JPWO2021110805A5 - - Google Patents
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- Publication number
- JPWO2021110805A5 JPWO2021110805A5 JP2022531534A JP2022531534A JPWO2021110805A5 JP WO2021110805 A5 JPWO2021110805 A5 JP WO2021110805A5 JP 2022531534 A JP2022531534 A JP 2022531534A JP 2022531534 A JP2022531534 A JP 2022531534A JP WO2021110805 A5 JPWO2021110805 A5 JP WO2021110805A5
- Authority
- JP
- Japan
- Prior art keywords
- isopropylphenyl
- pulmonary fibrosis
- fibrosis
- azetidin
- carbamoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 25
- 150000003839 salts Chemical class 0.000 claims 14
- 230000003510 anti-fibrotic effect Effects 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 208000019425 cirrhosis of liver Diseases 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 claims 6
- 229960003073 pirfenidone Drugs 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 208000027866 inflammatory disease Diseases 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 230000002265 prevention Effects 0.000 claims 5
- 230000009885 systemic effect Effects 0.000 claims 5
- 208000025721 COVID-19 Diseases 0.000 claims 4
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 4
- 201000010001 Silicosis Diseases 0.000 claims 4
- 239000010425 asbestos Substances 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 4
- 201000002793 renal fibrosis Diseases 0.000 claims 4
- 229910052895 riebeckite Inorganic materials 0.000 claims 4
- 201000000306 sarcoidosis Diseases 0.000 claims 4
- 208000032056 Radiation Fibrosis Syndrome Diseases 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- XZXHXSATPCNXJR-ZIADKAODSA-N nintedanib Chemical compound O=C1NC2=CC(C(=O)OC)=CC=C2\C1=C(C=1C=CC=CC=1)\NC(C=C1)=CC=C1N(C)C(=O)CN1CCN(C)CC1 XZXHXSATPCNXJR-ZIADKAODSA-N 0.000 claims 3
- 229960004378 nintedanib Drugs 0.000 claims 3
- -1 4-(3-((2-(difluoromethoxy)-6-methylpyridin-3-yl)carbamoyl)-3-(2-isopropylphenyl)azetidin-1-yl)-2,2-dimethyl-4-oxobutane Chemical compound 0.000 claims 2
- AHMHQDZHVSRILS-UHFFFAOYSA-N 4-[3-[[2-(difluoromethoxy)-6-methylpyridin-3-yl]carbamoyl]-3-(2-propan-2-ylphenyl)azetidin-1-yl]-2,2-dimethylbutanoic acid Chemical compound FC(OC1=NC(=CC=C1NC(=O)C1(CN(C1)CCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)C)F AHMHQDZHVSRILS-UHFFFAOYSA-N 0.000 claims 2
- UHFBJBPMIVQTBG-UHFFFAOYSA-N ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)OC Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)OC UHFBJBPMIVQTBG-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 208000020832 chronic kidney disease Diseases 0.000 claims 2
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- UXHGYVHOQNAHDR-UHFFFAOYSA-N 4-[3-[(6-chloro-4-ethoxypyridin-3-yl)carbamoyl]-3-(2-propan-2-ylphenyl)azetidin-1-yl]-2,2-dimethyl-4-oxobutanoic acid Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)C(CC(C(=O)O)(C)C)=O)C1=C(C=CC=C1)C(C)C)OCC UXHGYVHOQNAHDR-UHFFFAOYSA-N 0.000 claims 1
- IXZVCNYCFLJWLQ-UHFFFAOYSA-N 5-[3-[(6-chloro-4-ethoxypyridin-3-yl)carbamoyl]-3-(2-propan-2-ylphenyl)azetidin-1-yl]-2,2-dimethylpentanoic acid Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OCC IXZVCNYCFLJWLQ-UHFFFAOYSA-N 0.000 claims 1
- AEVSKFPVHQEJGE-UHFFFAOYSA-N 5-[3-[[2-(difluoromethoxy)-6-methylpyridin-3-yl]carbamoyl]-3-(2-propan-2-ylphenyl)azetidin-1-yl]-2,2-dimethylpentanoic acid Chemical compound FC(OC1=NC(=CC=C1NC(=O)C1(CN(C1)CCCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)C)F AEVSKFPVHQEJGE-UHFFFAOYSA-N 0.000 claims 1
- 208000024985 Alport syndrome Diseases 0.000 claims 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 1
