JPWO2020198009A5 - - Google Patents
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- JPWO2020198009A5 JPWO2020198009A5 JP2021556753A JP2021556753A JPWO2020198009A5 JP WO2020198009 A5 JPWO2020198009 A5 JP WO2020198009A5 JP 2021556753 A JP2021556753 A JP 2021556753A JP 2021556753 A JP2021556753 A JP 2021556753A JP WO2020198009 A5 JPWO2020198009 A5 JP WO2020198009A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- antigen
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024131936A JP2024160318A (ja) | 2019-03-22 | 2024-08-08 | ＥＧＦＲｘＣＤ２８多特異性抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962822124P | 2019-03-22 | 2019-03-22 | |
| US62/822,124 | 2019-03-22 | ||
| PCT/US2020/023857 WO2020198009A1 (en) | 2019-03-22 | 2020-03-20 | EGFR x CD28 MULTISPECIFIC ANTIBODIES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024131936A Division JP2024160318A (ja) | 2019-03-22 | 2024-08-08 | ＥＧＦＲｘＣＤ２８多特異性抗体 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022526764A JP2022526764A (ja) | 2022-05-26 |
| JP2022526764A5 JP2022526764A5 (https=) | 2023-03-29 |
| JPWO2020198009A5 true JPWO2020198009A5 (https=) | 2023-03-29 |
| JP7659501B2 JP7659501B2 (ja) | 2025-04-09 |
Family
ID=70228885
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021556753A Active JP7659501B2 (ja) | 2019-03-22 | 2020-03-20 | ＥＧＦＲｘＣＤ２８多特異性抗体 |
| JP2024131936A Pending JP2024160318A (ja) | 2019-03-22 | 2024-08-08 | ＥＧＦＲｘＣＤ２８多特異性抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024131936A Pending JP2024160318A (ja) | 2019-03-22 | 2024-08-08 | ＥＧＦＲｘＣＤ２８多特異性抗体 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11912767B2 (https=) |
| EP (1) | EP3941941A1 (https=) |
| JP (2) | JP7659501B2 (https=) |
| KR (1) | KR20210142659A (https=) |
| CN (1) | CN113661177B (https=) |
| AU (1) | AU2020247803A1 (https=) |
| BR (1) | BR112021018442A2 (https=) |
| CA (1) | CA3134335A1 (https=) |
| CL (2) | CL2021002446A1 (https=) |
| CO (1) | CO2021014076A2 (https=) |
| EA (1) | EA202192566A1 (https=) |
| IL (1) | IL286536A (https=) |
| MA (1) | MA55363A (https=) |
| MX (1) | MX2021011500A (https=) |
| MY (1) | MY209363A (https=) |
| PH (1) | PH12021552300A1 (https=) |
| SG (1) | SG11202110341WA (https=) |
| WO (1) | WO2020198009A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019246514A1 (en) * | 2018-06-21 | 2019-12-26 | Regeneron Pharmaceuticals, Inc. | Bispecific anti-psma x anti-cd28 antibodies and uses thereof |
| WO2020198009A1 (en) * | 2019-03-22 | 2020-10-01 | Regeneron Pharmaceuticals, Inc. | EGFR x CD28 MULTISPECIFIC ANTIBODIES |
| CA3192204A1 (en) | 2020-08-19 | 2022-02-24 | Xencor, Inc. | Anti-cd28 and/or anti-b7h3 compositions |
| WO2022094299A2 (en) * | 2020-10-30 | 2022-05-05 | Janux Therapeutics, Inc. | Multispecific antibodies for targeting cd28 and pd-l1 and methods of use thereof |
| KR20230098317A (ko) * | 2020-11-03 | 2023-07-03 | 도이체스크레브스포르슝스젠트룸스티프퉁데스외펜트리헨레크츠 | 표적 세포가 제한되는, 공동자극, 이중특이적 및 2가 항-cd28 항체 |
| EP4274901A1 (en) | 2021-01-11 | 2023-11-15 | Sana Biotechnology, Inc. | Use of cd8-targeted viral vectors |
