JPWO2021108677A5 - - Google Patents
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- JPWO2021108677A5 JPWO2021108677A5 JP2022531423A JP2022531423A JPWO2021108677A5 JP WO2021108677 A5 JPWO2021108677 A5 JP WO2021108677A5 JP 2022531423 A JP2022531423 A JP 2022531423A JP 2022531423 A JP2022531423 A JP 2022531423A JP WO2021108677 A5 JPWO2021108677 A5 JP WO2021108677A5
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- 239000000203 mixture Substances 0.000 claims 43
- 210000000822 natural killer cell Anatomy 0.000 claims 18
- 206010028980 Neoplasm Diseases 0.000 claims 12
- 201000011510 cancer Diseases 0.000 claims 9
- 230000000694 effects Effects 0.000 claims 6
- 239000003112 inhibitor Substances 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 150000003384 small molecules Chemical class 0.000 claims 5
- 102000003676 Glucocorticoid Receptors Human genes 0.000 claims 4
- 108090000079 Glucocorticoid Receptors Proteins 0.000 claims 4
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 4
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 4
- 229940125798 integrin inhibitor Drugs 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 4
- 102000004060 Transforming Growth Factor-beta Type II Receptor Human genes 0.000 claims 3
- 108010082684 Transforming Growth Factor-beta Type II Receptor Proteins 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 208000005017 glioblastoma Diseases 0.000 claims 3
- 102000006495 integrins Human genes 0.000 claims 3
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- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- MMHDBUJXLOFTLC-WOYTXXSLSA-N (2s)-2-[[(2r)-2-[[(2s)-2-[[(2s)-2-[[(2s)-1-acetylpyrrolidine-2-carbonyl]amino]-3-(1h-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-sulfanylpropanoyl]amino]butanediamide Chemical compound CC(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(N)=O)CC1=CN=CN1 MMHDBUJXLOFTLC-WOYTXXSLSA-N 0.000 claims 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 2
- 108091008874 T cell receptors Proteins 0.000 claims 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
- 108010009583 Transforming Growth Factors Proteins 0.000 claims 2
- 102000009618 Transforming Growth Factors Human genes 0.000 claims 2
- 108010011755 acetyl-prolyl-histidyl-seryl-cysteinyl-asparaginamide Proteins 0.000 claims 2
- 230000000735 allogeneic effect Effects 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
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- 108091007433 antigens Proteins 0.000 claims 2
- 210000004700 fetal blood Anatomy 0.000 claims 2
- 238000011275 oncology therapy Methods 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- NVVGCQABIHSJSQ-KFZSMJGVSA-N (2s)-1-[(2s)-2-[[(2s)-3-carboxy-2-[[(2s)-4-methyl-2-[[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]pentanoyl]amino]propanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carboxylic acid Chemical compound N([C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(O)=O)C(=O)CC(C=C1)=CC=C1NC(=O)NC1=CC=CC=C1C NVVGCQABIHSJSQ-KFZSMJGVSA-N 0.000 claims 1
- XKLHCUGVLCGKKX-RBUKOAKNSA-N (2s)-2-[[(4r)-3-(benzenesulfonyl)-5,5-dimethyl-1,3-thiazolidine-4-carbonyl]amino]-3-(benzylcarbamoylamino)propanoic acid Chemical compound C([C@H](NC(=O)[C@H]1N(CSC1(C)C)S(=O)(=O)C=1C=CC=CC=1)C(O)=O)NC(=O)NCC1=CC=CC=C1 XKLHCUGVLCGKKX-RBUKOAKNSA-N 0.000 claims 1
