JPWO2021100848A1 - - Google Patents

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Publication number
JPWO2021100848A1
JPWO2021100848A1 JP2021558467A JP2021558467A JPWO2021100848A1 JP WO2021100848 A1 JPWO2021100848 A1 JP WO2021100848A1 JP 2021558467 A JP2021558467 A JP 2021558467A JP 2021558467 A JP2021558467 A JP 2021558467A JP WO2021100848 A1 JPWO2021100848 A1 JP WO2021100848A1
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021558467A
Other versions
JPWO2021100848A5 (ja
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of JPWO2021100848A1 publication Critical patent/JPWO2021100848A1/ja
Publication of JPWO2021100848A5 publication Critical patent/JPWO2021100848A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/167—Heterorings having sulfur atoms as ring heteroatoms, e.g. vitamin B1, thiamine nucleus and open chain analogs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2021558467A 2019-11-22 2020-11-20 Pending JPWO2021100848A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019211797 2019-11-22
PCT/JP2020/043366 WO2021100848A1 (ja) 2019-11-22 2020-11-20 カルボニル還元酵素、これをコードする核酸、及びこれらを利用した光学活性化合物の製造方法

Publications (2)

Publication Number Publication Date
JPWO2021100848A1 true JPWO2021100848A1 (ja) 2021-05-27
JPWO2021100848A5 JPWO2021100848A5 (ja) 2024-05-08

Family

ID=75981600

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021558467A Pending JPWO2021100848A1 (ja) 2019-11-22 2020-11-20

Country Status (5)

Country Link
US (1) US20230025343A1 (ja)
EP (1) EP4063512A4 (ja)
JP (1) JPWO2021100848A1 (ja)
CN (1) CN114729374A (ja)
WO (1) WO2021100848A1 (ja)

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57183799A (en) 1981-04-17 1982-11-12 Kyowa Hakko Kogyo Co Ltd Novel plasmid
JPH0279866A (ja) 1988-09-16 1990-03-20 Konica Corp カラー画像形成装置
JP2648897B2 (ja) 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
JP3481325B2 (ja) 1994-09-06 2003-12-22 宇部興産株式会社 光学活性な３−オキシ−５−オキソ−６−ヘプテン酸誘導体の製法
CN1322129C (zh) * 2002-03-19 2007-06-20 三菱化学株式会社 新型羰基还原酶及其编码基因、以及利用它们制备光学活性醇的方法
JP4270918B2 (ja) * 2002-03-19 2009-06-03 三菱化学株式会社 新規カルボニル還元酵素及びこれをコードする遺伝子、ならびにこれらを利用した光学活性アルコールの製造方法
JP2005034025A (ja) 2003-07-18 2005-02-10 Mitsubishi Pharma Corp 大腸菌での異種遺伝子発現を促進させるプラスミドベクター、組換え大腸菌、該組換え大腸菌を用いた化学物質製造法及び組換えタンパク質の製造法
CA2533838A1 (en) * 2003-08-11 2005-02-24 Codexis, Inc. Improved ketoreductase polypeptides and related polynucleotides
US7794993B2 (en) * 2004-08-06 2010-09-14 Kaneka Corporation Carbonyl reductase, gene thereof and method of using the same
EP2562253B1 (en) * 2010-04-22 2017-08-02 Kaneka Corporation Modified carbonyl reductase, gene thereof, and method of producing optically active alcohols using these
EP3103878A4 (en) * 2014-02-06 2017-08-16 API Corporation Rosuvastatin calcium and process for producing intermediate thereof
CN107603961B (zh) * 2014-05-09 2020-04-24 凯莱英医药集团（天津）股份有限公司 双羰基还原酶突变体及其应用
WO2017022846A1 (ja) * 2015-08-05 2017-02-09 株式会社エーピーアイ コーポレーション ピタバスタチンカルシウムの製造方法
CN106243205B (zh) * 2016-08-17 2019-08-02 中国科学院植物研究所 一种降解棒曲霉素的蛋白及其编码基因与应用
EP3652328A1 (en) * 2017-07-14 2020-05-20 c-LEcta GmbH Ketoreductases
JP6828109B2 (ja) 2019-09-10 2021-02-10 キヤノン株式会社 画像形成装置
CN111454998B (zh) * 2020-04-21 2023-05-02 黄山科宏生物香料股份有限公司 一种手性羟基酸酯的生物制备方法
CN113430240B (zh) * 2021-06-29 2023-07-04 华东理工大学 一种连续流生物催化合成阿扎那韦中间体氯醇的方法

Also Published As

Publication number Publication date
EP4063512A1 (en) 2022-09-28
EP4063512A4 (en) 2024-01-03
WO2021100848A1 (ja) 2021-05-27
CN114729374A (zh) 2022-07-08
US20230025343A1 (en) 2023-01-26

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