JP2021567619A JP2021567619A JPWO2021132472A5 JP WO2021132472 A5 JPWO2021132472 A5 JP WO2021132472A5 JP 2021567619 A JP2021567619 A JP 2021567619A JP 2021567619 A JP2021567619 A JP 2021567619A JP WO2021132472 A5 JPWO2021132472 A5 JP WO2021132472A5
- Authority
- JP
- Japan
- Prior art keywords
- mpges
- trifluoromethyl
- inhibitor
- benzimidazole
- carboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101710096361 Prostaglandin E synthase Proteins 0.000 claims 6
- 239000003112 inhibitor Substances 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 208000000450 Pelvic Pain Diseases 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 208000013507 chronic prostatitis Diseases 0.000 claims 3
- 230000003449 preventive effect Effects 0.000 claims 3
- 201000007094 prostatitis Diseases 0.000 claims 3
- YNMKDEMTKFSAIN-UHFFFAOYSA-N n-(3-chloro-2-methylphenyl)-6-[[2-(trifluoromethyl)benzoyl]amino]-2-[1-(trifluoromethyl)cyclopropyl]-1h-benzimidazole-4-carboxamide Chemical compound CC1=C(Cl)C=CC=C1NC(=O)C1=CC(NC(=O)C=2C(=CC=CC=2)C(F)(F)F)=CC2=C1N=C(C1(CC1)C(F)(F)F)N2 YNMKDEMTKFSAIN-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 1
- ZPONWJXTHMDOSV-UHFFFAOYSA-N n-(3-chloro-2-methylphenyl)-2-(methoxymethyl)-6-[[2-(trifluoromethyl)benzoyl]amino]-1h-benzimidazole-4-carboxamide Chemical compound C1=C2NC(COC)=NC2=C(C(=O)NC=2C(=C(Cl)C=CC=2)C)C=C1NC(=O)C1=CC=CC=C1C(F)(F)F ZPONWJXTHMDOSV-UHFFFAOYSA-N 0.000 claims 1
- SVHXOMRTGZARGF-UHFFFAOYSA-N n-(3-chloro-2-methylphenyl)-2-(methoxymethyl)-6-[[2-(trifluoromethyl)benzoyl]amino]-1h-benzimidazole-4-carboxamide;4-methylbenzenesulfonic acid Chemical group CC1=CC=C(S(O)(=O)=O)C=C1.C1=C2NC(COC)=NC2=C(C(=O)NC=2C(=C(Cl)C=CC=2)C)C=C1NC(=O)C1=CC=CC=C1C(F)(F)F SVHXOMRTGZARGF-UHFFFAOYSA-N 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024090606A JP7779953B2 (ja) | 2019-12-25 | 2024-06-04 | 慢性前立腺炎／慢性骨盤痛症候群の予防及び／又は治療剤 |
| JP2025199177A JP2026015542A (ja) | 2019-12-25 | 2025-11-19 | 慢性前立腺炎／慢性骨盤痛症候群の予防及び／又は治療剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019233865 | 2019-12-25 | ||
| JP2019233865 | 2019-12-25 | ||
| PCT/JP2020/048479 WO2021132472A1 (ja) | 2019-12-25 | 2020-12-24 | 慢性前立腺炎／慢性骨盤痛症候群の予防及び／又は治療剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024090606A Division JP7779953B2 (ja) | 2019-12-25 | 2024-06-04 | 慢性前立腺炎／慢性骨盤痛症候群の予防及び／又は治療剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021132472A1 JPWO2021132472A1 (https=) | 2021-07-01 |
| JPWO2021132472A5 true JPWO2021132472A5 (https=) | 2024-04-30 |
| JP7499789B2 JP7499789B2 (ja) | 2024-06-14 |
Family
ID=76575232
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021567619A Active JP7499789B2 (ja) | 2019-12-25 | 2020-12-24 | 慢性前立腺炎／慢性骨盤痛症候群の予防及び／又は治療剤 |
| JP2024090606A Active JP7779953B2 (ja) | 2019-12-25 | 2024-06-04 | 慢性前立腺炎／慢性骨盤痛症候群の予防及び／又は治療剤 |
| JP2025199177A Pending JP2026015542A (ja) | 2019-12-25 | 2025-11-19 | 慢性前立腺炎／慢性骨盤痛症候群の予防及び／又は治療剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024090606A Active JP7779953B2 (ja) | 2019-12-25 | 2024-06-04 | 慢性前立腺炎／慢性骨盤痛症候群の予防及び／又は治療剤 |
| JP2025199177A Pending JP2026015542A (ja) | 2019-12-25 | 2025-11-19 | 慢性前立腺炎／慢性骨盤痛症候群の予防及び／又は治療剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US12599589B2 (https=) |
| EP (1) | EP4082573A4 (https=) |
| JP (3) | JP7499789B2 (https=) |
| KR (1) | KR20220120646A (https=) |
| CN (2) | CN119303087A (https=) |
| AU (1) | AU2020413313B2 (https=) |
| BR (1) | BR112022012485A2 (https=) |
| CA (1) | CA3165891A1 (https=) |
| CO (1) | CO2022010343A2 (https=) |
| EC (1) | ECSP22058286A (https=) |
| IL (1) | IL294191A (https=) |
| MX (1) | MX2022007936A (https=) |
| PE (1) | PE20230164A1 (https=) |
| PH (1) | PH12022551578A1 (https=) |
| UA (1) | UA130283C2 (https=) |
| WO (1) | WO2021132472A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116082247B (zh) * | 2023-01-19 | 2025-08-01 | 浙江工业大学 | 一种苯并咪唑类衍生物及其应用 |
| CN121401398A (zh) * | 2025-12-29 | 2026-01-27 | 汕头市中心医院 | 一种实验性自身免疫性前列腺炎大鼠模型的构建方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY32470A (es) | 2009-03-05 | 2010-10-29 | Boehringer Ingelheim Int | Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones |
| WO2011023812A1 (en) | 2009-08-27 | 2011-03-03 | Novasaid Ab | Microsomal prostaglandin e synthase-1 (mpges1) inhibitors |
| WO2011048004A1 (en) * | 2009-10-23 | 2011-04-28 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin e2 synthase-1 |
| TW201206440A (en) * | 2010-04-28 | 2012-02-16 | Astellas Pharma Inc | Prophylactic or therapeutic agent for diseases associated with pains in urinary organs |
| US8759537B2 (en) | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
| US8586604B2 (en) | 2010-08-20 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
| UY33779A (es) | 2010-12-10 | 2012-07-31 | Boehringer Ingelheim Int | ?2-(fenilamino)-1H-bencimidazol-5-carboxamidas novedosas? |
| AR086254A1 (es) | 2011-05-26 | 2013-11-27 | Lilly Co Eli | Derivados de imidazol utiles para el tratamiento de artritis |
| PH12014500326B1 (en) | 2011-08-18 | 2018-01-10 | Nippon Shinyaku Co Ltd | Heterocyclic derivative and pharmaceutical drug |
| CN104039956A (zh) * | 2011-11-04 | 2014-09-10 | 葛兰素史密斯克莱知识产权（第2号）有限公司 | 治疗方法 |
| EP3372589B1 (en) * | 2015-10-29 | 2021-10-20 | ASKA Pharmaceutical Co., Ltd. | Pyrimidine derivative |
-
2020
- 2020-12-24 CN CN202411363159.XA patent/CN119303087A/zh active Pending
- 2020-12-24 KR KR1020227025732A patent/KR20220120646A/ko active Pending
- 2020-12-24 EP EP20905872.6A patent/EP4082573A4/en active Pending
- 2020-12-24 WO PCT/JP2020/048479 patent/WO2021132472A1/ja not_active Ceased
- 2020-12-24 AU AU2020413313A patent/AU2020413313B2/en active Active
- 2020-12-24 US US17/788,516 patent/US12599589B2/en active Active
- 2020-12-24 PH PH1/2022/551578A patent/PH12022551578A1/en unknown
- 2020-12-24 PE PE2022001326A patent/PE20230164A1/es unknown
- 2020-12-24 IL IL294191A patent/IL294191A/en unknown
- 2020-12-24 JP JP2021567619A patent/JP7499789B2/ja active Active
- 2020-12-24 MX MX2022007936A patent/MX2022007936A/es unknown
- 2020-12-24 UA UAA202202629A patent/UA130283C2/uk unknown
- 2020-12-24 CN CN202080090316.8A patent/CN114867495B/zh active Active
- 2020-12-24 CA CA3165891A patent/CA3165891A1/en active Pending
- 2020-12-24 BR BR112022012485A patent/BR112022012485A2/pt unknown
-
2022
- 2022-07-22 CO CONC2022/0010343A patent/CO2022010343A2/es unknown
- 2022-07-25 EC ECSENADI202258286A patent/ECSP22058286A/es unknown
-
2024
- 2024-06-04 JP JP2024090606A patent/JP7779953B2/ja active Active
-
2025
- 2025-11-19 JP JP2025199177A patent/JP2026015542A/ja active Pending
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