- NNRFRJQMBSBXGO-CIUDSAMLSA-N (3s)-3-[[2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-oxobutanoic acid Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O NNRFRJQMBSBXGO-CIUDSAMLSA-N 0.000 claims 1
- NSLIQOPYDUKWTA-UHFFFAOYSA-N 1-[4-[[1-(4-fluorophenyl)pyrazol-4-yl]sulfonyl-methylamino]phenyl]-3-phenylurea Chemical compound C1=NN(C=2C=CC(F)=CC=2)C=C1S(=O)(=O)N(C)C(C=C1)=CC=C1NC(=O)NC1=CC=CC=C1 NSLIQOPYDUKWTA-UHFFFAOYSA-N 0.000 claims 1
- XLBBKEHLEPNMMF-SSUNCQRMSA-N 129038-42-2 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CS)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)[C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CCC(O)=O)C1=CC=CC=C1 XLBBKEHLEPNMMF-SSUNCQRMSA-N 0.000 claims 1
- 108010093960 2-((1-(3,5-dichlorobenzenesulfonyl)pyrrolidine-2-carbonyl)amino)-4-(4-methyl-2-(methyl-(2-(4-(3-o-tolylureido)phenyl)acetyl)amino)pentanoylamino)butyric acid Proteins 0.000 claims 1
- ITXAAOWFOURIHK-DEOSSOPVSA-N 2-[1-[(3s)-4-[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]morpholine-3-carbonyl]piperidin-4-yl]acetic acid Chemical compound CC1=CC=CC=C1NC(=O)NC(C=C1)=CC=C1CC(=O)N1[C@H](C(=O)N2CCC(CC(O)=O)CC2)COCC1 ITXAAOWFOURIHK-DEOSSOPVSA-N 0.000 claims 1
- YKRNPHOBDOUQTG-UHFFFAOYSA-N 2-[4-[4-(4-carbamimidoylphenyl)piperazin-1-yl]piperidin-1-yl]acetic acid;trihydrochloride Chemical compound Cl.Cl.Cl.C1=CC(C(=N)N)=CC=C1N1CCN(C2CCN(CC(O)=O)CC2)CC1 YKRNPHOBDOUQTG-UHFFFAOYSA-N 0.000 claims 1
- 108010029872 BIO 1211 Proteins 0.000 claims 1
- 108091033409 CRISPR Proteins 0.000 claims 1
- 238000010354 CRISPR gene editing Methods 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108010056764 Eptifibatide Proteins 0.000 claims 1
- 108020005004 Guide RNA Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 108010027703 R-BC154 Proteins 0.000 claims 1
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 229960000446 abciximab Drugs 0.000 claims 1
- 239000000074 antisense oligonucleotide Substances 0.000 claims 1
- 238000012230 antisense oligonucleotides Methods 0.000 claims 1
- 108010089975 arginyl-glycyl-aspartyl-serine Proteins 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- AMLYAMJWYAIXIA-VWNVYAMZSA-N cilengitide Chemical group N1C(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CC1=CC=CC=C1 AMLYAMJWYAIXIA-VWNVYAMZSA-N 0.000 claims 1
- 229950009003 cilengitide Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 108010025752 echistatin Proteins 0.000 claims 1
- 229960004468 eptifibatide Drugs 0.000 claims 1
- GLGOPUHVAZCPRB-LROMGURASA-N eptifibatide Chemical compound N1C(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCCNC(=N)N)NC(=O)CCSSC[C@@H](C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]1CC1=CN=C2[C]1C=CC=C2 GLGOPUHVAZCPRB-LROMGURASA-N 0.000 claims 1
- 230000002489 hematologic effect Effects 0.000 claims 1
- 238000001794 hormone therapy Methods 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 229960005027 natalizumab Drugs 0.000 claims 1
- XXWNADNJWWLFFP-UHFFFAOYSA-N obtustatin Chemical compound C=1C=C(O)C=CC=1CC(C(=O)N1C(CCC1)C(=O)NCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C1CCCN1C(=O)C(NC(=O)C(CC(O)=O)NC(=O)C(CSSCC(NC1=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCC(N)=O)C(=O)N2)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(C(C)O)NC3=O)CSSCC(C(NC(CC=4C5=CC=CC=C5NC=4)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(CO)C(=O)NC(CC=4N=CNC=4)C(=O)N4)C(C)O)C(C)O)=O)NC(=O)C(C(C)O)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(C)NC(=O)C5CCCN5C(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C2CSSCC(N)C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NCC(=O)N2CCCC2C(=O)NC1CSSCC3NC(=O)C4CC1=CC=C(O)C=C1 XXWNADNJWWLFFP-UHFFFAOYSA-N 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 239000002924 silencing RNA Substances 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 229960003425 tirofiban Drugs 0.000 claims 1
