CN119303087A - 慢性前列腺炎/慢性盆腔疼痛综合征的预防和/或治疗剂 - Google Patents
慢性前列腺炎/慢性盆腔疼痛综合征的预防和/或治疗剂 Download PDFInfo
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- CN119303087A CN119303087A CN202411363159.XA CN202411363159A CN119303087A CN 119303087 A CN119303087 A CN 119303087A CN 202411363159 A CN202411363159 A CN 202411363159A CN 119303087 A CN119303087 A CN 119303087A
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- LHSKJADCCDHQDJ-UHFFFAOYSA-N n-benzyl-2-(methoxymethyl)-6-[[2-(trifluoromethyl)benzoyl]amino]-1h-benzimidazole-4-carboxamide Chemical compound C1=C2NC(COC)=NC2=C(C(=O)NCC=2C=CC=CC=2)C=C1NC(=O)C1=CC=CC=C1C(F)(F)F LHSKJADCCDHQDJ-UHFFFAOYSA-N 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- HOHZAEDXKUGTLQ-UHFFFAOYSA-N n-cyclobutyl-2-methyl-6-[[2-(trifluoromethyl)benzoyl]amino]-1h-benzimidazole-4-carboxamide Chemical compound C1=C2NC(C)=NC2=C(C(=O)NC2CCC2)C=C1NC(=O)C1=CC=CC=C1C(F)(F)F HOHZAEDXKUGTLQ-UHFFFAOYSA-N 0.000 description 1
- OSOWJRHQGLQPKF-UHFFFAOYSA-N n-cyclohexyl-1-ethyl-6-[[2-(trifluoromethyl)benzoyl]amino]benzimidazole-4-carboxamide Chemical compound C1=C2N(CC)C=NC2=C(C(=O)NC2CCCCC2)C=C1NC(=O)C1=CC=CC=C1C(F)(F)F OSOWJRHQGLQPKF-UHFFFAOYSA-N 0.000 description 1
- QRWMNZANUWWGHM-UHFFFAOYSA-N n-cyclohexyl-1-methyl-6-[[2-(trifluoromethyl)benzoyl]amino]benzimidazole-4-carboxamide Chemical compound C1=C2N(C)C=NC2=C(C(=O)NC2CCCCC2)C=C1NC(=O)C1=CC=CC=C1C(F)(F)F QRWMNZANUWWGHM-UHFFFAOYSA-N 0.000 description 1
- QYQANUXYOSMPHE-UHFFFAOYSA-N n-cyclohexyl-2-(methoxymethyl)-6-[[2-(trifluoromethyl)benzoyl]amino]-1h-benzimidazole-4-carboxamide Chemical compound C1=C2NC(COC)=NC2=C(C(=O)NC2CCCCC2)C=C1NC(=O)C1=CC=CC=C1C(F)(F)F QYQANUXYOSMPHE-UHFFFAOYSA-N 0.000 description 1
- NRPJVWBSVHRQJL-UHFFFAOYSA-N n-cyclohexyl-2-ethyl-6-[[2-(trifluoromethyl)benzoyl]amino]-1h-benzimidazole-4-carboxamide Chemical compound C1=C2NC(CC)=NC2=C(C(=O)NC2CCCCC2)C=C1NC(=O)C1=CC=CC=C1C(F)(F)F NRPJVWBSVHRQJL-UHFFFAOYSA-N 0.000 description 1
- FJYDLPCCHWKOCV-UHFFFAOYSA-N n-cyclohexyl-2-methyl-6-[[2-(trifluoromethyl)benzoyl]amino]-1h-benzimidazole-4-carboxamide Chemical compound C1=C2NC(C)=NC2=C(C(=O)NC2CCCCC2)C=C1NC(=O)C1=CC=CC=C1C(F)(F)F FJYDLPCCHWKOCV-UHFFFAOYSA-N 0.000 description 1
- KPZLVCYOJRAIMO-UHFFFAOYSA-N n-cyclohexyl-5-[[2-(trifluoromethyl)benzoyl]amino]-1h-indazole-7-carboxamide Chemical compound FC(F)(F)C1=CC=CC=C1C(=O)NC1=CC(C(=O)NC2CCCCC2)=C(NN=C2)C2=C1 KPZLVCYOJRAIMO-UHFFFAOYSA-N 0.000 description 1
- AJVOLJVWWXHVJE-UHFFFAOYSA-N n-cyclohexyl-5-[[2-(trifluoromethyl)benzoyl]amino]-2,3-dihydro-1-benzofuran-7-carboxamide Chemical compound FC(F)(F)C1=CC=CC=C1C(=O)NC(C=C1C(=O)NC2CCCCC2)=CC2=C1OCC2 AJVOLJVWWXHVJE-UHFFFAOYSA-N 0.000 description 1
