JPWO2020210168A5 - - Google Patents
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- JPWO2020210168A5 JPWO2020210168A5 JP2021559429A JP2021559429A JPWO2020210168A5 JP WO2020210168 A5 JPWO2020210168 A5 JP WO2020210168A5 JP 2021559429 A JP2021559429 A JP 2021559429A JP 2021559429 A JP2021559429 A JP 2021559429A JP WO2020210168 A5 JPWO2020210168 A5 JP WO2020210168A5
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本開示の追加の側面および利益が、本開示の例証的実施形態のみが示され、説明される、以下の発明を実施するための形態から、当業者に容易に明白となるであろう。認識されるであろうように、本開示は、他の異なる実施形態が可能であり、そのいくつかの詳細は、全て本開示から逸脱することなく、種々の明白な点において修正が可能である。故に、図面および説明は、制限的ではなく、本質的に例証的と見なされるものである。
本発明は、例えば、以下を提供する。
(項目1)
光学アダプタであって、前記光学アダプタは、
(1)検鏡に解放可能に結合するように構成された第1の端部と、(2)カメラに解放可能に結合するように構成された第2の端部とを備えている筐体と、
前記筐体内の画像センサと、
前記筐体内に配置された光学系アセンブリと
を備え、
前記光学系アセンブリは、(i)対象の身体内の標的部位から反射され、前記検鏡を通して伝送される光信号を受け取り、(ii)前記光信号の第1の部分を前記画像センサまたは前記カメラのうちの一方の上に反射しながら、前記光信号の第2の部分が前記画像センサまたは前記カメラのうちの他方に至るまで通過することを可能にするように構成されている、光学アダプタ。
(項目2)
前記画像センサは、前記筐体に解放可能に結合されている、項目1に記載の光学アダプタ。
(項目3)
前記画像センサは、前記光信号の第1の部分から撮像データの第1の組を発生させるように構成され、前記カメラは、前記光信号の第2の部分から撮像データの第2の組を発生させるように構成されている、項目1に記載の光学アダプタ。
(項目4)
前記撮像データの第1の組は、レーザスペックルパターンを備え、前記撮像データの第2の組は、写真またはビデオ画像を備えている、項目2に記載の光学アダプタ。
(項目5)
前記画像センサは、レーザスペックル撮像のために使用される、項目1に記載の光学アダプタ。
(項目6)
前記光学系アセンブリは、ビームスプリッタを備えている、項目1に記載の光学アダプタ。
(項目7)
前記ビームスプリッタは、ダイクロイックミラーを備えている、項目6に記載の光学アダプタ。
(項目8)
前記光学系アセンブリは、前記光信号の前記第1の部分を前記画像センサ上に反射しながら、前記光信号の前記第2の部分が前記カメラに至るまで通過することを可能にするように構成されている、項目1に記載の光学アダプタ。
(項目9)
前記光学系アセンブリは、ショートパスダイクロイックミラーを備えている、項目8に記載の光学アダプタ。
(項目10)
前記光学系アセンブリは、前記光信号の前記第1の部分を前記カメラ上に反射しながら、前記光信号の前記第2の部分が前記画像センサに至るまで通過することを可能するように構成されている、項目1に記載の光学アダプタ。
(項目11)
前記光学系アセンブリは、ロングパスダイクロイックミラーを備えている、項目10に記載の光学アダプタ。
(項目12)
前記光信号の前記第1の部分は、前記標的部位が前記検鏡を介して伝送されるコヒーレントレーザ光を用いて照明されるときに発生させられる後方散乱光を備えている、項目1に記載の光学アダプタ。
(項目13)
前記コヒーレントレーザ光は、実質的に単一の波長を有する単一のレーザ源から提供される、項目12に記載の光学アダプタ。
(項目14)
前記コヒーレントレーザ光は、複数の異なる波長を有する複数のレーザ源から提供される、項目12に記載の光学アダプタ。
(項目15)
前記光信号の前記第2の部分は、前記標的部位が前記検鏡を介して伝送される白色光を用いて照明されるときに発生させられる反射光を備えている、項目1に記載の光学アダプタ。
(項目16)
前記単一の波長は、不可視スペクトル内に位置している、項目13に記載の光学アダプタ。
