JPWO2021020412A5 - - Google Patents

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Publication number
JPWO2021020412A5
JPWO2021020412A5 JP2021535370A JP2021535370A JPWO2021020412A5 JP WO2021020412 A5 JPWO2021020412 A5 JP WO2021020412A5 JP 2021535370 A JP2021535370 A JP 2021535370A JP 2021535370 A JP2021535370 A JP 2021535370A JP WO2021020412 A5 JPWO2021020412 A5 JP WO2021020412A5
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JP
Japan
Prior art keywords
seq
oligonucleotide consisting
nucleotide sequence
sequence
oligonucleotide
Prior art date
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JP2021535370A
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English (en)
Japanese (ja)
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JPWO2021020412A1 (https=
JP7692829B2 (ja
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Priority claimed from PCT/JP2020/028960 external-priority patent/WO2021020412A1/ja
Publication of JPWO2021020412A1 publication Critical patent/JPWO2021020412A1/ja
Publication of JPWO2021020412A5 publication Critical patent/JPWO2021020412A5/ja
Application granted granted Critical
Publication of JP7692829B2 publication Critical patent/JP7692829B2/ja
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JP2021535370A 2019-07-30 2020-07-29 Murf1を標的とする核酸医薬 Active JP7692829B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019140142 2019-07-30
JP2019140142 2019-07-30
PCT/JP2020/028960 WO2021020412A1 (ja) 2019-07-30 2020-07-29 Murf1を標的とする核酸医薬

Publications (3)

Publication Number Publication Date
JPWO2021020412A1 JPWO2021020412A1 (https=) 2021-02-04
JPWO2021020412A5 true JPWO2021020412A5 (https=) 2023-07-25
JP7692829B2 JP7692829B2 (ja) 2025-06-16

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ID=74229918

Family Applications (1)

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JP2021535370A Active JP7692829B2 (ja) 2019-07-30 2020-07-29 Murf1を標的とする核酸医薬

Country Status (4)

Country Link
US (1) US12584132B2 (https=)
EP (1) EP4005602A4 (https=)
JP (1) JP7692829B2 (https=)
WO (1) WO2021020412A1 (https=)

