JPWO2021108609A5 - - Google Patents
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- JPWO2021108609A5 JPWO2021108609A5 JP2022530253A JP2022530253A JPWO2021108609A5 JP WO2021108609 A5 JPWO2021108609 A5 JP WO2021108609A5 JP 2022530253 A JP2022530253 A JP 2022530253A JP 2022530253 A JP2022530253 A JP 2022530253A JP WO2021108609 A5 JPWO2021108609 A5 JP WO2021108609A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- acid sequence
- exogenous
- neurod1
- identity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 102100032063 Neurogenic differentiation factor 1 Human genes 0.000 claims description 20
- 210000001130 astrocyte Anatomy 0.000 claims description 12
- 210000002569 neuron Anatomy 0.000 claims description 12
- 150000007523 nucleic acids Chemical group 0.000 claims description 10
- 108050000588 Neurogenic differentiation factor 1 Proteins 0.000 claims description 6
- 210000004556 brain Anatomy 0.000 claims description 6
- 239000012634 fragment Substances 0.000 claims description 6
- 239000013604 expression vector Substances 0.000 claims description 5
- 102100020871 Forkhead box protein G1 Human genes 0.000 claims description 4
- 101000931525 Homo sapiens Forkhead box protein G1 Proteins 0.000 claims description 4
- 238000003259 recombinant expression Methods 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 101000638044 Homo sapiens Neurogenic differentiation factor 1 Proteins 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 14
- 239000003795 chemical substances by application Substances 0.000 claims 11
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 8
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 230000009529 traumatic brain injury Effects 0.000 claims 6
- 206010018341 Gliosis Diseases 0.000 claims 4
- 208000037875 astrocytosis Diseases 0.000 claims 4
- 230000007341 astrogliosis Effects 0.000 claims 4
- 102000053171 Glial Fibrillary Acidic Human genes 0.000 claims 3
- 101710193519 Glial fibrillary acidic protein Proteins 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 210000005046 glial fibrillary acidic protein Anatomy 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- 101000888419 Homo sapiens Glial fibrillary acidic protein Proteins 0.000 claims 2
- 102000051520 human GFAP Human genes 0.000 claims 2
- 210000004498 neuroglial cell Anatomy 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 208000018652 Closed Head injury Diseases 0.000 claims 1
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 208000032843 Hemorrhage Diseases 0.000 claims 1
- 108091023040 Transcription factor Proteins 0.000 claims 1
- 102000040945 Transcription factor Human genes 0.000 claims 1
- 238000002599 functional magnetic resonance imaging Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 230000001537 neural effect Effects 0.000 description 5
- 230000000946 synaptic effect Effects 0.000 description 3
- 102000016843 Calbindin 2 Human genes 0.000 description 2
- 108010028326 Calbindin 2 Proteins 0.000 description 2
- 102000008214 Glutamate decarboxylase Human genes 0.000 description 2
- 108091022930 Glutamate decarboxylase Proteins 0.000 description 2
- 101001092197 Homo sapiens RNA binding protein fox-1 homolog 3 Proteins 0.000 description 2
- 102000001675 Parvalbumin Human genes 0.000 description 2
- 108060005874 Parvalbumin Proteins 0.000 description 2
- 102100035530 RNA binding protein fox-1 homolog 3 Human genes 0.000 description 2
- 102000005157 Somatostatin Human genes 0.000 description 2
- 108010056088 Somatostatin Proteins 0.000 description 2
- 210000001787 dendrite Anatomy 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 2
- 229960000553 somatostatin Drugs 0.000 description 2
- -1 Ctip2 Proteins 0.000 description 1
- 101150059254 Cux1 gene Proteins 0.000 description 1
- 101150014889 Gad1 gene Proteins 0.000 description 1
- 102100035902 Glutamate decarboxylase 1 Human genes 0.000 description 1