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 1
- MMDMEZKSWCAEQP-UHFFFAOYSA-N BrC1=CC(=C(C=N1)NC(=O)C1(CN(C1)C(CC(C(=O)O)(C)C)=O)C1=C(C=CC=C1)C(C)C)OC Chemical compound BrC1=CC(=C(C=N1)NC(=O)C1(CN(C1)C(CC(C(=O)O)(C)C)=O)C1=C(C=CC=C1)C(C)C)OC MMDMEZKSWCAEQP-UHFFFAOYSA-N 0.000 claims 1
- PJBXDRPYGIEXTR-UHFFFAOYSA-N BrC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OC Chemical compound BrC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OC PJBXDRPYGIEXTR-UHFFFAOYSA-N 0.000 claims 1
- LYUHUWVPOGPQBN-UHFFFAOYSA-N C(C)(C)C1=C(C=CC=C1)C1(CN(C1)S(N)(=O)=O)C(=O)NC=1C(=NC(=CC=1)C)OC Chemical compound C(C)(C)C1=C(C=CC=C1)C1(CN(C1)S(N)(=O)=O)C(=O)NC=1C(=NC(=CC=1)C)OC LYUHUWVPOGPQBN-UHFFFAOYSA-N 0.000 claims 1
- NFTLCPKJANELJF-UHFFFAOYSA-N C(C)(C)OC1=NC(=CC=C1NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)C Chemical compound C(C)(C)OC1=NC(=CC=C1NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)C NFTLCPKJANELJF-UHFFFAOYSA-N 0.000 claims 1
- PHADFUHHMQVNHT-UHFFFAOYSA-N C(C)OC1=NC(=CC=C1NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)C Chemical compound C(C)OC1=NC(=CC=C1NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)C PHADFUHHMQVNHT-UHFFFAOYSA-N 0.000 claims 1
- RJQHNYDFUBUQBS-UHFFFAOYSA-N ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)C(CC(C(=O)O)(C)C)=O)C1=C(C=CC=C1)C(C)C)OC Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)C(CC(C(=O)O)(C)C)=O)C1=C(C=CC=C1)C(C)C)OC RJQHNYDFUBUQBS-UHFFFAOYSA-N 0.000 claims 1
- NTWIQNLJVMFOEB-UHFFFAOYSA-N ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OC Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OC NTWIQNLJVMFOEB-UHFFFAOYSA-N 0.000 claims 1
- PPFFNHUJOGQXML-UHFFFAOYSA-N ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OC(C)C Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OC(C)C PPFFNHUJOGQXML-UHFFFAOYSA-N 0.000 claims 1
- RXPPIFRABBTGPL-UHFFFAOYSA-N ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OCC Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OCC RXPPIFRABBTGPL-UHFFFAOYSA-N 0.000 claims 1
- OXCMUISOAICMMJ-UHFFFAOYSA-N ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OC Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OC OXCMUISOAICMMJ-UHFFFAOYSA-N 0.000 claims 1
- XNSGSFYMSSWMDL-UHFFFAOYSA-N ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)OC(C)C Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)OC(C)C XNSGSFYMSSWMDL-UHFFFAOYSA-N 0.000 claims 1
- ICOPNXVMXLFUCM-UHFFFAOYSA-N ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)OCC Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)OCC ICOPNXVMXLFUCM-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- WMPVNQNVSISYDP-UHFFFAOYSA-N FC(OC1=NC(=CC=C1NC(=O)C1(CN(C1)C(CCC(C(=O)O)(C)C)=O)C1=C(C=CC=C1)C(C)C)C)F Chemical compound FC(OC1=NC(=CC=C1NC(=O)C1(CN(C1)C(CCC(C(=O)O)(C)C)=O)C1=C(C=CC=C1)C(C)C)C)F WMPVNQNVSISYDP-UHFFFAOYSA-N 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000010159 IgA glomerulonephritis Diseases 0.000 claims 1
- 206010021263 IgA nephropathy Diseases 0.000 claims 1
- SBWVREBFWCRYRB-UHFFFAOYSA-N N-(4-methoxy-6-methylpyridin-3-yl)-3-(2-propan-2-ylphenyl)-1-sulfamoylazetidine-3-carboxamide Chemical compound C(C)(C)C1=C(C=CC=C1)C1(CN(C1)S(N)(=O)=O)C(=O)NC=1C=NC(=CC=1OC)C SBWVREBFWCRYRB-UHFFFAOYSA-N 0.000 claims 1
- AWIANFVBUOGQAV-UHFFFAOYSA-N N-(6-bromo-4-methoxypyridin-3-yl)-3-(2-propan-2-ylphenyl)-1-sulfamoylazetidine-3-carboxamide Chemical compound BrC1=CC(=C(C=N1)NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)OC AWIANFVBUOGQAV-UHFFFAOYSA-N 0.000 claims 1