(項目17)
前記複数の異なる波長は、不可視スペクトル内に位置している、項目14に記載の光学アダプタ。
(項目18)
前記反射光は、可視スペクトル内にある、項目15に記載の光学アダプタ。
(項目19)
前記筐体の前記第1の端部は、迅速解放機構を使用して前記検鏡に解放可能に結合するように構成されている、項目1に記載の光学アダプタ。
(項目20)
前記迅速解放機構は、前記光学アダプタを異なるサイズを有する種々のタイプの検鏡に解放可能に結合するように構成されている、項目19に記載の光学アダプタ。
(項目21)
前記迅速解放機構は、ユーザがツールの使用なしに前記筐体の前記第1の端部を前記検鏡に解放可能に結合することを可能にするように構成されている、項目19に記載の光学アダプタ。
(項目22)
前記迅速解放機構は、ユーザが30秒未満以内に前記筐体の前記第1の端部を前記検鏡に解放可能に結合することを可能にするように構成されている、項目19に記載の光学アダプタ。
(項目23)
前記筐体の前記第2の端部は、迅速解放機構を使用して前記カメラに解放可能に結合するように構成されている、項目1に記載の光学アダプタ。
(項目24)
前記迅速解放機構は、前記光学アダプタを異なるサイズを有する種々のタイプのカメラに解放可能に結合するように構成されている、項目23に記載の光学アダプタ。
(項目25)
前記迅速解放機構は、ユーザがツールの使用なしに前記筐体の前記第2の端部を前記カメラに解放可能に結合することを可能にするように構成されている、項目23に記載の光学アダプタ。
(項目26)
前記迅速解放機構は、ユーザが30秒未満以内に前記筐体の前記第2の端部を前記カメラに解放可能に結合することを可能にするように構成されている、項目23に記載の光学アダプタ。
(項目27)
前記光学系アセンブリは、前記画像センサのための集束デバイスをさらに備えている、項目1に記載の光学アダプタ。
(項目28)
前記光学系アセンブリは、(i)前記画像センサのための第1の集束デバイスと、(ii)前記カメラのための第2の集束デバイスとをさらに備えている、項目1に記載の光学アダプタ。
(項目29)
前記第1の集束デバイスおよび前記第2の集束デバイスは、前記画像センサおよび前記カメラのための集束が、並行して実施されることができるように、互いに動作可能に結合されている、項目28に記載の光学アダプタ。
(項目30)
前記第1の集束デバイスおよび前記第2の集束デバイスは、歯車伝動機構を介して互いに動作可能に結合されている、項目28に記載の光学アダプタ。
(項目31)
前記第1の集束デバイスおよび前記第2の集束デバイスは、別個に提供され、互いに独立して使用されるように構成されている、項目28に記載の光学アダプタ。
(項目32)
前記検鏡は、(1)照明源から組み合わせられた光ビームを受け取り、(2)前記組み合わせられた光ビームを前記対象の身体内の前記標的部位の上に向けるように構成されている、項目1に記載の光学アダプタ。
(項目33)
前記第1の端部と前記第2の端部とは、共通の縦方向軸を共有している、項目1に記載の光学アダプタ。
(項目34)
前記第1の端部と前記第2の端部とは、前記筐体の対向する側に提供されている、項目33に記載の光学アダプタ。
(項目35)
前記第1の端部と前記第2の端部とは、共通の縦方向軸を共有していない、項目1に記載の光学アダプタ。
(項目36)
前記第1の端部と前記第2の端部とは、前記筐体の実質的に直交する側に提供されている、項目35に記載の光学アダプタ。
(項目37)
前記画像センサと前記カメラとは、異なる光軸を有する、項目1に記載の光学アダプタ。
(項目38)
前記画像センサの光軸は、前記カメラの光軸に直交している、項目1に記載の光学アダプタ。
(項目39)
前記画像センサは、前記筐体の表面に解放可能に結合するように構成され、前記表面は、前記筐体の前記第1の端部または前記第2の端部に実質的に直交している、項目1に記載の光学アダプタ。
(項目40)
前記画像センサは、前記筐体の前記表面に解放可能に結合するように構成されたケーシングを備えている、項目39に記載の光学アダプタ。
(項目41)
前記画像センサは、使い捨てであり、医療撮像手技における単回使用のために構成されている、項目1に記載の光学アダプタ。
(項目42)
前記画像センサは、複数の医療撮像手技のために再使用可能であるように構成されている、項目1に記載の光学アダプタ。
(項目43)
撮像キットであって、前記撮像キットは、
項目1に記載の光学アダプタと、
照明源と
を備え、
前記照明源は、組み合わせられた光ビームを前記対象の身体内の前記標的部位の上に向けるために、前記組み合わせられた光ビームを前記検鏡に伝送するように構成されている、撮像キット。