| EP4320156A1 (en) | 2021-04-09 | 2024-02-14 | Ose Immunotherapeutics | Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains |
| WO2023015217A1 (en) | 2021-08-04 | 2023-02-09 | Sana Biotechnology, Inc. | Use of cd4-targeted viral vectors |
| EP4472646A1 (en) | 2022-02-01 | 2024-12-11 | Sana Biotechnology, Inc. | Cd3-targeted lentiviral vectors and uses thereof |
| CN119110809A (zh) | 2022-02-23 | 2024-12-10 | Xencor股份有限公司 | 抗CD28 x抗PSMA抗体 |
| IL314916A (en) | 2022-03-07 | 2024-10-01 | Novimmune Sa | Bispecific CD28 antibodies for targeted T cell activation |
| CN119095873A (zh) | 2022-03-14 | 2024-12-06 | 拉姆卡普生物伽马股份公司 | 用于靶向杀伤GPC3阳性恶性细胞的双特异性GPC3xCD28和GPC3xCD3抗体及其组合 |
| US20250222027A1 (en) | 2022-04-01 | 2025-07-10 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
| TW202405015A (zh) * | 2022-04-11 | 2024-02-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 特異性結合ｐｓｍａ和ｃｄ２８的抗原結合分子及其醫藥用途 |
| TW202413416A (zh) * | 2022-04-11 | 2024-04-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 特異性結合ｅｇｆｒ和ｃｄ２８的抗原結合分子及其醫藥用途 |
| JP2025523802A (ja) | 2022-07-13 | 2025-07-25 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 分析物を検出するための弱酸性免疫アッセイ |
| WO2024026377A1 (en) | 2022-07-27 | 2024-02-01 | Sana Biotechnology, Inc. | Methods of transduction using a viral vector and inhibitors of antiviral restriction factors |
| KR20250099774A (ko) | 2022-10-03 | 2025-07-02 | 리제너론 파아마슈티컬스, 인크. | 이중특이적 egfr x cd28 항체를 단독으로 또는 항-pd-1 항체와 조합하여 사용하여 암을 치료하는 방법 |
| WO2024084052A1 (en) | 2022-10-21 | 2024-04-25 | Novimmune Sa | Pd-l1xcd28 bispecific antibodies for immune checkpoint-dependent t cell activation |
| CN121532427A (zh) * | 2023-05-18 | 2026-02-13 | 首尔大学校产学协力团 | 抗cd40l/抗cd28双特异性抗体及其用途 |
| CN121666403A (zh) | 2023-07-10 | 2026-03-13 | 瑞泽恩制药公司 | 双特异性PD-L1xCD28抗体及其使用方法 |
| WO2025026356A1 (zh) * | 2023-07-31 | 2025-02-06 | 百奥泰生物制药股份有限公司 | 靶向肿瘤相关抗原与cd28的双特异性抗体及其应用 |
| CN120647771A (zh) * | 2024-03-15 | 2025-09-16 | 上海鑫湾生物科技有限公司 | 一种激活免疫细胞杀伤肿瘤细胞的融合蛋白及其重组病毒和用途 |
| WO2026078067A1 (en) | 2024-10-08 | 2026-04-16 | Novimmune Sa | Fcrh5 monospecific antibodies and derived fcrh5xcd28 bispecific antibodies and use thereof |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4740461A (en) | 1983-12-27 | 1988-04-26 | Genetics Institute, Inc. | Vectors and methods for transformation of eucaryotic cells |
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| US4959455A (en) | 1986-07-14 | 1990-09-25 | Genetics Institute, Inc. | Primate hematopoietic growth factors IL-3 and pharmaceutical compositions |
| US4912040A (en) | 1986-11-14 | 1990-03-27 | Genetics Institute, Inc. | Eucaryotic expression system |
| US7235641B2 (en) * | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
| WO2005103081A2 (en) | 2004-04-20 | 2005-11-03 | Genmab A/S | Human monoclonal antibodies against cd20 |
| AU2006301492B2 (en) * | 2005-10-11 | 2011-06-09 | Amgen Research (Munich) Gmbh | Compositions comprising cross-species-specific antibodies and uses thereof |
| ES2398076T3 (es) | 2006-06-02 | 2013-03-13 | Regeneron Pharmaceuticals, Inc. | Anticuerpos de alta afinidad contra el receptor de IL-6 humano |
