JPWO2020236841A5 - - Google Patents
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- JPWO2020236841A5 JPWO2020236841A5 JP2021568944A JP2021568944A JPWO2020236841A5 JP WO2020236841 A5 JPWO2020236841 A5 JP WO2020236841A5 JP 2021568944 A JP2021568944 A JP 2021568944A JP 2021568944 A JP2021568944 A JP 2021568944A JP WO2020236841 A5 JPWO2020236841 A5 JP WO2020236841A5
- Authority
- JP
- Japan
- Prior art keywords
- attachment
- point
- indicates
- nhc
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962850094P | 2019-05-20 | 2019-05-20 | |
| US62/850,094 | 2019-05-20 | ||
| PCT/US2020/033648 WO2020236841A2 (fr) | 2019-05-20 | 2020-05-19 | Conjugués anticorps-médicament ayant des lieurs comprenant des groupes hydrophiles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022533215A JP2022533215A (ja) | 2022-07-21 |
| JPWO2020236841A5 true JPWO2020236841A5 (fr) | 2023-05-26 |
Family
ID=71070004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021568944A Pending JP2022533215A (ja) | 2019-05-20 | 2020-05-19 | 親水性基を含むリンカーを有する抗体薬剤コンジュゲート |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230091510A1 (fr) |
| EP (1) | EP3972650A2 (fr) |
| JP (1) | JP2022533215A (fr) |
| KR (1) | KR20220010527A (fr) |
| CN (1) | CN113853219A (fr) |
| AU (1) | AU2020279731A1 (fr) |
| CA (1) | CA3140063A1 (fr) |
| IL (1) | IL287596A (fr) |
| WO (1) | WO2020236841A2 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117337195A (zh) * | 2021-04-29 | 2024-01-02 | 上海汇连生物医药有限公司 | 抗体偶联药物的制备方法及应用 |
| KR20240016287A (ko) | 2021-06-01 | 2024-02-06 | 아지노모토 가부시키가이샤 | 항체 및 기능성 물질의 콘쥬게이트 또는 이의 염, 및 이의 제조에 사용되는 화합물 또는 이의 염 |
| CN117295524A (zh) * | 2021-06-02 | 2023-12-26 | 百奥泰生物制药股份有限公司 | 药物偶联物及其用途 |
| WO2022262516A1 (fr) * | 2021-06-18 | 2022-12-22 | 北京海步医药科技有限公司 | Lieur et conjugué correspondant |
| WO2023198079A1 (fr) * | 2022-04-12 | 2023-10-19 | 百奥泰生物制药股份有限公司 | Méthode de traitement d'une tumeur solide positive à her2 |
| WO2023223097A1 (fr) * | 2022-05-20 | 2023-11-23 | Novartis Ag | Conjugués anticorps-médicaments |
| WO2024083162A1 (fr) * | 2022-10-19 | 2024-04-25 | Multitude Therapeutics Inc. | Anticorps, conjugués anticorps-médicament, préparations et utilisations associées |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2 Inc | Geänderte antikörper. |
| US4880078A (en) | 1987-06-29 | 1989-11-14 | Honda Giken Kogyo Kabushiki Kaisha | Exhaust muffler |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| AU666852B2 (en) | 1991-05-01 | 1996-02-29 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | A method for treating infectious respiratory diseases |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| AU4116793A (en) | 1992-04-24 | 1993-11-29 | Board Of Regents, The University Of Texas System | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
| US5934272A (en) | 1993-01-29 | 1999-08-10 | Aradigm Corporation | Device and method of creating aerosolized mist of respiratory drug |
| CA2163345A1 (fr) | 1993-06-16 | 1994-12-22 | Susan Adrienne Morgan | Anticorps |
| US6132764A (en) | 1994-08-05 | 2000-10-17 | Targesome, Inc. | Targeted polymerized liposome diagnostic and treatment agents |
| US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US6019968A (en) | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| PT885002E (pt) | 1996-03-04 | 2011-07-14 | Massachusetts Inst Technology | Materiais e métodos para aumento da internalização celular |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| ATE287257T1 (de) | 1997-01-16 | 2005-02-15 | Massachusetts Inst Technology | Zubereitung von partikelhaltigen arzneimitteln zur inhalation |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| EP1724282B1 (fr) | 1997-05-21 | 2013-05-15 | Merck Patent GmbH | Procédé de production de protéines non-immunogènes |
| ES2301198T3 (es) | 1997-06-12 | 2008-06-16 | Novartis International Pharmaceutical Ltd. | Polipeptidos artificiales de anticuerpos. |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| DK2180007T4 (da) | 1998-04-20 | 2017-11-27 | Roche Glycart Ag | Glycosyleringsteknik for antistoffer til forbedring af antistofafhængig cellecytotoxicitet |
| WO1999066903A2 (fr) | 1998-06-24 | 1999-12-29 | Advanced Inhalation Research, Inc. | Grandes particules poreuses emises par un inhalateur |
| KR101077001B1 (ko) | 1999-01-15 | 2011-10-26 | 제넨테크, 인크. | 효과기 기능이 변화된 폴리펩티드 변이체 |
| PT1176195E (pt) | 1999-04-09 | 2013-07-18 | Kyowa Hakko Kirin Co Ltd | Processo para controlar a actividade de uma molécula funcional sob o ponto de vista imunológico |
| KR100988949B1 (ko) | 2001-10-25 | 2010-10-20 | 제넨테크, 인크. | 당단백질 조성물 |
| EP2445520A4 (fr) | 2009-06-22 | 2013-03-06 | Medimmune Llc | Régions fc de synthèse pour une conjugaison spécifique à un site |
| MX2015006868A (es) | 2012-11-30 | 2015-10-05 | Novartis Ag | Metodos para la elaboracion de conjugados a partir de proteinas que contienen disulfuro. |
| CN105102455B (zh) * | 2012-12-21 | 2018-05-25 | 荷商台医(有限合伙)公司 | 亲水性自消耗连接子及其缀合物 |
| EA201591465A1 (ru) | 2013-02-08 | 2015-12-30 | АйАрЭм ЭлЭлСи | Специфичные участки для модификации антител для получения иммуноконъюгатов |
| WO2015057699A2 (fr) * | 2013-10-15 | 2015-04-23 | Seattle Genetics, Inc. | Lieurs de médicaments pégylés pour pharmacocinétique de conjugués ligand-médicament améliorée |
| US20190194315A1 (en) | 2015-06-17 | 2019-06-27 | Novartis Ag | Antibody drug conjugates |
| CN108066772B (zh) * | 2016-11-14 | 2021-07-13 | 中国科学院上海药物研究所 | 靶向tacstd2的抗体与药物偶联体(adc)分子 |
| US11135307B2 (en) * | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
-
2020
- 2020-05-19 WO PCT/US2020/033648 patent/WO2020236841A2/fr unknown
- 2020-05-19 CN CN202080036837.5A patent/CN113853219A/zh active Pending
- 2020-05-19 EP EP20731697.7A patent/EP3972650A2/fr active Pending
- 2020-05-19 US US17/612,280 patent/US20230091510A1/en active Pending
- 2020-05-19 JP JP2021568944A patent/JP2022533215A/ja active Pending
- 2020-05-19 AU AU2020279731A patent/AU2020279731A1/en active Pending
- 2020-05-19 CA CA3140063A patent/CA3140063A1/fr active Pending
- 2020-05-19 KR KR1020217041090A patent/KR20220010527A/ko unknown
-
2021
- 2021-10-26 IL IL287596A patent/IL287596A/en unknown
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