JPWO2020249716A5 - - Google Patents
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- Publication number
- JPWO2020249716A5 JPWO2020249716A5 JP2021573817A JP2021573817A JPWO2020249716A5 JP WO2020249716 A5 JPWO2020249716 A5 JP WO2020249716A5 JP 2021573817 A JP2021573817 A JP 2021573817A JP 2021573817 A JP2021573817 A JP 2021573817A JP WO2020249716 A5 JPWO2020249716 A5 JP WO2020249716A5
- Authority
- JP
- Japan
- Prior art keywords
- hap
- cap
- bone
- bone substitute
- collagen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 243
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 243
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 233
- 239000001506 calcium phosphate Substances 0.000 claims description 146
- 239000000316 bone substitute Substances 0.000 claims description 143
- 235000011010 calcium phosphates Nutrition 0.000 claims description 129
- 108010035532 Collagen Proteins 0.000 claims description 77
- 102000008186 Collagen Human genes 0.000 claims description 77
- 229920001436 collagen Polymers 0.000 claims description 77
- 239000002245 particle Substances 0.000 claims description 74
- 210000000988 bone and bone Anatomy 0.000 claims description 72
- 239000010410 layer Substances 0.000 claims description 64
- 230000002051 biphasic effect Effects 0.000 claims description 54
- 239000000463 material Substances 0.000 claims description 44
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 42
- 239000011707 mineral Substances 0.000 claims description 42
- 239000011159 matrix material Substances 0.000 claims description 36
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 33
- 239000013078 crystal Substances 0.000 claims description 32
- 239000002159 nanocrystal Substances 0.000 claims description 27
- 238000004630 atomic force microscopy Methods 0.000 claims description 26
- 239000002002 slurry Substances 0.000 claims description 24
- 239000000243 solution Substances 0.000 claims description 23
- 230000012010 growth Effects 0.000 claims description 22
- 239000011148 porous material Substances 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 14
- 238000010438 heat treatment Methods 0.000 claims description 8
- 239000012535 impurity Substances 0.000 claims description 8
- 239000008202 granule composition Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 239000000835 fiber Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims description 5
- 229910052753 mercury Inorganic materials 0.000 claims description 5
- 238000002459 porosimetry Methods 0.000 claims description 5
- 239000003929 acidic solution Substances 0.000 claims description 4
- 230000018044 dehydration Effects 0.000 claims description 4
- 238000006297 dehydration reaction Methods 0.000 claims description 4
- 238000004626 scanning electron microscopy Methods 0.000 claims description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 70
- 239000008187 granular material Substances 0.000 description 67
- 238000000034 method Methods 0.000 description 55
- 230000009466 transformation Effects 0.000 description 48
- 239000011162 core material Substances 0.000 description 40
- 230000008569 process Effects 0.000 description 32
- 239000011575 calcium Substances 0.000 description 21
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 16
- 235000019731 tricalcium phosphate Nutrition 0.000 description 16
- 229940078499 tricalcium phosphate Drugs 0.000 description 16
- 238000002360 preparation method Methods 0.000 description 15
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 13
- 229910052791 calcium Inorganic materials 0.000 description 13
- 238000001727 in vivo Methods 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 12
- 239000007864 aqueous solution Substances 0.000 description 12
- 229910001424 calcium ion Inorganic materials 0.000 description 12
- 239000011248 coating agent Substances 0.000 description 12
- 238000000576 coating method Methods 0.000 description 12
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 10
- 239000000872 buffer Substances 0.000 description 10
- 150000002191 fatty alcohols Chemical class 0.000 description 10
- 239000000843 powder Substances 0.000 description 10
- 239000007853 buffer solution Substances 0.000 description 9
- 230000007547 defect Effects 0.000 description 8
- 230000007704 transition Effects 0.000 description 8
- 102000004067 Osteocalcin Human genes 0.000 description 7
- 108090000573 Osteocalcin Proteins 0.000 description 7
- 102000004264 Osteopontin Human genes 0.000 description 7
- 108010081689 Osteopontin Proteins 0.000 description 7
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 7
- 238000001035 drying Methods 0.000 description 7
- 238000000338 in vitro Methods 0.000 description 7
- 230000009818 osteogenic differentiation Effects 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 6
- 210000001124 body fluid Anatomy 0.000 description 6
- 235000019700 dicalcium phosphate Nutrition 0.000 description 6
- 239000008363 phosphate buffer Substances 0.000 description 6
