JPWO2021020585A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2021020585A5
JPWO2021020585A5 JP2021535473A JP2021535473A JPWO2021020585A5 JP WO2021020585 A5 JPWO2021020585 A5 JP WO2021020585A5 JP 2021535473 A JP2021535473 A JP 2021535473A JP 2021535473 A JP2021535473 A JP 2021535473A JP WO2021020585 A5 JPWO2021020585 A5 JP WO2021020585A5
Authority
JP
Japan
Prior art keywords
group
thieno
piperidin
methyl
oxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021535473A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2021020585A1 (US06656730-20031202-C00002.png
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/JP2020/029589 external-priority patent/WO2021020585A1/ja
Publication of JPWO2021020585A1 publication Critical patent/JPWO2021020585A1/ja
Publication of JPWO2021020585A5 publication Critical patent/JPWO2021020585A5/ja
Pending legal-status Critical Current

Links

JP2021535473A 2019-07-31 2020-07-31 Pending JPWO2021020585A1 (US06656730-20031202-C00002.png)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019141699 2019-07-31
PCT/JP2020/029589 WO2021020585A1 (ja) 2019-07-31 2020-07-31 複素環化合物

Publications (2)

Publication Number Publication Date
JPWO2021020585A1 JPWO2021020585A1 (US06656730-20031202-C00002.png) 2021-02-04
JPWO2021020585A5 true JPWO2021020585A5 (US06656730-20031202-C00002.png) 2023-08-03

Family

ID=74228959

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021535473A Pending JPWO2021020585A1 (US06656730-20031202-C00002.png) 2019-07-31 2020-07-31

Country Status (4)

Country Link
US (1) US20220402935A1 (US06656730-20031202-C00002.png)
EP (1) EP4006037A4 (US06656730-20031202-C00002.png)
JP (1) JPWO2021020585A1 (US06656730-20031202-C00002.png)
WO (1) WO2021020585A1 (US06656730-20031202-C00002.png)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024026256A1 (en) * 2022-07-25 2024-02-01 Celgene Corporation Substituted imidazopyrazine compounds as ligand directed degraders of irak3
WO2024026262A1 (en) * 2022-07-25 2024-02-01 Celgene Corporation Substituted pyrazolyl-pyridinyl compounds as ligand directed degraders of irak3

