JPWO2021127359A5 - - Google Patents
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- Publication number
- JPWO2021127359A5 JPWO2021127359A5 JP2022537669A JP2022537669A JPWO2021127359A5 JP WO2021127359 A5 JPWO2021127359 A5 JP WO2021127359A5 JP 2022537669 A JP2022537669 A JP 2022537669A JP 2022537669 A JP2022537669 A JP 2022537669A JP WO2021127359 A5 JPWO2021127359 A5 JP WO2021127359A5
- Authority
- JP
- Japan
- Prior art keywords
- lemborexant
- acceptable salt
- patient
- pharmaceutically acceptable
- dosage form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MUGXRYIUWFITCP-PGRDOPGGSA-N (1r,2s)-2-[(2,4-dimethylpyrimidin-5-yl)oxymethyl]-2-(3-fluorophenyl)-n-(5-fluoropyridin-2-yl)cyclopropane-1-carboxamide Chemical compound CC1=NC(C)=NC=C1OC[C@]1(C=2C=C(F)C=CC=2)[C@H](C(=O)NC=2N=CC(F)=CC=2)C1 MUGXRYIUWFITCP-PGRDOPGGSA-N 0.000 claims 15
- 229950003528 lemborexant Drugs 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 15
- 239000002552 dosage form Substances 0.000 claims 14
- 208000019423 liver disease Diseases 0.000 claims 8
- 230000005976 liver dysfunction Effects 0.000 claims 8
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 5
- 206010022437 insomnia Diseases 0.000 claims 5
- 208000027700 hepatic dysfunction Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962951638P | 2019-12-20 | 2019-12-20 | |
| US62/951,638 | 2019-12-20 | ||
| PCT/US2020/065891 WO2021127359A1 (en) | 2019-12-20 | 2020-12-18 | Use of lemborexant for treating insomnia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023508011A JP2023508011A (ja) | 2023-02-28 |
| JPWO2021127359A5 true JPWO2021127359A5 (de) | 2023-12-22 |
Family
ID=74191874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022537669A Pending JP2023508011A (ja) | 2019-12-20 | 2020-12-18 | 不眠症を治療するためのレンボレキサントの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230051268A1 (de) |
| EP (1) | EP4076463A1 (de) |
| JP (1) | JP2023508011A (de) |
| KR (1) | KR20220119065A (de) |
| CN (1) | CN115003305A (de) |
| AU (1) | AU2020408557A1 (de) |
| BR (1) | BR112022012246A2 (de) |
| CA (1) | CA3165481A1 (de) |
| MX (1) | MX2022007304A (de) |
| TW (1) | TW202137986A (de) |
| WO (1) | WO2021127359A1 (de) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2220036A1 (en) | 1995-05-05 | 1996-11-07 | Human Genome Sciences, Inc. | Human neuropeptide receptor |
| US6309854B1 (en) | 1996-12-17 | 2001-10-30 | Smithkline Beecham Corporation | Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72 |
| US6020157A (en) | 1997-04-30 | 2000-02-01 | Smithkline Beecham Corporation | Polynucleotides encoding HFGAN72X receptor |
| US5935814A (en) | 1997-04-30 | 1999-08-10 | Smithkline Beecham Corporation | Polynucleotides encoding HFGAN72Y receptor |
| US6166193A (en) | 1997-07-25 | 2000-12-26 | Board Of Regents, University Of Texas System | Polynucleotides encoding MY1 receptor |
| EP2626350B1 (de) | 2010-09-22 | 2015-04-15 | Eisai R&D Management Co., Ltd. | Cyclopropanverbindung |
| WO2013123240A1 (en) | 2012-02-17 | 2013-08-22 | Eisai R&D Management Co., Ltd | Methods and compounds useful in the synthesis of orexin-2 receptor antagonists |
| SG11201703064WA (en) * | 2014-10-23 | 2017-05-30 | Eisai R&D Man Co Ltd | Compositions and methods for treating insomnia |
-
2020
- 2020-12-18 KR KR1020227023903A patent/KR20220119065A/ko unknown
- 2020-12-18 JP JP2022537669A patent/JP2023508011A/ja active Pending
- 2020-12-18 CA CA3165481A patent/CA3165481A1/en active Pending
- 2020-12-18 EP EP20842786.4A patent/EP4076463A1/de active Pending
- 2020-12-18 TW TW109145085A patent/TW202137986A/zh unknown
- 2020-12-18 MX MX2022007304A patent/MX2022007304A/es unknown
- 2020-12-18 WO PCT/US2020/065891 patent/WO2021127359A1/en unknown
- 2020-12-18 BR BR112022012246A patent/BR112022012246A2/pt unknown
- 2020-12-18 AU AU2020408557A patent/AU2020408557A1/en active Pending
- 2020-12-18 CN CN202080094379.0A patent/CN115003305A/zh active Pending
- 2020-12-18 US US17/757,672 patent/US20230051268A1/en active Pending
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