(項目44)
方法であって、前記方法は、
白色光をコヒーレントレーザ光と組み合わせ、組み合わせられた光ビームを発生させることと、
前記組み合わせられた光ビームを検鏡に提供することと、
前記検鏡を使用し、前記組み合わせられた光ビームを対象の身体内の標的部位の上に向けることと、
前記検鏡を介して、前記標的部位から反射される光信号を受け取ることと、
前記光信号の第1の部分を(i)光学アダプタ内の画像センサまたは(ii)カメラのうちの一方の上に反射しながら、前記光信号の第2の部分が(i)前記画像センサまたは(ii)前記カメラのうちの他方に至るまで通過することを可能にすることと
を含み、
前記光学アダプタは、前記検鏡および前記カメラの両方に解放可能に結合するように構成されている、方法。
(項目45)
前記光信号の前記第1の部分は、前記画像センサ上に反射される一方、前記光信号の前記第2の部分は、前記カメラに至るまで通過することを可能にされる、項目44に記載の方法。
(項目46)
前記光信号の前記第1の部分は、前記カメラ上に反射される一方、前記光信号の前記第2の部分は、前記画像センサに至るまで通過することを可能にされる、項目44に記載の方法。
(項目47)
前記光学アダプタは、前記検鏡および前記カメラに解放可能に結合されるとき、前記検鏡と前記カメラとの間に配置される、項目44に記載の方法。
(項目48)
前記検鏡と前記カメラとは、前記光学アダプタの直交する側に解放可能に結合される、項目44に記載の方法。
(項目49)
方法であって、前記方法は、
筐体を備えている光学アダプタを提供することであって、画像センサが、前記筐体内にある、ことと、
前記筐体の第1の端部を検鏡に解放可能に結合することと、
前記筐体の第2の端部をカメラに解放可能に結合することと、
組み合わせられた光ビームを前記検鏡に提供することであって、前記組み合わせられた光ビームは、コヒーレントレーザ光と組み合わせられた白色光を備えている、ことと、
前記検鏡を使用し、前記組み合わせられた光ビームを対象の身体内の標的部位の上に向けることと、
前記検鏡を介して、前記標的部位から反射される光信号を受け取ることと、
前記光信号の第1の部分を前記画像センサまたは前記カメラのうちの一方の上に反射しながら、前記光信号の第2の部分が前記画像センサまたは前記カメラのうちの他方に至るまで通過することを可能にすることと、
前記画像センサを使用し、前記光信号の前記第1の部分から撮像データの第1の組を発生させ、前記カメラを使用し、前記光信号の前記第2の部分から撮像データの第2の組を発生させることと
を含む、方法。
(項目50)
前記光信号の前記第1の部分は、前記画像センサ上に反射される一方、前記光信号の前記第2の部分は、前記カメラに至るまで通過することを可能にされる、項目49に記載の方法。
(項目51)
前記光信号の前記第1の部分は、前記カメラ上に反射される一方、前記光信号の前記第2の部分は、前記画像センサに至るまで通過することを可能にされる、項目49に記載の方法。
(項目52)
前記撮像データの前記第1の組は、レーザスペックルパターンを備えている、項目49に記載の方法。
(項目53)
前記撮像データの前記第2の組は、写真またはビデオ画像を備えている、項目49に記載の方法。
Additional aspects and benefits of the present disclosure will become readily apparent to those skilled in the art from the following detailed description, in which only illustrative embodiments of the present disclosure are shown and described. As will be realized, the disclosure is capable of other and different embodiments, and its several details are capable of modifications in various obvious respects, all without departing from the disclosure. . Accordingly, the drawings and description are to be regarded as illustrative in nature rather than restrictive.