- DGFUVKOGJQTWAI-UHFFFAOYSA-N N-(6-fluoro-4-methoxypyridin-3-yl)-3-(2-propan-2-ylphenyl)-1-sulfamoylazetidine-3-carboxamide Chemical compound FC1=CC(=C(C=N1)NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)OC DGFUVKOGJQTWAI-UHFFFAOYSA-N 0.000 claims 1
- YXRNQUBUJDLVPK-UHFFFAOYSA-N N-[2-(difluoromethoxy)-6-methylpyridin-3-yl]-3-(2-propan-2-ylphenyl)-1-sulfamoylazetidine-3-carboxamide Chemical compound FC(OC1=NC(=CC=C1NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)C)F YXRNQUBUJDLVPK-UHFFFAOYSA-N 0.000 claims 1
- 206010035600 Pleural fibrosis Diseases 0.000 claims 1
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 1
- 206010048302 Tubulointerstitial nephritis Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 210000000013 bile duct Anatomy 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 230000003176 fibrotic effect Effects 0.000 claims 1
- 201000005206 focal segmental glomerulosclerosis Diseases 0.000 claims 1
- 231100000854 focal segmental glomerulosclerosis Toxicity 0.000 claims 1
- 230000001434 glomerular Effects 0.000 claims 1
- 208000003215 hereditary nephritis Diseases 0.000 claims 1
- 230000000642 iatrogenic effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 201000006334 interstitial nephritis Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000008383 nephritis Diseases 0.000 claims 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2019083757 | 2019-12-04 | ||
| EPPCT/EP2019/083757 | 2019-12-04 | ||
| PCT/EP2020/084401 WO2021110805A1 (fr) | 2019-12-04 | 2020-12-03 | Combinaison d'un antagoniste du récepteur lpa1 de l'azétidine avec de la pirfénidone et/ou du nintedanib destinée à être utilisée dans le traitement de maladies fibrotiques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023504415A JP2023504415A (ja) | 2023-02-03 |
| JPWO2021110805A5 true JPWO2021110805A5 (fr) | 2023-12-12 |
Family
ID=76221504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022531534A Pending JP2023504415A (ja) | 2019-12-04 | 2020-12-03 | 線維性疾患の治療に使用するためのアゼチジンｌｐａ１受容体アンタゴニストのピルフェニドン及び／又はニンテダニブとの合剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20230000846A1 (fr) |
| EP (1) | EP4069227A1 (fr) |
| JP (1) | JP2023504415A (fr) |
| KR (1) | KR20220109439A (fr) |
| CN (1) | CN114761001A (fr) |
| AU (1) | AU2020397207A1 (fr) |
| BR (1) | BR112022010891A2 (fr) |
| CA (1) | CA3160410A1 (fr) |
| CL (1) | CL2022001439A1 (fr) |
| IL (1) | IL293474A (fr) |
| MX (1) | MX2022006736A (fr) |
| TW (1) | TW202133844A (fr) |
| WO (1) | WO2021110805A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220101137A (ko) | 2019-11-15 | 2022-07-19 | 길리애드 사이언시즈, 인코포레이티드 | Lpa 수용체 길항제로서의 트라이아졸 카르바메이트 피리딜 설폰아미드 및 이의 용도 |
| CN115867556A (zh) | 2020-06-03 | 2023-03-28 | 吉利德科学公司 | Lpa受体拮抗剂及其用途 |
| TWI838626B (zh) | 2020-06-03 | 2024-04-11 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
| EP4337641A1 (fr) | 2021-05-11 | 2024-03-20 | Gilead Sciences, Inc. | Antagonistes du récepteur lpa et leurs utilisations |
| WO2023107938A1 (fr) | 2021-12-08 | 2023-06-15 | Gilead Sciences, Inc. | Antagonistes du récepteur lpa et leurs utilisations |
| WO2023192646A1 (fr) * | 2022-03-31 | 2023-10-05 | Puretech Lyt 100, Inc. | Méthodes de traitement de maladies et de troubles médiés par la fibrose et le collagène avec de la deupirfénidone |
| WO2024138185A1 (fr) * | 2022-12-23 | 2024-06-27 | Bristol-Myers Squibb Company | Antagonistes de lpa1 pour le traitement d'une maladie pulmonaire interstitielle |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6762180B1 (en) | 1999-10-13 | 2004-07-13 | Boehringer Ingelheim Pharma Kg | Substituted indolines which inhibit receptor tyrosine kinases |
| DE10233500A1 (de) | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel |
| US20040204458A1 (en) | 2002-08-16 | 2004-10-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of Lck inhibitors for treatment of immunologic diseases |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| NZ591443A (en) | 2005-09-22 | 2013-04-26 | Intermune Inc | Granule formation of pirfenidone and pharmaceutically acceptable excipients |
| US7767700B2 (en) | 2006-12-18 | 2010-08-03 | Intermune, Inc. | Method of providing pirfenidone therapy to a patient |
| PL2299987T3 (pl) | 2008-06-06 | 2018-08-31 | Boehringer Ingelheim International Gmbh | Farmaceutyczna postać dawkowania w formie kapsułki zawierająca formulację zwiesiny pochodnej indolinonu |
| US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
| US7566729B1 (en) | 2008-11-10 | 2009-07-28 | Intermune, Inc. | Modifying pirfenidone treatment for patients with atypical liver function |
| US7635707B1 (en) | 2008-11-10 | 2009-12-22 | Intermune, Inc. | Pirfenidone treatment for patients with atypical liver function |
| GB2470833B (en) | 2009-06-03 | 2011-06-01 | Amira Pharmaceuticals Inc | Polycyclic antagonists of lysophosphatidic acid receptors |
| US8084475B2 (en) | 2009-12-04 | 2011-12-27 | Intermune, Inc. | Pirfenidone therapy and inducers of cytochrome P450 |
| US7816383B1 (en) | 2009-12-04 | 2010-10-19 | Intermune, Inc. | Methods of administering pirfenidone therapy |
| PL2648726T3 (pl) | 2010-12-07 | 2018-10-31 | Amira Pharmaceuticals, Inc. | Policykliczny antagonista lpa1 i jego zastosowania |
| SG195110A1 (en) | 2011-05-25 | 2013-12-30 | Intermune Inc | Pirfenidone and anti-fibrotic therapy in selected patients |
| CN104066729A (zh) * | 2011-08-15 | 2014-09-24 | 英特穆恩公司 | 溶血磷脂酸受体拮抗剂 |
| CA2819967C (fr) | 2012-08-31 | 2016-03-22 | Intermune, Inc. | Utilisation de pirfenidone en simultanee avec du ciprofloxacin |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| CA2943363A1 (fr) | 2014-04-02 | 2015-10-08 | Intermune, Inc. | Pyridinones anti-fibrotiques |
| EP3463353A1 (fr) * | 2016-06-01 | 2019-04-10 | Boehringer Ingelheim International GmbH | Utilisation de biomarqueurs de matrice extracellulaire pour déterminer le moment d'instauration d'un traitement sous nintédanib et pirfénidone |
| AU2019215172B2 (en) | 2018-02-02 | 2023-08-10 | Genentech, Inc. | Pharmaceutical compound, salts thereof, formulations thereof, and methods of making and using same |
| MX2020013291A (es) | 2018-06-07 | 2021-04-29 | Idorsia Pharmaceuticals Ltd | Derivados de piridinilo alcoxisustituido como antagonistas del receptor lpa1 y su uso en el tratamiento de la fibrosis. |
| AR119162A1 (es) * | 2019-06-18 | 2021-12-01 | Idorsia Pharmaceuticals Ltd | Derivados de piridin-3-ilo |
-
2020
- 2020-12-03 CA CA3160410A patent/CA3160410A1/fr active Pending
- 2020-12-03 EP EP20816188.5A patent/EP4069227A1/fr active Pending
- 2020-12-03 JP JP2022531534A patent/JP2023504415A/ja active Pending
- 2020-12-03 BR BR112022010891A patent/BR112022010891A2/pt unknown
- 2020-12-03 WO PCT/EP2020/084401 patent/WO2021110805A1/fr unknown
- 2020-12-03 KR KR1020227022458A patent/KR20220109439A/ko unknown
- 2020-12-03 CN CN202080083930.1A patent/CN114761001A/zh active Pending
- 2020-12-03 TW TW109142607A patent/TW202133844A/zh unknown
- 2020-12-03 AU AU2020397207A patent/AU2020397207A1/en active Pending
- 2020-12-03 MX MX2022006736A patent/MX2022006736A/es unknown
- 2020-12-03 IL IL293474A patent/IL293474A/en unknown
- 2020-12-03 US US17/782,530 patent/US20230000846A1/en active Pending
-
2022
- 2022-06-01 CL CL2022001439A patent/CL2022001439A1/es unknown
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