- VEEDELAWJQWODW-UHFFFAOYSA-N n-cyclohexyl-6-[[2-(trifluoromethyl)benzoyl]amino]-1h-benzimidazole-4-carboxamide Chemical compound FC(F)(F)C1=CC=CC=C1C(=O)NC1=CC(C(=O)NC2CCCCC2)=C(N=CN2)C2=C1 VEEDELAWJQWODW-UHFFFAOYSA-N 0.000 description 1
- FPPVJOTXZIRXTF-UHFFFAOYSA-N n-cyclopentyl-1-(5,6-dimethyl-1-propan-2-ylbenzimidazol-2-yl)piperidine-4-carboxamide Chemical compound N=1C2=CC(C)=C(C)C=C2N(C(C)C)C=1N(CC1)CCC1C(=O)NC1CCCC1 FPPVJOTXZIRXTF-UHFFFAOYSA-N 0.000 description 1
- NLMKERLVCMSZEG-UHFFFAOYSA-N n-cyclopentyl-2-methyl-6-[[2-(trifluoromethyl)benzoyl]amino]-1h-benzimidazole-4-carboxamide Chemical compound C1=C2NC(C)=NC2=C(C(=O)NC2CCCC2)C=C1NC(=O)C1=CC=CC=C1C(F)(F)F NLMKERLVCMSZEG-UHFFFAOYSA-N 0.000 description 1
- 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 210000002640 perineum Anatomy 0.000 description 1
- 125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 description 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- YIBNHAJFJUQSRA-YNNPMVKQSA-N prostaglandin H2 Chemical compound C1[C@@H]2OO[C@H]1[C@H](/C=C/[C@@H](O)CCCCC)[C@H]2C\C=C/CCCC(O)=O YIBNHAJFJUQSRA-YNNPMVKQSA-N 0.000 description 1
- 210000001095 prostate stromal cell Anatomy 0.000 description 1
- 201000004240 prostatic hypertrophy Diseases 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 description 1
- 125000004940 pyridazin-4-yl group Chemical group N1=NC=C(C=C1)* 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 description 1
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 description 1
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 125000004159 quinolin-2-yl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C([H])C(*)=NC2=C1[H] 0.000 description 1
- 125000004548 quinolin-3-yl group Chemical group N1=CC(=CC2=CC=CC=C12)* 0.000 description 1
- 125000004549 quinolin-4-yl group Chemical group N1=CC=C(C2=CC=CC=C12)* 0.000 description 1
- 125000004550 quinolin-6-yl group Chemical group N1=CC=CC2=CC(=CC=C12)* 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- MSPYBZDJCHZFHM-RUZDIDTESA-N tert-butyl (2r)-2-[4-[(3-chloro-2-methylphenyl)carbamoyl]-6-[[2-(trifluoromethyl)benzoyl]amino]-1h-benzimidazol-2-yl]pyrrolidine-1-carboxylate Chemical compound CC1=C(Cl)C=CC=C1NC(=O)C1=CC(NC(=O)C=2C(=CC=CC=2)C(F)(F)F)=CC2=C1N=C([C@@H]1N(CCC1)C(=O)OC(C)(C)C)N2 MSPYBZDJCHZFHM-RUZDIDTESA-N 0.000 description 1
- MSPYBZDJCHZFHM-VWLOTQADSA-N tert-butyl (2s)-2-[4-[(3-chloro-2-methylphenyl)carbamoyl]-6-[[2-(trifluoromethyl)benzoyl]amino]-1h-benzimidazol-2-yl]pyrrolidine-1-carboxylate Chemical compound CC1=C(Cl)C=CC=C1NC(=O)C1=CC(NC(=O)C=2C(=CC=CC=2)C(F)(F)F)=CC2=C1N=C([C@H]1N(CCC1)C(=O)OC(C)(C)C)N2 MSPYBZDJCHZFHM-VWLOTQADSA-N 0.000 description 1
