JPWO2020179781A5 - - Google Patents
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- Publication number
- JPWO2020179781A5 JPWO2020179781A5 JP2021504108A JP2021504108A JPWO2020179781A5 JP WO2020179781 A5 JPWO2020179781 A5 JP WO2020179781A5 JP 2021504108 A JP2021504108 A JP 2021504108A JP 2021504108 A JP2021504108 A JP 2021504108A JP WO2020179781 A5 JPWO2020179781 A5 JP WO2020179781A5
- Authority
- JP
- Japan
- Prior art keywords
- thieno
- pyrimido
- diazepine
- diffraction
- dimethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013078 crystal Substances 0.000 claims 14
- HNDGEYCCZGRMTN-UHFFFAOYSA-N thieno[3,2-f:4,5-f]bis[1]benzothiophene Chemical compound S1C2=CC=3SC=CC=3C=C2C2=C1C=C(SC=C1)C1=C2 HNDGEYCCZGRMTN-UHFFFAOYSA-N 0.000 claims 14
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 11
- 238000000634 powder X-ray diffraction Methods 0.000 claims 8
- 238000001069 Raman spectroscopy Methods 0.000 claims 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- -1 5,6,9,10,11,12-hexahydropyrido[4′′,3′′:4′,5′]thieno[2′,3′:4,5]pyrimido[1,2-a ] thieno[3,2-f][1,4]diazepine-4,13-dione monohydrochloride Chemical compound 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000000371 solid-state nuclear magnetic resonance spectroscopy Methods 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019039349 | 2019-03-05 | ||
| JP2019039349 | 2019-03-05 | ||
| PCT/JP2020/008889 WO2020179781A1 (ja) | 2019-03-05 | 2020-03-03 | 五環式化合物の塩およびそれらの結晶 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2020179781A1 JPWO2020179781A1 (https=) | 2020-09-10 |
| JPWO2020179781A5 true JPWO2020179781A5 (https=) | 2023-02-28 |
| JP7508441B2 JP7508441B2 (ja) | 2024-07-01 |
Family
ID=72337486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021504108A Active JP7508441B2 (ja) | 2019-03-05 | 2020-03-03 | 五環式化合物の塩およびそれらの結晶 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11420980B2 (https=) |
| EP (1) | EP3936189A4 (https=) |
| JP (1) | JP7508441B2 (https=) |
| KR (1) | KR102921161B1 (https=) |
| CN (1) | CN113646046B (https=) |
| AU (1) | AU2020233452B2 (https=) |
| BR (1) | BR112021015979A2 (https=) |
| CA (1) | CA3129764A1 (https=) |
| MX (1) | MX2021009774A (https=) |
| TW (2) | TWI870286B (https=) |
| WO (1) | WO2020179781A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020179780A1 (ja) | 2019-03-05 | 2020-09-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 五環式複素環化合物 |
| PT119624A (pt) * | 2024-07-29 | 2026-01-29 | Silva Escada Guilherme | Máquina modular para a dobragem de tubos de pvc |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4187306A (en) * | 1977-07-26 | 1980-02-05 | Bayer Aktiengesellschaft | Benzodiazepine-diones, a process for their production and their use as medicaments |
| DD258234A1 (de) | 1987-03-05 | 1988-07-13 | Univ Leipzig | Verfahren zur herstellung von pyrido/3',2':4,5/thieno/2,3-e/imidazo-/1,2-c/pyrimidinen sowie strukturanaloger -pyrimido/1,2-c/pyrimidine bzw. -1,3-diazepino/1,2-c/pyrimidine |
| RU2117670C1 (ru) | 1988-10-31 | 1998-08-20 | Эйсай Ко., Лтд. | Производные триазоло[1,4]диазепина и способы их получения |
| TW197442B (https=) * | 1990-02-08 | 1993-01-01 | Pfizer | |
| US5621100A (en) * | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | K-252a derivatives for treatment of neurological disorders |
| US5756494A (en) * | 1992-07-24 | 1998-05-26 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
| KR100203456B1 (ko) * | 1995-06-20 | 1999-06-15 | 한승수 | 디하이드로에보디아민-에이치씨1를 유효성분으로 함유하는 알츠하이머병에 의한 치매 치료제 |
| CL2004000348A1 (es) | 1997-04-15 | 2005-01-14 | Cephalon Inc & Kyowa Hakko Kog | Compuesto derivado de estaurosporina bis-n-sustituida, util para potenciar la funcion de neuronas colinergicas, estriadas, del prosencefalo basal y sensoriales. |
| CL2004000352A1 (es) | 1998-05-26 | 2005-05-27 | Cephalon Inc & Kyowa Hakko Kog | Uso de compuestos derivados de estaurosporina para potenciar la funcion de neuronas colinergicas, estriadas, de prosencefalo basal y sensoriales. |
| FR2779652B1 (fr) | 1998-06-15 | 2001-06-08 | Sod Conseils Rech Applic | Utilisation de diazepines pour la preparation de medicaments destines a traiter les etats pathologiques ou les maladies dans lesquels un des recepteurs de la somatostatine est implique |
| US8252520B2 (en) | 2002-10-11 | 2012-08-28 | Taivex Therapeutics Corporation | Methods and compounds for inhibiting Hec1 activity for the treatment of proliferative diseases |
| AU2005299031B2 (en) | 2004-10-20 | 2011-11-10 | F. Hoffmann-La Roche Ag | Halogen substituted benzodiazepine derivatives |
| US9314318B2 (en) * | 2008-08-26 | 2016-04-19 | Zest Ip Holdings, Llc | Dental anchor apparatus and method |
| JP6557441B1 (ja) * | 2017-09-07 | 2019-08-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 五環式化合物 |
| WO2020179780A1 (ja) | 2019-03-05 | 2020-09-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 五環式複素環化合物 |
-
2020
- 2020-03-03 WO PCT/JP2020/008889 patent/WO2020179781A1/ja not_active Ceased
- 2020-03-03 EP EP20766851.8A patent/EP3936189A4/en active Pending
- 2020-03-03 TW TW113114065A patent/TWI870286B/zh active
- 2020-03-03 KR KR1020217025603A patent/KR102921161B1/ko active Active
- 2020-03-03 TW TW109106928A patent/TWI849070B/zh active
- 2020-03-03 BR BR112021015979-7A patent/BR112021015979A2/pt unknown
- 2020-03-03 AU AU2020233452A patent/AU2020233452B2/en active Active
- 2020-03-03 MX MX2021009774A patent/MX2021009774A/es unknown
- 2020-03-03 JP JP2021504108A patent/JP7508441B2/ja active Active
- 2020-03-03 CA CA3129764A patent/CA3129764A1/en active Pending
- 2020-03-03 CN CN202080014060.2A patent/CN113646046B/zh active Active
- 2020-09-15 US US17/021,544 patent/US11420980B2/en active Active
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