The present invention provides, for example, the following.
(Item 1)
An optical adapter, the optical adapter comprising:
A housing having (1) a first end configured to releasably couple to a speculum and (2) a second end configured to releasably couple to a camera. and,
an image sensor in the housing;
an optics assembly disposed within the housing; and
with
The optics assembly (i) receives a light signal reflected from a target site within a subject's body and transmitted through the speculum, and (ii) transmits a first portion of the light signal to the image sensor or the camera. An optical adapter configured to allow a second portion of the optical signal to pass all the way to the other of the image sensor or the camera while reflecting onto one of them.
(Item 2)
2. Optical adapter according to item 1, wherein the image sensor is releasably coupled to the housing.
(Item 3)
The image sensor is configured to generate a first set of imaging data from a first portion of the light signal and the camera generates a second set of imaging data from a second portion of the light signal. 2. Optical adapter according to item 1, configured to generate.
(Item 4)
3. The optical adapter of item 2, wherein the first set of imaging data comprises a laser speckle pattern and the second set of imaging data comprises a photographic or video image.
(Item 5)
2. Optical adapter according to item 1, wherein the image sensor is used for laser speckle imaging.
(Item 6)
The optical adapter of item 1, wherein the optics assembly comprises a beam splitter.
(Item 7)
7. Optical adapter according to item 6, wherein the beam splitter comprises a dichroic mirror.
(Item 8)
The optics assembly is configured to reflect the first portion of the optical signal onto the image sensor while allowing the second portion of the optical signal to pass through to the camera. The optical adapter according to item 1, wherein the optical adapter is
(Item 9)
9. Optical adapter according to item 8, wherein the optics assembly comprises a short pass dichroic mirror.
(Item 10)
The optics assembly is configured to reflect the first portion of the optical signal onto the camera while allowing the second portion of the optical signal to pass to the image sensor. The optical adapter of item 1, wherein the optical adapter is
(Item 11)
11. The optical adapter of item 10, wherein the optics assembly comprises a longpass dichroic mirror.
(Item 12)
Clause 1, wherein the first portion of the optical signal comprises backscattered light generated when the target site is illuminated with coherent laser light transmitted through the speculum. optical adapter.
(Item 13)
13. Optical adapter according to item 12, wherein the coherent laser light is provided from a single laser source having substantially a single wavelength.
(Item 14)
13. The optical adapter of item 12, wherein the coherent laser light is provided from multiple laser sources having multiple different wavelengths.
(Item 15)
The optics of item 1, wherein the second portion of the optical signal comprises reflected light generated when the target site is illuminated with white light transmitted through the speculum. adapter.
(Item 16)
14. Optical adapter according to item 13, wherein the single wavelength lies in the non-visible spectrum.
(Item 17)
15. The optical adapter of item 14, wherein the plurality of different wavelengths are located within the non-visible spectrum.
(Item 18)
16. Optical adapter according to item 15, wherein the reflected light is in the visible spectrum.
(Item 19)
The optical adapter of item 1, wherein the first end of the housing is configured to releasably couple to the speculum using a quick release mechanism.