- NCKZAXPLKFSSCR-UHFFFAOYSA-N tert-butyl 3-[4-[(3-chloro-2-methylphenyl)carbamoyl]-6-[[2-(trifluoromethyl)benzoyl]amino]-1h-benzimidazol-2-yl]azetidine-1-carboxylate Chemical compound CC1=C(Cl)C=CC=C1NC(=O)C1=CC(NC(=O)C=2C(=CC=CC=2)C(F)(F)F)=CC2=C1N=C(C1CN(C1)C(=O)OC(C)(C)C)N2 NCKZAXPLKFSSCR-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 125000006223 tetrahydrofuranylmethyl group Chemical group 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000005301 thienylmethyl group Chemical group [H]C1=C([H])C([H])=C(S1)C([H])([H])* 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019233865 | 2019-12-25 | ||
| JP2019-233865 | 2019-12-25 | ||
| PCT/JP2020/048479 WO2021132472A1 (ja) | 2019-12-25 | 2020-12-24 | 慢性前立腺炎/慢性骨盤痛症候群の予防及び/又は治療剤 |
| CN202080090316.8A CN114867495B (zh) | 2019-12-25 | 2020-12-24 | 慢性前列腺炎/慢性盆腔疼痛综合征的预防和/或治疗剂 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN202080090316.8A Division CN114867495B (zh) | 2019-12-25 | 2020-12-24 | 慢性前列腺炎/慢性盆腔疼痛综合征的预防和/或治疗剂 |
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| CN119303087A true CN119303087A (zh) | 2025-01-14 |
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| CN202080090316.8A Active CN114867495B (zh) | 2019-12-25 | 2020-12-24 | 慢性前列腺炎/慢性盆腔疼痛综合征的预防和/或治疗剂 |
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| Country | Link |
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| US (1) | US12599589B2 (https=) |
| EP (1) | EP4082573A4 (https=) |
| JP (3) | JP7499789B2 (https=) |
| KR (1) | KR20220120646A (https=) |
| CN (2) | CN119303087A (https=) |
| AU (1) | AU2020413313B2 (https=) |
| BR (1) | BR112022012485A2 (https=) |
| CA (1) | CA3165891A1 (https=) |
| CO (1) | CO2022010343A2 (https=) |
| EC (1) | ECSP22058286A (https=) |
| IL (1) | IL294191A (https=) |
| MX (1) | MX2022007936A (https=) |
| PE (1) | PE20230164A1 (https=) |
| PH (1) | PH12022551578A1 (https=) |
| UA (1) | UA130283C2 (https=) |
| WO (1) | WO2021132472A1 (https=) |
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| CN121401398A (zh) * | 2025-12-29 | 2026-01-27 | 汕头市中心医院 | 一种实验性自身免疫性前列腺炎大鼠模型的构建方法 |
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| WO2011023812A1 (en) | 2009-08-27 | 2011-03-03 | Novasaid Ab | Microsomal prostaglandin e synthase-1 (mpges1) inhibitors |
| WO2011048004A1 (en) * | 2009-10-23 | 2011-04-28 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin e2 synthase-1 |
| TW201206440A (en) * | 2010-04-28 | 2012-02-16 | Astellas Pharma Inc | Prophylactic or therapeutic agent for diseases associated with pains in urinary organs |
| US8759537B2 (en) | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
| US8586604B2 (en) | 2010-08-20 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
| UY33779A (es) | 2010-12-10 | 2012-07-31 | Boehringer Ingelheim Int | ?2-(fenilamino)-1H-bencimidazol-5-carboxamidas novedosas? |
| AR086254A1 (es) | 2011-05-26 | 2013-11-27 | Lilly Co Eli | Derivados de imidazol utiles para el tratamiento de artritis |