- COKMIXFXJJXBQG-NRFANRHFSA-N tirofiban Chemical compound C1=CC(C[C@H](NS(=O)(=O)CCCC)C(O)=O)=CC=C1OCCCCC1CCNCC1 COKMIXFXJJXBQG-NRFANRHFSA-N 0.000 claims 1
- 229960004914 vedolizumab Drugs 0.000 claims 1
- 108010035546 vipegitide Proteins 0.000 claims 1
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962941050P | 2019-11-27 | 2019-11-27 | |
US62/941,050 | 2019-11-27 | ||
US202063022936P | 2020-05-11 | 2020-05-11 | |
US63/022,936 | 2020-05-11 | ||
PCT/US2020/062381 WO2021108677A1 (fr) | 2019-11-27 | 2020-11-25 | Immunothérapie par cellules tueuses naturelles pour le traitement du glioblastome et d'autres cancers |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2023504081A JP2023504081A (ja) | 2023-02-01 |
JPWO2021108677A5 true JPWO2021108677A5 (fr) | 2023-12-04 |
Family
ID=76129960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022531423A Pending JP2023504081A (ja) | 2019-11-27 | 2020-11-25 | 神経膠芽細胞腫及び他の癌を処置するためのナチュラルキラー細胞免疫療法 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20220378739A1 (fr) |
EP (1) | EP4065691A4 (fr) |
JP (1) | JP2023504081A (fr) |
CN (1) | CN114929853A (fr) |
WO (1) | WO2021108677A1 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113855670B (zh) * | 2021-11-03 | 2023-06-09 | 上海市肺科医院 | A205804在制备治疗脓毒症药物中的应用 |
WO2024107866A1 (fr) * | 2022-11-15 | 2024-05-23 | Celularity Inc. | Compositions et méthodes pour traiter le cancer |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013176916A1 (fr) * | 2012-05-25 | 2013-11-28 | Roman Galetto | Utilisation de pré-t alpha ou d'un variant fonctionnel de celui-ci pour expanser des lymphocytes t déficients en tcr-alpha |
US20150285802A1 (en) * | 2012-07-18 | 2015-10-08 | Dana-Farber Cancer Institute, Inc. | Methods for treating, preventing and predicting risk of developing breast cancer |
WO2018161064A1 (fr) * | 2017-03-03 | 2018-09-07 | F1 Oncology, Inc. | Procédés et compositions pour la transduction et l'expansion de lymphocytes et la régulation de l'activité de ces derniers |
JP2020517259A (ja) * | 2017-04-19 | 2020-06-18 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 操作された抗原受容体を発現する免疫細胞 |
EP3710039A4 (fr) * | 2017-11-13 | 2021-08-04 | The Broad Institute, Inc. | Méthodes et compositions de traitement du cancer par ciblage de la voie clec2d-klrb1 |
WO2019149743A1 (fr) * | 2018-01-30 | 2019-08-08 | Cellectis | Association comprenant des cellules immunitaires allogéniques déficientes pour un antigène présent sur les cellules t et sur des cellules pathologiques, et anticorps thérapeutique contre ledit antigène |
KR20200133218A (ko) * | 2018-03-15 | 2020-11-26 | 케이에스큐 세러퓨틱스 인코포레이티드 | 개선된 면역요법을 위한 유전자-조절 조성물 및 방법 |
-
2020
- 2020-11-25 JP JP2022531423A patent/JP2023504081A/ja active Pending
- 2020-11-25 US US17/755,881 patent/US20220378739A1/en active Pending
- 2020-11-25 CN CN202080092852.1A patent/CN114929853A/zh active Pending
- 2020-11-25 WO PCT/US2020/062381 patent/WO2021108677A1/fr unknown
- 2020-11-25 EP EP20894513.9A patent/EP4065691A4/fr active Pending
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