| SI2501817T2 (sl) | 2010-02-08 | 2021-09-30 | Regeneron Pharmaceuticals, Inc. | Miš z navadno lahko verigo |
| LT2794658T (lt) | 2011-12-19 | 2017-05-10 | Synimmune Gmbh | Bispecifinė antikūno molekulė |
| TWI641619B (zh) | 2012-06-25 | 2018-11-21 | 美商再生元醫藥公司 | 抗－ｅｇｆｒ抗體及其用途 |
| US20150203591A1 (en) | 2012-08-02 | 2015-07-23 | Regeneron Pharmaceuticals, Inc. | Mutivalent antigen-binding proteins |
| JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
| TWI682941B (zh) | 2013-02-01 | 2020-01-21 | 美商再生元醫藥公司 | 含嵌合恆定區之抗體 |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| CN104558190B (zh) | 2015-01-06 | 2018-08-10 | 中国药科大学 | 一种全人源靶向EGFR/KDR的IgG样双特异性抗体 |
| JOP20160154B1 (ar) | 2015-07-31 | 2021-08-17 | Regeneron Pharma | أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها |
| LT3353212T (lt) | 2015-09-23 | 2021-12-27 | Regeneron Pharmaceuticals, Inc. | Optimizuoti anti-cd3 bispecifiniai antikūnai ir jų naudojimas |
| MY194596A (en) | 2016-09-23 | 2022-12-06 | Regeneron Pharma | Bi Specific Anti-Muc16-CD3 Antibodies And Anti-Muc16 Drug Conjugates |
| MX2019003325A (es) | 2016-09-23 | 2019-08-05 | Regeneron Pharma | Anticuerpos anti-steap2, conjugados anticuerpo-farmaco, y moleculas de fijacion al antigeno biespecificas que se fijan a steap2 y cd3, y usos de estos. |
| CN106632681B (zh) * | 2016-10-11 | 2017-11-14 | 北京东方百泰生物科技有限公司 | 抗egfr和抗cd3双特异抗体及其应用 |
| MA54540A (fr) * | 2018-12-19 | 2021-10-27 | Regeneron Pharma | Anticorps anti-cd28 x anti-cd22 bispécifiques et leurs utilisations |
| WO2020198009A1 (en) | 2019-03-22 | 2020-10-01 | Regeneron Pharmaceuticals, Inc. | EGFR x CD28 MULTISPECIFIC ANTIBODIES |
-
2020
- 2020-03-20 WO PCT/US2020/023857 patent/WO2020198009A1/en not_active Ceased
- 2020-03-20 MX MX2021011500A patent/MX2021011500A/es unknown
- 2020-03-20 JP JP2021556753A patent/JP7659501B2/ja active Active
- 2020-03-20 MA MA055363A patent/MA55363A/fr unknown
- 2020-03-20 KR KR1020217032287A patent/KR20210142659A/ko active Pending
- 2020-03-20 CN CN202080022975.8A patent/CN113661177B/zh active Active
- 2020-03-20 US US16/825,179 patent/US11912767B2/en active Active
- 2020-03-20 AU AU2020247803A patent/AU2020247803A1/en active Pending
- 2020-03-20 BR BR112021018442A patent/BR112021018442A2/pt unknown
- 2020-03-20 MY MYPI2021005486A patent/MY209363A/en unknown
- 2020-03-20 CA CA3134335A patent/CA3134335A1/en active Pending
- 2020-03-20 PH PH1/2021/552300A patent/PH12021552300A1/en unknown
- 2020-03-20 EP EP20718108.2A patent/EP3941941A1/en active Pending
- 2020-03-20 SG SG11202110341WA patent/SG11202110341WA/en unknown
- 2020-03-20 EA EA202192566A patent/EA202192566A1/ru unknown
-
2021
- 2021-09-19 IL IL286536A patent/IL286536A/en unknown
- 2021-09-21 CL CL2021002446A patent/CL2021002446A1/es unknown
- 2021-10-21 CO CONC2021/0014076A patent/CO2021014076A2/es unknown
-
2023
- 2023-02-07 US US18/165,515 patent/US12415856B2/en active Active
- 2023-09-21 CL CL2023002805A patent/CL2023002805A1/es unknown
-
2024
- 2024-08-08 JP JP2024131936A patent/JP2024160318A/ja active Pending
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