| PH12014500326B1 (en) | 2011-08-18 | 2018-01-10 | Nippon Shinyaku Co Ltd | Heterocyclic derivative and pharmaceutical drug |
| CN104039956A (zh) * | 2011-11-04 | 2014-09-10 | 葛兰素史密斯克莱知识产权(第2号)有限公司 | 治疗方法 |
| EP3372589B1 (en) * | 2015-10-29 | 2021-10-20 | ASKA Pharmaceutical Co., Ltd. | Pyrimidine derivative |
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2020
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- 2020-12-24 KR KR1020227025732A patent/KR20220120646A/ko active Pending
- 2020-12-24 EP EP20905872.6A patent/EP4082573A4/en active Pending
- 2020-12-24 WO PCT/JP2020/048479 patent/WO2021132472A1/ja not_active Ceased
- 2020-12-24 AU AU2020413313A patent/AU2020413313B2/en active Active
- 2020-12-24 US US17/788,516 patent/US12599589B2/en active Active
- 2020-12-24 PH PH1/2022/551578A patent/PH12022551578A1/en unknown
- 2020-12-24 PE PE2022001326A patent/PE20230164A1/es unknown
- 2020-12-24 IL IL294191A patent/IL294191A/en unknown
- 2020-12-24 JP JP2021567619A patent/JP7499789B2/ja active Active
- 2020-12-24 MX MX2022007936A patent/MX2022007936A/es unknown
- 2020-12-24 UA UAA202202629A patent/UA130283C2/uk unknown
- 2020-12-24 CN CN202080090316.8A patent/CN114867495B/zh active Active
- 2020-12-24 CA CA3165891A patent/CA3165891A1/en active Pending
- 2020-12-24 BR BR112022012485A patent/BR112022012485A2/pt unknown
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2022
- 2022-07-22 CO CONC2022/0010343A patent/CO2022010343A2/es unknown
- 2022-07-25 EC ECSENADI202258286A patent/ECSP22058286A/es unknown
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2024
- 2024-06-04 JP JP2024090606A patent/JP7779953B2/ja active Active
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2025
- 2025-11-19 JP JP2025199177A patent/JP2026015542A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP22058286A (es) | 2022-09-30 |
| JP2024103724A (ja) | 2024-08-01 |
| JP2026015542A (ja) | 2026-01-29 |
| MX2022007936A (es) | 2022-10-27 |
| PE20230164A1 (es) | 2023-02-01 |
| CA3165891A1 (en) | 2021-07-01 |
| BR112022012485A2 (pt) | 2022-09-06 |
| AU2020413313B2 (en) | 2025-11-27 |
| EP4082573A4 (en) | 2024-01-10 |
| JPWO2021132472A1 (https=) | 2021-07-01 |
| NZ789736A (en) | 2025-10-31 |
| CO2022010343A2 (es) | 2022-10-31 |
| JP7779953B2 (ja) | 2025-12-03 |
| US12599589B2 (en) | 2026-04-14 |
| US20230094705A1 (en) | 2023-03-30 |
| CN114867495A (zh) | 2022-08-05 |
| AU2020413313A1 (en) | 2022-07-14 |
| JP7499789B2 (ja) | 2024-06-14 |
| PH12022551578A1 (en) | 2023-11-29 |
| WO2021132472A1 (ja) | 2021-07-01 |
| EP4082573A1 (en) | 2022-11-02 |
| KR20220120646A (ko) | 2022-08-30 |
| UA130283C2 (uk) | 2026-01-07 |
| CN114867495B (zh) | 2024-10-18 |
| IL294191A (en) | 2022-08-01 |
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