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005017116A1 (de) 2005-04-13 2006-10-26 Novartis Ag Hemmstoffe für Inhibitoren von Apoptose Proteinen (IAP)
JP2009512719A (ja) 2005-10-25 2009-03-26 アエゲラ セラピューティクス インコーポレイテッド Ｉａｐｂｉｒドメイン結合化合物
CN101374829A (zh) 2005-12-19 2009-02-25 健泰科生物技术公司 Iap的抑制剂
TWI543988B (zh) 2006-03-16 2016-08-01 科學製藥股份有限公司 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物
MY159563A (en) 2006-05-16 2017-01-13 Pharmascience Inc Iap bir domain binding compounds
PE20110218A1 (es) 2006-08-02 2011-04-01 Novartis Ag DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS
RU2009117701A (ru) 2006-10-12 2010-11-20 Новартис АГ (CH) Производные пирролидина в качестве ингибиторов iap
AU2007337104A1 (en) 2006-12-19 2008-07-03 Genentech, Inc. Imidazopyridine inhibitors of IAP
NZ580468A (en) 2007-04-13 2012-02-24 Univ Michigan Diazo bicyclic smac mimetics and the uses thereof
US20100317593A1 (en) 2009-06-12 2010-12-16 Astrazeneca Ab 2,3-dihydro-1h-indene compounds
US8283372B2 (en) 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
BR112012000828A8 (pt) 2009-07-06 2017-10-10 Ontorii Inc Novas pró-drogas de ácido nucleico e métodos de uso das mesmas
US9271980B2 (en) 2009-08-03 2016-03-01 Daljit Singh Dhanoa Deuterium-enriched pyrimidine compounds and derivatives
RU2567544C2 (ru) 2010-02-12 2015-11-10 Фармасайенс Инк. Bir домен iap связывающие соединения
JP2012106958A (ja) 2010-11-18 2012-06-07 Takeda Chem Ind Ltd 複素環化合物
JP2012176934A (ja) 2011-02-03 2012-09-13 Takeda Chem Ind Ltd 複素環化合物
GB201106817D0 (en) 2011-04-21 2011-06-01 Astex Therapeutics Ltd New compound
WO2013019966A1 (en) 2011-08-04 2013-02-07 Allergan, Inc. Aromatic bycyclic derivatives as cxcr4 receptor modulators
JP5934986B2 (ja) 2011-09-07 2016-06-15 公益財団法人ヒューマンサイエンス振興財団 アポトーシス阻害タンパク質リガンド−エストロゲン受容体リガンドハイブリッド化合物並びにそれを利用したエストロゲン受容体分解誘導剤及び乳癌、子宮頚癌又は卵巣癌の予防及び治療剤
NO2755614T3 (US06656730-20031202-C00002.png) 2012-01-03 2018-03-31
US9394263B2 (en) 2012-08-09 2016-07-19 F. Hoffmann-La Roche Ag Substituted hetero-azepinones
GB201218850D0 (en) 2012-10-19 2012-12-05 Astex Therapeutics Ltd Bicyclic heterocycle compounds and their uses in therapy
EP2917218B1 (en) 2012-11-09 2017-01-04 Ensemble Therapeutics Corporation Macrocyclic compounds for inhibition of inhibitors of apoptosis
CN103242341B (zh) 2013-04-19 2015-12-09 中国科学院广州生物医药与健康研究院 噻吩并2，4取代嘧啶类化合物及其药物组合物与应用
WO2016040330A1 (en) 2014-09-09 2016-03-17 The Regents Of The University Of Michigan Thienopyrimidine and thienopyridine compounds and methods of use thereof
GB201506871D0 (en) 2015-04-22 2015-06-03 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201506872D0 (en) 2015-04-22 2015-06-03 Ge Oil & Gas Uk Ltd Novel compounds
EP3322986A4 (en) 2015-07-13 2018-09-05 Arvinas, Inc. Alanine-based modulators of proteolysis and associated methods of use
JP2019514878A (ja) 2016-04-20 2019-06-06 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｒｉｐｋ２阻害剤を含むコンジュゲート
JP2019522633A (ja) 2016-05-20 2019-08-15 ジェネンテック， インコーポレイテッド Ｐｒｏｔａｃ抗体コンジュゲート及び使用方法
GB201610147D0 (en) * 2016-06-10 2016-07-27 Glaxosmithkline Ip Dev Ltd Novel compounds
JP6899993B2 (ja) 2016-10-04 2021-07-07 国立医薬品食品衛生研究所長 複素環化合物
BR112019012878A2 (pt) 2016-12-23 2019-11-26 Arvinas Operations Inc compostos e métodos para a degradação alvo de polipeptídos de fibrossarcoma rapidamente acelerados
US11191741B2 (en) 2016-12-24 2021-12-07 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide
WO2019099926A1 (en) 2017-11-17 2019-05-23 Arvinas, Inc. Compounds and methods for the targeted degradation of interleukin-1 receptor-associated kinase 4 polypeptides
JP2021508703A (ja) 2017-12-26 2021-03-11 カイメラ セラピューティクス， インコーポレイテッド Ｉｒａｋ分解剤およびそれらの使用

Similar Documents

Publication Publication Date Title
CA3089936C (en) Substituted quinazoline and pyridopyrimidine derivatives useful as anticancer agents
US11034685B2 (en) Aminopyridine derivatives as TAM family kinase inhibitors
CN112707893B (zh) 作为usp30抑制剂的1-氰基吡咯烷化合物
JP2021138734A (ja) 新規化合物
ES2651843T3 (es) Derivados de pirazolopirrolidina y su uso en el tratamiento de enfermedades
ES2898835T3 (es) Azol amidas y aminas como inhibidores de la integrina alfav
KR20220042204A (ko) Rip1 억제 화합물 및 그를 제조 및 사용하는 방법
IL258159A (en) New protein inhibitors
WO2018177403A1 (zh) 1H-咪唑[4,5-h]喹唑啉类化合物作为蛋白激酶抑制剂
KR20190091537A (ko) C-kit 억제제로서의 아미노티아졸 화합물
AU2015275730A1 (en) Substituted indazole compounds as IRAK4 inhibitors
US20150051185A1 (en) Chemical Compounds 251
WO2014004863A2 (en) Compounds, compositions, and therapeutic uses thereof
ES2944657T3 (es) Compuestos de alqueno como moduladores del receptor farnesoide X
KR20220079919A (ko) 헤테로시클릭 rip1 억제 화합물
BR112020008157A2 (pt) compostos espirocíclicos como moduladores do receptor farnesoide x
JPWO2021020585A5 (US06656730-20031202-C00002.png)
EP3600312B1 (en) Piperidinyl- and piperazinyl-substituted heteroaromatic carboxamides as modulators of gpr6
WO2017073743A1 (ja) 三環性化合物
TW202320787A (zh) 一種周期蛋白依賴性激酶抑制劑
IL291418B2 (en) Substances that function as modulators of cMYC-mRNA translation and their uses for cancer treatment
WO2023049199A1 (en) Azole compounds
US20230365551A1 (en) Inhibitors of human respiratory syncytial virus and metapneumovirus
TW202409011A (zh) 人類呼吸道融合病毒及間質肺病毒抑制劑
TW201247647A (en) Glycine transport inhibitor