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 6
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 description 5
- 239000012620 biological material Substances 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 229910000019 calcium carbonate Inorganic materials 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000001605 fetal effect Effects 0.000 description 5
- 230000014509 gene expression Effects 0.000 description 5
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 5
- 230000000399 orthopedic effect Effects 0.000 description 5
- 230000002188 osteogenic effect Effects 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 238000002791 soaking Methods 0.000 description 5
- 238000001356 surgical procedure Methods 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 4
- 238000001354 calcination Methods 0.000 description 4
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 4
- 239000000920 calcium hydroxide Substances 0.000 description 4
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000002131 composite material Substances 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 239000007943 implant Substances 0.000 description 4
- 238000002513 implantation Methods 0.000 description 4
- 230000011164 ossification Effects 0.000 description 4
- 210000002997 osteoclast Anatomy 0.000 description 4
- 239000002243 precursor Substances 0.000 description 4
- 238000007873 sieving Methods 0.000 description 4
- 238000005245 sintering Methods 0.000 description 4
- 239000011343 solid material Substances 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 3
- 108010009565 Bio-Gide Proteins 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 230000010478 bone regeneration Effects 0.000 description 3
- 239000004568 cement Substances 0.000 description 3
- 239000000084 colloidal system Substances 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- -1 hydroxyl ions Chemical class 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 229920005615 natural polymer Polymers 0.000 description 3
- 230000000278 osteoconductive effect Effects 0.000 description 3
- 229910052697 platinum Inorganic materials 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 230000008929 regeneration Effects 0.000 description 3
- 238000011069 regeneration method Methods 0.000 description 3
- 230000003746 surface roughness Effects 0.000 description 3
- 229920001059 synthetic polymer Polymers 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000010146 3D printing Methods 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 241000209094 Oryza Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 238000011529 RT qPCR Methods 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000012062 aqueous buffer Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 229910010293 ceramic material Inorganic materials 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 210000003109 clavicle Anatomy 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000004567 concrete Substances 0.000 description 2
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- 230000004069 differentiation Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 210000001624 hip Anatomy 0.000 description 2
- 210000001847 jaw Anatomy 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 210000003041 ligament Anatomy 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 210000004373 mandible Anatomy 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000003801 milling Methods 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 230000006911 nucleation Effects 0.000 description 2
- 238000010899 nucleation Methods 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 238000000634 powder X-ray diffraction Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 210000000614 rib Anatomy 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 210000003625 skull Anatomy 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 239000004254 Ammonium phosphate Substances 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 108700039887 Essential Genes Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 229910000148 ammonium phosphate Inorganic materials 0.000 description 1
- 235000019289 ammonium phosphates Nutrition 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 239000003637 basic solution Substances 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
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- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001473 dynamic force microscopy Methods 0.000 description 1
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- 210000002744 extracellular matrix Anatomy 0.000 description 1
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- 238000002073 fluorescence micrograph Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
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- 150000002500 ions Chemical class 0.000 description 1
