AU2020391479A1 - Brain repair after traumatic brain injury through NeuroDl-mediated astrocyte-to-neuron conversion - Google Patents
Brain repair after traumatic brain injury through NeuroDl-mediated astrocyte-to-neuron conversion Download PDFInfo
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A01K2227/00—Animals characterised by species
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- A01K2227/105—Murine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
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Landscapes
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| US201962939978P | 2019-11-25 | 2019-11-25 | |
| US62/939,978 | 2019-11-25 | ||
| PCT/US2020/062299 WO2021108609A1 (en) | 2019-11-25 | 2020-11-25 | Brain repair after traumatic brain injury through neurod1-mediated astrocyte-to-neuron conversion |
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| AU2020391479A1 true AU2020391479A1 (en) | 2022-06-16 |
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| AU2020391479A Abandoned AU2020391479A1 (en) | 2019-11-25 | 2020-11-25 | Brain repair after traumatic brain injury through NeuroDl-mediated astrocyte-to-neuron conversion |
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| EP (1) | EP4065227A4 (https=) |
| JP (1) | JP2023502782A (https=) |
| CN (1) | CN115135382A (https=) |
| AU (1) | AU2020391479A1 (https=) |
| CA (1) | CA3162891A1 (https=) |
| WO (1) | WO2021108609A1 (https=) |
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| CN120418229A (zh) * | 2022-12-28 | 2025-08-01 | 安斯泰来制药株式会社 | 4-氨基哌啶化合物、其脂质纳米粒子和含有其的药物组合物 |
| WO2024162304A1 (ja) * | 2023-01-31 | 2024-08-08 | アステラス製薬株式会社 | 環状アミンを有するカルバモイル脂質又はウレア脂質、それを含む脂質ナノ粒子、及び医薬組成物 |
| WO2025143118A1 (ja) * | 2023-12-27 | 2025-07-03 | アステラス製薬株式会社 | 脊髄損傷の治療用医薬組成物及び脊髄損傷の非ヒト霊長類動物モデルの作製方法 |
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| US6087168A (en) * | 1999-01-20 | 2000-07-11 | Cedars Sinai Medical Center | Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells |
| US10561742B2 (en) * | 2012-07-19 | 2020-02-18 | The Penn State Research Foundation | Methods and compositions for treatment of disease or injury of the nervous system |
| US10076574B2 (en) * | 2013-10-25 | 2018-09-18 | Wayne State University | Methods, systems and compositions relating to cell conversion via protein-induced in-vivo cell reprogramming |
| CA2903933C (en) * | 2015-09-11 | 2020-02-25 | Nomadogen Biotechnologies Inc. | Methods and compositions for the packaging of nucleic acids into microglial exosomes for the targeted expression of polypeptides in neural cells |
| US9840542B2 (en) * | 2015-09-11 | 2017-12-12 | Nomadogen Biotechnologies Inc. | Methods and compositions for the packaging of nucleic acids into microglial exosomes for the targeted expression of polypeptides in neural cells |
| US10973930B2 (en) * | 2016-02-18 | 2021-04-13 | The Penn State Research Foundation | Generating GABAergic neurons in brains |
| US20200054711A1 (en) * | 2017-02-28 | 2020-02-20 | The Penn State Research Foundation | Regenerating functional neurons for treatment of neural injury caused by disruption of blood flow |
| EP3746109A4 (en) * | 2018-02-02 | 2021-11-03 | The Penn State Research Foundation | METHODS AND MATERIALS FOR TREATING BRAIN INJURY |
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- 2020-11-25 AU AU2020391479A patent/AU2020391479A1/en not_active Abandoned
- 2020-11-25 CA CA3162891A patent/CA3162891A1/en active Pending
- 2020-11-25 JP JP2022530253A patent/JP2023502782A/ja active Pending
- 2020-11-25 WO PCT/US2020/062299 patent/WO2021108609A1/en not_active Ceased
- 2020-11-25 CN CN202080081784.9A patent/CN115135382A/zh active Pending
Also Published As
| Publication number | Publication date |
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| JP2023502782A (ja) | 2023-01-25 |
| CN115135382A (zh) | 2022-09-30 |
| CA3162891A1 (en) | 2021-06-03 |
| WO2021108609A1 (en) | 2021-06-03 |
| EP4065227A4 (en) | 2023-12-20 |
| EP4065227A1 (en) | 2022-10-05 |
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| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |