JPWO2021086899A5 - - Google Patents

Info

Publication number

JPWO2021086899A5

JPWO2021086899A5 JP2022523575A JP2022523575A JPWO2021086899A5 JP WO2021086899 A5 JPWO2021086899 A5 JP WO2021086899A5 JP 2022523575 A JP2022523575 A JP 2022523575A JP 2022523575 A JP2022523575 A JP 2022523575A JP WO2021086899 A5 JPWO2021086899 A5 JP WO2021086899A5

Authority

JP

Japan

Prior art keywords

antigen

binding fragment

isolated antibody

pharmaceutical composition

antibody

Prior art date

2023-09-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000000427 antigen Substances 0.000 claims description 91
• 102000036639 antigens Human genes 0.000 claims description 91
• 108091007433 antigens Proteins 0.000 claims description 91
• 239000012634 fragment Substances 0.000 claims description 91
• 241000124008 Mammalia Species 0.000 claims description 80
• 239000008194 pharmaceutical composition Substances 0.000 claims description 44
• 230000004083 survival effect Effects 0.000 claims description 30
• 230000000069 prophylactic effect Effects 0.000 claims description 25
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 24
• 206010022000 influenza Diseases 0.000 claims description 23
• 238000000034 method Methods 0.000 claims description 22
• 239000003814 drug Substances 0.000 claims description 20
• 101710154606 Hemagglutinin Proteins 0.000 claims description 18
• 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 18
• 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 18
• 101710176177 Protein A56 Proteins 0.000 claims description 18
• 239000000185 hemagglutinin Substances 0.000 claims description 18
• 239000003443 antiviral agent Substances 0.000 claims description 12
• 208000037797 influenza A Diseases 0.000 claims description 12
• 208000037798 influenza B Diseases 0.000 claims description 12
• 208000024891 symptom Diseases 0.000 claims description 12
• 229940124597 therapeutic agent Drugs 0.000 claims description 12
• VSZGPKBBMSAYNT-RRFJBIMHSA-N oseltamivir Chemical compound CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 VSZGPKBBMSAYNT-RRFJBIMHSA-N 0.000 claims description 10
• 229960003752 oseltamivir Drugs 0.000 claims description 10
• 241000713196 Influenza B virus Species 0.000 claims description 8
• 239000002260 anti-inflammatory agent Substances 0.000 claims description 8
• 229940124599 anti-inflammatory drug Drugs 0.000 claims description 8
• 230000037396 body weight Effects 0.000 claims description 8
• 235000015872 dietary supplement Nutrition 0.000 claims description 8
• 229940079593 drug Drugs 0.000 claims description 8
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 6
• 206010011224 Cough Diseases 0.000 claims description 6
• 208000000059 Dyspnea Diseases 0.000 claims description 6
• 206010013975 Dyspnoeas Diseases 0.000 claims description 6
• 241001465754 Metazoa Species 0.000 claims description 6
• 206010035664 Pneumonia Diseases 0.000 claims description 6
• 206010037660 Pyrexia Diseases 0.000 claims description 6
• 208000036071 Rhinorrhea Diseases 0.000 claims description 6
• 206010039101 Rhinorrhoea Diseases 0.000 claims description 6
• 206010006451 bronchitis Diseases 0.000 claims description 6
• 102000040430 polynucleotide Human genes 0.000 claims description 6
• 108091033319 polynucleotide Proteins 0.000 claims description 6
• 239000002157 polynucleotide Substances 0.000 claims description 6
• 208000013220 shortness of breath Diseases 0.000 claims description 6
• 238000001990 intravenous administration Methods 0.000 claims description 5
• 206010012735 Diarrhoea Diseases 0.000 claims description 4
• 206010019233 Headaches Diseases 0.000 claims description 4
• 206010028735 Nasal congestion Diseases 0.000 claims description 4
• 206010068319 Oropharyngeal pain Diseases 0.000 claims description 4
• 208000002193 Pain Diseases 0.000 claims description 4
• 201000007100 Pharyngitis Diseases 0.000 claims description 4
• 206010047700 Vomiting Diseases 0.000 claims description 4
• 239000003963 antioxidant agent Substances 0.000 claims description 4
• 230000003078 antioxidant effect Effects 0.000 claims description 4
• 239000003246 corticosteroid Substances 0.000 claims description 4
• 229960001334 corticosteroids Drugs 0.000 claims description 4
• 201000010099 disease Diseases 0.000 claims description 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
• 231100000869 headache Toxicity 0.000 claims description 4
• 208000015181 infectious disease Diseases 0.000 claims description 4
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 4
• 238000009116 palliative therapy Methods 0.000 claims description 4
• 229960005486 vaccine Drugs 0.000 claims description 4
• 230000008673 vomiting Effects 0.000 claims description 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
• 206010061598 Immunodeficiency Diseases 0.000 claims description 2
• 208000027499 body ache Diseases 0.000 claims description 2
• 206010012601 diabetes mellitus Diseases 0.000 claims description 2
• 239000003085 diluting agent Substances 0.000 claims description 2
• 239000003937 drug carrier Substances 0.000 claims description 2
• 238000007918 intramuscular administration Methods 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 230000001747 exhibiting effect Effects 0.000 description 1
• 230000001568 sexual effect Effects 0.000 description 1