EP4065227A4 - Brain repair after traumatic brain injury through neurod1-mediated astrocyte-to-neuron conversion - Google Patents

Brain repair after traumatic brain injury through neurod1-mediated astrocyte-to-neuron conversion Download PDF

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Publication number
EP4065227A4
EP4065227A4 EP20894844.8A EP20894844A EP4065227A4 EP 4065227 A4 EP4065227 A4 EP 4065227A4 EP 20894844 A EP20894844 A EP 20894844A EP 4065227 A4 EP4065227 A4 EP 4065227A4
Authority
EP
European Patent Office
Prior art keywords
neurod1
repair
brain
neuron conversion
brain injury
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20894844.8A
Other languages
German (de)
French (fr)
Other versions
EP4065227A1 (en
Inventor
Gong Chen
Zhou-Fan LEI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Penn State Research Foundation
Original Assignee
Penn State Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Penn State Research Foundation filed Critical Penn State Research Foundation
Publication of EP4065227A1 publication Critical patent/EP4065227A1/en
Publication of EP4065227A4 publication Critical patent/EP4065227A4/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Immunology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
EP20894844.8A 2019-11-25 2020-11-25 Brain repair after traumatic brain injury through neurod1-mediated astrocyte-to-neuron conversion Pending EP4065227A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962939978P 2019-11-25 2019-11-25
PCT/US2020/062299 WO2021108609A1 (en) 2019-11-25 2020-11-25 Brain repair after traumatic brain injury through neurod1-mediated astrocyte-to-neuron conversion

Publications (2)

Publication Number Publication Date
EP4065227A1 EP4065227A1 (en) 2022-10-05
EP4065227A4 true EP4065227A4 (en) 2023-12-20

Family

ID=76130727

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20894844.8A Pending EP4065227A4 (en) 2019-11-25 2020-11-25 Brain repair after traumatic brain injury through neurod1-mediated astrocyte-to-neuron conversion

Country Status (6)

Country Link
EP (1) EP4065227A4 (en)
JP (1) JP2023502782A (en)
CN (1) CN115135382A (en)
AU (1) AU2020391479A1 (en)
CA (1) CA3162891A1 (en)
WO (1) WO2021108609A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024143444A1 (en) * 2022-12-28 2024-07-04 アステラス製薬株式会社 4-aminopiperidine compound, lipid nanoparticles thereof, and pharmaceutical composition containing same
WO2024162304A1 (en) * 2023-01-31 2024-08-08 アステラス製薬株式会社 Carbamoyl lipid or urea lipid each having cyclic amine, lipid nanoparticles containing same, and pharmaceutical composition

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2903933A1 (en) * 2015-09-11 2017-03-11 Nomadogen Biotechnologies Inc. Methods and compositions for the packaging of nucleic acids into microglial exosomes for the targeted expression of polypeptides in neural cells
US20170073382A1 (en) * 2015-09-11 2017-03-16 Nomadogen Biotechnologies Inc. Methods and Compositions For The Packaging of Nucleic Acids Into Microglial Exosomes For The Targeted Expression of Polypeptides in Neural Cells
WO2019152857A1 (en) * 2018-02-02 2019-08-08 Gong Chen Methods and materials for treating brain injuries

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118384297A (en) * 2017-02-28 2024-07-26 宾州研究基金会 Regeneration of functional neurons for treatment of nerve damage due to blood flow disruption

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2903933A1 (en) * 2015-09-11 2017-03-11 Nomadogen Biotechnologies Inc. Methods and compositions for the packaging of nucleic acids into microglial exosomes for the targeted expression of polypeptides in neural cells
US20170073382A1 (en) * 2015-09-11 2017-03-16 Nomadogen Biotechnologies Inc. Methods and Compositions For The Packaging of Nucleic Acids Into Microglial Exosomes For The Targeted Expression of Polypeptides in Neural Cells
WO2019152857A1 (en) * 2018-02-02 2019-08-08 Gong Chen Methods and materials for treating brain injuries

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LETHBRIDGE BRAINIACS: "Team:Lethbridge/project - 2014.igem.org", 2 July 2015 (2015-07-02), XP055652357, Retrieved from the Internet <URL:https://web.archive.org/web/20150702194117/http://2014.igem.org/Team:Lethbridge/project> [retrieved on 20191212] *
See also references of WO2021108609A1 *
WESTON NICOLE M ET AL: "The Potential of Stem Cells in Treatment of Traumatic Brain Injury", CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, SPRINGER US, NEW YORK, vol. 18, no. 1, 25 January 2018 (2018-01-25), pages 1 - 10, XP036423434, ISSN: 1528-4042, [retrieved on 20180125], DOI: 10.1007/S11910-018-0812-Z *

Also Published As

Publication number Publication date
EP4065227A1 (en) 2022-10-05
AU2020391479A1 (en) 2022-06-16
WO2021108609A1 (en) 2021-06-03
CN115135382A (en) 2022-09-30
JP2023502782A (en) 2023-01-25
CA3162891A1 (en) 2021-06-03

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