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- 108020004999 messenger RNA Proteins 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 230000002138 osteoinductive effect Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 229960000502 poloxamer Drugs 0.000 description 1
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- 238000004321 preservation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000001878 scanning electron micrograph Methods 0.000 description 1
- 239000012890 simulated body fluid Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
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- 210000001519 tissue Anatomy 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19180350 | 2019-06-14 | ||
| EP19180350.1 | 2019-06-14 | ||
| PCT/EP2020/066279 WO2020249716A1 (en) | 2019-06-14 | 2020-06-12 | Collagen matrix or granulate blend of bone substitute material |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022537697A JP2022537697A (ja) | 2022-08-29 |
| JPWO2020249716A5 true JPWO2020249716A5 (ko) | 2023-04-04 |
| JP7476240B2 JP7476240B2 (ja) | 2024-04-30 |
Family
ID=66867071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021573817A Active JP7476240B2 (ja) | 2019-06-14 | 2020-06-12 | 骨代用材のコラーゲンマトリクス又は顆粒状ブレンド |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10960107B2 (ko) |
| EP (1) | EP3946488B1 (ko) |
| JP (1) | JP7476240B2 (ko) |
| KR (1) | KR102636183B1 (ko) |
| CN (1) | CN114761048B (ko) |
| AU (1) | AU2020293633B2 (ko) |
| BR (1) | BR112021021629B1 (ko) |
| CA (1) | CA3140519A1 (ko) |
| ES (1) | ES2939266T3 (ko) |
| TW (1) | TW202112404A (ko) |
| WO (1) | WO2020249716A1 (ko) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220257832A1 (en) * | 2021-02-17 | 2022-08-18 | Warsaw Orthopedic, Inc. | Compositions comprising coated ceramic particles and methods of making them |
| CN116036372B (zh) * | 2023-03-07 | 2023-11-10 | 江苏创英医疗器械有限公司 | 一种口腔用骨填充物的制备方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60220056A (ja) * | 1984-04-18 | 1985-11-02 | 三菱マテリアル株式会社 | 人工歯 |
| CA1260391A (en) * | 1985-03-28 | 1989-09-26 | Karl A. Piez | Xenogeneic collagen/mineral preparations in bone repair |
| US4865602A (en) | 1986-11-06 | 1989-09-12 | Collagen Corporation | Gamma irradiation of collagen/mineral mixtures |
| DE3711426A1 (de) | 1987-04-04 | 1988-10-13 | Mtu Muenchen Gmbh | Implantat mit bioaktivem ueberzug |
| GB8813033D0 (en) | 1988-06-02 | 1988-07-06 | Geistlich Soehne Ag | Chemical compound |
| DE69331096T2 (de) | 1992-02-28 | 2002-08-14 | Cohesion Tech Inc | Injektierbare, keramische verbindungen sowie verfahren zur deren herstellung und anwendung |
| US5763092A (en) | 1993-09-15 | 1998-06-09 | Etex Corporation | Hydroxyapatite coatings and a method of their manufacture |
| GB9400163D0 (en) | 1994-01-06 | 1994-03-02 | Geistlich Soehne Ag | Membrane |
| IT1288038B1 (it) | 1996-04-30 | 1998-09-10 | Flametal S P A | Procedimento per la preparazione di rivestimenti di idrossiapatite |
| US6338752B1 (en) | 2000-04-20 | 2002-01-15 | Purzer Pharmaceutical Co., Ltd. | α-TCP/HAP biphasic cement and its preparing process |
| US20030026770A1 (en) | 2001-07-25 | 2003-02-06 | Szymaitis Dennis W. | Periodontal regeneration composition and method of using same |
| US20070026030A1 (en) | 2005-07-27 | 2007-02-01 | Berkeley Advanced Biomaterials, Inc. | Method of preparing rheological materials for bone and cartilage repair |
| WO2008051555A2 (en) | 2006-10-24 | 2008-05-02 | Biomet 3I, Llc. | Deposition of discrete nanoparticles on a nanostructured surface of an implant |
| US8734524B2 (en) * | 2009-06-23 | 2014-05-27 | Geistlich Pharma Ag | Bone substitute material |
| WO2011094604A1 (en) | 2010-01-29 | 2011-08-04 | Georgia Tech Research Corporation | Surface modification of implant devices |
| US9107983B2 (en) | 2010-10-27 | 2015-08-18 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising statins |
| PL2654816T3 (pl) * | 2010-12-22 | 2015-05-29 | Geistlich Pharma Ag | Materiał stanowiący substytut kości |
| GB201122405D0 (en) | 2011-12-23 | 2012-02-08 | Univ Aberdeen | Calcium phosphate material |
| US9474718B2 (en) | 2013-05-15 | 2016-10-25 | Europesearch S.R.L. | Collagen powder, composition and use |
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| EP2826495A1 (en) | 2013-07-19 | 2015-01-21 | Geistlich Pharma AG | Biomimetic collagen-hydroxyapatite composite material |
| JP2016011247A (ja) * | 2014-06-03 | 2016-01-21 | 株式会社豊田中央研究所 | 板状リン酸化合物粒子、それを含む板状リン酸化合物粉体、及び、板状リン酸化合物粉体の製造方法、並びに板状リン酸化合物粉体を用いた結晶配向アパタイトの製造方法 |
| CN106046399A (zh) * | 2016-07-20 | 2016-10-26 | 太原理工大学 | 一种壳聚糖微球表面矿化的制备方法 |
| CN106754665A (zh) * | 2016-12-28 | 2017-05-31 | 浙江大学 | 促进间充质干细胞分化的微纳米拓扑结构制备及分化方法 |
| TWI783093B (zh) | 2017-12-14 | 2022-11-11 | 瑞士商蓋茲特利製藥公司 | 骨替代材料及其製備及應用 |
| EP3713615B1 (en) | 2017-12-14 | 2021-10-27 | Geistlich Pharma AG | Use of a dried implant composition for the preparation of an injectable aqueous implant formulation |
| PT3544643T (pt) | 2017-12-14 | 2020-07-27 | Geistlich Pharma Ag | Material de substituição óssea |
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2020
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