(Item 20)
20. The optical adapter of item 19, wherein the quick release mechanism is configured to releasably couple the optical adapter to various types of speculum having different sizes.
(Item 21)
20. of paragraph 19, wherein the quick release mechanism is configured to allow a user to releasably couple the first end of the housing to the speculum without the use of tools. optical adapter.
(Item 22)
20. Clause 20, wherein the quick release mechanism is configured to allow a user to releasably couple the first end of the housing to the speculum in less than 30 seconds. optical adapter.
(Item 23)
2. The optical adapter of item 1, wherein the second end of the housing is configured to releasably couple to the camera using a quick release mechanism.
(Item 24)
24. An optical adapter according to item 23, wherein the quick release mechanism is configured to releasably couple the optical adapter to various types of cameras having different sizes.
(Item 25)
24. The optic of item 23, wherein the quick release mechanism is configured to allow a user to releasably couple the second end of the housing to the camera without the use of tools. adapter.
(Item 26)
24. The optic of item 23, wherein the quick release mechanism is configured to allow a user to releasably couple the second end of the housing to the camera within less than 30 seconds. adapter.
(Item 27)
The optical adapter of item 1, wherein the optics assembly further comprises a focusing device for the image sensor.
(Item 28)
The optical adapter of item 1, wherein the optics assembly further comprises (i) a first focusing device for the image sensor and (ii) a second focusing device for the camera.
(Item 29)
Item 28, wherein said first focusing device and said second focusing device are operably coupled to each other such that focusing for said image sensor and said camera can be performed in parallel. optical adapter described in .
(Item 30)
29. The optical adapter of item 28, wherein the first focusing device and the second focusing device are operably coupled to each other via a gear transmission.
(Item 31)
29. The optical adapter of item 28, wherein the first focusing device and the second focusing device are provided separately and configured to be used independently of each other.
(Item 32)
wherein said speculum is configured to (1) receive a combined light beam from an illumination source; and (2) direct said combined light beam onto said target site within said subject's body. 2. The optical adapter according to 1.
(Item 33)
2. The optical adapter of item 1, wherein the first end and the second end share a common longitudinal axis.
(Item 34)
34. The optical adapter of item 33, wherein the first end and the second end are provided on opposite sides of the housing.
(Item 35)
2. The optical adapter of item 1, wherein the first end and the second end do not share a common longitudinal axis.
(Item 36)
36. Optical adapter according to item 35, wherein the first end and the second end are provided on substantially orthogonal sides of the housing.
(Item 37)
The optical adapter according to item 1, wherein the image sensor and the camera have different optical axes.
(Item 38)
The optical adapter according to item 1, wherein the optical axis of the image sensor is orthogonal to the optical axis of the camera.
(Item 39)
The image sensor is configured to releasably couple to a surface of the housing, the surface being substantially orthogonal to the first end or the second end of the housing. 3. The optical adapter according to claim 1.
(Item 40)
40. The optical adapter of item 39, wherein the image sensor comprises a casing configured to releasably couple to the surface of the housing.
(Item 41)
2. The optical adapter of item 1, wherein the image sensor is disposable and configured for single use in a medical imaging procedure.
(Item 42)
2. The optical adapter of item 1, wherein the image sensor is configured to be reusable for multiple medical imaging procedures.
(Item 43)
An imaging kit, the imaging kit comprising:
an optical adapter according to item 1;
illumination source and
with
The imaging kit, wherein the illumination source is configured to transmit the combined light beam to the speculum to direct the combined light beam onto the target site within the subject's body.
(Item 44)
A method, the method comprising:
combining white light with coherent laser light to generate a combined light beam;
providing the combined light beam to a speculum;
using the speculum to direct the combined light beam over a target site within a subject's body;
receiving optical signals reflected from the target site via the speculum;
Reflecting a first portion of the optical signal onto one of (i) an image sensor in an optical adapter or (ii) a camera while reflecting a second portion of the optical signal onto (i) the image sensor or (ii) allowing passage to the other of said cameras;
including
The method, wherein the optical adapter is configured to releasably couple to both the speculum and the camera.