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692265B1 (fr) 1992-05-25 1996-11-08 Centre Nat Rech Scient Composes biologiquement actifs de type phosphotriesters.
FR2705099B1 (fr) 1993-05-12 1995-08-04 Centre Nat Rech Scient Oligonucléotides phosphorothioates triesters et procédé de préparation.
JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
JP4236812B2 (ja) 1997-09-12 2009-03-11 エクシコン エ/エス オリゴヌクレオチド類似体
KR20020013513A (ko) 1999-03-18 2002-02-20 추후제출 Xylo-lna 유사체
US7098192B2 (en) 1999-04-08 2006-08-29 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of STAT3 expression
EP1481983A4 (en) 2002-02-13 2008-04-02 Takeshi Imanishi NUCLEOSIDE ANALOGUE AND OLIGONUCLEOTIDE DERIVATIVES CONTAINING A NUCLEOTIDE ANALOGON THEREOF
EP1572713A4 (en) 2002-08-14 2006-05-24 Pharmacia Corp ANTISENSE MODULATION OF ACYL-COA SYNTHETASE 1 EXPRESSION
AU2003295600A1 (en) 2002-11-14 2004-06-15 Dharmacon, Inc. Functional and hyperfunctional sirna
WO2004063331A2 (en) 2003-01-03 2004-07-29 Gencia Corporation SiRNA MEDIATED POST-TRANSRIPTIONAL GENE SILENCING OF GENES INVOLVED IN ALOPECIA
EP1661905B9 (en) 2003-08-28 2012-12-19 IMANISHI, Takeshi Novel artificial nucleic acids of n-o bond crosslinkage type
FR2894582B1 (fr) 2005-12-12 2008-02-22 Fabre Pierre Dermo Cosmetique Sirna anti myosine va et depigmentation de la peau
JP2009536222A (ja) 2006-05-05 2009-10-08 アイシス ファーマシューティカルズ, インコーポレーテッド Pcsk9の発現を調節するための化合物および方法
CA2927045A1 (en) 2006-10-03 2008-04-10 Muthiah Manoharan Lipid containing formulations
EP2215229B1 (en) 2007-11-28 2015-07-08 National University Corporation Tokyo Medical and Dental University System for delivering nucleic acids for suppressing target gene expression by utilizing endogenous chylomicron
EP2238249A2 (en) 2007-12-07 2010-10-13 Santaris Pharma A/S Rna antagonist compounds for the modulation of mcl-1
EP2264167B1 (en) 2008-03-31 2016-10-12 National Institute of Advanced Industrial Science and Technology Double-stranded lipid-modified rna having high rna interference effect
CA2721183C (en) 2008-04-11 2019-07-16 Alnylam Pharmaceuticals, Inc. Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
CA2721333C (en) 2008-04-15 2020-12-01 Protiva Biotherapeutics, Inc. Novel lipid formulations for nucleic acid delivery
JP2010184879A (ja) 2009-02-10 2010-08-26 Univ Of Tokyo 抗筋萎縮剤
CA2778171C (en) 2009-10-29 2017-07-25 Osaka University Bridged artificial nucleoside and nucleotide
EP2327783A1 (en) 2009-11-27 2011-06-01 Universitätsklinikum Freiburg Pharmaceutical composition comprising miRNA-100 and its use in the modulation of blood vessel growth
AU2011235276B2 (en) 2010-03-29 2015-09-03 Alnylam Pharmaceuticals, Inc. SiRNA therapy for transthyretin (TTR) related ocular amyloidosis
EP2576785A4 (en) 2010-06-04 2014-12-24 Univ Texas METABOLIC CHANGE BY ME-378
CA2812046A1 (en) 2010-09-15 2012-03-22 Alnylam Pharmaceuticals, Inc. Modified irna agents
SI3366775T2 (sl) 2011-11-18 2025-12-31 Alnylam Pharmaceuticals, Inc. Modificirana sredstva RNAI
EP3730618A1 (en) 2011-11-18 2020-10-28 Alnylam Pharmaceuticals, Inc. Rnai agents, compositions and methods of use thereof for treating transthyretin (ttr) associated diseases
JP2015502365A (ja) 2011-12-12 2015-01-22 オンコイミューニン,インコーポレイティド オリゴヌクレオチドのイン−ビボ送達
JP6112569B2 (ja) 2011-12-16 2017-04-12 国立大学法人 東京医科歯科大学 キメラ2重鎖核酸
EA030211B1 (ru) 2012-04-25 2018-07-31 Регьюлэс Терапьютикс Инк. Соединения на основе микрорнк и способы модулирования активности mir-21
US9163235B2 (en) 2012-06-21 2015-10-20 MiRagen Therapeutics, Inc. Inhibitors of the miR-15 family of micro-RNAs
US20150337002A1 (en) 2013-01-15 2015-11-26 Shionogi & Co., Ltd. Nucleoside and nucleotide having sulfonamide structure
WO2014126229A1 (ja) 2013-02-18 2014-08-21 塩野義製薬株式会社 含窒素複素環構造を有するヌクレオシド及びヌクレオチド
JP6482475B2 (ja) 2014-01-07 2019-03-13 レナセラピューティクス株式会社 アンチセンスオリゴヌクレオチド及び糖誘導体を含む二本鎖オリゴヌクレオチド
US20170051286A1 (en) 2014-05-01 2017-02-23 Larry J. Smith METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT
US10264976B2 (en) 2014-12-26 2019-04-23 The University Of Akron Biocompatible flavonoid compounds for organelle and cell imaging
US10610564B2 (en) * 2015-02-26 2020-04-07 Stc.Unm IRGM and precision autophagy controls for antimicrobial and inflammatory disease states and methods of detection of autophagy
EP3603648B1 (en) 2017-03-29 2025-09-17 Shionogi & Co., Ltd Complex of nucleic acid medicine and multibranched lipid
AU2018378812B2 (en) 2017-12-06 2025-05-22 Avidity Biosciences, Inc. Compositions and methods of treating muscle atrophy and myotonic dystrophy

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