- 101000979001 Homo sapiens Methionine aminopeptidase 2 Proteins 0.000 description 1
- 101000969087 Homo sapiens Microtubule-associated protein 2 Proteins 0.000 description 1
- 102100021118 Microtubule-associated protein 2 Human genes 0.000 description 1
- 210000003050 axon Anatomy 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000003520 dendritic spine Anatomy 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- BPGXUIVWLQTVLZ-OFGSCBOVSA-N neuropeptide y(npy) Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 BPGXUIVWLQTVLZ-OFGSCBOVSA-N 0.000 description 1
- 230000003957 neurotransmitter release Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 210000000225 synapse Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962939978P | 2019-11-25 | 2019-11-25 | |
| US62/939,978 | 2019-11-25 | ||
| PCT/US2020/062299 WO2021108609A1 (en) | 2019-11-25 | 2020-11-25 | Brain repair after traumatic brain injury through neurod1-mediated astrocyte-to-neuron conversion |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023502782A JP2023502782A (ja) | 2023-01-25 |
| JP2023502782A5 JP2023502782A5 (https=) | 2023-12-01 |
| JPWO2021108609A5 true JPWO2021108609A5 (https=) | 2023-12-01 |
Family
ID=76130727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022530253A Pending JP2023502782A (ja) | 2019-11-25 | 2020-11-25 | 星状細胞からニューロンへのＮｅｕｒｏＤ１媒介性変換を介した外傷性脳損傷後の脳の修復 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP4065227A4 (https=) |
| JP (1) | JP2023502782A (https=) |
| CN (1) | CN115135382A (https=) |
| AU (1) | AU2020391479A1 (https=) |
| CA (1) | CA3162891A1 (https=) |
| WO (1) | WO2021108609A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120418229A (zh) * | 2022-12-28 | 2025-08-01 | 安斯泰来制药株式会社 | 4-氨基哌啶化合物、其脂质纳米粒子和含有其的药物组合物 |
| WO2024162304A1 (ja) * | 2023-01-31 | 2024-08-08 | アステラス製薬株式会社 | 環状アミンを有するカルバモイル脂質又はウレア脂質、それを含む脂質ナノ粒子、及び医薬組成物 |
| WO2025143118A1 (ja) * | 2023-12-27 | 2025-07-03 | アステラス製薬株式会社 | 脊髄損傷の治療用医薬組成物及び脊髄損傷の非ヒト霊長類動物モデルの作製方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6087168A (en) * | 1999-01-20 | 2000-07-11 | Cedars Sinai Medical Center | Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells |
| US10561742B2 (en) * | 2012-07-19 | 2020-02-18 | The Penn State Research Foundation | Methods and compositions for treatment of disease or injury of the nervous system |
| US10076574B2 (en) * | 2013-10-25 | 2018-09-18 | Wayne State University | Methods, systems and compositions relating to cell conversion via protein-induced in-vivo cell reprogramming |
| CA2903933C (en) * | 2015-09-11 | 2020-02-25 | Nomadogen Biotechnologies Inc. | Methods and compositions for the packaging of nucleic acids into microglial exosomes for the targeted expression of polypeptides in neural cells |
| US9840542B2 (en) * | 2015-09-11 | 2017-12-12 | Nomadogen Biotechnologies Inc. | Methods and compositions for the packaging of nucleic acids into microglial exosomes for the targeted expression of polypeptides in neural cells |
| US10973930B2 (en) * | 2016-02-18 | 2021-04-13 | The Penn State Research Foundation | Generating GABAergic neurons in brains |
| US20200054711A1 (en) * | 2017-02-28 | 2020-02-20 | The Penn State Research Foundation | Regenerating functional neurons for treatment of neural injury caused by disruption of blood flow |
| EP3746109A4 (en) * | 2018-02-02 | 2021-11-03 | The Penn State Research Foundation | METHODS AND MATERIALS FOR TREATING BRAIN INJURY |
-
2020
- 2020-11-25 EP EP20894844.8A patent/EP4065227A4/en not_active Withdrawn
- 2020-11-25 AU AU2020391479A patent/AU2020391479A1/en not_active Abandoned
- 2020-11-25 CA CA3162891A patent/CA3162891A1/en active Pending
- 2020-11-25 JP JP2022530253A patent/JP2023502782A/ja active Pending
- 2020-11-25 WO PCT/US2020/062299 patent/WO2021108609A1/en not_active Ceased
- 2020-11-25 CN CN202080081784.9A patent/CN115135382A/zh active Pending
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