(Item 45)
45. Claimed in item 44, wherein the first part of the light signal is reflected onto the image sensor, while the second part of the light signal is allowed to pass all the way to the camera. the method of.
(Item 46)
45. Claimed in item 44, wherein the first part of the light signal is reflected onto the camera, while the second part of the light signal is allowed to pass all the way to the image sensor. the method of.
(Item 47)
45. The method of item 44, wherein the optical adapter is positioned between the speculum and the camera when releasably coupled to the speculum and the camera.
(Item 48)
45. The method of item 44, wherein the speculum and the camera are releasably coupled to orthogonal sides of the optical adapter.
(Item 49)
A method, the method comprising:
providing an optical adapter comprising a housing, wherein an image sensor is within the housing;
releasably coupling the first end of the housing to a speculum;
releasably coupling the second end of the housing to a camera;
providing a combined light beam to the speculum, the combined light beam comprising white light combined with coherent laser light;
using the speculum to direct the combined light beam over a target site within a subject's body;
receiving optical signals reflected from the target site via the speculum;
Reflecting a first portion of the optical signal onto one of the image sensor or the camera while a second portion of the optical signal passes through to the other of the image sensor or the camera. and
using the image sensor to generate a first set of imaging data from the first portion of the light signal; using the camera to generate a second set of imaging data from the second portion of the light signal; generating pairs and
A method, including
(Item 50)
50. According to item 49, wherein the first part of the light signal is reflected onto the image sensor, while the second part of the light signal is allowed to pass all the way to the camera. the method of.
(Item 51)
50. According to item 49, wherein the first part of the light signal is reflected onto the camera, while the second part of the light signal is allowed to pass all the way to the image sensor. the method of.
(Item 52)
50. The method of item 49, wherein the first set of imaging data comprises a laser speckle pattern.
(Item 53)
50. The method of item 49, wherein the second set of imaging data comprises photographic or video images.
Claims (26)
(1)検鏡に解放可能に結合するように構成された第1の部分と、(2)カメラに解放可能に結合するように構成された第2の部分とを備えている筐体と、
前記筐体内の画像センサと、
前記筐体内に配置された光学系アセンブリと
を備え、
前記光学系アセンブリは、(i)対象の身体内の標的部位から反射され、前記検鏡を通して伝送される光信号を受け取り、(ii)前記光信号の第1の部分を前記画像センサまたは前記カメラのうちの一方の上に反射しながら、前記標的部位の多波長撮像を可能にするように前記光信号の第2の部分が前記画像センサまたは前記カメラのうちの他方に至るまで通過することを可能にするように構成され、
前記画像センサは、第1の範囲内の波長を検出するように構成され、前記カメラは、前記第1の範囲と異なる第2の範囲内の波長を検出するように構成され、前記第1の範囲または前記第2の範囲は、前記標的部位からのレーザスペックルを備えている反射光信号を備えている、光学モジュール。 An optical module , the optical module comprising:
a housing comprising (1) a first portion configured to releasably couple to a speculum; and (2) a second portion configured to releasably couple to a camera;
an image sensor in the housing ;
an optics assembly disposed within the housing;
The optics assembly (i) receives a light signal reflected from a target site within a subject's body and transmitted through the speculum, and (ii) transmits a first portion of the light signal to the image sensor or the camera. allowing a second portion of the optical signal to pass through to the other of the image sensor or the camera to enable multi-wavelength imaging of the target site while being reflected onto one of the configured to allow
The image sensor is configured to detect wavelengths within a first range , the camera is configured to detect wavelengths within a second range different from the first range , The optics module , wherein the range or said second range comprises a reflected light signal comprising laser speckle from said target site .
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